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The map label for this gene is dxr

Identifier: 78356170

GI number: 78356170

Start: 1153601

End: 1154824

Strand: Reverse

Name: dxr

Synonym: Dde_1123

Alternate gene names: 78356170

Gene position: 1154824-1153601 (Counterclockwise)

Preceding gene: 78356171

Following gene: 78356169

Centisome position: 30.96

GC content: 61.03

Gene sequence:

>1224_bases
GTGAATGGCTATATATCCCCCCTGCCCGACGCCGCGTGGAACAGCCGTTTTCCGCGTTCACTGGTGCTGCTGGGCAGCAC
CGGTTCCATAGGCACCAGTGCCCTGCGCGTGGTGGAAAGGCAGCCGGAACTTTTCCGCATCACCGCACTGGCAGGCGCCC
GCAATGTGCGTCTGCTGGCACGTCAGGCGGCAGCCTACCGCCCGCCTCATCTGGCAGTCATCAACGGTAACGCTGCCGAT
GAGCTTGCATCGCTGCTGCCCGCCGGATACAGACCGCGCATACATACAGGACAGGAAGGATACGAATTTCTGGCCGCCCT
GCCCGAAGCCGACTGTGTGCTTTCCGCGCAGGTGGGCGCTGCGGGACTGCGCGCCACCGTGGCCGCCGCCCGGGCTGGTA
AAACCATCGCGCTGGCCAACAAAGAATCGCTTGTGCTTGCCGGCGGACTCATCCGCAGGCTGTGCCACGAAACAGGTGCC
TCCGTTCTGCCTGTGGACTCCGAACACAACGCAATCTTTCAGGCGCTGCAGGGCCACGACGCCGCGCAGATGCGGCGCAT
CATCCTCACCGCGTCAGGAGGGCCTTTCCGCGGGCGTGACAGAACGTTTCTGCAATCTGTCACCCGTGAACAGGCCCTGA
ACCATCCCAACTGGAGCATGGGAGCTAAAATATCCATTGACTCGGCAACGCTGATGAACAAAGGGCTGGAGGTCATCGAA
GCCTGCCATCTGTACAACGCTCCGCTGGAAAAGGTGGAAGTGGTGGTACATCCCCAGTCCATCATCCACTCGCTGGTGGA
ATACAACGACGGGTCGCAGATAGCCCACATGGGCACACCCGACATGCGCATAGCCATTGCCTACTGTCTGGGCTGGCCGC
GGGTCATGCATACCGGAGTGGAACCGCTCGACCTGCTGTCAGTGGGCAGCTTGACCTTTGAATCTCCGGACATATCTCTG
TTTCCATGCCTTGAGCTTGCACGGAAGGCATACGCCGGAGGCAACGGTCTGCCTGTGGTCCTGAACGCCGCCAATGAAGT
TGCCGTGGACCTTTTTCTGCAGGGCGCCATCGCCTTTCTGGATATTCCCCGGCTTATCGAAGCGGCCATGCAGGCACACG
ATGCGGCACCGCACCAAAACATGTATGATGAGGTTGAAAGCATCCTCACACTGGATAAGACGACACGACGCGTCACGGCC
GACCTTGCGGGCGCCCGCGGCTAG

Upstream 100 bases:

>100_bases
ACCACACCGGAAGACATTACGCTTATTTTCAACACGCTTACTGCCATAGGCACACGGATTGCCCGGCCGGATGAACATGA
AACAGCAGGAGAATGACGGC

Downstream 100 bases:

>100_bases
ACGCGTTTTCTCCGCGGCCTGCGCCGCGATACTTCGGAACCCGCCTGGATAACCTATATGGTAAGCACTCTTTCCGTCAT
TCTTGTCATCGGCGGACTTA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNGYISPLPDAAWNSRFPRSLVLLGSTGSIGTSALRVVERQPELFRITALAGARNVRLLARQAAAYRPPHLAVINGNAAD
ELASLLPAGYRPRIHTGQEGYEFLAALPEADCVLSAQVGAAGLRATVAAARAGKTIALANKESLVLAGGLIRRLCHETGA
SVLPVDSEHNAIFQALQGHDAAQMRRIILTASGGPFRGRDRTFLQSVTREQALNHPNWSMGAKISIDSATLMNKGLEVIE
ACHLYNAPLEKVEVVVHPQSIIHSLVEYNDGSQIAHMGTPDMRIAIAYCLGWPRVMHTGVEPLDLLSVGSLTFESPDISL
FPCLELARKAYAGGNGLPVVLNAANEVAVDLFLQGAIAFLDIPRLIEAAMQAHDAAPHQNMYDEVESILTLDKTTRRVTA
DLAGARG

Sequences:

>Translated_407_residues
MNGYISPLPDAAWNSRFPRSLVLLGSTGSIGTSALRVVERQPELFRITALAGARNVRLLARQAAAYRPPHLAVINGNAAD
ELASLLPAGYRPRIHTGQEGYEFLAALPEADCVLSAQVGAAGLRATVAAARAGKTIALANKESLVLAGGLIRRLCHETGA
SVLPVDSEHNAIFQALQGHDAAQMRRIILTASGGPFRGRDRTFLQSVTREQALNHPNWSMGAKISIDSATLMNKGLEVIE
ACHLYNAPLEKVEVVVHPQSIIHSLVEYNDGSQIAHMGTPDMRIAIAYCLGWPRVMHTGVEPLDLLSVGSLTFESPDISL
FPCLELARKAYAGGNGLPVVLNAANEVAVDLFLQGAIAFLDIPRLIEAAMQAHDAAPHQNMYDEVESILTLDKTTRRVTA
DLAGARG
>Mature_407_residues
MNGYISPLPDAAWNSRFPRSLVLLGSTGSIGTSALRVVERQPELFRITALAGARNVRLLARQAAAYRPPHLAVINGNAAD
ELASLLPAGYRPRIHTGQEGYEFLAALPEADCVLSAQVGAAGLRATVAAARAGKTIALANKESLVLAGGLIRRLCHETGA
SVLPVDSEHNAIFQALQGHDAAQMRRIILTASGGPFRGRDRTFLQSVTREQALNHPNWSMGAKISIDSATLMNKGLEVIE
ACHLYNAPLEKVEVVVHPQSIIHSLVEYNDGSQIAHMGTPDMRIAIAYCLGWPRVMHTGVEPLDLLSVGSLTFESPDISL
FPCLELARKAYAGGNGLPVVLNAANEVAVDLFLQGAIAFLDIPRLIEAAMQAHDAAPHQNMYDEVESILTLDKTTRRVTA
DLAGARG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=45.7800511508951, Blast_Score=309, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_DESDG (Q313H2)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387619.1
- ProteinModelPortal:   Q313H2
- SMR:   Q313H2
- STRING:   Q313H2
- GeneID:   3755147
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1123
- NMPDR:   fig|207559.3.peg.952
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   GLLPTIE
- ProtClustDB:   PRK05447
- BioCyc:   DDES207559:DDE_1123-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43574; Mature: 43574

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: BINDING 141-141 BINDING 168-168 BINDING 192-192 BINDING 215-215 BINDING 237-237

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGYISPLPDAAWNSRFPRSLVLLGSTGSIGTSALRVVERQPELFRITALAGARNVRLLA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
RQAAAYRPPHLAVINGNAADELASLLPAGYRPRIHTGQEGYEFLAALPEADCVLSAQVGA
HHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCC
AGLRATVAAARAGKTIALANKESLVLAGGLIRRLCHETGASVLPVDSEHNAIFQALQGHD
CHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCC
AAQMRRIILTASGGPFRGRDRTFLQSVTREQALNHPNWSMGAKISIDSATLMNKGLEVIE
HHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHH
ACHLYNAPLEKVEVVVHPQSIIHSLVEYNDGSQIAHMGTPDMRIAIAYCLGWPRVMHTGV
HHHHCCCCHHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHCCC
EPLDLLSVGSLTFESPDISLFPCLELARKAYAGGNGLPVVLNAANEVAVDLFLQGAIAFL
CHHHHHEECCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHH
DIPRLIEAAMQAHDAAPHQNMYDEVESILTLDKTTRRVTADLAGARG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNGYISPLPDAAWNSRFPRSLVLLGSTGSIGTSALRVVERQPELFRITALAGARNVRLLA
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
RQAAAYRPPHLAVINGNAADELASLLPAGYRPRIHTGQEGYEFLAALPEADCVLSAQVGA
HHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCC
AGLRATVAAARAGKTIALANKESLVLAGGLIRRLCHETGASVLPVDSEHNAIFQALQGHD
CHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHCCC
AAQMRRIILTASGGPFRGRDRTFLQSVTREQALNHPNWSMGAKISIDSATLMNKGLEVIE
HHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHH
ACHLYNAPLEKVEVVVHPQSIIHSLVEYNDGSQIAHMGTPDMRIAIAYCLGWPRVMHTGV
HHHHCCCCHHHEEEEECCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCHHHHHCCC
EPLDLLSVGSLTFESPDISLFPCLELARKAYAGGNGLPVVLNAANEVAVDLFLQGAIAFL
CHHHHHEECCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHH
DIPRLIEAAMQAHDAAPHQNMYDEVESILTLDKTTRRVTADLAGARG
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA