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The map label for this gene is pyrD [H]

Identifier: 78355103

GI number: 78355103

Start: 45695

End: 46621

Strand: Reverse

Name: pyrD [H]

Synonym: Dde_0056

Alternate gene names: 78355103

Gene position: 46621-45695 (Counterclockwise)

Preceding gene: 78355104

Following gene: 78355101

Centisome position: 1.25

GC content: 61.7

Gene sequence:

>927_bases
GTGGATTTGCATGTCACCATACCCAGCGGCCTGCACGGCCTTGAGCTGAAAAACCCCGTCATGACGGCCTCCGGCACATT
CGGCTACGGTGTCGAATTTGCCCCTTACGGCGACCTTGCCCGTCTGGGCGGCATAGTGGTCAAAGGTCTGTCGCTTAAAG
CCCGTGCCGGCAACCCCATGCCGCGCATCGCCGAAACCGCATGCGGCATGCTGAACGCCGTGGGGCTGCAGAACTCCGGC
GTCGAAAACTTCATCACGCAGAAGCTGCCGCAGCTGCCCTGGCAGGAAACACCCGTCATCGCCAACCTGTATGCCTGCGA
CCCTGACGAATTTGCCGAACTGGCCGGCATACTTGCCGCCGAAGAAGGCATTGCCGCCATTGAAGTGAACATCTCGTGCC
CCAACGTAAGTGAAGGGGGCATACTCTTCGGGCAGGATGCAAGACAGGCCGCCCGGGTGACCGGCGCCGTAAAACGCCGT
TCCGGCACCAAGCCCGTCATCGTCAAACTGTCGCCCAATGTCACCGACATTGCCGAAATTGCCCGTGCAGTGGAAGACAG
CGGGGCGGACATGCTTTCGTGCATCAACACGCTGAGCGGCATGGCCGTGGACATCCGCAGCCGCAAGCCTCTGCTGGCCA
ATGTCATCGGCGGACTTTCCGGCCCTGCCATCAAACCCGTGGCCCTGCGCTGCGTATGGCAGGCCGCCCGCTCTGTCAGC
ATTCCGGTCATCGGCATCGGCGGAGCCACCACGGCAGAAGACATACTGGAATTCATGCTGGTGGGCGCACACGCCGTACA
GATAGGCACCGCCAACTTCATGCGCCCCGACTGCGCCTTCCGGCTGGTGGATGAACTGCAGCAGCTGGTGGATACGCTGG
GCATCACCAGCTGGGATGACTTCAGAGGCTCGCTGGACATCAGATAA

Upstream 100 bases:

>100_bases
CACCTGCACCACACGCAGGCGGGCAAAGCGCAGGTCTGCAACAACGGTCCGGTTTTCTGGGCCGATCAGGTAGACCTGGA
TAAAGCATAGGAGCGCTGTC

Downstream 100 bases:

>100_bases
GTTTTCGGCAAATTACCGGAAACCCGCCCGGAACGCCGTTCATTCTGCGGCATTGCGGCATGTTATCACAGCGGCACGGC
ACAACACCGCCATCAGGCCG

Product: dihydroorotate oxidase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MDLHVTIPSGLHGLELKNPVMTASGTFGYGVEFAPYGDLARLGGIVVKGLSLKARAGNPMPRIAETACGMLNAVGLQNSG
VENFITQKLPQLPWQETPVIANLYACDPDEFAELAGILAAEEGIAAIEVNISCPNVSEGGILFGQDARQAARVTGAVKRR
SGTKPVIVKLSPNVTDIAEIARAVEDSGADMLSCINTLSGMAVDIRSRKPLLANVIGGLSGPAIKPVALRCVWQAARSVS
IPVIGIGGATTAEDILEFMLVGAHAVQIGTANFMRPDCAFRLVDELQQLVDTLGITSWDDFRGSLDIR

Sequences:

>Translated_308_residues
MDLHVTIPSGLHGLELKNPVMTASGTFGYGVEFAPYGDLARLGGIVVKGLSLKARAGNPMPRIAETACGMLNAVGLQNSG
VENFITQKLPQLPWQETPVIANLYACDPDEFAELAGILAAEEGIAAIEVNISCPNVSEGGILFGQDARQAARVTGAVKRR
SGTKPVIVKLSPNVTDIAEIARAVEDSGADMLSCINTLSGMAVDIRSRKPLLANVIGGLSGPAIKPVALRCVWQAARSVS
IPVIGIGGATTAEDILEFMLVGAHAVQIGTANFMRPDCAFRLVDELQQLVDTLGITSWDDFRGSLDIR
>Mature_308_residues
MDLHVTIPSGLHGLELKNPVMTASGTFGYGVEFAPYGDLARLGGIVVKGLSLKARAGNPMPRIAETACGMLNAVGLQNSG
VENFITQKLPQLPWQETPVIANLYACDPDEFAELAGILAAEEGIAAIEVNISCPNVSEGGILFGQDARQAARVTGAVKRR
SGTKPVIVKLSPNVTDIAEIARAVEDSGADMLSCINTLSGMAVDIRSRKPLLANVIGGLSGPAIKPVALRCVWQAARSVS
IPVIGIGGATTAEDILEFMLVGAHAVQIGTANFMRPDCAFRLVDELQQLVDTLGITSWDDFRGSLDIR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=295, Percent_Identity=31.1864406779661, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI45006951, Length=315, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082059, Length=302, Percent_Identity=28.8079470198675, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71984108, Length=176, Percent_Identity=34.0909090909091, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322633, Length=305, Percent_Identity=28.8524590163934, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24640763, Length=194, Percent_Identity=34.020618556701, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI18858217, Length=194, Percent_Identity=34.020618556701, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32402; Mature: 32402

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHVTIPSGLHGLELKNPVMTASGTFGYGVEFAPYGDLARLGGIVVKGLSLKARAGNPM
CCEEEECCCCCCCCCCCCCEEECCCCCCCCEEECCCCCHHHHHHHHHCCCEEEECCCCCC
PRIAETACGMLNAVGLQNSGVENFITQKLPQLPWQETPVIANLYACDPDEFAELAGILAA
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
EEGIAAIEVNISCPNVSEGGILFGQDARQAARVTGAVKRRSGTKPVIVKLSPNVTDIAEI
CCCEEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
ARAVEDSGADMLSCINTLSGMAVDIRSRKPLLANVIGGLSGPAIKPVALRCVWQAARSVS
HHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
IPVIGIGGATTAEDILEFMLVGAHAVQIGTANFMRPDCAFRLVDELQQLVDTLGITSWDD
CEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
FRGSLDIR
CCCCCCCC
>Mature Secondary Structure
MDLHVTIPSGLHGLELKNPVMTASGTFGYGVEFAPYGDLARLGGIVVKGLSLKARAGNPM
CCEEEECCCCCCCCCCCCCEEECCCCCCCCEEECCCCCHHHHHHHHHCCCEEEECCCCCC
PRIAETACGMLNAVGLQNSGVENFITQKLPQLPWQETPVIANLYACDPDEFAELAGILAA
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHHHHHHH
EEGIAAIEVNISCPNVSEGGILFGQDARQAARVTGAVKRRSGTKPVIVKLSPNVTDIAEI
CCCEEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHH
ARAVEDSGADMLSCINTLSGMAVDIRSRKPLLANVIGGLSGPAIKPVALRCVWQAARSVS
HHHHHCCCHHHHHHHHHHCCCEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
IPVIGIGGATTAEDILEFMLVGAHAVQIGTANFMRPDCAFRLVDELQQLVDTLGITSWDD
CEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
FRGSLDIR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA