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The map label for this gene is patB [H]

Identifier: 78355323

GI number: 78355323

Start: 267790

End: 268980

Strand: Reverse

Name: patB [H]

Synonym: Dde_0276

Alternate gene names: 78355323

Gene position: 268980-267790 (Counterclockwise)

Preceding gene: 304570577

Following gene: 78355322

Centisome position: 7.21

GC content: 63.31

Gene sequence:

>1191_bases
ATGACATACGATTTTGATACCCGTCTGAACAGGCTCGGCACGCGTTCCGAAAAGTGGGACGAAATGGAAACACGCTTCGG
CGTTCCTGCACAGGGCGACCCGCAGGGCATTGCCATGTGGGTGGCGGATATGGACTTCCGCTCTCCGCCCGCTGTAAACG
ATGCCGTGGCCGCCATGGCCCGTTCCGGCCTGTACGGCTACCCCGGTGCATGGCGCGATCACGACGAAGCGCTGTGCGGC
TGGCTGCAACAGCGCCACGGCTGGGACATCCGTCCGCAGTGGGTGCTGCGCATGCCCAACGTGGTCACGGTGCTGCACCT
TGCCATTCAGGCGTTCACCCGCCCGGGCGAAGGCGTCATAGTGCAGCCGCCGGTGTATCCGCCTTTCATGCTTGCTCCGG
GCAACTGCGGCCGCACCGTGCTCGAAAACCCGCTGCGCTGTGAAGACGGGCCGCACGGCCCCCGCTTTGTCATGGATTAT
GACCATCTGGAACAGCAGATAGATGCCGGCGGCAAACTGCTGCTGCTGTGCAGCCCGCACAACCCCGGCGGCAGGGTATG
GTCCCGCGGCGAACTGCAGCGTCTGGCCGAAATATGCCTTGCCCGCGACGTCATCATCATCAGCGACGAAATCCACCACG
ACCTTGTCTACCCGGAACATACGCACACAGTTCTGGCCCGTATGTCACCGGAAATAGCCGACAGAACGGTCACCTGCATT
TCCGCCACCAAAACGTTCAACATTGCCGGATCCATGCTGGGCATGGCCGTGGTGCAGAACGACGGCCTGCGGGCGCGCCT
GCAGCAGGCCATGCACGGCGCGGGACTGTTCGACCCTTCGGCATTCGGGCTGGCCATGGGAATTGCCGCATACAGACACG
GCAATCCGTGGCGGGAAGCACTGCTGAGCTATCTGGACGGCAACAGACGTCTGGTGCACGACACCCTGTCGGCGCTGGAC
GGCGTATCTCCCATGCTGCCGGAAGCCACCTATCTCAGCTGGCTTGATTTCAACGGCACGGGACTGGCTTCGGAACAGAT
CATCGACCGGCTGCAGAGCACGGCCCGTCTGGCTCTCAACCACGGGCCCAGCTTCGGCACCGGCGGAAACGGCTGCATGC
GCCTTAACTTCGCCTGCCCGCGCAGCGTGCTGCATGAAGCTCTCGGGCGGATAGTGCGCGCGTTCAGCTAG

Upstream 100 bases:

>100_bases
GCCCGTGTATGCTTCTGCACCGCCGCATGTACCTGCATCCCCGCGCATAACGGCACGCGGCACTGCAGCGCTCCAAAGCA
GCACAGCAACCGGAGATTCC

Downstream 100 bases:

>100_bases
GCACCGCCGCCCCGGCAGACACCATGCCCGGCCGCCGCCCCCGCAGCGCACCCGGCCGAAATAGCATGGGAATCAAACAT
GTTACAAAAATGTCATTGTG

Product: class I/II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTYDFDTRLNRLGTRSEKWDEMETRFGVPAQGDPQGIAMWVADMDFRSPPAVNDAVAAMARSGLYGYPGAWRDHDEALCG
WLQQRHGWDIRPQWVLRMPNVVTVLHLAIQAFTRPGEGVIVQPPVYPPFMLAPGNCGRTVLENPLRCEDGPHGPRFVMDY
DHLEQQIDAGGKLLLLCSPHNPGGRVWSRGELQRLAEICLARDVIIISDEIHHDLVYPEHTHTVLARMSPEIADRTVTCI
SATKTFNIAGSMLGMAVVQNDGLRARLQQAMHGAGLFDPSAFGLAMGIAAYRHGNPWREALLSYLDGNRRLVHDTLSALD
GVSPMLPEATYLSWLDFNGTGLASEQIIDRLQSTARLALNHGPSFGTGGNGCMRLNFACPRSVLHEALGRIVRAFS

Sequences:

>Translated_396_residues
MTYDFDTRLNRLGTRSEKWDEMETRFGVPAQGDPQGIAMWVADMDFRSPPAVNDAVAAMARSGLYGYPGAWRDHDEALCG
WLQQRHGWDIRPQWVLRMPNVVTVLHLAIQAFTRPGEGVIVQPPVYPPFMLAPGNCGRTVLENPLRCEDGPHGPRFVMDY
DHLEQQIDAGGKLLLLCSPHNPGGRVWSRGELQRLAEICLARDVIIISDEIHHDLVYPEHTHTVLARMSPEIADRTVTCI
SATKTFNIAGSMLGMAVVQNDGLRARLQQAMHGAGLFDPSAFGLAMGIAAYRHGNPWREALLSYLDGNRRLVHDTLSALD
GVSPMLPEATYLSWLDFNGTGLASEQIIDRLQSTARLALNHGPSFGTGGNGCMRLNFACPRSVLHEALGRIVRAFS
>Mature_395_residues
TYDFDTRLNRLGTRSEKWDEMETRFGVPAQGDPQGIAMWVADMDFRSPPAVNDAVAAMARSGLYGYPGAWRDHDEALCGW
LQQRHGWDIRPQWVLRMPNVVTVLHLAIQAFTRPGEGVIVQPPVYPPFMLAPGNCGRTVLENPLRCEDGPHGPRFVMDYD
HLEQQIDAGGKLLLLCSPHNPGGRVWSRGELQRLAEICLARDVIIISDEIHHDLVYPEHTHTVLARMSPEIADRTVTCIS
ATKTFNIAGSMLGMAVVQNDGLRARLQQAMHGAGLFDPSAFGLAMGIAAYRHGNPWREALLSYLDGNRRLVHDTLSALDG
VSPMLPEATYLSWLDFNGTGLASEQIIDRLQSTARLALNHGPSFGTGGNGCMRLNFACPRSVLHEALGRIVRAFS

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=238, Percent_Identity=29.8319327731092, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI56713254, Length=238, Percent_Identity=29.8319327731092, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI95147551, Length=244, Percent_Identity=27.0491803278689, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI169881279, Length=244, Percent_Identity=27.0491803278689, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI169881281, Length=229, Percent_Identity=26.2008733624454, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787909, Length=398, Percent_Identity=30.6532663316583, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786816, Length=158, Percent_Identity=27.8481012658228, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994476, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17567369, Length=154, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=158, Percent_Identity=28.4810126582279, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=252, Percent_Identity=26.5873015873016, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573069, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646114, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573067, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573065, Length=255, Percent_Identity=29.0196078431373, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43754; Mature: 43622

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYDFDTRLNRLGTRSEKWDEMETRFGVPAQGDPQGIAMWVADMDFRSPPAVNDAVAAMA
CCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
RSGLYGYPGAWRDHDEALCGWLQQRHGWDIRPQWVLRMPNVVTVLHLAIQAFTRPGEGVI
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEECCHHHHHHHHHHHHHCCCCCCEE
VQPPVYPPFMLAPGNCGRTVLENPLRCEDGPHGPRFVMDYDHLEQQIDAGGKLLLLCSPH
ECCCCCCCEEECCCCCCHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCEEEEECCC
NPGGRVWSRGELQRLAEICLARDVIIISDEIHHDLVYPEHTHTVLARMSPEIADRTVTCI
CCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCHHHHHHHHCCHHHHHCEEEEE
SATKTFNIAGSMLGMAVVQNDGLRARLQQAMHGAGLFDPSAFGLAMGIAAYRHGNPWREA
ECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHH
LLSYLDGNRRLVHDTLSALDGVSPMLPEATYLSWLDFNGTGLASEQIIDRLQSTARLALN
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
HGPSFGTGGNGCMRLNFACPRSVLHEALGRIVRAFS
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYDFDTRLNRLGTRSEKWDEMETRFGVPAQGDPQGIAMWVADMDFRSPPAVNDAVAAMA
CCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHH
RSGLYGYPGAWRDHDEALCGWLQQRHGWDIRPQWVLRMPNVVTVLHLAIQAFTRPGEGVI
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEECCHHHHHHHHHHHHHCCCCCCEE
VQPPVYPPFMLAPGNCGRTVLENPLRCEDGPHGPRFVMDYDHLEQQIDAGGKLLLLCSPH
ECCCCCCCEEECCCCCCHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCEEEEECCC
NPGGRVWSRGELQRLAEICLARDVIIISDEIHHDLVYPEHTHTVLARMSPEIADRTVTCI
CCCCCCCCHHHHHHHHHHHHHCCEEEEECCHHHCCCCCCHHHHHHHHCCHHHHHCEEEEE
SATKTFNIAGSMLGMAVVQNDGLRARLQQAMHGAGLFDPSAFGLAMGIAAYRHGNPWREA
ECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHH
LLSYLDGNRRLVHDTLSALDGVSPMLPEATYLSWLDFNGTGLASEQIIDRLQSTARLALN
HHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
HGPSFGTGGNGCMRLNFACPRSVLHEALGRIVRAFS
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]