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The map label for this gene is dnaA [H]

Identifier: 78355048

GI number: 78355048

Start: 189

End: 1499

Strand: Direct

Name: dnaA [H]

Synonym: Dde_0001

Alternate gene names: 78355048

Gene position: 189-1499 (Clockwise)

Preceding gene: NA

Following gene: 78355049

Centisome position: 0.01

GC content: 53.01

Gene sequence:

>1311_bases
GTGTTAAAAAAAGCGCTGCGCCAACACTTCAGGCAGTCCTGCACCGAACAGGATCTGCACCGGTGGTTTGATCCGCTGGA
TATCACCCTGGCCGATGAAAAACGGCTTGAGGTGCGTTTTCCGCATCGTTTTTTTGCGGAATGGTTTTCCACTCAGGTGC
AGGGCCGTTTCGAGTCAGAACTGAACACATTCATGGGAGAAGGCACCACTGTGGAATACACCACAGGCTGCTGCCCCGTG
CTGTCTTCGTCTCCCCTGCCGCCGGCCGCCGTTTCCAAAAAACTTTCGGCACCTTTCGGCCGCGAATACACGTTCGAGAC
ATTCATCTCCAACAAGCGTAATTTCTTTCCTGTTGCTTCGGCGCGCGAACTGGCCAGACAGGAAGAGGAAATACGTTACA
ACCCCTTTGTTCTCTGCGGCCCCGCAGGCAGCGGAAAAACCCACCTGCTGCGCGCCATAGCCAACGAGCTGAGCAAGACT
GTATATAAAAAACATATTTTTATCAGCACAATAGACGATTTAGGAACACTGTTTAGTAACAATGGTTCCGGCGATCCGGC
ACAGGTGCGCCAGCAGCTTTCGGCATGTCACTATCTGCTGCTTGACGACCTGCACCGCCTGCGCGAACAGCCCCAGTTGC
AGGATGAGCTGACAGTGCTGTTCAACAGTTTTTACGACCGGCAGAAGCAGATGGTATTCACCTGCCCCGGCAAGCTGTCA
GAACTTGATTTTCTGGAAACCGGCCTGCGGTCGCGTCTGGAATGGGGACTGATTGTCACCATGAAGCCCCCCGATCTGGA
AATACTGGTCACGTTTATCCAGCGGCAGTGCAAGCTTCACAAACTGCAGCTTGCCAAAGAGCATGTTTTCACGCTGGCAC
AACGTTTCCGCGATTTCAGACATCTGCAGGGTGTGCTTAACAGACTTACCGCCTACCGCGATCTTGTTAACCGCACACTG
GCTGACACTGATTTCGAGCAGGTGCTCAGCCATACCGAGGCCGGTGCCGGCCGCCCGCTGACAGCAGACAGAATAATAGC
CCTGTGCGCAGGACGTTTTTCATTGCCGCCAAAGGATGTCACCGGCGACAAACGCCACCAGAAAGTGGTTCTGGCGCGTC
AGGTTGCCATGTACCTCTGCCGCGAACTCATGGGCAGTTCATACCCTGTTCTTGGCCGGACTTTTGGTGGTAAGGACCAT
TCAACGGCGATGTATGCTGTTAAAAAAATAAAGAAAATGATAGATAGTGACAAAACGACCAGGCAGTTGGTCACAGAGTT
GAAGAAACAGTGTCTATCCGGTGCGGAATAA

Upstream 100 bases:

>100_bases
TGTTTCTAAGGTTGGATTGTACTGCTCCGGCATGCTGTAATTTTCTTTTGCCCATGCCATGCCGTCCCGCATTTAAAAAT
ACATAATTTGCAATAGATAC

Downstream 100 bases:

>100_bases
CCGCCGCCGGCCATGGCACTGTCAATACAGTTCGTATAAACTCACAATACAGGCACTTAAAATAATCATATATAAAAAGT
AGTTATGCAGGTTGCCTACA

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLKKALRQHFRQSCTEQDLHRWFDPLDITLADEKRLEVRFPHRFFAEWFSTQVQGRFESELNTFMGEGTTVEYTTGCCPV
LSSSPLPPAAVSKKLSAPFGREYTFETFISNKRNFFPVASARELARQEEEIRYNPFVLCGPAGSGKTHLLRAIANELSKT
VYKKHIFISTIDDLGTLFSNNGSGDPAQVRQQLSACHYLLLDDLHRLREQPQLQDELTVLFNSFYDRQKQMVFTCPGKLS
ELDFLETGLRSRLEWGLIVTMKPPDLEILVTFIQRQCKLHKLQLAKEHVFTLAQRFRDFRHLQGVLNRLTAYRDLVNRTL
ADTDFEQVLSHTEAGAGRPLTADRIIALCAGRFSLPPKDVTGDKRHQKVVLARQVAMYLCRELMGSSYPVLGRTFGGKDH
STAMYAVKKIKKMIDSDKTTRQLVTELKKQCLSGAE

Sequences:

>Translated_436_residues
MLKKALRQHFRQSCTEQDLHRWFDPLDITLADEKRLEVRFPHRFFAEWFSTQVQGRFESELNTFMGEGTTVEYTTGCCPV
LSSSPLPPAAVSKKLSAPFGREYTFETFISNKRNFFPVASARELARQEEEIRYNPFVLCGPAGSGKTHLLRAIANELSKT
VYKKHIFISTIDDLGTLFSNNGSGDPAQVRQQLSACHYLLLDDLHRLREQPQLQDELTVLFNSFYDRQKQMVFTCPGKLS
ELDFLETGLRSRLEWGLIVTMKPPDLEILVTFIQRQCKLHKLQLAKEHVFTLAQRFRDFRHLQGVLNRLTAYRDLVNRTL
ADTDFEQVLSHTEAGAGRPLTADRIIALCAGRFSLPPKDVTGDKRHQKVVLARQVAMYLCRELMGSSYPVLGRTFGGKDH
STAMYAVKKIKKMIDSDKTTRQLVTELKKQCLSGAE
>Mature_436_residues
MLKKALRQHFRQSCTEQDLHRWFDPLDITLADEKRLEVRFPHRFFAEWFSTQVQGRFESELNTFMGEGTTVEYTTGCCPV
LSSSPLPPAAVSKKLSAPFGREYTFETFISNKRNFFPVASARELARQEEEIRYNPFVLCGPAGSGKTHLLRAIANELSKT
VYKKHIFISTIDDLGTLFSNNGSGDPAQVRQQLSACHYLLLDDLHRLREQPQLQDELTVLFNSFYDRQKQMVFTCPGKLS
ELDFLETGLRSRLEWGLIVTMKPPDLEILVTFIQRQCKLHKLQLAKEHVFTLAQRFRDFRHLQGVLNRLTAYRDLVNRTL
ADTDFEQVLSHTEAGAGRPLTADRIIALCAGRFSLPPKDVTGDKRHQKVVLARQVAMYLCRELMGSSYPVLGRTFGGKDH
STAMYAVKKIKKMIDSDKTTRQLVTELKKQCLSGAE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=431, Percent_Identity=26.6821345707657, Blast_Score=167, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 49844; Mature: 49844

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKALRQHFRQSCTEQDLHRWFDPLDITLADEKRLEVRFPHRFFAEWFSTQVQGRFESE
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHH
LNTFMGEGTTVEYTTGCCPVLSSSPLPPAAVSKKLSAPFGREYTFETFISNKRNFFPVAS
HHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHH
ARELARQEEEIRYNPFVLCGPAGSGKTHLLRAIANELSKTVYKKHIFISTIDDLGTLFSN
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGSGDPAQVRQQLSACHYLLLDDLHRLREQPQLQDELTVLFNSFYDRQKQMVFTCPGKLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCH
ELDFLETGLRSRLEWGLIVTMKPPDLEILVTFIQRQCKLHKLQLAKEHVFTLAQRFRDFR
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLQGVLNRLTAYRDLVNRTLADTDFEQVLSHTEAGAGRPLTADRIIALCAGRFSLPPKDV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
TGDKRHQKVVLARQVAMYLCRELMGSSYPVLGRTFGGKDHSTAMYAVKKIKKMIDSDKTT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
RQLVTELKKQCLSGAE
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKKALRQHFRQSCTEQDLHRWFDPLDITLADEKRLEVRFPHRFFAEWFSTQVQGRFESE
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHH
LNTFMGEGTTVEYTTGCCPVLSSSPLPPAAVSKKLSAPFGREYTFETFISNKRNFFPVAS
HHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHH
ARELARQEEEIRYNPFVLCGPAGSGKTHLLRAIANELSKTVYKKHIFISTIDDLGTLFSN
HHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NGSGDPAQVRQQLSACHYLLLDDLHRLREQPQLQDELTVLFNSFYDRQKQMVFTCPGKLS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCH
ELDFLETGLRSRLEWGLIVTMKPPDLEILVTFIQRQCKLHKLQLAKEHVFTLAQRFRDFR
HHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLQGVLNRLTAYRDLVNRTLADTDFEQVLSHTEAGAGRPLTADRIIALCAGRFSLPPKDV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
TGDKRHQKVVLARQVAMYLCRELMGSSYPVLGRTFGGKDHSTAMYAVKKIKKMIDSDKTT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
RQLVTELKKQCLSGAE
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA