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The map label for this gene is cobH [H]

Identifier: 78355389

GI number: 78355389

Start: 332321

End: 332983

Strand: Reverse

Name: cobH [H]

Synonym: Dde_0342

Alternate gene names: 78355389

Gene position: 332983-332321 (Counterclockwise)

Preceding gene: 78355390

Following gene: 78355388

Centisome position: 8.93

GC content: 63.35

Gene sequence:

>663_bases
ATGGATACCCCCGTTCTTCAGCAATGCTTCGCACCTCAGGCCATCGAGGCGCGCTCCTTTGCCATTATCGATTCGGAAGT
GCCCGAGCCGCGCCCCTTCTGCGGTGCCCACTGGCACATAGCGCGCAGACTGGTGCATACCACCGCCGATTTTGACCTGC
TGAACCACATACGGTTTCATCCGCAGGCAGTGGAGGCGGGTATACGCGCCCTGCAAAACGGCTGCACCATATTCACAGAC
ACGGAGATGGCCCGCTCCGGCATACCCCTGCGCCGCATGACACCGCTGGGCTGCACGGTAACGTGTCTGCTGAACCGCCC
CGATGTGGTACACGCGGCGCAGCGCGACAACACAACCCGCGCCCATGCCGCCATGAACGCCGCCAGCAGCGAACTGGCGG
GAGCCATAGTGGCCATAGGCAACGCACCCACGGCGCTCATCCGGCTGGCCGGACATCTGGAACAGGGCTGCCCTGCGCCC
GCACTGGTCATCGCCATGCCCGTGGGCTTTGTAAACGCGGCGGAATCCAAGGCGCTGTTCATACAGCAAAACCGTGTACC
ATGGATTACCATAGAGGGCAGAAAAGGCGGGTCTGCACTGGCGGCAGCCACCGTGAACGCACTGGCCGTGATGGCGCTGG
AATCTTCACCCGCCGCCCCGTGA

Upstream 100 bases:

>100_bases
ATCCTGCCCCGACGCGGCCCGCGCTTTTGTCGGCGCATGCCGCCGTTCATCCGTAACCACGCCCTGACAGCGCAACATCC
GCAGTGCCGGAGGAAAATAT

Downstream 100 bases:

>100_bases
TACCGCACTGCGTGCGCCTTGCGCATCTATGCCGCGGTTGCTATGATAGCAGATTATGTGCGCCGCACGAACATTGTCTG
TTCACACTGCCGCAGTGCAC

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MDTPVLQQCFAPQAIEARSFAIIDSEVPEPRPFCGAHWHIARRLVHTTADFDLLNHIRFHPQAVEAGIRALQNGCTIFTD
TEMARSGIPLRRMTPLGCTVTCLLNRPDVVHAAQRDNTTRAHAAMNAASSELAGAIVAIGNAPTALIRLAGHLEQGCPAP
ALVIAMPVGFVNAAESKALFIQQNRVPWITIEGRKGGSALAAATVNALAVMALESSPAAP

Sequences:

>Translated_220_residues
MDTPVLQQCFAPQAIEARSFAIIDSEVPEPRPFCGAHWHIARRLVHTTADFDLLNHIRFHPQAVEAGIRALQNGCTIFTD
TEMARSGIPLRRMTPLGCTVTCLLNRPDVVHAAQRDNTTRAHAAMNAASSELAGAIVAIGNAPTALIRLAGHLEQGCPAP
ALVIAMPVGFVNAAESKALFIQQNRVPWITIEGRKGGSALAAATVNALAVMALESSPAAP
>Mature_220_residues
MDTPVLQQCFAPQAIEARSFAIIDSEVPEPRPFCGAHWHIARRLVHTTADFDLLNHIRFHPQAVEAGIRALQNGCTIFTD
TEMARSGIPLRRMTPLGCTVTCLLNRPDVVHAAQRDNTTRAHAAMNAASSELAGAIVAIGNAPTALIRLAGHLEQGCPAP
ALVIAMPVGFVNAAESKALFIQQNRVPWITIEGRKGGSALAAATVNALAVMALESSPAAP

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 23336; Mature: 23336

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTPVLQQCFAPQAIEARSFAIIDSEVPEPRPFCGAHWHIARRLVHTTADFDLLNHIRFH
CCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PQAVEAGIRALQNGCTIFTDTEMARSGIPLRRMTPLGCTVTCLLNRPDVVHAAQRDNTTR
HHHHHHHHHHHHCCCEEEECHHHHHCCCCHHHCCCCCEEEEEEECCCCEEEHHHCCCCHH
AHAAMNAASSELAGAIVAIGNAPTALIRLAGHLEQGCPAPALVIAMPVGFVNAAESKALF
HHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEE
IQQNRVPWITIEGRKGGSALAAATVNALAVMALESSPAAP
EECCCCCEEEEECCCCCCHHHHHHHHHHEEEEECCCCCCC
>Mature Secondary Structure
MDTPVLQQCFAPQAIEARSFAIIDSEVPEPRPFCGAHWHIARRLVHTTADFDLLNHIRFH
CCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PQAVEAGIRALQNGCTIFTDTEMARSGIPLRRMTPLGCTVTCLLNRPDVVHAAQRDNTTR
HHHHHHHHHHHHCCCEEEECHHHHHCCCCHHHCCCCCEEEEEEECCCCEEEHHHCCCCHH
AHAAMNAASSELAGAIVAIGNAPTALIRLAGHLEQGCPAPALVIAMPVGFVNAAESKALF
HHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEEE
IQQNRVPWITIEGRKGGSALAAATVNALAVMALESSPAAP
EECCCCCEEEEECCCCCCHHHHHHHHHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]