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The map label for this gene is mtnA

Identifier: 78355123

GI number: 78355123

Start: 65266

End: 66333

Strand: Reverse

Name: mtnA

Synonym: Dde_0076

Alternate gene names: 78355123

Gene position: 66333-65266 (Counterclockwise)

Preceding gene: 78355125

Following gene: 78355122

Centisome position: 1.78

GC content: 61.42

Gene sequence:

>1068_bases
ATGGAGACCCATATCCGATACTCGCGGCAGGACAGAACGCTCATCCTGCTGGACCAGCGCGTGCTGCCCACCGTGGAAGA
AGATTTTTACTGCAACGACGTGGCTGACACCATTTACGCTCTGCAGACCATGGTGGTGCGCGGCGCACCGGCCATAGGCG
TCACCGCGGCCTACGGCTGCTGCCTTGCCGCGTATGAGGCAGGTCATCCCGCCCCGCACGCGCAATGGCAGAAAGAACTG
GATACCCTGCTTGAAAAACTGGCACAGGCACGCCCCACGGCGGTCAACCTGCGCTGGGCCGTGGAACGCATGCGCTCTGT
CTGGAAAAGCATGGGCGACCCCGACCTGAACACCCTTATCGCACGGTGGCTGGACGAGGCAGAAGCCATCCACGAAGAGG
ACAAAAGCATCAACCGAGCCATAGGCAGACACGGAGCCACGCTGATACAGGATAATGACTGTATAATGACCCACTGCAAC
GCCGGTGCGCTGGCCACAGCAGGTTACGGCACGGCGCTGGGTGTGGTACGCGGAGCAGTGGATGCCGGCAGGACCGGTAT
AACCGTTATCGCCAACGAAACACGGCCGTTTCTGCAGGGTGCGCGTCTGACGGCATACGAACTGCACAAGGACGGTATTC
CCGTAACCGTGGCGTGTGACAACGCATGCGGCCTGCTGATGCAGCGCGGCATGGTGCAGAAAGTGGTTGTGGGAGCCGAC
CGCATTGCGGCCAACGGCGATGCCGCCAACAAGATAGGCACCTATTCCGTGGCCCTGCTGGCCCGCGAACACGGCATCCC
TTTCTATGTGGCCGCCCCTCTTTCCACCATCGACCGTGCCACGCCCTCCGGAAAGCAGATACCCATCGAAGAACGCCCGG
CGGAAGAGGTGACACATGTGGGGGAAACCCGCATAACGCCCGAAGGCGTACCCGTATACAACTACGCCTTTGATGTCACA
CCCGCGCACCTTATCGCAGGCATCGTGACTGAGCAGGGCGTGCTGCGCCCCCCGTATACGGCCAGCATTGCCCGGGCCTT
TGCCGCCGCCGACAAAGACAGATCATAA

Upstream 100 bases:

>100_bases
TACACCGTGGCATATATTGCATAACAATGCCGACGGGATTCCATGTCCCGCATGCGGCGCATTCCCTGTCATCATATACC
GCTCCGGAGAATCACATACC

Downstream 100 bases:

>100_bases
CCTTCCGCGGGGCGGCCATCAGTCCGCCCCGCAGCAAAACAGTATTCCGACTGCACCGCCACGCACAGGAGCACATGATG
CGCACCTGCATTTTCATTCC

Product: translation initiation factor 2B subunit I

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
METHIRYSRQDRTLILLDQRVLPTVEEDFYCNDVADTIYALQTMVVRGAPAIGVTAAYGCCLAAYEAGHPAPHAQWQKEL
DTLLEKLAQARPTAVNLRWAVERMRSVWKSMGDPDLNTLIARWLDEAEAIHEEDKSINRAIGRHGATLIQDNDCIMTHCN
AGALATAGYGTALGVVRGAVDAGRTGITVIANETRPFLQGARLTAYELHKDGIPVTVACDNACGLLMQRGMVQKVVVGAD
RIAANGDAANKIGTYSVALLAREHGIPFYVAAPLSTIDRATPSGKQIPIEERPAEEVTHVGETRITPEGVPVYNYAFDVT
PAHLIAGIVTEQGVLRPPYTASIARAFAAADKDRS

Sequences:

>Translated_355_residues
METHIRYSRQDRTLILLDQRVLPTVEEDFYCNDVADTIYALQTMVVRGAPAIGVTAAYGCCLAAYEAGHPAPHAQWQKEL
DTLLEKLAQARPTAVNLRWAVERMRSVWKSMGDPDLNTLIARWLDEAEAIHEEDKSINRAIGRHGATLIQDNDCIMTHCN
AGALATAGYGTALGVVRGAVDAGRTGITVIANETRPFLQGARLTAYELHKDGIPVTVACDNACGLLMQRGMVQKVVVGAD
RIAANGDAANKIGTYSVALLAREHGIPFYVAAPLSTIDRATPSGKQIPIEERPAEEVTHVGETRITPEGVPVYNYAFDVT
PAHLIAGIVTEQGVLRPPYTASIARAFAAADKDRS
>Mature_355_residues
METHIRYSRQDRTLILLDQRVLPTVEEDFYCNDVADTIYALQTMVVRGAPAIGVTAAYGCCLAAYEAGHPAPHAQWQKEL
DTLLEKLAQARPTAVNLRWAVERMRSVWKSMGDPDLNTLIARWLDEAEAIHEEDKSINRAIGRHGATLIQDNDCIMTHCN
AGALATAGYGTALGVVRGAVDAGRTGITVIANETRPFLQGARLTAYELHKDGIPVTVACDNACGLLMQRGMVQKVVVGAD
RIAANGDAANKIGTYSVALLAREHGIPFYVAAPLSTIDRATPSGKQIPIEERPAEEVTHVGETRITPEGVPVYNYAFDVT
PAHLIAGIVTEQGVLRPPYTASIARAFAAADKDRS

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=347, Percent_Identity=43.8040345821326, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI23943880, Length=337, Percent_Identity=39.4658753709199, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI4503503, Length=193, Percent_Identity=31.0880829015544, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7657058, Length=158, Percent_Identity=34.1772151898734, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=331, Percent_Identity=35.3474320241692, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17557123, Length=272, Percent_Identity=23.5294117647059, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6325375, Length=390, Percent_Identity=32.8205128205128, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6322878, Length=271, Percent_Identity=26.9372693726937, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357667, Length=352, Percent_Identity=44.3181818181818, Blast_Score=264, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24651647, Length=352, Percent_Identity=44.3181818181818, Blast_Score=264, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_DESDG (Q317L9)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_386572.1
- ProteinModelPortal:   Q317L9
- SMR:   Q317L9
- STRING:   Q317L9
- GeneID:   3755234
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_0076
- NMPDR:   fig|207559.3.peg.582
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK704399
- BioCyc:   DDES207559:DDE_0076-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38380; Mature: 38380

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: ACT_SITE 240-240 BINDING 91-91 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHIRYSRQDRTLILLDQRVLPTVEEDFYCNDVADTIYALQTMVVRGAPAIGVTAAYGC
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
CLAAYEAGHPAPHAQWQKELDTLLEKLAQARPTAVNLRWAVERMRSVWKSMGDPDLNTLI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHH
ARWLDEAEAIHEEDKSINRAIGRHGATLIQDNDCIMTHCNAGALATAGYGTALGVVRGAV
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCEEECCCHHHHHHHHHHH
DAGRTGITVIANETRPFLQGARLTAYELHKDGIPVTVACDNACGLLMQRGMVQKVVVGAD
HCCCCCEEEEECCCCHHHCCCCCEEEEECCCCCCEEEEECCHHHHHHHCCHHHHHHHCHH
RIAANGDAANKIGTYSVALLAREHGIPFYVAAPLSTIDRATPSGKQIPIEERPAEEVTHV
HHCCCCCCCCCCCHHHEEEEHHHCCCCEEEECCHHHHHCCCCCCCCCCCCCCCHHHHHHC
GETRITPEGVPVYNYAFDVTPAHLIAGIVTEQGVLRPPYTASIARAFAAADKDRS
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
METHIRYSRQDRTLILLDQRVLPTVEEDFYCNDVADTIYALQTMVVRGAPAIGVTAAYGC
CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
CLAAYEAGHPAPHAQWQKELDTLLEKLAQARPTAVNLRWAVERMRSVWKSMGDPDLNTLI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHH
ARWLDEAEAIHEEDKSINRAIGRHGATLIQDNDCIMTHCNAGALATAGYGTALGVVRGAV
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCCEEECCCHHHHHHHHHHH
DAGRTGITVIANETRPFLQGARLTAYELHKDGIPVTVACDNACGLLMQRGMVQKVVVGAD
HCCCCCEEEEECCCCHHHCCCCCEEEEECCCCCCEEEEECCHHHHHHHCCHHHHHHHCHH
RIAANGDAANKIGTYSVALLAREHGIPFYVAAPLSTIDRATPSGKQIPIEERPAEEVTHV
HHCCCCCCCCCCCHHHEEEEHHHCCCCEEEECCHHHHHCCCCCCCCCCCCCCCHHHHHHC
GETRITPEGVPVYNYAFDVTPAHLIAGIVTEQGVLRPPYTASIARAFAAADKDRS
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA