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The map label for this gene is hdrA2 [H]

Identifier: 78356158

GI number: 78356158

Start: 1138442

End: 1139680

Strand: Direct

Name: hdrA2 [H]

Synonym: Dde_1111

Alternate gene names: 78356158

Gene position: 1138442-1139680 (Clockwise)

Preceding gene: 78356157

Following gene: 78356159

Centisome position: 30.52

GC content: 57.63

Gene sequence:

>1239_bases
ATGTCGAACTCCATACTTGTCGTCGGAGGCGGGTTCAGCGGACTTACGGCCGCTCTCGAAGCTGCCGAAGTCGGCTATGA
AGTGTTCATCGTCGAGAAAACCCCATTTCTTGGCGGACGGGTCATGCAGCTCAGTAAATATTTTCCCAAGCTCTGCCCGC
CGTCCTGCGGACTGGAAATCCAGTACCAGCGTATCCGCAACAACCCTAAAATCAAGTTCTTCACTCAGGCCACCGTGCAG
GCGGTCAAAGGTGAAGCCGGCAACTACACCGTAAAGGTTGCCATCAAGCCGCGCCACACCGCACCTTACAGCGCCGACCT
CGGCCTTCTGGCCTCCTCTCTGGAAGGAGAATCAACCAGCGAGTTCGATTTCGGTCTGGCAAAGCGCAAACCTCTGTACC
TCAGCGTTCCTTTCGCTTTCCCCAACAGATACGTGCTCGACAAAGAAGCTCTCACCAAGGCGGATGAGCTGAAAGTGGGC
CGTTCCGTTGCCGTGGACATGAATGAAGCGGCGCGTGAGATAGAGCTGGAAGTCGGCTCCATCGTGCTGGCAACGGGCTG
GAAGCCGTACGATGTGACCCGTCTTACCAATCTGGGTGCCGGGCAGATAGCAAACTGCGTGAGCAACATGCAGCTTGAGC
GTCTTGCCGCATCGGGCGGACCCACCGGCGGTGCCATCCGTCGTCCTTCTGACGGCAAGGCTCCCAAAAAGGTGGCGTTT
GTCCAGTGTGCGGGCTCGCGTGATCAGAATCACCTCAACTACTGTTCCTACATCTGCTGCATGGCTTCGCTCAAGCAGGC
CACCTATGTGCGCGAACAGTACCCCGACGCTGAAGTCACCGTCTATTACATCGACCTGCGCACCCCCGGACGCTATGACA
AGTTCATGCGCAAGGTCCGCGCCGATGAAAAGATCAGCCTTGTCAAAGGCAAGGTGGCCGGCGTGGAGGAAGATGCAGCT
TCCGGCGATGTGATTGTGGAAGTTGAAGACGCCGTGAAGGGTGAAAAGAAAAAGGTGCGGTACGACATGGTTGTGCTGGC
TACCGGCATGCGTCCCACTCTTGCCGACGAAAAGCTGCCCGTTGACGTGCCTGTTGACGAGGACGGCTTCATCGTGGGCG
GAGAGGACAAGGGCATATTTGCTGCCGGCTGTGCCAAAATGCCTCTCGATGTCATGAGATCCGCCCAGTCCGGCACCAGT
GCCGCGCTGCAAGCGATTCAAACGGTGAAGGGGAGGTAG

Upstream 100 bases:

>100_bases
CCCCAGACGGTCTGAGCCGGGGCAGTAAGCGCCGCTTATTGTCTGGGCTTAGGCCGTTTTGATGAAAAAGGCCCTAAAAA
CCGTAGGGAGGATTGCTCCA

Downstream 100 bases:

>100_bases
CGAGCAATGGCCAAGAAAATAGGCGTATATTTCGATAAGTCCAACATCGGCGCCGGGCTTGATCTTGACGCGCTTTCCGA
TGTGGTGACCGGCAAGTTCG

Product: heterodisulfide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSNSILVVGGGFSGLTAALEAAEVGYEVFIVEKTPFLGGRVMQLSKYFPKLCPPSCGLEIQYQRIRNNPKIKFFTQATVQ
AVKGEAGNYTVKVAIKPRHTAPYSADLGLLASSLEGESTSEFDFGLAKRKPLYLSVPFAFPNRYVLDKEALTKADELKVG
RSVAVDMNEAAREIELEVGSIVLATGWKPYDVTRLTNLGAGQIANCVSNMQLERLAASGGPTGGAIRRPSDGKAPKKVAF
VQCAGSRDQNHLNYCSYICCMASLKQATYVREQYPDAEVTVYYIDLRTPGRYDKFMRKVRADEKISLVKGKVAGVEEDAA
SGDVIVEVEDAVKGEKKKVRYDMVVLATGMRPTLADEKLPVDVPVDEDGFIVGGEDKGIFAAGCAKMPLDVMRSAQSGTS
AALQAIQTVKGR

Sequences:

>Translated_412_residues
MSNSILVVGGGFSGLTAALEAAEVGYEVFIVEKTPFLGGRVMQLSKYFPKLCPPSCGLEIQYQRIRNNPKIKFFTQATVQ
AVKGEAGNYTVKVAIKPRHTAPYSADLGLLASSLEGESTSEFDFGLAKRKPLYLSVPFAFPNRYVLDKEALTKADELKVG
RSVAVDMNEAAREIELEVGSIVLATGWKPYDVTRLTNLGAGQIANCVSNMQLERLAASGGPTGGAIRRPSDGKAPKKVAF
VQCAGSRDQNHLNYCSYICCMASLKQATYVREQYPDAEVTVYYIDLRTPGRYDKFMRKVRADEKISLVKGKVAGVEEDAA
SGDVIVEVEDAVKGEKKKVRYDMVVLATGMRPTLADEKLPVDVPVDEDGFIVGGEDKGIFAAGCAKMPLDVMRSAQSGTS
AALQAIQTVKGR
>Mature_411_residues
SNSILVVGGGFSGLTAALEAAEVGYEVFIVEKTPFLGGRVMQLSKYFPKLCPPSCGLEIQYQRIRNNPKIKFFTQATVQA
VKGEAGNYTVKVAIKPRHTAPYSADLGLLASSLEGESTSEFDFGLAKRKPLYLSVPFAFPNRYVLDKEALTKADELKVGR
SVAVDMNEAAREIELEVGSIVLATGWKPYDVTRLTNLGAGQIANCVSNMQLERLAASGGPTGGAIRRPSDGKAPKKVAFV
QCAGSRDQNHLNYCSYICCMASLKQATYVREQYPDAEVTVYYIDLRTPGRYDKFMRKVRADEKISLVKGKVAGVEEDAAS
GDVIVEVEDAVKGEKKKVRYDMVVLATGMRPTLADEKLPVDVPVDEDGFIVGGEDKGIFAAGCAKMPLDVMRSAQSGTSA
ALQAIQTVKGR

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 44565; Mature: 44433

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSILVVGGGFSGLTAALEAAEVGYEVFIVEKTPFLGGRVMQLSKYFPKLCPPSCGLEI
CCCCEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEE
QYQRIRNNPKIKFFTQATVQAVKGEAGNYTVKVAIKPRHTAPYSADLGLLASSLEGESTS
EEHHHCCCCCEEEEEHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCC
EFDFGLAKRKPLYLSVPFAFPNRYVLDKEALTKADELKVGRSVAVDMNEAAREIELEVGS
CCCCCCCCCCCEEEECCCCCCCCEEECHHHHCCHHHHCCCCEEEEEHHHHHHEEEEEECE
IVLATGWKPYDVTRLTNLGAGQIANCVSNMQLERLAASGGPTGGAIRRPSDGKAPKKVAF
EEEECCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
VQCAGSRDQNHLNYCSYICCMASLKQATYVREQYPDAEVTVYYIDLRTPGRYDKFMRKVR
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHC
ADEKISLVKGKVAGVEEDAASGDVIVEVEDAVKGEKKKVRYDMVVLATGMRPTLADEKLP
CCCCEEEEECCCCCCCCCCCCCCEEEEEHHHCCCCCHHEEEEEEEEEECCCCCCCCCCCC
VDVPVDEDGFIVGGEDKGIFAAGCAKMPLDVMRSAQSGTSAALQAIQTVKGR
EECCCCCCCEEECCCCCCEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNSILVVGGGFSGLTAALEAAEVGYEVFIVEKTPFLGGRVMQLSKYFPKLCPPSCGLEI
CCCEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEE
QYQRIRNNPKIKFFTQATVQAVKGEAGNYTVKVAIKPRHTAPYSADLGLLASSLEGESTS
EEHHHCCCCCEEEEEHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHCCCCCCC
EFDFGLAKRKPLYLSVPFAFPNRYVLDKEALTKADELKVGRSVAVDMNEAAREIELEVGS
CCCCCCCCCCCEEEECCCCCCCCEEECHHHHCCHHHHCCCCEEEEEHHHHHHEEEEEECE
IVLATGWKPYDVTRLTNLGAGQIANCVSNMQLERLAASGGPTGGAIRRPSDGKAPKKVAF
EEEECCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEE
VQCAGSRDQNHLNYCSYICCMASLKQATYVREQYPDAEVTVYYIDLRTPGRYDKFMRKVR
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHC
ADEKISLVKGKVAGVEEDAASGDVIVEVEDAVKGEKKKVRYDMVVLATGMRPTLADEKLP
CCCCEEEEECCCCCCCCCCCCCCEEEEEHHHCCCCCHHEEEEEEEEEECCCCCCCCCCCC
VDVPVDEDGFIVGGEDKGIFAAGCAKMPLDVMRSAQSGTSAALQAIQTVKGR
EECCCCCCCEEECCCCCCEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]