Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 78224441

GI number: 78224441

Start: 3659261

End: 3659896

Strand: Direct

Name: tmk [H]

Synonym: Gmet_3250

Alternate gene names: 78224441

Gene position: 3659261-3659896 (Clockwise)

Preceding gene: 78224440

Following gene: 78224442

Centisome position: 91.54

GC content: 58.33

Gene sequence:

>636_bases
GTGAGAAAAGGAAAACTTATCGTCATTGAGGGAATCAGCGGCTCGGGCCAGCAGGTCAAGGCGGCCATCGTGGGGCTGCA
CAAGGCGCTGACAGGAATGAAATACGACGTGGTCGAATGCGCCAACCCCGATTCCGGCCGGGCAAAGGAACTCGGGATCG
ACAATCTTCTCAACTGGCCCTTCGGCAGGACCCCCCGGGCCGACTTCATGTTCGAGGCCGCGGTCCGGACCGAGGTCTTC
AAGAACATCGTCGAGCCGGCGCTCCAGGATGACAAGATCGTCCTGTGCAAGCAATCGAGCATCTCTTCCCTGGCAAACGC
CTGGGTCAGCGGTTACACCAAGCATTTCGACGTGCTGCGCCATATCGAAAAGCTTTCCCGGGGATTTCTCTTCGAGGATG
AGATCTATCCGGACCTGACCCTCTTCATCGACGTGCCGGCCCAGGAGGCCTTCGAGCGGATCGAGGATGTCCTGCAGATC
CACCACGAAGGGGGCATCGAATACTATGAGAAGATGCGGGAGTTCTATCTCAAGGAGATTTCCCGCTGGCATGGCGCCAG
CATCGCCGCTGGAGCCGACAGGTCGGAAGAGGAGATAAACGCCGACATCTGGGCCAAGGTTCAAACCATCCTCTAG

Upstream 100 bases:

>100_bases
CTGCCCGCATCCGCCGGCCCCGCCCGGAAAGGCGGGGTCGGTTTTTATGGGCCGGCCGAATTGCCTTGCCTGAACTAACA
CCAACATTCGGGAGGATACC

Downstream 100 bases:

>100_bases
CCGCACAACCCACCGACGCGCCCCTGCTGAACACCACGGCGGGGGCCGTTTTCATTTTCAGGACACGAATTATCCACCGG
AAGGAGAACACCATGAGCAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRKGKLIVIEGISGSGQQVKAAIVGLHKALTGMKYDVVECANPDSGRAKELGIDNLLNWPFGRTPRADFMFEAAVRTEVF
KNIVEPALQDDKIVLCKQSSISSLANAWVSGYTKHFDVLRHIEKLSRGFLFEDEIYPDLTLFIDVPAQEAFERIEDVLQI
HHEGGIEYYEKMREFYLKEISRWHGASIAAGADRSEEEINADIWAKVQTIL

Sequences:

>Translated_211_residues
MRKGKLIVIEGISGSGQQVKAAIVGLHKALTGMKYDVVECANPDSGRAKELGIDNLLNWPFGRTPRADFMFEAAVRTEVF
KNIVEPALQDDKIVLCKQSSISSLANAWVSGYTKHFDVLRHIEKLSRGFLFEDEIYPDLTLFIDVPAQEAFERIEDVLQI
HHEGGIEYYEKMREFYLKEISRWHGASIAAGADRSEEEINADIWAKVQTIL
>Mature_211_residues
MRKGKLIVIEGISGSGQQVKAAIVGLHKALTGMKYDVVECANPDSGRAKELGIDNLLNWPFGRTPRADFMFEAAVRTEVF
KNIVEPALQDDKIVLCKQSSISSLANAWVSGYTKHFDVLRHIEKLSRGFLFEDEIYPDLTLFIDVPAQEAFERIEDVLQI
HHEGGIEYYEKMREFYLKEISRWHGASIAAGADRSEEEINADIWAKVQTIL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23842; Mature: 23842

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGKLIVIEGISGSGQQVKAAIVGLHKALTGMKYDVVECANPDSGRAKELGIDNLLNWP
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHCCHHHHHCCC
FGRTPRADFMFEAAVRTEVFKNIVEPALQDDKIVLCKQSSISSLANAWVSGYTKHFDVLR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
HIEKLSRGFLFEDEIYPDLTLFIDVPAQEAFERIEDVLQIHHEGGIEYYEKMREFYLKEI
HHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SRWHGASIAAGADRSEEEINADIWAKVQTIL
HHHCCCCEECCCCCCHHHHCHHHHHHHHHCC
>Mature Secondary Structure
MRKGKLIVIEGISGSGQQVKAAIVGLHKALTGMKYDVVECANPDSGRAKELGIDNLLNWP
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHHCCHHHHHCCC
FGRTPRADFMFEAAVRTEVFKNIVEPALQDDKIVLCKQSSISSLANAWVSGYTKHFDVLR
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
HIEKLSRGFLFEDEIYPDLTLFIDVPAQEAFERIEDVLQIHHEGGIEYYEKMREFYLKEI
HHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SRWHGASIAAGADRSEEEINADIWAKVQTIL
HHHCCCCEECCCCCCHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA