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The map label for this gene is nuoL [H]

Identifier: 78224534

GI number: 78224534

Start: 3760632

End: 3762641

Strand: Reverse

Name: nuoL [H]

Synonym: Gmet_3344

Alternate gene names: 78224534

Gene position: 3762641-3760632 (Counterclockwise)

Preceding gene: 78224535

Following gene: 78224533

Centisome position: 94.13

GC content: 49.9

Gene sequence:

>2010_bases
ATGTTCGAGTACGTATGGCTGATACCACTGTTCCCTCTGATCGGCGTCGTCATAAACGGCCTTCTTGGGAAGAAGATCAA
GAACGAGACCGTGATCGGTGGAATAGGATCACTCATGGTGTTCGGTTCGTTTCTTGTGTCATTCGGCATCCTGATCGAGC
TTCTCTCGAGATCTGCGGAAGAGCGCGTCTTTGAGAAGGTGCTCTTTACGTGGATTAAATCCGGTAACTTCAACGCTGAG
ATCGGTTTTCTTATCGATCCGCTTTCCGCGCTGATGATCATGGTCGTGACGGGTGTTGGTTTCCTGATTCATGTTTACTC
CATCGGCTATATGCACGGTGAAGAGGGCTTCTATCGGTATTTTACCTACTTGAACCTTTTCACTTTCTCTATGCTCCTTT
TGGTGCTCGGGAACAACCTCCTGCTTATGTTTGTCGGTTGGGAAGGAGTCGGTCTCTGCTCTTACCTCCTTATTGGTTAC
TATTTCCATAAGAAATCAGCGGGAGACGCCGGCAAGAAGGCATTCGTAATGAACCGGGTAGGTGACTTCGGTTTTCTGCT
GGGTGTCTTCACGCTCTACTGGTATCTCGGACAAAACCATAATGTCTGGACCATCAATTTCCGTCAATTGGCAGCAAATG
CCCATCTTCTTCCGGTTGGTGGCGTAGTTACGGTAATTGCACTCTGCTTCTTCCTGGGTGCTACCGGCAAGTCAGCACAG
CTTCCACTCTATACATGGCTTCCTGATGCCATGGAAGGCCCGACGCCAGTATCCGCACTCATCCATGCGGCAACAATGGT
CACAGCTGGCGTATATATGATCGGTCGTTTGAATTTCGTATATATTCGTTCGCATGAGACGATGATGATTGTTGCCATAG
TTGGTGCGGCTACAGCCATTTTTGCTGCGACTATTGGTACTGCTCAAAACGATATCAAACGCGTCCTTGCCTATTCAACA
GTATCGCAGCTTGGTTTCATGTTCCTCGCCATGGGTGTTGGCGCCTTTACTGCGGGTATTTTTCACCTGATGACTCACGC
GTTCTTCAAGGCCTGCCTCTTCCTAGGGTCTGGTTCAGTCATTCATTCAATGCACCATGCCTTGCATCATGCCCATTCCC
ATGATGACCCGCAGGACATGCGTAACATGGGTGGTCTGAAGAAGCAGATGCCGATAACCTTCCTGACATTCCTTGTGTCA
ACTATTGCTATCGCCGGTATCCCAGGTTTCTCCGGGTTTTTCTCCAAAGATGAGATTCTCTGGCAGGCCTTTGCCAACCC
GCTCCATGGAGACCTGAATATTATTCTCTGGGCAACTGGCGCTATAGCCGCAGGTTTCACGGCGTTCTATATGTTCAGAC
TTGTGTTTATGACCTTCTTCGGTGAGTGTCGCATCGTGGAAAAGGCAAAGAGCCACCTCCATGAATCTCCCCTTGTCATT
ACTTTTCCGCTGATGGTACTTGGTTTGCTGGCTGTCGTAGGTGGTTACGTTGGCATACCGAAGCTGATTGGCGAGCTTTT
TGGGGGCATTCCGAATTATCTTGAGCACTATCTTGAGCCAGTATTCAAGGGATCCGAAGAGTTCATGGCTCAGCAGCTCG
CTCATGGTGCGGCTCACCATAGCCCTGCACTTGAGTGGGGACTCATGGGCACGTCTGTTGTGATCGCGCTGATCGGTATC
TCCATTGCCTTCTTCCTCTATGTGGTGTCACCGTCCATTCCTGCAAAATTCACAGCTGCCTTCCCGGCGCTCCACCGGGC
AGTTTATAACAAGTGGTATGTTGACGAACTCTACGATTTTCTCTTCGTCAACCCCTGCAAGGCGCTCGGTAATGGTCTCT
GGAAAGGTTTTGACGTCGTGGTGGTAGATGGTGTTGTCAACGGTGTTGCGGCAATCGTCAAGGGTTTCGGTGGCGCGCTC
AGAAACATTCAGACAGGGTATGTGCACAACTATGCCCTTGGCATGTCACTCGGTGTTGTAGTTATCGTTGCCTTCTATCT
CTTCCGCTAA

Upstream 100 bases:

>100_bases
TGAGTCTATTGACGTTGAAGATATCAAGCTCATGAGACTGTAGCAGTTCTGACAGAACTTACGAAATTCTGAATTACTCG
CGATAATAAAGGAGTCAGGA

Downstream 100 bases:

>100_bases
CTCTGAATTACCAATAGGACTAAAGGAGCAGATTCATGAGTCAGTTTCCCTTAATCAGCGTGATGACCTTTCTACCACTT
CTAGGGGTCGTACTGCTCTT

Product: NADH-plastoquinone oxidoreductase, chain 5

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MFEYVWLIPLFPLIGVVINGLLGKKIKNETVIGGIGSLMVFGSFLVSFGILIELLSRSAEERVFEKVLFTWIKSGNFNAE
IGFLIDPLSALMIMVVTGVGFLIHVYSIGYMHGEEGFYRYFTYLNLFTFSMLLLVLGNNLLLMFVGWEGVGLCSYLLIGY
YFHKKSAGDAGKKAFVMNRVGDFGFLLGVFTLYWYLGQNHNVWTINFRQLAANAHLLPVGGVVTVIALCFFLGATGKSAQ
LPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIVGAATAIFAATIGTAQNDIKRVLAYST
VSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSVIHSMHHALHHAHSHDDPQDMRNMGGLKKQMPITFLTFLVS
TIAIAGIPGFSGFFSKDEILWQAFANPLHGDLNIILWATGAIAAGFTAFYMFRLVFMTFFGECRIVEKAKSHLHESPLVI
TFPLMVLGLLAVVGGYVGIPKLIGELFGGIPNYLEHYLEPVFKGSEEFMAQQLAHGAAHHSPALEWGLMGTSVVIALIGI
SIAFFLYVVSPSIPAKFTAAFPALHRAVYNKWYVDELYDFLFVNPCKALGNGLWKGFDVVVVDGVVNGVAAIVKGFGGAL
RNIQTGYVHNYALGMSLGVVVIVAFYLFR

Sequences:

>Translated_669_residues
MFEYVWLIPLFPLIGVVINGLLGKKIKNETVIGGIGSLMVFGSFLVSFGILIELLSRSAEERVFEKVLFTWIKSGNFNAE
IGFLIDPLSALMIMVVTGVGFLIHVYSIGYMHGEEGFYRYFTYLNLFTFSMLLLVLGNNLLLMFVGWEGVGLCSYLLIGY
YFHKKSAGDAGKKAFVMNRVGDFGFLLGVFTLYWYLGQNHNVWTINFRQLAANAHLLPVGGVVTVIALCFFLGATGKSAQ
LPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIVGAATAIFAATIGTAQNDIKRVLAYST
VSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSVIHSMHHALHHAHSHDDPQDMRNMGGLKKQMPITFLTFLVS
TIAIAGIPGFSGFFSKDEILWQAFANPLHGDLNIILWATGAIAAGFTAFYMFRLVFMTFFGECRIVEKAKSHLHESPLVI
TFPLMVLGLLAVVGGYVGIPKLIGELFGGIPNYLEHYLEPVFKGSEEFMAQQLAHGAAHHSPALEWGLMGTSVVIALIGI
SIAFFLYVVSPSIPAKFTAAFPALHRAVYNKWYVDELYDFLFVNPCKALGNGLWKGFDVVVVDGVVNGVAAIVKGFGGAL
RNIQTGYVHNYALGMSLGVVVIVAFYLFR
>Mature_669_residues
MFEYVWLIPLFPLIGVVINGLLGKKIKNETVIGGIGSLMVFGSFLVSFGILIELLSRSAEERVFEKVLFTWIKSGNFNAE
IGFLIDPLSALMIMVVTGVGFLIHVYSIGYMHGEEGFYRYFTYLNLFTFSMLLLVLGNNLLLMFVGWEGVGLCSYLLIGY
YFHKKSAGDAGKKAFVMNRVGDFGFLLGVFTLYWYLGQNHNVWTINFRQLAANAHLLPVGGVVTVIALCFFLGATGKSAQ
LPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIVGAATAIFAATIGTAQNDIKRVLAYST
VSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSVIHSMHHALHHAHSHDDPQDMRNMGGLKKQMPITFLTFLVS
TIAIAGIPGFSGFFSKDEILWQAFANPLHGDLNIILWATGAIAAGFTAFYMFRLVFMTFFGECRIVEKAKSHLHESPLVI
TFPLMVLGLLAVVGGYVGIPKLIGELFGGIPNYLEHYLEPVFKGSEEFMAQQLAHGAAHHSPALEWGLMGTSVVIALIGI
SIAFFLYVVSPSIPAKFTAAFPALHRAVYNKWYVDELYDFLFVNPCKALGNGLWKGFDVVVVDGVVNGVAAIVKGFGGAL
RNIQTGYVHNYALGMSLGVVVIVAFYLFR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=399, Percent_Identity=37.844611528822, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1788614, Length=658, Percent_Identity=41.6413373860182, Blast_Score=404, Evalue=1e-113,
Organism=Escherichia coli, GI1788829, Length=375, Percent_Identity=33.6, Blast_Score=169, Evalue=7e-43,
Organism=Escherichia coli, GI1788831, Length=361, Percent_Identity=30.4709141274238, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788827, Length=446, Percent_Identity=26.6816143497758, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI2367154, Length=459, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788613, Length=368, Percent_Identity=27.7173913043478, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI145693160, Length=297, Percent_Identity=27.9461279461279, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 73281; Mature: 73281

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYVWLIPLFPLIGVVINGLLGKKIKNETVIGGIGSLMVFGSFLVSFGILIELLSRSAE
CCCEEHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ERVFEKVLFTWIKSGNFNAEIGFLIDPLSALMIMVVTGVGFLIHVYSIGYMHGEEGFYRY
HHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHH
FTYLNLFTFSMLLLVLGNNLLLMFVGWEGVGLCSYLLIGYYFHKKSAGDAGKKAFVMNRV
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
GDFGFLLGVFTLYWYLGQNHNVWTINFRQLAANAHLLPVGGVVTVIALCFFLGATGKSAQ
CHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCC
LPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIVGAATAI
CCEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCEEEHHHHHHHHHH
FAATIGTAQNDIKRVLAYSTVSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IHSMHHALHHAHSHDDPQDMRNMGGLKKQMPITFLTFLVSTIAIAGIPGFSGFFSKDEIL
HHHHHHHHHHHCCCCCHHHHHHCCCCCHHCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
WQAFANPLHGDLNIILWATGAIAAGFTAFYMFRLVFMTFFGECRIVEKAKSHLHESPLVI
HHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
TFPLMVLGLLAVVGGYVGIPKLIGELFGGIPNYLEHYLEPVFKGSEEFMAQQLAHGAAHH
EHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
SPALEWGLMGTSVVIALIGISIAFFLYVVSPSIPAKFTAAFPALHRAVYNKWYVDELYDF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVNPCKALGNGLWKGFDVVVVDGVVNGVAAIVKGFGGALRNIQTGYVHNYALGMSLGVV
HHHCHHHHHCCHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VIVAFYLFR
HHHHHHHCC
>Mature Secondary Structure
MFEYVWLIPLFPLIGVVINGLLGKKIKNETVIGGIGSLMVFGSFLVSFGILIELLSRSAE
CCCEEHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ERVFEKVLFTWIKSGNFNAEIGFLIDPLSALMIMVVTGVGFLIHVYSIGYMHGEEGFYRY
HHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCHHHHH
FTYLNLFTFSMLLLVLGNNLLLMFVGWEGVGLCSYLLIGYYFHKKSAGDAGKKAFVMNRV
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHC
GDFGFLLGVFTLYWYLGQNHNVWTINFRQLAANAHLLPVGGVVTVIALCFFLGATGKSAQ
CHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCC
LPLYTWLPDAMEGPTPVSALIHAATMVTAGVYMIGRLNFVYIRSHETMMIVAIVGAATAI
CCEEECCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCEEEHHHHHHHHHH
FAATIGTAQNDIKRVLAYSTVSQLGFMFLAMGVGAFTAGIFHLMTHAFFKACLFLGSGSV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IHSMHHALHHAHSHDDPQDMRNMGGLKKQMPITFLTFLVSTIAIAGIPGFSGFFSKDEIL
HHHHHHHHHHHCCCCCHHHHHHCCCCCHHCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
WQAFANPLHGDLNIILWATGAIAAGFTAFYMFRLVFMTFFGECRIVEKAKSHLHESPLVI
HHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
TFPLMVLGLLAVVGGYVGIPKLIGELFGGIPNYLEHYLEPVFKGSEEFMAQQLAHGAAHH
EHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
SPALEWGLMGTSVVIALIGISIAFFLYVVSPSIPAKFTAAFPALHRAVYNKWYVDELYDF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LFVNPCKALGNGLWKGFDVVVVDGVVNGVAAIVKGFGGALRNIQTGYVHNYALGMSLGVV
HHHCHHHHHCCHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
VIVAFYLFR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]