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The map label for this gene is capD [H]

Identifier: 78355407

GI number: 78355407

Start: 348717

End: 350666

Strand: Reverse

Name: capD [H]

Synonym: Dde_0360

Alternate gene names: 78355407

Gene position: 350666-348717 (Counterclockwise)

Preceding gene: 78355408

Following gene: 78355405

Centisome position: 9.4

GC content: 59.79

Gene sequence:

>1950_bases
ATGCGAATAGCACTGCGCACCGCCAACTTCTACATCATGATGTGCGTGGACCTGCTGTGCTTTGCAGCCGCGCTGTACGC
CGCCTATATGCTGCGGTTCGACTTTTCCATTCCCTATCTGCATGTCGAACGCATGAAAGGACTGCTGCCATGGGTACTGC
CCATGAAGCTCGCCGTGTTCGTGGTATTTTCCATGTACCGCGGCATGTGGCGCTACACCAGCCTGCGCGACTCCATACTG
CTGCTGCGCGCCGCAAGCGTGCAGAGCCTGCTTGTCATCGCAGGGGTGGCATACCTTACCGGATTTGCGGGCTATTCACG
CGCCGTCTTCGGCATGGACTTTCTGCTTACCTTTCTGTTCACCGGCGGCGCGCGTCTGGGTATCCGCATTCTGTTCTCCC
TGCGCGAGACAGGGCGCTTCTGGCTGCCCATGACGGGCCGCACCGCGCGCAAGGGAGCCAGAAGGGTCATCATAATCGGC
GCCGGCAGAGCCGGAGAACGGCTGGTCAGCGAACTGAACCGTGATGTGTCGCTGGGCTACTTCCCCGTGGGGTTCGTGGA
CAACAACCCCGCCCTGAAAGGCAGAACCATCCACGGCCGTCCCGTCATGGGCACGCTGGACCGCCTGCCCGAAGCCATTG
TCTCCACCCGTGCCGAAGAACTGCTCATCGCCCTTACGGAAGCTTCTTCCGAGCAGGTGCGCCACATAGTGCAGGCCTGT
TCGGAAACGGGTCTGCCCTGCAAAATACTGCCGCCCATGAACGAAATTCTGGATTTCAAACGCGGCATAAAAAACATGCG
CGAGGTCAACTACCTCGACCTGCTGGGCCGGTCGCCGGTGGAACTGGATACCGGAGCCATCAGCCGCTACCTGCAGGGCA
AATGCATTCTGGTCACCGGCTGCGGCGGCTCCATAGGATCAGAGCTGGTCAGGCAGATTATCCGGTATGCTCCCGCCCGT
CTGGTGCTGGTGGATGCCAGCGAATTCAATCTGTATAAAATACAGATGGATCTTGAACACGTACACGGCTTTCACGACTA
TGTGGCCATACTGGGCAATATCCGCGATGCCCACCTGATGCGCACCACATTTGCCGCACACAAACCAGAGGCTGTCTTCC
ACGCCGCGGCGTACAAGCATGTGCCCATGCTTGAGCGTAACCCGTGGCAGGCCGTGCAGAACAATATTCTGGGCACCCAG
ACACTCATGCAGGCCGCCCACGATGCCGGAGTGCAGCGTTTTGTGGTGGTCTCCACCGACAAGGCGGTACGCCCCACCAA
CGTCATGGGGGCTTCCAAGCGGGTAACAGAACTGCTCATGCGCAGGTTCTCCGGCAGTTCCACACGGTTTATGGCCGTGC
GCTTCGGCAATGTGGTCGGGTCGTCCGGCTCCGTTGTGCCGCTGTTTCTCGACCAGATTGCCAGAGGCGGCCCCGTCACG
GTCACGCATCCCGAAGTAACCCGATACTTCATGTCCATTGCCGAAGCCGCGCAGCTTATTCTGCAGGCGGGCACCATGGC
GCAGGGCGGCGAGATATTTGTGCTGGATATGGGGGTACCTGTCAAAATAGCAGATATGGCCAAAGACCTTATCCGCCTTG
CCGGACTGGAACCCGAAGTGGATATTCCCATTGTCTTCACCGGCCTGCGCGAAGGTGAAAAACTGTACGAAGAGCTGATT
ACCGCTGACGAAGGCGTGGTGCGCACCGAGCATGACAAGATTATGGTGCTGCGCTGCTGTGACAGCGCCCAGATATCTGA
AAGCGCCCTGCAGACTCTGGAACAGGGCCTGCAACAGGCCGTGCAGGCAGCACAGGCGCACGACGGTGCAGCAGTGCGCA
GAGCGCTGCATGTGCTGGTGCCCGAATACACCGAAGTTGAACATACGCACACAGAGACCGGCGCGTCTGGCGCGCCGGAA
CCTGCCGCACTCCGGCCGGAACCTGCGTGA

Upstream 100 bases:

>100_bases
TCTTCCACACCGGTCTGTGCCTGCCTTCGGGTACCGCCATGACCGGACAAGACCTGACCCGCGTAACGGATGCCATCCTG
CGCGCGCTTGACGGACAGCC

Downstream 100 bases:

>100_bases
CGTTCGCTGCCCCGCAGATAAAACAAACGGCCCCGGCATGACGCCGGGGCCGCTTTTTTATGATCATGAAATATAAAAAA
ATATCACACTTTGCCCGCAA

Product: lipopolysaccharide biosynthesis protein (WbpM)-like

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MRIALRTANFYIMMCVDLLCFAAALYAAYMLRFDFSIPYLHVERMKGLLPWVLPMKLAVFVVFSMYRGMWRYTSLRDSIL
LLRAASVQSLLVIAGVAYLTGFAGYSRAVFGMDFLLTFLFTGGARLGIRILFSLRETGRFWLPMTGRTARKGARRVIIIG
AGRAGERLVSELNRDVSLGYFPVGFVDNNPALKGRTIHGRPVMGTLDRLPEAIVSTRAEELLIALTEASSEQVRHIVQAC
SETGLPCKILPPMNEILDFKRGIKNMREVNYLDLLGRSPVELDTGAISRYLQGKCILVTGCGGSIGSELVRQIIRYAPAR
LVLVDASEFNLYKIQMDLEHVHGFHDYVAILGNIRDAHLMRTTFAAHKPEAVFHAAAYKHVPMLERNPWQAVQNNILGTQ
TLMQAAHDAGVQRFVVVSTDKAVRPTNVMGASKRVTELLMRRFSGSSTRFMAVRFGNVVGSSGSVVPLFLDQIARGGPVT
VTHPEVTRYFMSIAEAAQLILQAGTMAQGGEIFVLDMGVPVKIADMAKDLIRLAGLEPEVDIPIVFTGLREGEKLYEELI
TADEGVVRTEHDKIMVLRCCDSAQISESALQTLEQGLQQAVQAAQAHDGAAVRRALHVLVPEYTEVEHTHTETGASGAPE
PAALRPEPA

Sequences:

>Translated_649_residues
MRIALRTANFYIMMCVDLLCFAAALYAAYMLRFDFSIPYLHVERMKGLLPWVLPMKLAVFVVFSMYRGMWRYTSLRDSIL
LLRAASVQSLLVIAGVAYLTGFAGYSRAVFGMDFLLTFLFTGGARLGIRILFSLRETGRFWLPMTGRTARKGARRVIIIG
AGRAGERLVSELNRDVSLGYFPVGFVDNNPALKGRTIHGRPVMGTLDRLPEAIVSTRAEELLIALTEASSEQVRHIVQAC
SETGLPCKILPPMNEILDFKRGIKNMREVNYLDLLGRSPVELDTGAISRYLQGKCILVTGCGGSIGSELVRQIIRYAPAR
LVLVDASEFNLYKIQMDLEHVHGFHDYVAILGNIRDAHLMRTTFAAHKPEAVFHAAAYKHVPMLERNPWQAVQNNILGTQ
TLMQAAHDAGVQRFVVVSTDKAVRPTNVMGASKRVTELLMRRFSGSSTRFMAVRFGNVVGSSGSVVPLFLDQIARGGPVT
VTHPEVTRYFMSIAEAAQLILQAGTMAQGGEIFVLDMGVPVKIADMAKDLIRLAGLEPEVDIPIVFTGLREGEKLYEELI
TADEGVVRTEHDKIMVLRCCDSAQISESALQTLEQGLQQAVQAAQAHDGAAVRRALHVLVPEYTEVEHTHTETGASGAPE
PAALRPEPA
>Mature_649_residues
MRIALRTANFYIMMCVDLLCFAAALYAAYMLRFDFSIPYLHVERMKGLLPWVLPMKLAVFVVFSMYRGMWRYTSLRDSIL
LLRAASVQSLLVIAGVAYLTGFAGYSRAVFGMDFLLTFLFTGGARLGIRILFSLRETGRFWLPMTGRTARKGARRVIIIG
AGRAGERLVSELNRDVSLGYFPVGFVDNNPALKGRTIHGRPVMGTLDRLPEAIVSTRAEELLIALTEASSEQVRHIVQAC
SETGLPCKILPPMNEILDFKRGIKNMREVNYLDLLGRSPVELDTGAISRYLQGKCILVTGCGGSIGSELVRQIIRYAPAR
LVLVDASEFNLYKIQMDLEHVHGFHDYVAILGNIRDAHLMRTTFAAHKPEAVFHAAAYKHVPMLERNPWQAVQNNILGTQ
TLMQAAHDAGVQRFVVVSTDKAVRPTNVMGASKRVTELLMRRFSGSSTRFMAVRFGNVVGSSGSVVPLFLDQIARGGPVT
VTHPEVTRYFMSIAEAAQLILQAGTMAQGGEIFVLDMGVPVKIADMAKDLIRLAGLEPEVDIPIVFTGLREGEKLYEELI
TADEGVVRTEHDKIMVLRCCDSAQISESALQTLEQGLQQAVQAAQAHDGAAVRRALHVLVPEYTEVEHTHTETGASGAPE
PAALRPEPA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=266, Percent_Identity=25.9398496240602, Blast_Score=87, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 71531; Mature: 71531

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIALRTANFYIMMCVDLLCFAAALYAAYMLRFDFSIPYLHVERMKGLLPWVLPMKLAVF
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCHHHHHHHHHHH
VVFSMYRGMWRYTSLRDSILLLRAASVQSLLVIAGVAYLTGFAGYSRAVFGMDFLLTFLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGGARLGIRILFSLRETGRFWLPMTGRTARKGARRVIIIGAGRAGERLVSELNRDVSLGY
HCCCHHHHHHHEEHHHCCCEEEECCCCHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCE
FPVGFVDNNPALKGRTIHGRPVMGTLDRLPEAIVSTRAEELLIALTEASSEQVRHIVQAC
EEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHHCHHHHEEEECCCCHHHHHHHHHHH
SETGLPCKILPPMNEILDFKRGIKNMREVNYLDLLGRSPVELDTGAISRYLQGKCILVTG
HCCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHCCCEEEEEC
CGGSIGSELVRQIIRYAPARLVLVDASEFNLYKIQMDLEHVHGFHDYVAILGNIRDAHLM
CCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEEHHHHCCHHHHHHHHHCCCHHHHH
RTTFAAHKPEAVFHAAAYKHVPMLERNPWQAVQNNILGTQTLMQAAHDAGVQRFVVVSTD
HHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECC
KAVRPTNVMGASKRVTELLMRRFSGSSTRFMAVRFGNVVGSSGSVVPLFLDQIARGGPVT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCEECCCCCCHHHHHHHHCCCCCEE
VTHPEVTRYFMSIAEAAQLILQAGTMAQGGEIFVLDMGVPVKIADMAKDLIRLAGLEPEV
EECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHCCCCCCC
DIPIVFTGLREGEKLYEELITADEGVVRTEHDKIMVLRCCDSAQISESALQTLEQGLQQA
CCCEEEECCCCHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VQAAQAHDGAAVRRALHVLVPEYTEVEHTHTETGASGAPEPAALRPEPA
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIALRTANFYIMMCVDLLCFAAALYAAYMLRFDFSIPYLHVERMKGLLPWVLPMKLAVF
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCCHHHHHHHHHHH
VVFSMYRGMWRYTSLRDSILLLRAASVQSLLVIAGVAYLTGFAGYSRAVFGMDFLLTFLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGGARLGIRILFSLRETGRFWLPMTGRTARKGARRVIIIGAGRAGERLVSELNRDVSLGY
HCCCHHHHHHHEEHHHCCCEEEECCCCHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCE
FPVGFVDNNPALKGRTIHGRPVMGTLDRLPEAIVSTRAEELLIALTEASSEQVRHIVQAC
EEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHHCHHHHEEEECCCCHHHHHHHHHHH
SETGLPCKILPPMNEILDFKRGIKNMREVNYLDLLGRSPVELDTGAISRYLQGKCILVTG
HCCCCCEEECCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHCCCEEEEEC
CGGSIGSELVRQIIRYAPARLVLVDASEFNLYKIQMDLEHVHGFHDYVAILGNIRDAHLM
CCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEEHHHHCCHHHHHHHHHCCCHHHHH
RTTFAAHKPEAVFHAAAYKHVPMLERNPWQAVQNNILGTQTLMQAAHDAGVQRFVVVSTD
HHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECC
KAVRPTNVMGASKRVTELLMRRFSGSSTRFMAVRFGNVVGSSGSVVPLFLDQIARGGPVT
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCEECCCCCCHHHHHHHHCCCCCEE
VTHPEVTRYFMSIAEAAQLILQAGTMAQGGEIFVLDMGVPVKIADMAKDLIRLAGLEPEV
EECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEHHHHHHHHHHHCCCCCCC
DIPIVFTGLREGEKLYEELITADEGVVRTEHDKIMVLRCCDSAQISESALQTLEQGLQQA
CCCEEEECCCCHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
VQAAQAHDGAAVRRALHVLVPEYTEVEHTHTETGASGAPEPAALRPEPA
HHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.019 {NAD+}} 0.034 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: TDP; TTP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]