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The map label for this gene is sbm [H]

Identifier: 78224442

GI number: 78224442

Start: 3659989

End: 3661647

Strand: Direct

Name: sbm [H]

Synonym: Gmet_3251

Alternate gene names: 78224442

Gene position: 3659989-3661647 (Clockwise)

Preceding gene: 78224441

Following gene: 78224443

Centisome position: 91.56

GC content: 63.35

Gene sequence:

>1659_bases
ATGAGCATCAGCGACAAGAAACAGGCCTGGCAGGACACTGTCGTGGCCAAGAGCATCGCCAGATCCCCGGAGCGGAAGCC
CGAATTCCGCACCACTTCCAATATCGAGATGGAGCGCTGCTTCACTCCCGGCTTCGACGACTATCCGGGCTACGAAGAGG
AGCTCGGCTTCCCGGGCCAGTACCCCTTCACCCGCGGCGTCCAGCCCACCATGTACCGGGGCCGCTTCTGGACCATGCGC
CAGTACGCCGGTTTCGGCACGGCCAAGGAATCCAACGAGCGCTACAAATATCTGCTTCAGGCGGGTCAGACCGGCCTTTC
CGTCGCCTTCGACCTCCCCACCCAGATGGGGTACGACTCCGACGCCGCCATGGCCCAGGGCGAAGTTGGTAAAGTAGGGG
TCGCCATCGACTCCCTGGCCGACATGGAGATCCTCTTCGACGGCATCCCCCTGGACAAGGTCTCCACCTCCATGACCATC
AACTCCACCGCCGCTATCCTCCTAGCCATGTACATCGCCGTGGCCGAGAAGCAGGGTGTCTCGCCGGAGAAGATTTCCGG
CACCATCCAAAACGACATCCTCAAAGAATACATGGCCCGGGGGACTTACATCTACCCCCCCCAGGAGTCGATGCGGATCA
TCACCGACATCTTCGCCTACTGCAAAGACAACGTCCCCAAGTGGAACACCATCTCCATCTCCGGCTACCACATCCGCGAG
GCGGGCTCCAGCGCCGTGCAGGAAGTGGCCTTCACCCTGGCCGACGGCATCGCCTACGTGGAAGCCGCCATCAAGGCTGG
CCTCAACGTGGATGAATTCGCCCCCCGGCTCGCCTTCTTCTTCAACGCCCACAACAACCTCTTGGAGGAAGTCGCCAAGT
TCCGGGCCGCCCGCCGCATGTGGGCCACCATCATGAAAGAGCGGTTCGGGGCCAAGGATCCCAAGTCCCTCATGCTCCGC
TTCCACACCCAGACCGCCGGCTGCACCCTCACCGCCCAGCAGCCCGACAACAACATCATGCGGGTCACCATCCAGGCCCT
GGCCGCCGTTCTCGGCGGCACCCAGTCGCTCCACACCAACTCCCGCGACGAGGCCCTGGCGCTCCCCACCGAAGACTCGG
TCCGGATAGCGCTCCGCACCCAGCAGGTCATCGCCTACGAATCGGGCGTGGCCGACTCCATCGACCCCCTGGCCGGCAGC
TTCCTCGTGGAATCCCTCACCGACCAGATCGAAATGGCCGCCACCGAGTACATCAACAAGATCGACTCCCTCGGCGGCGC
CGTCGAAGCCATCTCCCGCGGCTTCCAGCAGAAGGAAATCCAGGACTCCGCCTACGCCTACCAGCGGGCCATCGAAACCG
ACGACCTGATCATCGTCGGGGTCAACAAGTTCACCGTCACCGGCGAGCCGGCCCCCGAGCTTCTCAAGATCAAGGAAGAG
GTCGAAATCGCCCAGAAGAAGTCCCTCGGCGACATGAAGGCCAAACGCGACGACGCAAGGGTCAAGGAAACCCTCGCCGC
CCTCGCCGCCGCCGCCAAGGGAACCGACAACCTCATGCCGCCGATCCTCAACGCTGTCAAGGCCTACGCCACCCTCGGCG
AAATCGCCAACGTCCTCCGCGACGTCTTCGGTGTCCACCGGGAGACGGTGGTGCTGTAA

Upstream 100 bases:

>100_bases
TCCTCTAGCCGCACAACCCACCGACGCGCCCCTGCTGAACACCACGGCGGGGGCCGTTTTCATTTTCAGGACACGAATTA
TCCACCGGAAGGAGAACACC

Downstream 100 bases:

>100_bases
TTTTATGGGAATAACACGGAGAGACGGAGAAACGGAGAAAAAGCTCTTAGAATCAGAATTGACCGACCTGATTATTGGCA
AAGCCATTGTTGTCCACAGT

Product: methylmalonyl-CoA mutase

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MSISDKKQAWQDTVVAKSIARSPERKPEFRTTSNIEMERCFTPGFDDYPGYEEELGFPGQYPFTRGVQPTMYRGRFWTMR
QYAGFGTAKESNERYKYLLQAGQTGLSVAFDLPTQMGYDSDAAMAQGEVGKVGVAIDSLADMEILFDGIPLDKVSTSMTI
NSTAAILLAMYIAVAEKQGVSPEKISGTIQNDILKEYMARGTYIYPPQESMRIITDIFAYCKDNVPKWNTISISGYHIRE
AGSSAVQEVAFTLADGIAYVEAAIKAGLNVDEFAPRLAFFFNAHNNLLEEVAKFRAARRMWATIMKERFGAKDPKSLMLR
FHTQTAGCTLTAQQPDNNIMRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQVIAYESGVADSIDPLAGS
FLVESLTDQIEMAATEYINKIDSLGGAVEAISRGFQQKEIQDSAYAYQRAIETDDLIIVGVNKFTVTGEPAPELLKIKEE
VEIAQKKSLGDMKAKRDDARVKETLAALAAAAKGTDNLMPPILNAVKAYATLGEIANVLRDVFGVHRETVVL

Sequences:

>Translated_552_residues
MSISDKKQAWQDTVVAKSIARSPERKPEFRTTSNIEMERCFTPGFDDYPGYEEELGFPGQYPFTRGVQPTMYRGRFWTMR
QYAGFGTAKESNERYKYLLQAGQTGLSVAFDLPTQMGYDSDAAMAQGEVGKVGVAIDSLADMEILFDGIPLDKVSTSMTI
NSTAAILLAMYIAVAEKQGVSPEKISGTIQNDILKEYMARGTYIYPPQESMRIITDIFAYCKDNVPKWNTISISGYHIRE
AGSSAVQEVAFTLADGIAYVEAAIKAGLNVDEFAPRLAFFFNAHNNLLEEVAKFRAARRMWATIMKERFGAKDPKSLMLR
FHTQTAGCTLTAQQPDNNIMRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQVIAYESGVADSIDPLAGS
FLVESLTDQIEMAATEYINKIDSLGGAVEAISRGFQQKEIQDSAYAYQRAIETDDLIIVGVNKFTVTGEPAPELLKIKEE
VEIAQKKSLGDMKAKRDDARVKETLAALAAAAKGTDNLMPPILNAVKAYATLGEIANVLRDVFGVHRETVVL
>Mature_551_residues
SISDKKQAWQDTVVAKSIARSPERKPEFRTTSNIEMERCFTPGFDDYPGYEEELGFPGQYPFTRGVQPTMYRGRFWTMRQ
YAGFGTAKESNERYKYLLQAGQTGLSVAFDLPTQMGYDSDAAMAQGEVGKVGVAIDSLADMEILFDGIPLDKVSTSMTIN
STAAILLAMYIAVAEKQGVSPEKISGTIQNDILKEYMARGTYIYPPQESMRIITDIFAYCKDNVPKWNTISISGYHIREA
GSSAVQEVAFTLADGIAYVEAAIKAGLNVDEFAPRLAFFFNAHNNLLEEVAKFRAARRMWATIMKERFGAKDPKSLMLRF
HTQTAGCTLTAQQPDNNIMRVTIQALAAVLGGTQSLHTNSRDEALALPTEDSVRIALRTQQVIAYESGVADSIDPLAGSF
LVESLTDQIEMAATEYINKIDSLGGAVEAISRGFQQKEIQDSAYAYQRAIETDDLIIVGVNKFTVTGEPAPELLKIKEEV
EIAQKKSLGDMKAKRDDARVKETLAALAAAAKGTDNLMPPILNAVKAYATLGEIANVLRDVFGVHRETVVL

Specific function: Unknown

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=497, Percent_Identity=51.307847082495, Blast_Score=500, Evalue=1e-141,
Organism=Escherichia coli, GI1789284, Length=488, Percent_Identity=54.5081967213115, Blast_Score=504, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI25144500, Length=491, Percent_Identity=52.9531568228106, Blast_Score=519, Evalue=1e-147,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 60704; Mature: 60573

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISDKKQAWQDTVVAKSIARSPERKPEFRTTSNIEMERCFTPGFDDYPGYEEELGFPGQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHCCCCCC
YPFTRGVQPTMYRGRFWTMRQYAGFGTAKESNERYKYLLQAGQTGLSVAFDLPTQMGYDS
CCCCCCCCCCEECCCEEEHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHCCCCC
DAAMAQGEVGKVGVAIDSLADMEILFDGIPLDKVSTSMTINSTAAILLAMYIAVAEKQGV
CHHHHCCCCCEEEEHHHHHHCHHHHCCCCCHHHHCCCEEECHHHHHHHHHHHHHHHHCCC
SPEKISGTIQNDILKEYMARGTYIYPPQESMRIITDIFAYCKDNVPKWNTISISGYHIRE
CHHHHCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEHH
AGSSAVQEVAFTLADGIAYVEAAIKAGLNVDEFAPRLAFFFNAHNNLLEEVAKFRAARRM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WATIMKERFGAKDPKSLMLRFHTQTAGCTLTAQQPDNNIMRVTIQALAAVLGGTQSLHTN
HHHHHHHHCCCCCCHHHHEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHCCCC
SRDEALALPTEDSVRIALRTQQVIAYESGVADSIDPLAGSFLVESLTDQIEMAATEYINK
CCCCEEECCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDSLGGAVEAISRGFQQKEIQDSAYAYQRAIETDDLIIVGVNKFTVTGEPAPELLKIKEE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCHHHHHHHHH
VEIAQKKSLGDMKAKRDDARVKETLAALAAAAKGTDNLMPPILNAVKAYATLGEIANVLR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DVFGVHRETVVL
HHHCCCHHHCCC
>Mature Secondary Structure 
SISDKKQAWQDTVVAKSIARSPERKPEFRTTSNIEMERCFTPGFDDYPGYEEELGFPGQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCHHHCCCCCC
YPFTRGVQPTMYRGRFWTMRQYAGFGTAKESNERYKYLLQAGQTGLSVAFDLPTQMGYDS
CCCCCCCCCCEECCCEEEHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEEEECCHHCCCCC
DAAMAQGEVGKVGVAIDSLADMEILFDGIPLDKVSTSMTINSTAAILLAMYIAVAEKQGV
CHHHHCCCCCEEEEHHHHHHCHHHHCCCCCHHHHCCCEEECHHHHHHHHHHHHHHHHCCC
SPEKISGTIQNDILKEYMARGTYIYPPQESMRIITDIFAYCKDNVPKWNTISISGYHIRE
CHHHHCCHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEHH
AGSSAVQEVAFTLADGIAYVEAAIKAGLNVDEFAPRLAFFFNAHNNLLEEVAKFRAARRM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WATIMKERFGAKDPKSLMLRFHTQTAGCTLTAQQPDNNIMRVTIQALAAVLGGTQSLHTN
HHHHHHHHCCCCCCHHHHEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHCCCC
SRDEALALPTEDSVRIALRTQQVIAYESGVADSIDPLAGSFLVESLTDQIEMAATEYINK
CCCCEEECCCCCCEEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDSLGGAVEAISRGFQQKEIQDSAYAYQRAIETDDLIIVGVNKFTVTGEPAPELLKIKEE
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCHHHHHHHHH
VEIAQKKSLGDMKAKRDDARVKETLAALAAAAKGTDNLMPPILNAVKAYATLGEIANVLR
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DVFGVHRETVVL
HHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]