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The map label for this gene is prsA [H]

Identifier: 78224731

GI number: 78224731

Start: 3982844

End: 3983815

Strand: Direct

Name: prsA [H]

Synonym: Gmet_3548

Alternate gene names: 78224731

Gene position: 3982844-3983815 (Clockwise)

Preceding gene: 78224730

Following gene: 78224732

Centisome position: 99.64

GC content: 59.26

Gene sequence:

>972_bases
ATGAGCCTGAAAAGGAGTTTCAACGTGAAACGAACAGCGGTTCTGACGATCCTCTCGGCCACCCTCCTGGCGGTCCCGTT
CACCGGCTGCAAAGGAAAGACCGAAACCGGCACTGCCACGGCCCCCGCCAAGAAGGCCGGGGAAGTGATCGCCGAGGTTA
ACGGCGACACCATCACCACCGGCGACTTCCAGAAGGAGCTGGAAAACCTTCCCCCCTACCTGAAGCCCATGGCCGACACT
GCCGAAGGGAAAAAGGAACTCCTCGATACCATGGTGGTCCGGGAGCTGATCCTCCAGCAGGCCAGAAAGGACGGCCTGGA
CAAGAGCCCCGACGTGGCAGCCAAGCTGGAGGAGCTCAAGAAGCGGGTCGTAGTGGAGGCGTTCCTCAAGAAGAAAGTGG
AGGAGCAGGCCAAAGTCTCCGACGAGGAGATGAAGAAATTCTACGAAGAAAACAAGGACAAATTCAAGACCGGTCCCCAG
GTCCACGCGAGCCACATTCTCATGAAGAGCGAGGACGAAGCCCAGAAGGTCCTCAAGGAACTCAAAGAAGGGGGGAACTT
CGAGGAGCTGGCCAAGAAGCACTCCATCGACTCCGCCGCGGCCAAGGGAGGCGACCTGGGATGGTTCAGCAAGGGCTCCA
TGGTCCCCGAATTCGAAAAGGTGGTATTCGGCCTGAAAGAGGGGGAAACCTCCGGCATCGTCAAGACCAAGTTCGGCTAC
CACATTATCAAGCTGACCGGCAAGCGGCCGGCCGGCATCCGTACCTTCGACGAGGTGAAAGAGCAGCTCAGGGCAGCCAT
CCTCCCCAGCAAGCAGCAGGAAGTCTTCCAGAAGCTCAAGGATGACATCAAGAAGGGGGCCAAGGTCACCATCAAGGAGG
ACGTCCTCAAGGGAATCGGAGGCGCCGCCGCGGAAAAGCCGGCACCCGCGGGCCCCGAGAGCACTCCGGCAAAGAAAGCG
GAAACGAAGTAA

Upstream 100 bases:

>100_bases
GCTTGCCGACACCTCCTTCGAGGGGGTCCTGGAAGAGGCCAGAAATCTCTTGAAAAGGCTTGGGTGATGTGCTAGCTTCC
GTAAGATTCTTCAATACTTA

Downstream 100 bases:

>100_bases
GCGCACCGGGGCTGCCGGCAGCAACGTCGGCAGCCCCGTGCCCCCTCCCCAACGGAAACCATGATCAAAACCCTCATCAC
AGCCACCCTTGTCCTTATCG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSLKRSFNVKRTAVLTILSATLLAVPFTGCKGKTETGTATAPAKKAGEVIAEVNGDTITTGDFQKELENLPPYLKPMADT
AEGKKELLDTMVVRELILQQARKDGLDKSPDVAAKLEELKKRVVVEAFLKKKVEEQAKVSDEEMKKFYEENKDKFKTGPQ
VHASHILMKSEDEAQKVLKELKEGGNFEELAKKHSIDSAAAKGGDLGWFSKGSMVPEFEKVVFGLKEGETSGIVKTKFGY
HIIKLTGKRPAGIRTFDEVKEQLRAAILPSKQQEVFQKLKDDIKKGAKVTIKEDVLKGIGGAAAEKPAPAGPESTPAKKA
ETK

Sequences:

>Translated_323_residues
MSLKRSFNVKRTAVLTILSATLLAVPFTGCKGKTETGTATAPAKKAGEVIAEVNGDTITTGDFQKELENLPPYLKPMADT
AEGKKELLDTMVVRELILQQARKDGLDKSPDVAAKLEELKKRVVVEAFLKKKVEEQAKVSDEEMKKFYEENKDKFKTGPQ
VHASHILMKSEDEAQKVLKELKEGGNFEELAKKHSIDSAAAKGGDLGWFSKGSMVPEFEKVVFGLKEGETSGIVKTKFGY
HIIKLTGKRPAGIRTFDEVKEQLRAAILPSKQQEVFQKLKDDIKKGAKVTIKEDVLKGIGGAAAEKPAPAGPESTPAKKA
ETK
>Mature_322_residues
SLKRSFNVKRTAVLTILSATLLAVPFTGCKGKTETGTATAPAKKAGEVIAEVNGDTITTGDFQKELENLPPYLKPMADTA
EGKKELLDTMVVRELILQQARKDGLDKSPDVAAKLEELKKRVVVEAFLKKKVEEQAKVSDEEMKKFYEENKDKFKTGPQV
HASHILMKSEDEAQKVLKELKEGGNFEELAKKHSIDSAAAKGGDLGWFSKGSMVPEFEKVVFGLKEGETSGIVKTKFGYH
IIKLTGKRPAGIRTFDEVKEQLRAAILPSKQQEVFQKLKDDIKKGAKVTIKEDVLKGIGGAAAEKPAPAGPESTPAKKAE
TK

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=111, Percent_Identity=38.7387387387387, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1786645, Length=154, Percent_Identity=34.4155844155844, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790211, Length=83, Percent_Identity=51.8072289156626, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537235, Length=98, Percent_Identity=40.8163265306122, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322478, Length=96, Percent_Identity=41.6666666666667, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356303, Length=100, Percent_Identity=39, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 35295; Mature: 35164

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKRSFNVKRTAVLTILSATLLAVPFTGCKGKTETGTATAPAKKAGEVIAEVNGDTITT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEC
GDFQKELENLPPYLKPMADTAEGKKELLDTMVVRELILQQARKDGLDKSPDVAAKLEELK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KRVVVEAFLKKKVEEQAKVSDEEMKKFYEENKDKFKTGPQVHASHILMKSEDEAQKVLKE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHCCCCCHHHHHHHHCCCHHHHHHHHH
LKEGGNFEELAKKHSIDSAAAKGGDLGWFSKGSMVPEFEKVVFGLKEGETSGIVKTKFGY
HHCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCE
HIIKLTGKRPAGIRTFDEVKEQLRAAILPSKQQEVFQKLKDDIKKGAKVTIKEDVLKGIG
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHCC
GAAAEKPAPAGPESTPAKKAETK
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLKRSFNVKRTAVLTILSATLLAVPFTGCKGKTETGTATAPAKKAGEVIAEVNGDTITT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEC
GDFQKELENLPPYLKPMADTAEGKKELLDTMVVRELILQQARKDGLDKSPDVAAKLEELK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KRVVVEAFLKKKVEEQAKVSDEEMKKFYEENKDKFKTGPQVHASHILMKSEDEAQKVLKE
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHCCCCCHHHHHHHHCCCHHHHHHHHH
LKEGGNFEELAKKHSIDSAAAKGGDLGWFSKGSMVPEFEKVVFGLKEGETSGIVKTKFGY
HHCCCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCE
HIIKLTGKRPAGIRTFDEVKEQLRAAILPSKQQEVFQKLKDDIKKGAKVTIKEDVLKGIG
EEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHCC
GAAAEKPAPAGPESTPAKKAETK
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]