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The map label for this gene is hldE [H]

Identifier: 78355075

GI number: 78355075

Start: 22658

End: 23692

Strand: Reverse

Name: hldE [H]

Synonym: Dde_0028

Alternate gene names: 78355075

Gene position: 23692-22658 (Counterclockwise)

Preceding gene: 78355076

Following gene: 78355074

Centisome position: 0.64

GC content: 55.65

Gene sequence:

>1035_bases
ATGACCTATTCTTTTGATACTGAACGCCTGTGCGCCGCCATACCGGCTCTGACCGGCAAAAGAGTGCTTATCGTCGGCGA
CGTGATGGTGGACGAGTACCTGATCGGCGATGCAGAGCGTATATCACCCGAAGCTCCCGTGCCTGTGGTGGGTGTTGAGC
GCGAGCAACTGCTTATCGGCGGAGCCGGCAACGTGGCCAAAAATATCCAGTCACTGGGCGGAAAGCCGGAACTGATAAGC
CTGTGCGGTACGGGCAGCAACGCAGCAACGCTGCGCCATGTACTGCAAAACGAAAACCTGCAGGCAAATCTGATTGATAT
AGAAGGCAGAAGAACGACCATTAAAACAAGAGTGCTGGCCAGACAGCAGCAGATGGTACGCATAGACCGCGAAGACACCT
CTCCGCTGACCGGCACCGGACTGGACAGAGTGCTTGAAGCCATAAAAGACAGGCTGCCGCACCATGATGTAATCATTCTT
TCCGACTACGGAAAAGGACTGGTTACAGACGTCTTCATGTCTCGGCTGAATACGCTTCTGGATACATATGCCGCCCGGCA
CGGCGTACGCCACAATGTTTTTGTCGACCCCAAAACACGGAACTTCCGGCTGTATAAAGATGTCTTCATCCTGACACCGA
ACGCCAAGGAAACAAGCGAAGGCGCAGGTATGCCAGCCGGTTCGCGTGAAGAAATTCTTGCCGCAGGCAAACGTATCTTC
GAACTGCTCAACTGCAGCAAACTGCTGACCACACTGGGGGCCTCCGGCATGGCGCTCTTTAACGGTCAGGATGAAGTGTG
GCACATACCCACCACTGGGCAGGCCGTATTTGACGTAACAGGCGCAGGCGACACTGTCATAGCAACGCTGGCTCTGGCAC
AGGCTGCCGGCATATCTCTGCTGGACAGCTGCATGCTGGCAAACTTTGCCGCAGGTGTTGTTGTGGGACAGGTCGGGGCT
GCATCCGTATCGCCTCCTGAACTTGAAGAAGCCGTCCGCAGGCATCAGGCACCCGCTATCAGCCGCTGGCTGTAA

Upstream 100 bases:

>100_bases
GGAAGAAAAAGGAAAAGTAACGTTGTCTTTTTCTTCTCAGGAAGAGCTGGCAAGGGTTCTTTCACTGCTGGGCATTGAAC
TGTAGCAAAGGCGCCACTCC

Downstream 100 bases:

>100_bases
ATAAAAGCTCCGGATCCTTCCGGAGCTTTTTTGCTTTGTCCGGTATATCCATCCCAAACTGCCTCCGGCGGGCAGGGAGA
TGATCTCCCTGCACCCTCGG

Product: D-alpha,beta-D-heptose 7-phosphate 1-kinase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTYSFDTERLCAAIPALTGKRVLIVGDVMVDEYLIGDAERISPEAPVPVVGVEREQLLIGGAGNVAKNIQSLGGKPELIS
LCGTGSNAATLRHVLQNENLQANLIDIEGRRTTIKTRVLARQQQMVRIDREDTSPLTGTGLDRVLEAIKDRLPHHDVIIL
SDYGKGLVTDVFMSRLNTLLDTYAARHGVRHNVFVDPKTRNFRLYKDVFILTPNAKETSEGAGMPAGSREEILAAGKRIF
ELLNCSKLLTTLGASGMALFNGQDEVWHIPTTGQAVFDVTGAGDTVIATLALAQAAGISLLDSCMLANFAAGVVVGQVGA
ASVSPPELEEAVRRHQAPAISRWL

Sequences:

>Translated_344_residues
MTYSFDTERLCAAIPALTGKRVLIVGDVMVDEYLIGDAERISPEAPVPVVGVEREQLLIGGAGNVAKNIQSLGGKPELIS
LCGTGSNAATLRHVLQNENLQANLIDIEGRRTTIKTRVLARQQQMVRIDREDTSPLTGTGLDRVLEAIKDRLPHHDVIIL
SDYGKGLVTDVFMSRLNTLLDTYAARHGVRHNVFVDPKTRNFRLYKDVFILTPNAKETSEGAGMPAGSREEILAAGKRIF
ELLNCSKLLTTLGASGMALFNGQDEVWHIPTTGQAVFDVTGAGDTVIATLALAQAAGISLLDSCMLANFAAGVVVGQVGA
ASVSPPELEEAVRRHQAPAISRWL
>Mature_343_residues
TYSFDTERLCAAIPALTGKRVLIVGDVMVDEYLIGDAERISPEAPVPVVGVEREQLLIGGAGNVAKNIQSLGGKPELISL
CGTGSNAATLRHVLQNENLQANLIDIEGRRTTIKTRVLARQQQMVRIDREDTSPLTGTGLDRVLEAIKDRLPHHDVIILS
DYGKGLVTDVFMSRLNTLLDTYAARHGVRHNVFVDPKTRNFRLYKDVFILTPNAKETSEGAGMPAGSREEILAAGKRIFE
LLNCSKLLTTLGASGMALFNGQDEVWHIPTTGQAVFDVTGAGDTVIATLALAQAAGISLLDSCMLANFAAGVVVGQVGAA
SVSPPELEEAVRRHQAPAISRWL

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=320, Percent_Identity=40.625, Blast_Score=205, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 36972; Mature: 36841

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSFDTERLCAAIPALTGKRVLIVGDVMVDEYLIGDAERISPEAPVPVVGVEREQLLIG
CCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHCCCHHHCCCCCCCCEEECCCCEEEEE
GAGNVAKNIQSLGGKPELISLCGTGSNAATLRHVLQNENLQANLIDIEGRRTTIKTRVLA
CCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
RQQQMVRIDREDTSPLTGTGLDRVLEAIKDRLPHHDVIILSDYGKGLVTDVFMSRLNTLL
HHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHH
DTYAARHGVRHNVFVDPKTRNFRLYKDVFILTPNAKETSEGAGMPAGSREEILAAGKRIF
HHHHHHCCCCCCEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ELLNCSKLLTTLGASGMALFNGQDEVWHIPTTGQAVFDVTGAGDTVIATLALAQAAGISL
HHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
LDSCMLANFAAGVVVGQVGAASVSPPELEEAVRRHQAPAISRWL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TYSFDTERLCAAIPALTGKRVLIVGDVMVDEYLIGDAERISPEAPVPVVGVEREQLLIG
CCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHCCCHHHCCCCCCCCEEECCCCEEEEE
GAGNVAKNIQSLGGKPELISLCGTGSNAATLRHVLQNENLQANLIDIEGRRTTIKTRVLA
CCCHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
RQQQMVRIDREDTSPLTGTGLDRVLEAIKDRLPHHDVIILSDYGKGLVTDVFMSRLNTLL
HHHHHHEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHH
DTYAARHGVRHNVFVDPKTRNFRLYKDVFILTPNAKETSEGAGMPAGSREEILAAGKRIF
HHHHHHCCCCCCEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHH
ELLNCSKLLTTLGASGMALFNGQDEVWHIPTTGQAVFDVTGAGDTVIATLALAQAAGISL
HHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
LDSCMLANFAAGVVVGQVGAASVSPPELEEAVRRHQAPAISRWL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA