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The map label for this gene is polC [H]

Identifier: 78355675

GI number: 78355675

Start: 647281

End: 648000

Strand: Reverse

Name: polC [H]

Synonym: Dde_0628

Alternate gene names: 78355675

Gene position: 648000-647281 (Counterclockwise)

Preceding gene: 78355676

Following gene: 78355674

Centisome position: 17.37

GC content: 62.22

Gene sequence:

>720_bases
ATGGGAATACGCTCGTTATTGCGCAGCCTGCGCCACAGACCGCCGCTGCATCCTGCCCTGCAGCGCAACAGAAGCGCATT
TGCCGACTTCAATCAGGATATACCGCTTGAAGACTGCGAATTTGCGGTGACAGACATGGAAATGACAGGGCTTGACCCCG
AGCATGACGAAATTGTCGCCATTGGTGCCGTGCGCATCCGCGGTCTGTCCATCATCACCGGCGACGTGTTTCACACCTAT
GTCAGGCCGCAGCGCTCCATGGCCCGTCCGGCCACGCTCATCCACCGCATCACACCGGCGCAGCTGCAGCACAGCCCGGC
ACTGGCCGGTCTGCTGCCCGGCTTTGTGGACTGGTGCGGACAGGCGCTGATTACCGGCCACCACGTGGGGCTGGACATGG
GCTTTCTGACACGGGCGTGCAGACGGCATCTGGGCGGCGCCCCGGCCACCCCCTGTGTGGATACCATGCGGCTGGCGCAG
GCATGGGAGCGTGAACGCTGGGAGCGGTCTTTCGATCCTTTTCAGCCCACGGTGTCATATACCCTTGCCGATCTTTCCGC
CCGATACGGTCTGCCGCAGTTCCGCGCACACGACGCGCTGGAAGACGCCCTGCAGACCGCCTATCTTTTTCTGTATCTTG
TGCGTAAACTGAAAGGCGGCGGCATAACCACGCTGCGCGGGCTGCATGCCGCCGGAAGAAGCTGGCGCTGGTATCTGTAA

Upstream 100 bases:

>100_bases
CGAGCGGCTGCAGGCATTCACCCGGCAACGTTTCAAGCTGGATGTGTCCTGAAAGTTCTGTGCACGCAGCAGGCGTGTAC
AGCTATCCGGAGAAGTTATT

Downstream 100 bases:

>100_bases
CATCCCCGCCCGCGCCGGAAGCACTGCCTCTGCCGCGTGCCGCAAAGCGGCATAATTGACCCTGCCGCCGGTTTGCCGTA
TCTCCAGACGCATCATTTTG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MGIRSLLRSLRHRPPLHPALQRNRSAFADFNQDIPLEDCEFAVTDMEMTGLDPEHDEIVAIGAVRIRGLSIITGDVFHTY
VRPQRSMARPATLIHRITPAQLQHSPALAGLLPGFVDWCGQALITGHHVGLDMGFLTRACRRHLGGAPATPCVDTMRLAQ
AWERERWERSFDPFQPTVSYTLADLSARYGLPQFRAHDALEDALQTAYLFLYLVRKLKGGGITTLRGLHAAGRSWRWYL

Sequences:

>Translated_239_residues
MGIRSLLRSLRHRPPLHPALQRNRSAFADFNQDIPLEDCEFAVTDMEMTGLDPEHDEIVAIGAVRIRGLSIITGDVFHTY
VRPQRSMARPATLIHRITPAQLQHSPALAGLLPGFVDWCGQALITGHHVGLDMGFLTRACRRHLGGAPATPCVDTMRLAQ
AWERERWERSFDPFQPTVSYTLADLSARYGLPQFRAHDALEDALQTAYLFLYLVRKLKGGGITTLRGLHAAGRSWRWYL
>Mature_238_residues
GIRSLLRSLRHRPPLHPALQRNRSAFADFNQDIPLEDCEFAVTDMEMTGLDPEHDEIVAIGAVRIRGLSIITGDVFHTYV
RPQRSMARPATLIHRITPAQLQHSPALAGLLPGFVDWCGQALITGHHVGLDMGFLTRACRRHLGGAPATPCVDTMRLAQA
WERERWERSFDPFQPTVSYTLADLSARYGLPQFRAHDALEDALQTAYLFLYLVRKLKGGGITTLRGLHAAGRSWRWYL

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 26888; Mature: 26757

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRSLLRSLRHRPPLHPALQRNRSAFADFNQDIPLEDCEFAVTDMEMTGLDPEHDEIVA
CCHHHHHHHHHCCCCCCHHHHHCHHHHHCCCCCCCCCCCCEEEECCEECCCCCCCCCEEE
IGAVRIRGLSIITGDVFHTYVRPQRSMARPATLIHRITPAQLQHSPALAGLLPGFVDWCG
EEHHHCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHH
QALITGHHVGLDMGFLTRACRRHLGGAPATPCVDTMRLAQAWERERWERSFDPFQPTVSY
HHHHCCHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TLADLSARYGLPQFRAHDALEDALQTAYLFLYLVRKLKGGGITTLRGLHAAGRSWRWYL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GIRSLLRSLRHRPPLHPALQRNRSAFADFNQDIPLEDCEFAVTDMEMTGLDPEHDEIVA
CHHHHHHHHHCCCCCCHHHHHCHHHHHCCCCCCCCCCCCEEEECCEECCCCCCCCCEEE
IGAVRIRGLSIITGDVFHTYVRPQRSMARPATLIHRITPAQLQHSPALAGLLPGFVDWCG
EEHHHCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHH
QALITGHHVGLDMGFLTRACRRHLGGAPATPCVDTMRLAQAWERERWERSFDPFQPTVSY
HHHHCCHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
TLADLSARYGLPQFRAHDALEDALQTAYLFLYLVRKLKGGGITTLRGLHAAGRSWRWYL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9826752; 10360571 [H]