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The map label for this gene is pepP [H]

Identifier: 78355858

GI number: 78355858

Start: 830759

End: 832174

Strand: Reverse

Name: pepP [H]

Synonym: Dde_0811

Alternate gene names: 78355858

Gene position: 832174-830759 (Counterclockwise)

Preceding gene: 78355859

Following gene: 78355857

Centisome position: 22.31

GC content: 63.21

Gene sequence:

>1416_bases
ATGCACTACCGCACGTTATTCGACACCGGCACATACGTACAGCGCCGTTCCGCGCTGCTGAGCGACCTTTCGGCCCGCAC
AGGCGGCATCGTGCTGCTGCCCGGCCACACGGAATCTCCCGTCAACTATCCCGACAACTGCTATCCCTTCCGTCAGGACA
GCACGTTTCTTTACTTTTTCGGCCACGATGTTCCGGACATGGCGGGCACGCTGGATCTGGACTCCGGCGAAGTCATGCTG
TGGGGAACGGACGCCACCATGGACGACATCATCTGGACCGGTCCGGTTCCTGCCATGGCAGAAAGGGCTGAACGCTGCGG
CGCGGCATGGGGCGGAGACGCCACCGCTCTTATGGCCTACGTCGGGGGGGCCGCAAGCAGCGGCAGGACCATACATTATC
TGCCCCCCTACCGCGCAGAAACACGCGAACTGCTGACCAGACTCACCGGCATTGCCGGCAGCGACCTGCCGCGGCGGGTA
TCGCAGCCGCTTACCGGGGCAGTGGTGACGCTGCGCAGCGTGAAAACCGCGGAGGAAGTGGCGGAAATAGAGTCGGCACT
GGCAATCAGCCATGAAATGTACATGACAGCCATGCGCACAGTGCGCCCCGGCATGACCGAACGCGCCCTGTGCGGAACCC
TGCAGGGCATCGCCGCCTCGGCAGGGTCCGGCATGCATTCCTTCCGCACCATTCTCACCGTGCGCGGCGAAACCCTGCAC
AACCACGGGCACGCCTGCACCATGCAGGACGGCGACCTGTTGCTCATCGATTCCGGTGCCGAATCGCTGCGGCGCTACGC
TTCGGACATCACGCGCACGCTGCCTGTCTCCGGCCGGTTCGGCGGCAGGCAAAAGGCAATATATGAAACAGTGCTCAACG
CCCAGCTGGCGGGCATAGCCCGCGCCACCGCCGGCAGGCGCTTTCTGGATGCACATCTGGCCGCGGCACAGGTGATGGTG
GAAGGGCTGAAGGAAGCCGGCATAATGAAAGGCAACACGCAGGATGCCGTGGCCGAAGGAGCCCATGCCCTGTTTTTCCC
GCACGGGCTCGGACACATGATGGGTCTGGACGTGCACGACATGGAACATCTGGGTGAAGACAACGCCGGCTACGCCGGCG
AGGTGGAGCGGTCACGCCAGTTCGGACTGCGCGGTCTGCGGCTGGCCCGCACCCTGCACGAAGGCTTTGTGCTCACCGTG
GAACCGGGAGTGTACTTCATACCCGACCTCATAGCCCGCTGGACAGGAGAACGGCGCTGCGCCGACTTCATATGTTATGA
CAGGCTGCACGAATGGAGCGGTTTTGGCGGCATACGCATAGAGGATGACGTGCTGGTGACTGCCGGAGGACCGCAGGTGC
TGGGCAGACCCATTCCCAAAACCGTACGCGAAATCGAAGAAGCCATGCGCGGATAA

Upstream 100 bases:

>100_bases
CTGAAGTACCGTACCGTTCCGCCCGTGTCGCGCGGCTTGACTTCCCGGACGCCGTGGCGCACTCACATGTGTGCAACCAC
CTTCCGCTCAAGGAGAACTC

Downstream 100 bases:

>100_bases
CCCGCGGCGGATATTATGCATACCATAAGGGACTCCGGTCCCTTTTTTATTTATCCGCCGGTTACTGCAAACCGCTGTCT
GATATCCCTTGCGGCACAGA

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MHYRTLFDTGTYVQRRSALLSDLSARTGGIVLLPGHTESPVNYPDNCYPFRQDSTFLYFFGHDVPDMAGTLDLDSGEVML
WGTDATMDDIIWTGPVPAMAERAERCGAAWGGDATALMAYVGGAASSGRTIHYLPPYRAETRELLTRLTGIAGSDLPRRV
SQPLTGAVVTLRSVKTAEEVAEIESALAISHEMYMTAMRTVRPGMTERALCGTLQGIAASAGSGMHSFRTILTVRGETLH
NHGHACTMQDGDLLLIDSGAESLRRYASDITRTLPVSGRFGGRQKAIYETVLNAQLAGIARATAGRRFLDAHLAAAQVMV
EGLKEAGIMKGNTQDAVAEGAHALFFPHGLGHMMGLDVHDMEHLGEDNAGYAGEVERSRQFGLRGLRLARTLHEGFVLTV
EPGVYFIPDLIARWTGERRCADFICYDRLHEWSGFGGIRIEDDVLVTAGGPQVLGRPIPKTVREIEEAMRG

Sequences:

>Translated_471_residues
MHYRTLFDTGTYVQRRSALLSDLSARTGGIVLLPGHTESPVNYPDNCYPFRQDSTFLYFFGHDVPDMAGTLDLDSGEVML
WGTDATMDDIIWTGPVPAMAERAERCGAAWGGDATALMAYVGGAASSGRTIHYLPPYRAETRELLTRLTGIAGSDLPRRV
SQPLTGAVVTLRSVKTAEEVAEIESALAISHEMYMTAMRTVRPGMTERALCGTLQGIAASAGSGMHSFRTILTVRGETLH
NHGHACTMQDGDLLLIDSGAESLRRYASDITRTLPVSGRFGGRQKAIYETVLNAQLAGIARATAGRRFLDAHLAAAQVMV
EGLKEAGIMKGNTQDAVAEGAHALFFPHGLGHMMGLDVHDMEHLGEDNAGYAGEVERSRQFGLRGLRLARTLHEGFVLTV
EPGVYFIPDLIARWTGERRCADFICYDRLHEWSGFGGIRIEDDVLVTAGGPQVLGRPIPKTVREIEEAMRG
>Mature_471_residues
MHYRTLFDTGTYVQRRSALLSDLSARTGGIVLLPGHTESPVNYPDNCYPFRQDSTFLYFFGHDVPDMAGTLDLDSGEVML
WGTDATMDDIIWTGPVPAMAERAERCGAAWGGDATALMAYVGGAASSGRTIHYLPPYRAETRELLTRLTGIAGSDLPRRV
SQPLTGAVVTLRSVKTAEEVAEIESALAISHEMYMTAMRTVRPGMTERALCGTLQGIAASAGSGMHSFRTILTVRGETLH
NHGHACTMQDGDLLLIDSGAESLRRYASDITRTLPVSGRFGGRQKAIYETVLNAQLAGIARATAGRRFLDAHLAAAQVMV
EGLKEAGIMKGNTQDAVAEGAHALFFPHGLGHMMGLDVHDMEHLGEDNAGYAGEVERSRQFGLRGLRLARTLHEGFVLTV
EPGVYFIPDLIARWTGERRCADFICYDRLHEWSGFGGIRIEDDVLVTAGGPQVLGRPIPKTVREIEEAMRG

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=466, Percent_Identity=32.8326180257511, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI260593665, Length=330, Percent_Identity=37.8787878787879, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI260593663, Length=461, Percent_Identity=31.236442516269, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI11559925, Length=485, Percent_Identity=27.2164948453608, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789275, Length=469, Percent_Identity=28.997867803838, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790282, Length=291, Percent_Identity=29.8969072164948, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788728, Length=299, Percent_Identity=29.0969899665552, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508215, Length=473, Percent_Identity=32.5581395348837, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71989583, Length=303, Percent_Identity=24.4224422442244, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321118, Length=421, Percent_Identity=28.5035629453682, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320922, Length=451, Percent_Identity=24.6119733924612, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357079, Length=476, Percent_Identity=31.5126050420168, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI19920384, Length=436, Percent_Identity=23.394495412844, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 51181; Mature: 51181

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYRTLFDTGTYVQRRSALLSDLSARTGGIVLLPGHTESPVNYPDNCYPFRQDSTFLYFF
CCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
GHDVPDMAGTLDLDSGEVMLWGTDATMDDIIWTGPVPAMAERAERCGAAWGGDATALMAY
CCCCCCCCCEEECCCCCEEEEECCCCHHCEEECCCCHHHHHHHHHCCCCCCCCHHHHHHH
VGGAASSGRTIHYLPPYRAETRELLTRLTGIAGSDLPRRVSQPLTGAVVTLRSVKTAEEV
HCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
AEIESALAISHEMYMTAMRTVRPGMTERALCGTLQGIAASAGSGMHSFRTILTVRGETLH
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCHHH
NHGHACTMQDGDLLLIDSGAESLRRYASDITRTLPVSGRFGGRQKAIYETVLNAQLAGIA
CCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
RATAGRRFLDAHLAAAQVMVEGLKEAGIMKGNTQDAVAEGAHALFFPHGLGHMMGLDVHD
HHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEECCCCHHHHCCCHHH
MEHLGEDNAGYAGEVERSRQFGLRGLRLARTLHEGFVLTVEPGVYFIPDLIARWTGERRC
HHHCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCHHH
ADFICYDRLHEWSGFGGIRIEDDVLVTAGGPQVLGRPIPKTVREIEEAMRG
HHHHHHHHHHHHCCCCCEEEECCEEEECCCHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MHYRTLFDTGTYVQRRSALLSDLSARTGGIVLLPGHTESPVNYPDNCYPFRQDSTFLYFF
CCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
GHDVPDMAGTLDLDSGEVMLWGTDATMDDIIWTGPVPAMAERAERCGAAWGGDATALMAY
CCCCCCCCCEEECCCCCEEEEECCCCHHCEEECCCCHHHHHHHHHCCCCCCCCHHHHHHH
VGGAASSGRTIHYLPPYRAETRELLTRLTGIAGSDLPRRVSQPLTGAVVTLRSVKTAEEV
HCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
AEIESALAISHEMYMTAMRTVRPGMTERALCGTLQGIAASAGSGMHSFRTILTVRGETLH
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCHHH
NHGHACTMQDGDLLLIDSGAESLRRYASDITRTLPVSGRFGGRQKAIYETVLNAQLAGIA
CCCCEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
RATAGRRFLDAHLAAAQVMVEGLKEAGIMKGNTQDAVAEGAHALFFPHGLGHMMGLDVHD
HHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEECCCCHHHHCCCHHH
MEHLGEDNAGYAGEVERSRQFGLRGLRLARTLHEGFVLTVEPGVYFIPDLIARWTGERRC
HHHCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCCHHH
ADFICYDRLHEWSGFGGIRIEDDVLVTAGGPQVLGRPIPKTVREIEEAMRG
HHHHHHHHHHHHCCCCCEEEECCEEEECCCHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]