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The map label for this gene is hdrA [H]

Identifier: 78356159

GI number: 78356159

Start: 1139687

End: 1141957

Strand: Direct

Name: hdrA [H]

Synonym: Dde_1112

Alternate gene names: 78356159

Gene position: 1139687-1141957 (Clockwise)

Preceding gene: 78356158

Following gene: 78356160

Centisome position: 30.55

GC content: 57.73

Gene sequence:

>2271_bases
ATGGCCAAGAAAATAGGCGTATATTTCGATAAGTCCAACATCGGCGCCGGGCTTGATCTTGACGCGCTTTCCGATGTGGT
GACCGGCAAGTTCGGCGGCTCGTGTCCTGTTGTAAAAGTATTTCCTGTGCTCGGTGCGGAAACCGCCCGTCAGGAAATCC
GTCAGGACATAGCTGAAAATGAACTTGACGGTGTACTCATTATCGGTTCGTCGCCCCGTGTGGACTGGGACCTGTACCGC
TTTGAAGGCGTGACCGTGGAACGCGTTAACCTGCGCGAGCAGGGCGTTCTTGGCTACGGTGCAAAAGTGGAAGCAGGCGA
GGATGCCGAAGCCGACGAAGATCTTTTCAAACTGGCTGCCGACTATGTCCGCATGGGTGTGGTCAAGCTGACCAAAATGG
AAGAAGCCGGCGGCGGCGAAGTGGAAAGCGTGCGCACCATCATGGTGCTGGGTGGCGGATGGACCGGTCTTACCGCGGCT
GTCAATGCGGCCAATTCCGGTTACGATGTGGTGCTGGTGGAAAAGGAAGCCGAACTTGGCGGACGTGCCAAGGGGCTTTT
GAAGACCGTGCCGCTGAAGTATCCCTACACCGATGTGCACGATACGGGCATTGAGCAGAAAATAGCTGCCGTTGAAGGCA
ATGAGCGCATCACTGTGCTTACCTCTGCCAAGGTGCGCAAGGTTTCGGGGCAGCCGGGCCAGTTTACCGCGGTTGTAAAA
ACCAAGGACGGCAATCAGGAAATTCCGGTAGGTGCCATTGTGATGGCCACCGGCTGGCAGCCCATGGATGCCGGTGTCAT
GGCTCCCTTCGGCTATGGAACTCTCGAAGGTGTGGTCACCGCTGCAGAGTTTGAAAAAATGGCCAAGGAAGGCACCCTGA
AAGCCAGAAGAGTAGCTTTCATCCTGAATACCGGCCTTGTGGACGGCGGTGATATTTACACGTCTGTCTGCGATGAAGAA
CCCGCAGAGGCCGCCGCAGCCAAGCCCGAGGCCGAAGACGACGAGCAGACCTCCTACGAGCACAAGGACCTTGAGTCCTT
GCGCCACCTGCCGTACACCAACGCCATCAGCAGCGTTGTGGCTCTGAAGCAGGCAGGCTATGTGTGCGATGCCAGCGAAG
ACGGACAGGCTTTTATCCTGTACGACTCCATGGTGGTGCAGGGCATACACGAGCGCTTCTACAAAGCCGCTCAGGACAAG
CTGGGCGTCATGATGTCCAAGGCCGACATTACCGGTGTCGCACAGGCCGAAGACGGTGGCCTGCTGGTGCGCGCTGCCAA
CACCCTGATGGGTGAAGATGTCGAAATCAGGGTGGACATGGTTGTACTGCCCACCGGTATGGTTCCTTCCACCGCCAAAG
ACCCGGTGGTATGGTTCGATTACCGTCAGGGGCCGAATCTGCCCGACCTTGATCTCTTTGACGGCTATGCCGATTCCAAC
TACATCTGCTTCCCCTACGAAACCCGTCGTACCGGGTTGTACGCCGCAGGCTGCGTCCGTCAGCCCATGATGCTGGACGC
GGCCGAAGAAGATGCCATCGGGGCCACCATGAAGGCCATCCAGTGCATCGAATCGGCCAACCGCGGCATGGCTGTACATC
CCCGTTCGGGCGACCTGTCGTACCCCATATTCAACTTCGTGCGTTGCACCCAGTGCAAACGCTGCACCGAGGAATGTCCG
TTCGGCGCGCTGGACGACGATGAAAAGGGAACGCCGAAGCCCAACTTCAGCCGGTGCCGCCGCTGCGGTACCTGCATGGG
CGCCTGCCCCGAGCGTGTCATTTCGTTCGCCAACTACAACATCGATCAGATCGGTTCCATGATCCGCGAGATCGAAGTTC
CGGACGACATGAACGCCGGCGGTCCCCGCGTTCTCATTCTGGCCTGCGAAAACGACGCCTATCCTGCGCTGGATATGGCC
GCACTTCGCGGGCATCACTGGAGTCCCTACGTGCGTATCATTCCTGTGCGCTGCCTTGGATCGGTTAACGCAATCTGGGT
TGCCGACGCCATGTCAAAGGGTATCGACGGTGTGATGCTGCTGGGCTGCAAGTACGGTGACGATTACCAGTGCCATTTTG
TCAAAGGCTCTGAAATCTGCAACCGCCGCAAGGAAAACATTGCCGAGACGCTCAACCGTCTTGGTGTGGAACCTGAACGC
GTGGAGCAGTACGAAGTCGCCATCGACGAATACGACAAGCTGCCCGGCATGATCGACGAGTTCATGAACATGATCCTTGA
AAAGGGCCCCAACCCGTTCAAGGGTTACTAG

Upstream 100 bases:

>100_bases
CGGCTGTGCCAAAATGCCTCTCGATGTCATGAGATCCGCCCAGTCCGGCACCAGTGCCGCGCTGCAAGCGATTCAAACGG
TGAAGGGGAGGTAGCGAGCA

Downstream 100 bases:

>100_bases
GAGGAGATGGAAGATGGCTCAGCCTGTACGTATCGAACCAGATCTGCAGTTTGTGAAGGAGTTGCAAGCTGTCGGTGGAG
AGTCGCTGAAAAAGTGCTAT

Product: heterodisulfide reductase, iron-sulfur-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 756; Mature: 755

Protein sequence:

>756_residues
MAKKIGVYFDKSNIGAGLDLDALSDVVTGKFGGSCPVVKVFPVLGAETARQEIRQDIAENELDGVLIIGSSPRVDWDLYR
FEGVTVERVNLREQGVLGYGAKVEAGEDAEADEDLFKLAADYVRMGVVKLTKMEEAGGGEVESVRTIMVLGGGWTGLTAA
VNAANSGYDVVLVEKEAELGGRAKGLLKTVPLKYPYTDVHDTGIEQKIAAVEGNERITVLTSAKVRKVSGQPGQFTAVVK
TKDGNQEIPVGAIVMATGWQPMDAGVMAPFGYGTLEGVVTAAEFEKMAKEGTLKARRVAFILNTGLVDGGDIYTSVCDEE
PAEAAAAKPEAEDDEQTSYEHKDLESLRHLPYTNAISSVVALKQAGYVCDASEDGQAFILYDSMVVQGIHERFYKAAQDK
LGVMMSKADITGVAQAEDGGLLVRAANTLMGEDVEIRVDMVVLPTGMVPSTAKDPVVWFDYRQGPNLPDLDLFDGYADSN
YICFPYETRRTGLYAAGCVRQPMMLDAAEEDAIGATMKAIQCIESANRGMAVHPRSGDLSYPIFNFVRCTQCKRCTEECP
FGALDDDEKGTPKPNFSRCRRCGTCMGACPERVISFANYNIDQIGSMIREIEVPDDMNAGGPRVLILACENDAYPALDMA
ALRGHHWSPYVRIIPVRCLGSVNAIWVADAMSKGIDGVMLLGCKYGDDYQCHFVKGSEICNRRKENIAETLNRLGVEPER
VEQYEVAIDEYDKLPGMIDEFMNMILEKGPNPFKGY

Sequences:

>Translated_756_residues
MAKKIGVYFDKSNIGAGLDLDALSDVVTGKFGGSCPVVKVFPVLGAETARQEIRQDIAENELDGVLIIGSSPRVDWDLYR
FEGVTVERVNLREQGVLGYGAKVEAGEDAEADEDLFKLAADYVRMGVVKLTKMEEAGGGEVESVRTIMVLGGGWTGLTAA
VNAANSGYDVVLVEKEAELGGRAKGLLKTVPLKYPYTDVHDTGIEQKIAAVEGNERITVLTSAKVRKVSGQPGQFTAVVK
TKDGNQEIPVGAIVMATGWQPMDAGVMAPFGYGTLEGVVTAAEFEKMAKEGTLKARRVAFILNTGLVDGGDIYTSVCDEE
PAEAAAAKPEAEDDEQTSYEHKDLESLRHLPYTNAISSVVALKQAGYVCDASEDGQAFILYDSMVVQGIHERFYKAAQDK
LGVMMSKADITGVAQAEDGGLLVRAANTLMGEDVEIRVDMVVLPTGMVPSTAKDPVVWFDYRQGPNLPDLDLFDGYADSN
YICFPYETRRTGLYAAGCVRQPMMLDAAEEDAIGATMKAIQCIESANRGMAVHPRSGDLSYPIFNFVRCTQCKRCTEECP
FGALDDDEKGTPKPNFSRCRRCGTCMGACPERVISFANYNIDQIGSMIREIEVPDDMNAGGPRVLILACENDAYPALDMA
ALRGHHWSPYVRIIPVRCLGSVNAIWVADAMSKGIDGVMLLGCKYGDDYQCHFVKGSEICNRRKENIAETLNRLGVEPER
VEQYEVAIDEYDKLPGMIDEFMNMILEKGPNPFKGY
>Mature_755_residues
AKKIGVYFDKSNIGAGLDLDALSDVVTGKFGGSCPVVKVFPVLGAETARQEIRQDIAENELDGVLIIGSSPRVDWDLYRF
EGVTVERVNLREQGVLGYGAKVEAGEDAEADEDLFKLAADYVRMGVVKLTKMEEAGGGEVESVRTIMVLGGGWTGLTAAV
NAANSGYDVVLVEKEAELGGRAKGLLKTVPLKYPYTDVHDTGIEQKIAAVEGNERITVLTSAKVRKVSGQPGQFTAVVKT
KDGNQEIPVGAIVMATGWQPMDAGVMAPFGYGTLEGVVTAAEFEKMAKEGTLKARRVAFILNTGLVDGGDIYTSVCDEEP
AEAAAAKPEAEDDEQTSYEHKDLESLRHLPYTNAISSVVALKQAGYVCDASEDGQAFILYDSMVVQGIHERFYKAAQDKL
GVMMSKADITGVAQAEDGGLLVRAANTLMGEDVEIRVDMVVLPTGMVPSTAKDPVVWFDYRQGPNLPDLDLFDGYADSNY
ICFPYETRRTGLYAAGCVRQPMMLDAAEEDAIGATMKAIQCIESANRGMAVHPRSGDLSYPIFNFVRCTQCKRCTEECPF
GALDDDEKGTPKPNFSRCRRCGTCMGACPERVISFANYNIDQIGSMIREIEVPDDMNAGGPRVLILACENDAYPALDMAA
LRGHHWSPYVRIIPVRCLGSVNAIWVADAMSKGIDGVMLLGCKYGDDYQCHFVKGSEICNRRKENIAETLNRLGVEPERV
EQYEVAIDEYDKLPGMIDEFMNMILEKGPNPFKGY

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 82207; Mature: 82076

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKIGVYFDKSNIGAGLDLDALSDVVTGKFGGSCPVVKVFPVLGAETARQEIRQDIAEN
CCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHC
ELDGVLIIGSSPRVDWDLYRFEGVTVERVNLREQGVLGYGAKVEAGEDAEADEDLFKLAA
CCCEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCEECCCEECCCCCCCCHHHHHHHHH
DYVRMGVVKLTKMEEAGGGEVESVRTIMVLGGGWTGLTAAVNAANSGYDVVLVEKEAELG
HHHHHHHHHEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCCC
GRAKGLLKTVPLKYPYTDVHDTGIEQKIAAVEGNERITVLTSAKVRKVSGQPGQFTAVVK
CCCCCHHHHCCCCCCCCCCCCCCCHHHHEEECCCCEEEEEECCEEEECCCCCCEEEEEEE
TKDGNQEIPVGAIVMATGWQPMDAGVMAPFGYGTLEGVVTAAEFEKMAKEGTLKARRVAF
ECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
ILNTGLVDGGDIYTSVCDEEPAEAAAAKPEAEDDEQTSYEHKDLESLRHLPYTNAISSVV
EEECCCCCCCHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
ALKQAGYVCDASEDGQAFILYDSMVVQGIHERFYKAAQDKLGVMMSKADITGVAQAEDGG
HHHHCCCEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCCCC
LLVRAANTLMGEDVEIRVDMVVLPTGMVPSTAKDPVVWFDYRQGPNLPDLDLFDGYADSN
EEEEEEHHHCCCCEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
YICFPYETRRTGLYAAGCVRQPMMLDAAEEDAIGATMKAIQCIESANRGMAVHPRSGDLS
EEEECCHHCCCCEEEHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCC
YPIFNFVRCTQCKRCTEECPFGALDDDEKGTPKPNFSRCRRCGTCMGACPERVISFANYN
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCC
IDQIGSMIREIEVPDDMNAGGPRVLILACENDAYPALDMAALRGHHWSPYVRIIPVRCLG
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEEECCC
SVNAIWVADAMSKGIDGVMLLGCKYGDDYQCHFVKGSEICNRRKENIAETLNRLGVEPER
CCCEEEEEHHHHCCCCEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHH
VEQYEVAIDEYDKLPGMIDEFMNMILEKGPNPFKGY
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AKKIGVYFDKSNIGAGLDLDALSDVVTGKFGGSCPVVKVFPVLGAETARQEIRQDIAEN
CCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEHHCCHHHHHHHHHHHHHC
ELDGVLIIGSSPRVDWDLYRFEGVTVERVNLREQGVLGYGAKVEAGEDAEADEDLFKLAA
CCCEEEEECCCCCCCEEEEEECCEEEEEECCCCCCCEECCCEECCCCCCCCHHHHHHHHH
DYVRMGVVKLTKMEEAGGGEVESVRTIMVLGGGWTGLTAAVNAANSGYDVVLVEKEAELG
HHHHHHHHHEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEEEECCCCCC
GRAKGLLKTVPLKYPYTDVHDTGIEQKIAAVEGNERITVLTSAKVRKVSGQPGQFTAVVK
CCCCCHHHHCCCCCCCCCCCCCCCHHHHEEECCCCEEEEEECCEEEECCCCCCEEEEEEE
TKDGNQEIPVGAIVMATGWQPMDAGVMAPFGYGTLEGVVTAAEFEKMAKEGTLKARRVAF
ECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
ILNTGLVDGGDIYTSVCDEEPAEAAAAKPEAEDDEQTSYEHKDLESLRHLPYTNAISSVV
EEECCCCCCCHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
ALKQAGYVCDASEDGQAFILYDSMVVQGIHERFYKAAQDKLGVMMSKADITGVAQAEDGG
HHHHCCCEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEECCCCC
LLVRAANTLMGEDVEIRVDMVVLPTGMVPSTAKDPVVWFDYRQGPNLPDLDLFDGYADSN
EEEEEEHHHCCCCEEEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
YICFPYETRRTGLYAAGCVRQPMMLDAAEEDAIGATMKAIQCIESANRGMAVHPRSGDLS
EEEECCHHCCCCEEEHHHHCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCC
YPIFNFVRCTQCKRCTEECPFGALDDDEKGTPKPNFSRCRRCGTCMGACPERVISFANYN
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCC
IDQIGSMIREIEVPDDMNAGGPRVLILACENDAYPALDMAALRGHHWSPYVRIIPVRCLG
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCEEEEEEEECCC
SVNAIWVADAMSKGIDGVMLLGCKYGDDYQCHFVKGSEICNRRKENIAETLNRLGVEPER
CCCEEEEEHHHHCCCCEEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHH
VEQYEVAIDEYDKLPGMIDEFMNMILEKGPNPFKGY
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]