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The map label for this gene is coaBC [H]

Identifier: 78355086

GI number: 78355086

Start: 31436

End: 32662

Strand: Reverse

Name: coaBC [H]

Synonym: Dde_0039

Alternate gene names: 78355086

Gene position: 32662-31436 (Counterclockwise)

Preceding gene: 78355087

Following gene: 78355085

Centisome position: 0.88

GC content: 60.8

Gene sequence:

>1227_bases
GTGAGCCCTGCATCCGTCAATGCGCATCTGGCTTTTACAGGCTATCTCGGCAGACGCCTGCACATGGGCGTGTGCGGTTC
CGTAGCCGCCTACAAGGCGCTTGATCTGCTGCGCCGGTTTAAAGATACCGGCGCGGATACCGGTGTGACCCTGACGGACA
GCGCGTGCCAGTTCATCACGCCGCTCAGCTTCGAAGCGCTGGGGGCTTCTCCCGTATATACCGGCATGTACCCCGTGGGT
GACGATGTTTTCGGACATCTCACCCCCGGGGATGCCTGCCACGCATTTCTCATCGCTCCCGCCACGGCGGCCACGCTGGC
GCGTCTGGCCTGCGGTCTGGCAGACGACATGCTTTCGTGCCAGGCTCTGGCCTTTGAAGGACCGCTGGTCATTGCCCCCG
CCATGAACCCGCGCATGTGGAACAATCCGGCAACGCAGGAAAACTGGGCCAGACTGAAACAGCGCGGCCACGTGGCCGTG
GAACCCGGCTGCGGGCGCATGGCGTGCATGGATGTGGGGCAGGGCAGGCTGGCAGACCTTGATACCATTTTTCTGTATAC
GCTGCGGGCCATGACACCGCAGGACATGACCGGACAGCAGGTCATGGTCACTCTGGGCCCCACCCGCGAACAGTGGGACG
GCGTACGTTTCTGGTCCAATCCCTCTTCGGGGGTCATGGGTGCCTGTTTTGCCGTGGCCGCATGGCTGCGGGGCGCACAG
GTGCATGCCGTCTGCGGACCGGCAACACCGTGGCTGCCCGCAGACATCACACGGCACGATGTAACCGGTGCGGCGCAGAT
GTATCAGGCAGCAGCCGACCTGTGGCCCCGCATGGACACCGGTATATTCACTGCCGCAGTCGCCGACTTCAGTCCGGAGC
CTTTCGGTGCTGAAAAATTCAAAAAATCCGGCACGGAAACGCTGTCCATCCGGTTCACTCCCAACACCGACATTCTGAAA
ACGCTGGGCACCGCCAAGCGCGAAAACCAGCGCATTGTCGGGTTTGCCGCAGAAACGGGCAACCTGCATGAAAACGCCGT
CGGCAAGCTGCGGCGCAAAAACGCTGACATGATAGTCGGCAATATTGTCGGCACACCGGAAAGCGGTTTTCAATCGGCCA
CCAACAAAGTTTTTGTGGCTGACAAAACAGGCCGGACCGAAGAATGGCCCGTACAGCCCAAAACCGAAGTGGCATGGAGG
ATTCTGGATTGGCTGTTGCAAATGTAG

Upstream 100 bases:

>100_bases
CCCGCCGTGACAATGTGGGGCTCGAAAAACCCATTCTGGACACGCCTTCCATGGCCGTACCCGGCGACATCACCATCAAA
GAAGAAGGACTGGTCAACTA

Downstream 100 bases:

>100_bases
CCATCCGCGAAGACCTGCGCCCGTGGTATCAGGCCGGTGTACAGCATCTTTTTATGGATGATGCGGTAACCGCATGGATA
GAGCAGGGCAGGCGGGAACA

Product: phosphopantothenate-cysteine ligase / phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSPASVNAHLAFTGYLGRRLHMGVCGSVAAYKALDLLRRFKDTGADTGVTLTDSACQFITPLSFEALGASPVYTGMYPVG
DDVFGHLTPGDACHAFLIAPATAATLARLACGLADDMLSCQALAFEGPLVIAPAMNPRMWNNPATQENWARLKQRGHVAV
EPGCGRMACMDVGQGRLADLDTIFLYTLRAMTPQDMTGQQVMVTLGPTREQWDGVRFWSNPSSGVMGACFAVAAWLRGAQ
VHAVCGPATPWLPADITRHDVTGAAQMYQAAADLWPRMDTGIFTAAVADFSPEPFGAEKFKKSGTETLSIRFTPNTDILK
TLGTAKRENQRIVGFAAETGNLHENAVGKLRRKNADMIVGNIVGTPESGFQSATNKVFVADKTGRTEEWPVQPKTEVAWR
ILDWLLQM

Sequences:

>Translated_408_residues
MSPASVNAHLAFTGYLGRRLHMGVCGSVAAYKALDLLRRFKDTGADTGVTLTDSACQFITPLSFEALGASPVYTGMYPVG
DDVFGHLTPGDACHAFLIAPATAATLARLACGLADDMLSCQALAFEGPLVIAPAMNPRMWNNPATQENWARLKQRGHVAV
EPGCGRMACMDVGQGRLADLDTIFLYTLRAMTPQDMTGQQVMVTLGPTREQWDGVRFWSNPSSGVMGACFAVAAWLRGAQ
VHAVCGPATPWLPADITRHDVTGAAQMYQAAADLWPRMDTGIFTAAVADFSPEPFGAEKFKKSGTETLSIRFTPNTDILK
TLGTAKRENQRIVGFAAETGNLHENAVGKLRRKNADMIVGNIVGTPESGFQSATNKVFVADKTGRTEEWPVQPKTEVAWR
ILDWLLQM
>Mature_407_residues
SPASVNAHLAFTGYLGRRLHMGVCGSVAAYKALDLLRRFKDTGADTGVTLTDSACQFITPLSFEALGASPVYTGMYPVGD
DVFGHLTPGDACHAFLIAPATAATLARLACGLADDMLSCQALAFEGPLVIAPAMNPRMWNNPATQENWARLKQRGHVAVE
PGCGRMACMDVGQGRLADLDTIFLYTLRAMTPQDMTGQQVMVTLGPTREQWDGVRFWSNPSSGVMGACFAVAAWLRGAQV
HAVCGPATPWLPADITRHDVTGAAQMYQAAADLWPRMDTGIFTAAVADFSPEPFGAEKFKKSGTETLSIRFTPNTDILKT
LGTAKRENQRIVGFAAETGNLHENAVGKLRRKNADMIVGNIVGTPESGFQSATNKVFVADKTGRTEEWPVQPKTEVAWRI
LDWLLQM

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=174, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87082301, Length=394, Percent_Identity=38.0710659898477, Blast_Score=232, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=29.6296296296296, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44014; Mature: 43883

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPASVNAHLAFTGYLGRRLHMGVCGSVAAYKALDLLRRFKDTGADTGVTLTDSACQFIT
CCCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHC
PLSFEALGASPVYTGMYPVGDDVFGHLTPGDACHAFLIAPATAATLARLACGLADDMLSC
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
QALAFEGPLVIAPAMNPRMWNNPATQENWARLKQRGHVAVEPGCGRMACMDVGQGRLADL
HHEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHH
DTIFLYTLRAMTPQDMTGQQVMVTLGPTREQWDGVRFWSNPSSGVMGACFAVAAWLRGAQ
HHHHHHHHHHCCCCCCCCCEEEEEECCCHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCE
VHAVCGPATPWLPADITRHDVTGAAQMYQAAADLWPRMDTGIFTAAVADFSPEPFGAEKF
EEEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCCHHEEHHHCCCCCCCCHHHH
KKSGTETLSIRFTPNTDILKTLGTAKRENQRIVGFAAETGNLHENAVGKLRRKNADMIVG
HCCCCEEEEEEECCCHHHHHHHCCHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEE
NIVGTPESGFQSATNKVFVADKTGRTEEWPVQPKTEVAWRILDWLLQM
EEECCCCHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPASVNAHLAFTGYLGRRLHMGVCGSVAAYKALDLLRRFKDTGADTGVTLTDSACQFIT
CCCCCEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHC
PLSFEALGASPVYTGMYPVGDDVFGHLTPGDACHAFLIAPATAATLARLACGLADDMLSC
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
QALAFEGPLVIAPAMNPRMWNNPATQENWARLKQRGHVAVEPGCGRMACMDVGQGRLADL
HHEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEECCCCCCHHH
DTIFLYTLRAMTPQDMTGQQVMVTLGPTREQWDGVRFWSNPSSGVMGACFAVAAWLRGAQ
HHHHHHHHHHCCCCCCCCCEEEEEECCCHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCE
VHAVCGPATPWLPADITRHDVTGAAQMYQAAADLWPRMDTGIFTAAVADFSPEPFGAEKF
EEEEECCCCCCCCCCCCHHCCHHHHHHHHHHHHHCCCCCCCHHEEHHHCCCCCCCCHHHH
KKSGTETLSIRFTPNTDILKTLGTAKRENQRIVGFAAETGNLHENAVGKLRRKNADMIVG
HCCCCEEEEEEECCCHHHHHHHCCHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEE
NIVGTPESGFQSATNKVFVADKTGRTEEWPVQPKTEVAWRILDWLLQM
EEECCCCHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]