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The map label for this gene is hemY [H]

Identifier: 78224734

GI number: 78224734

Start: 3985948

End: 3987435

Strand: Direct

Name: hemY [H]

Synonym: Gmet_3551

Alternate gene names: 78224734

Gene position: 3985948-3987435 (Clockwise)

Preceding gene: 78224732

Following gene: 78224735

Centisome position: 99.71

GC content: 63.37

Gene sequence:

>1488_bases
ATGTTTACTTTCTTGACAGCCGCCCATGCAGGGTCTATCAATGATCAGAGTGCATTCATCGAACGGCGAGGAGCAGGGAT
GAAAAAAGTTATCGTGGTGGGGGGCGGCATTTCTGGGCTCGCAACCGCCTTTGAGCTGCGCAATAAAGGAGCAGAGGCGG
GCATCGAGCTGGATGTGACCCTGCTGGAAAAGGAAGAGCGGGTCGGCGGCAAGATCTGGAGCATCAAGGAGGAGGGATAC
CTCTGCGAGTGGGGGCCCAACGGCTTTCTGGACTCCAAGCCCCAGACCCTCGACCTCTGCCGGGACCTGGGTGCCTCGGA
AAGGCTCCTGCGGAGTAACGATAACGCCCGTAAGCGCTTCATCTACACCGGGGGCGTTCTGAACCGGCTCCCCGAGAACG
GCCCCACGTTTCTCAAGAGCAGCCTCATCTCGTGGCCCGGCAAACTCCGCTTGGCAATGGAACCCTTCATCTCGAAGCGG
ACCGACGGCACCGACGAGACCCTCGCCTCCTTTGGCCGCCGGCGCCTCGGCGAGGAGGCCCTCCAGAAGCTCATCTCCCC
CATGGTGTCGGGGATCTTCGCCGGCGACCCGGAAACCATGTCGCTCCGCTCCTGCTTCCCCCGCATCGCGGAACTGGAGG
ACGAATACGGTAGCCTCATAAAAGCCATGATCAAACTGGCGAAAAAGAAGAAGCAGGAAGCGGCCCAGGGAAAGGCGGTA
TCGAGCGCCGCCGGCCCCGGTGGAGTCCTCACCTCTTTCCGATGGGGGATCCAGGAGCTGACCGACATCCTGGCGGAGCA
GCTCGGTTCCGCGACCGTGGTTACGGGTCAGCCCGTGACGGGCTTGACCAGGGGATCGAGCGTCCCGTGGCGGCTGAAGA
CACCCACCGTCGATATCGACGCCGACGTGGTGATTCTCGCCTCGCCGGCCCATGCCACCGCCGGCATCGTCAGCGGCGTT
GACGCCGCCATGGCCCAGGTGCTGGGGGAGATCCCCTACGCCTCCATGACCGTGGTCTGCTTCGGCTTCGAACGGGAGCG
GATCGCCTACGACCTGAACGGCTTCGGCTACCTGATCCCCAAGGATGAGGGGATGAACACCCTCGGTACCCTCTGGGACT
CCAGCATCTTCGAAAACCGTGCCCCAGAGGGTAAGGTGTTACTGCGGAGCATGCTCGGCGGCGCCTGCTTCCCCGAGTAC
GTGAAACTTTCCGACGCGGAGGTGATGCAGCGGGTGAAGGCAGATCTCAAGGCGACCATGGGAATCACGGCGGACCCCTC
CTTCATCAGGATCTTCCGCCATCCCCAGGCCATCCCCCAGTACACCGTCGGCCACGGAAAGCGCTTGGCGGCCCTCCAGG
AACGCTCCTCGGCCCTCCCGGGGCTCTTCCTTACCGGAAACTCCTACCGCGGCATCGGCCTCAACGACTGCGCCACCGCC
GCCAACCGCACCACCGACGAGGTGGTGGCCTATCTGAAGGGCCGATAG

Upstream 100 bases:

>100_bases
TAGTAATCCGTTTGCGCCATCTGAAAATCCTTTCCGTAGGTCTTGAAAGAATGTAAGCGCTCCGGAGTACCCTGTCAACG
GTTCAGCTGGAGAAGGCTCC

Downstream 100 bases:

>100_bases
TTAATGCTTGAACATACGACGATCACATTCTATTCTTCCCGTACCCCGTACGGGCATTCACACCAATACCAAGGAGGAAG
ACCATGAAGAAAACCCTGCT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MFTFLTAAHAGSINDQSAFIERRGAGMKKVIVVGGGISGLATAFELRNKGAEAGIELDVTLLEKEERVGGKIWSIKEEGY
LCEWGPNGFLDSKPQTLDLCRDLGASERLLRSNDNARKRFIYTGGVLNRLPENGPTFLKSSLISWPGKLRLAMEPFISKR
TDGTDETLASFGRRRLGEEALQKLISPMVSGIFAGDPETMSLRSCFPRIAELEDEYGSLIKAMIKLAKKKKQEAAQGKAV
SSAAGPGGVLTSFRWGIQELTDILAEQLGSATVVTGQPVTGLTRGSSVPWRLKTPTVDIDADVVILASPAHATAGIVSGV
DAAMAQVLGEIPYASMTVVCFGFERERIAYDLNGFGYLIPKDEGMNTLGTLWDSSIFENRAPEGKVLLRSMLGGACFPEY
VKLSDAEVMQRVKADLKATMGITADPSFIRIFRHPQAIPQYTVGHGKRLAALQERSSALPGLFLTGNSYRGIGLNDCATA
ANRTTDEVVAYLKGR

Sequences:

>Translated_495_residues
MFTFLTAAHAGSINDQSAFIERRGAGMKKVIVVGGGISGLATAFELRNKGAEAGIELDVTLLEKEERVGGKIWSIKEEGY
LCEWGPNGFLDSKPQTLDLCRDLGASERLLRSNDNARKRFIYTGGVLNRLPENGPTFLKSSLISWPGKLRLAMEPFISKR
TDGTDETLASFGRRRLGEEALQKLISPMVSGIFAGDPETMSLRSCFPRIAELEDEYGSLIKAMIKLAKKKKQEAAQGKAV
SSAAGPGGVLTSFRWGIQELTDILAEQLGSATVVTGQPVTGLTRGSSVPWRLKTPTVDIDADVVILASPAHATAGIVSGV
DAAMAQVLGEIPYASMTVVCFGFERERIAYDLNGFGYLIPKDEGMNTLGTLWDSSIFENRAPEGKVLLRSMLGGACFPEY
VKLSDAEVMQRVKADLKATMGITADPSFIRIFRHPQAIPQYTVGHGKRLAALQERSSALPGLFLTGNSYRGIGLNDCATA
ANRTTDEVVAYLKGR
>Mature_495_residues
MFTFLTAAHAGSINDQSAFIERRGAGMKKVIVVGGGISGLATAFELRNKGAEAGIELDVTLLEKEERVGGKIWSIKEEGY
LCEWGPNGFLDSKPQTLDLCRDLGASERLLRSNDNARKRFIYTGGVLNRLPENGPTFLKSSLISWPGKLRLAMEPFISKR
TDGTDETLASFGRRRLGEEALQKLISPMVSGIFAGDPETMSLRSCFPRIAELEDEYGSLIKAMIKLAKKKKQEAAQGKAV
SSAAGPGGVLTSFRWGIQELTDILAEQLGSATVVTGQPVTGLTRGSSVPWRLKTPTVDIDADVVILASPAHATAGIVSGV
DAAMAQVLGEIPYASMTVVCFGFERERIAYDLNGFGYLIPKDEGMNTLGTLWDSSIFENRAPEGKVLLRSMLGGACFPEY
VKLSDAEVMQRVKADLKATMGITADPSFIRIFRHPQAIPQYTVGHGKRLAALQERSSALPGLFLTGNSYRGIGLNDCATA
ANRTTDEVVAYLKGR

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. May have an essential extracellular function during development, possibly as a pheromone [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=486, Percent_Identity=30.8641975308642, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4506001, Length=486, Percent_Identity=30.8641975308642, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320851, Length=432, Percent_Identity=24.537037037037, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24649745, Length=454, Percent_Identity=28.4140969162996, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 53434; Mature: 53434

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTFLTAAHAGSINDQSAFIERRGAGMKKVIVVGGGISGLATAFELRNKGAEAGIELDVT
CCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEE
LLEKEERVGGKIWSIKEEGYLCEWGPNGFLDSKPQTLDLCRDLGASERLLRSNDNARKRF
EECCHHHCCCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCEEE
IYTGGVLNRLPENGPTFLKSSLISWPGKLRLAMEPFISKRTDGTDETLASFGRRRLGEEA
EEECHHHHHCCCCCHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LQKLISPMVSGIFAGDPETMSLRSCFPRIAELEDEYGSLIKAMIKLAKKKKQEAAQGKAV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SSAAGPGGVLTSFRWGIQELTDILAEQLGSATVVTGQPVTGLTRGSSVPWRLKTPTVDID
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCEEECCCEEECC
ADVVILASPAHATAGIVSGVDAAMAQVLGEIPYASMTVVCFGFERERIAYDLNGFGYLIP
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCEEEEEE
KDEGMNTLGTLWDSSIFENRAPEGKVLLRSMLGGACFPEYVKLSDAEVMQRVKADLKATM
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHC
GITADPSFIRIFRHPQAIPQYTVGHGKRLAALQERSSALPGLFLTGNSYRGIGLNDCATA
CCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
ANRTTDEVVAYLKGR
CCCCHHHHHHHHCCC
>Mature Secondary Structure
MFTFLTAAHAGSINDQSAFIERRGAGMKKVIVVGGGISGLATAFELRNKGAEAGIELDVT
CCEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEE
LLEKEERVGGKIWSIKEEGYLCEWGPNGFLDSKPQTLDLCRDLGASERLLRSNDNARKRF
EECCHHHCCCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCEEE
IYTGGVLNRLPENGPTFLKSSLISWPGKLRLAMEPFISKRTDGTDETLASFGRRRLGEEA
EEECHHHHHCCCCCHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LQKLISPMVSGIFAGDPETMSLRSCFPRIAELEDEYGSLIKAMIKLAKKKKQEAAQGKAV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
SSAAGPGGVLTSFRWGIQELTDILAEQLGSATVVTGQPVTGLTRGSSVPWRLKTPTVDID
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCEEECCCEEECC
ADVVILASPAHATAGIVSGVDAAMAQVLGEIPYASMTVVCFGFERERIAYDLNGFGYLIP
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCEEEEEE
KDEGMNTLGTLWDSSIFENRAPEGKVLLRSMLGGACFPEYVKLSDAEVMQRVKADLKATM
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHC
GITADPSFIRIFRHPQAIPQYTVGHGKRLAALQERSSALPGLFLTGNSYRGIGLNDCATA
CCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
ANRTTDEVVAYLKGR
CCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1372277; 8621504 [H]