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The map label for this gene is etfA [H]

Identifier: 78224492

GI number: 78224492

Start: 3713948

End: 3714862

Strand: Direct

Name: etfA [H]

Synonym: Gmet_3301

Alternate gene names: 78224492

Gene position: 3713948-3714862 (Clockwise)

Preceding gene: 78224491

Following gene: 78224493

Centisome position: 92.91

GC content: 61.86

Gene sequence:

>915_bases
GTGCTTCTGGTGGGAGAATACCGCGAAGGAAAGCTCCGCGAGGAAAGTTACGATCTAGTGGCCTTTGCCGACGCCCTTGG
TGCCCAGCGCTCCATGGTTCTCGTGGCGCCGGCGGGGACGGTGCCAACCGTGGACGGGACCCTCTACATTGCCGACGCGG
CGCAGTGCGGCGAGTACAACCCGGAGCACCACAAGAGAATAATCCTCGCTGCCGTAGAGCGGGAAGACCCTGACTGCATC
GCTTTTGTCCACTCATCCTACGGCTGGGATCTGGCCCCGCGGTTGGCGGTTGCACTCGGGGCTGCACAGGTGTCGGAAGT
GGTTGCGGTTGCCGGCGACGGCGCCTACGAGGTGAACTGCTGCAACGCCAAACTACGCCGCGCCGTGACGCCAAAAACAC
CCAGGACCATACTCACCATCCAGGCCGGGGCATTCAGCCTTGAGAGAGAACCTGCGGGAATGCCGGCAATAGTCCCCCTC
GACGTCCCCCTTGAACCGGACCGGATTCAATTCGACGGCTACGAGGCTGCGGAGAAAAAGGGGGTTGATCTCGGCCGGGC
AGAAATAGTCGTCAGTGCCGGCAGGGGTGTCGGAAAGAAGGAAAACGTGGGGGTCATTGCCGAGCTTGCCAAGGTGCTTG
GCGGAGAGTTGGGGGCAAGTCGGCCGGTGGTCGATGCCAAATGGGTTGACCATAGCCACCAGGTGGGAACCACTGGCCAG
GTGGTCAGCCCCAAGCTCTATGTGGCCTGTGGTATCTCCGGTGCCATCCAGCATGTTGCAGGAATGAAAAAGGCTGACTT
TGTGGTGGCCATCAACAAGGACCGGGATGCCCCCATCGGAGAGGTTGCCGACGTCCTGGTGGTGGCCGATGTCATGCAGT
TCGTGCCGGCCCTGACAGCACGGGTCATGCGGTGA

Upstream 100 bases:

>100_bases
TGGGGATACTGAAGCAGAAAACCATGGTGCTGAGGTAGTGACAACATGCCGGCCGCGATCAACGGTTCCGCGGCCCGCCT
ATGAAGGAGGTTCTATGAAG

Downstream 100 bases:

>100_bases
CAAACGGCATATCTTCTACAAAAGTGGCACAGACTATCGGGAGGCTTCGATGAATGAAATATTTGTGGTTGATGCTCTGA
GAACACCGTTTGGTTCATTT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLLVGEYREGKLREESYDLVAFADALGAQRSMVLVAPAGTVPTVDGTLYIADAAQCGEYNPEHHKRIILAAVEREDPDCI
AFVHSSYGWDLAPRLAVALGAAQVSEVVAVAGDGAYEVNCCNAKLRRAVTPKTPRTILTIQAGAFSLEREPAGMPAIVPL
DVPLEPDRIQFDGYEAAEKKGVDLGRAEIVVSAGRGVGKKENVGVIAELAKVLGGELGASRPVVDAKWVDHSHQVGTTGQ
VVSPKLYVACGISGAIQHVAGMKKADFVVAINKDRDAPIGEVADVLVVADVMQFVPALTARVMR

Sequences:

>Translated_304_residues
MLLVGEYREGKLREESYDLVAFADALGAQRSMVLVAPAGTVPTVDGTLYIADAAQCGEYNPEHHKRIILAAVEREDPDCI
AFVHSSYGWDLAPRLAVALGAAQVSEVVAVAGDGAYEVNCCNAKLRRAVTPKTPRTILTIQAGAFSLEREPAGMPAIVPL
DVPLEPDRIQFDGYEAAEKKGVDLGRAEIVVSAGRGVGKKENVGVIAELAKVLGGELGASRPVVDAKWVDHSHQVGTTGQ
VVSPKLYVACGISGAIQHVAGMKKADFVVAINKDRDAPIGEVADVLVVADVMQFVPALTARVMR
>Mature_304_residues
MLLVGEYREGKLREESYDLVAFADALGAQRSMVLVAPAGTVPTVDGTLYIADAAQCGEYNPEHHKRIILAAVEREDPDCI
AFVHSSYGWDLAPRLAVALGAAQVSEVVAVAGDGAYEVNCCNAKLRRAVTPKTPRTILTIQAGAFSLEREPAGMPAIVPL
DVPLEPDRIQFDGYEAAEKKGVDLGRAEIVVSAGRGVGKKENVGVIAELAKVLGGELGASRPVVDAKWVDHSHQVGTTGQ
VVSPKLYVACGISGAIQHVAGMKKADFVVAINKDRDAPIGEVADVLVVADVMQFVPALTARVMR

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=253, Percent_Identity=36.3636363636364, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI189181759, Length=253, Percent_Identity=36.3636363636364, Blast_Score=132, Evalue=3e-31,
Organism=Escherichia coli, GI1786226, Length=176, Percent_Identity=40.3409090909091, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787990, Length=257, Percent_Identity=31.1284046692607, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI87082157, Length=242, Percent_Identity=32.6446280991736, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=306, Percent_Identity=34.3137254901961, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325261, Length=246, Percent_Identity=31.3008130081301, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17136898, Length=321, Percent_Identity=32.0872274143302, Blast_Score=140, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24652801, Length=321, Percent_Identity=32.0872274143302, Blast_Score=140, Evalue=9e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32146; Mature: 32146

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVGEYREGKLREESYDLVAFADALGAQRSMVLVAPAGTVPTVDGTLYIADAAQCGEYN
CEEECCCCCCCCCCCCCCEEEEHHHHCCCCCEEEEECCCCCCCCCCEEEEEECHHCCCCC
PEHHKRIILAAVEREDPDCIAFVHSSYGWDLAPRLAVALGAAQVSEVVAVAGDGAYEVNC
CCHHCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEE
CNAKLRRAVTPKTPRTILTIQAGAFSLEREPAGMPAIVPLDVPLEPDRIQFDGYEAAEKK
CCHHHHHCCCCCCCCEEEEEECCCEEECCCCCCCCEEEEECCCCCCCCEEECCCHHHHHC
GVDLGRAEIVVSAGRGVGKKENVGVIAELAKVLGGELGASRPVVDAKWVDHSHQVGTTGQ
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCC
VVSPKLYVACGISGAIQHVAGMKKADFVVAINKDRDAPIGEVADVLVVADVMQFVPALTA
EECCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RVMR
HHCC
>Mature Secondary Structure
MLLVGEYREGKLREESYDLVAFADALGAQRSMVLVAPAGTVPTVDGTLYIADAAQCGEYN
CEEECCCCCCCCCCCCCCEEEEHHHHCCCCCEEEEECCCCCCCCCCEEEEEECHHCCCCC
PEHHKRIILAAVEREDPDCIAFVHSSYGWDLAPRLAVALGAAQVSEVVAVAGDGAYEVNC
CCHHCEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEECCCCEEEEE
CNAKLRRAVTPKTPRTILTIQAGAFSLEREPAGMPAIVPLDVPLEPDRIQFDGYEAAEKK
CCHHHHHCCCCCCCCEEEEEECCCEEECCCCCCCCEEEEECCCCCCCCEEECCCHHHHHC
GVDLGRAEIVVSAGRGVGKKENVGVIAELAKVLGGELGASRPVVDAKWVDHSHQVGTTGQ
CCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCC
VVSPKLYVACGISGAIQHVAGMKKADFVVAINKDRDAPIGEVADVLVVADVMQFVPALTA
EECCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RVMR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]