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The map label for this gene is czcR [H]

Identifier: 78224573

GI number: 78224573

Start: 3797128

End: 3797802

Strand: Reverse

Name: czcR [H]

Synonym: Gmet_3383

Alternate gene names: 78224573

Gene position: 3797802-3797128 (Counterclockwise)

Preceding gene: 78224574

Following gene: 78224572

Centisome position: 95.01

GC content: 59.11

Gene sequence:

>675_bases
ATGAAGATTCTCGTGGTAGAGGACGAAAAGAAGGTTTCGAGCTTCATAAAGCGCGGTCTTGAGGAGGAGCGGTACGAGGT
TGAGGCCGCCTTCAACGGCGAGGATGGTCTCAAGATGGCCCTGGAGAAAGGGTTTGATCTGATTATCCTCGATGTCATGC
TCCCCAAGAAGGACGGACTGAGCGTGGTGCGGGAACTGCGGGAGAGGAAAAACGCAACGCCGGTTCTCATGCTGACCGCC
AAGGATTCCGTGGAGGACATCGTGGCGGGGCTCGATTCCGGTTCCGACGACTACCTGACGAAACCCTTCGCCTTTGCCGA
GCTCCTGGCCCGGGTACGGGCCCTGGTGCGGCGCAGCGAGCAGGACCGGGGCGCCGAGATCCGCTTCGCCGATCTGCGGC
TCGATCCGGTCACCCACAAGGTGTGGCGCAAGGACAAGGAGATCGACCTGACCGCCAAGGAGTACTCGCTGCTGGAATAC
TTCATGCGGAACCCGAACCAGGTCCTGACTCGGACCATGATCGCCGAGCACGTCTGGGACTACACCTTCGACAGTTTCAC
CAACATCATCGATGTGTATGTGAACTACCTGCGGAAGAAGATCGACCGCGAGGCCGACAAGAAGCTGATCCACACGGTAC
GGGGCGTGGGCTACATCCTGAAGGAAGAGGAGTGA

Upstream 100 bases:

>100_bases
CGATCGGTGGAAGAGTCGGCGGCGGAAATCATACAGAAACTCTGCAGCTAGAAACCATGAGTCCGCAGCATCGGAAAACA
GAGAAAGGGAGGTGCAGACA

Downstream 100 bases:

>100_bases
CCCGTTGTTCTTCCGGTCGATCCGCTTTTCCCTTACCCTCTGGTATGCGGTCACCCTGGCGGTCATCCTCGTTCTGTTCA
GCTCGTTCATCTACCTTATC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKILVVEDEKKVSSFIKRGLEEERYEVEAAFNGEDGLKMALEKGFDLIILDVMLPKKDGLSVVRELRERKNATPVLMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEY
FMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE

Sequences:

>Translated_224_residues
MKILVVEDEKKVSSFIKRGLEEERYEVEAAFNGEDGLKMALEKGFDLIILDVMLPKKDGLSVVRELRERKNATPVLMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEY
FMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE
>Mature_224_residues
MKILVVEDEKKVSSFIKRGLEEERYEVEAAFNGEDGLKMALEKGFDLIILDVMLPKKDGLSVVRELRERKNATPVLMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEY
FMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=50.9009009009009, Blast_Score=217, Evalue=4e-58,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=45.8715596330275, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.219730941704, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=36.8888888888889, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=35.7466063348416, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=34.0909090909091, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.0316742081448, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=33.6363636363636, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.8828828828829, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=32.3008849557522, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=32.7433628318584, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=30.8695652173913, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=37.037037037037, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790299, Length=128, Percent_Identity=27.34375, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=34.9514563106796, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788191, Length=111, Percent_Identity=34.2342342342342, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26006; Mature: 26006

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDEKKVSSFIKRGLEEERYEVEAAFNGEDGLKMALEKGFDLIILDVMLPKKDGL
CEEEEECCHHHHHHHHHHCCHHHHEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCH
SVVRELRERKNATPVLMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSE
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
QDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEYFMRNPNQVLTRTMIAEHVWD
CCCCCEEEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MKILVVEDEKKVSSFIKRGLEEERYEVEAAFNGEDGLKMALEKGFDLIILDVMLPKKDGL
CEEEEECCHHHHHHHHHHCCHHHHEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCH
SVVRELRERKNATPVLMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSE
HHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
QDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEYFMRNPNQVLTRTMIAEHVWD
CCCCCEEEEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
YTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]