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The map label for this gene is proA

Identifier: 78224390

GI number: 78224390

Start: 3599883

End: 3601139

Strand: Direct

Name: proA

Synonym: Gmet_3199

Alternate gene names: 78224390

Gene position: 3599883-3601139 (Clockwise)

Preceding gene: 78224389

Following gene: 78224391

Centisome position: 90.06

GC content: 64.92

Gene sequence:

>1257_bases
GTGACCATCGCTGAACAGATCCGCACCATCGCCGCCGACGCCCGCCAGGCCGCCATCGCCATGGCGAAGCTCCCCACCAC
GGCCAAGAACGACCTCCTCATGGCCATGGCCATGGCCCTCATCAGCAACACCCCGCACCTGATCGACGAGAACCGCAAGG
ACCTTGAGGCCGGGGAGAAGAAGGGGCTTTCCAGCGCCATGCTCGACCGCCTCATGCTGGATGAGGCACGCATCAAGGCC
ATGGCCGACGGCCTGCGGGAGGTGGCGGGACTCCCCGATCCCGTGGGGGAAGTGACGCGGATGTGGAAACGCCCCAACAA
CCTCATGGTGGGGAAGATGCGGATTCCGCTGGGGGTCATCGGCATCATCTACGAGGCGCGCCCTAACGTGACGGCCGACG
CCGCAGCCCTCTGTCTCAAGGCGGGGAACAGCGTGATTCTGCGGGGGGGCTCCGAGGCCATCCACTCCAACCTCGCCATC
GCCCGCATCCTGGGGGAGGAGATGGAGCGGGCCGGCATCCCGAAGGCGGCCCTGTCGGTCATCCCGTTCCCGGAGCGCGA
GGGGGTCCTGGAGATGCTCAAGCAGGAGGAGTTCATCGACCTCATCATCCCGAGGGGGGGCGAGAGCCTGATCCGCTTCG
TGGTGGAGCATTCGAAGATCCCGGTCATCAAGCACTACAAGGGGGTTTGCCACGTTTTTGTGGATGCGTCGGCTGATTTC
GACATGGCCGAGCGGATCGTGGTGAACGCCAAGGTCCAGCGCCCCGGAGTCTGCAACGCCTTGGAGACGCTCCTTATCCA
CAAGGATGTGGCCGAGGCCTTCATCCCCCGCATCGCCGCAACCCTGACCGACCTCAAGGTGGAGCTGCGGGGCGATGACT
GCGTCCGCCAGTTCGCCCCCCAGGCGAAGAAGGCCACGGAAGAGGACTGGCAGGCCGAGTACCTGGAGCTGATCCTGGCC
GTCCGGGTGGTGGACGGCCTGAACGAAGCCATCGACCACATCAATGCCTACGGCTCCCTCCACACCGAGGCCATCGTCAC
CCGGGACTACCACAATTCCCAGCGCTTCATCCGGGAGGTGAACTCCAGCACGGTCCTCGTGAATGCCTCCACCCGCTTCG
CCGACGGGAACCAGCTGGGGCTCGGCGCGGAGATCGGCATCTCCACCACCAAGCTCCATTCCTTCGGCCCCATGGGACTT
GAGGATCTGACGACCACCAAGTTCATCGTCTACGGCGACGGCCAGGTAAGGCAGTGA

Upstream 100 bases:

>100_bases
TATAAAGAAAGAATTCAGGAGTCAGAATTCAGAATCCAGTAAGTTTTTCTCCTGAATTCTGACTCCTGTCTCCTGACTAC
TCATAACGGAGGTACCTCCC

Downstream 100 bases:

>100_bases
CCAGGGACCAGGGACCAGAGACCGGCAAAGCATGAGAACGGGGATTCTCGGCGGCACCTTCAACCCGATCCACCACGCCC
ACCTCCGCATTGCGGAGGAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTIAEQIRTIAADARQAAIAMAKLPTTAKNDLLMAMAMALISNTPHLIDENRKDLEAGEKKGLSSAMLDRLMLDEARIKA
MADGLREVAGLPDPVGEVTRMWKRPNNLMVGKMRIPLGVIGIIYEARPNVTADAAALCLKAGNSVILRGGSEAIHSNLAI
ARILGEEMERAGIPKAALSVIPFPEREGVLEMLKQEEFIDLIIPRGGESLIRFVVEHSKIPVIKHYKGVCHVFVDASADF
DMAERIVVNAKVQRPGVCNALETLLIHKDVAEAFIPRIAATLTDLKVELRGDDCVRQFAPQAKKATEEDWQAEYLELILA
VRVVDGLNEAIDHINAYGSLHTEAIVTRDYHNSQRFIREVNSSTVLVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGL
EDLTTTKFIVYGDGQVRQ

Sequences:

>Translated_418_residues
MTIAEQIRTIAADARQAAIAMAKLPTTAKNDLLMAMAMALISNTPHLIDENRKDLEAGEKKGLSSAMLDRLMLDEARIKA
MADGLREVAGLPDPVGEVTRMWKRPNNLMVGKMRIPLGVIGIIYEARPNVTADAAALCLKAGNSVILRGGSEAIHSNLAI
ARILGEEMERAGIPKAALSVIPFPEREGVLEMLKQEEFIDLIIPRGGESLIRFVVEHSKIPVIKHYKGVCHVFVDASADF
DMAERIVVNAKVQRPGVCNALETLLIHKDVAEAFIPRIAATLTDLKVELRGDDCVRQFAPQAKKATEEDWQAEYLELILA
VRVVDGLNEAIDHINAYGSLHTEAIVTRDYHNSQRFIREVNSSTVLVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGL
EDLTTTKFIVYGDGQVRQ
>Mature_417_residues
TIAEQIRTIAADARQAAIAMAKLPTTAKNDLLMAMAMALISNTPHLIDENRKDLEAGEKKGLSSAMLDRLMLDEARIKAM
ADGLREVAGLPDPVGEVTRMWKRPNNLMVGKMRIPLGVIGIIYEARPNVTADAAALCLKAGNSVILRGGSEAIHSNLAIA
RILGEEMERAGIPKAALSVIPFPEREGVLEMLKQEEFIDLIIPRGGESLIRFVVEHSKIPVIKHYKGVCHVFVDASADFD
MAERIVVNAKVQRPGVCNALETLLIHKDVAEAFIPRIAATLTDLKVELRGDDCVRQFAPQAKKATEEDWQAEYLELILAV
RVVDGLNEAIDHINAYGSLHTEAIVTRDYHNSQRFIREVNSSTVLVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLE
DLTTTKFIVYGDGQVRQ

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=407, Percent_Identity=37.8378378378378, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI62912457, Length=407, Percent_Identity=37.8378378378378, Blast_Score=270, Evalue=2e-72,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=45.343137254902, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=35.4916067146283, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=35.4916067146283, Blast_Score=252, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=35.796766743649, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=37.8640776699029, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_GEOMG (Q39QR2)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386137.1
- ProteinModelPortal:   Q39QR2
- SMR:   Q39QR2
- STRING:   Q39QR2
- GeneID:   3741109
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3199
- NMPDR:   fig|269799.3.peg.2433
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   HRIEAMA
- PhylomeDB:   Q39QR2
- ProtClustDB:   PRK00197
- BioCyc:   GMET269799:GMET_3199-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45717; Mature: 45585

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAEQIRTIAADARQAAIAMAKLPTTAKNDLLMAMAMALISNTPHLIDENRKDLEAGEK
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHH
KGLSSAMLDRLMLDEARIKAMADGLREVAGLPDPVGEVTRMWKRPNNLMVGKMRIPLGVI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEE
GIIYEARPNVTADAAALCLKAGNSVILRGGSEAIHSNLAIARILGEEMERAGIPKAALSV
EEEEECCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IPFPEREGVLEMLKQEEFIDLIIPRGGESLIRFVVEHSKIPVIKHYKGVCHVFVDASADF
CCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCHHHHCCCEEEEEEECCCCH
DMAERIVVNAKVQRPGVCNALETLLIHKDVAEAFIPRIAATLTDLKVELRGDDCVRQFAP
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHCC
QAKKATEEDWQAEYLELILAVRVVDGLNEAIDHINAYGSLHTEAIVTRDYHNSQRFIREV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHHHC
NSSTVLVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLEDLTTTKFIVYGDGQVRQ
CCCEEEEECCCEECCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TIAEQIRTIAADARQAAIAMAKLPTTAKNDLLMAMAMALISNTPHLIDENRKDLEAGEK
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHH
KGLSSAMLDRLMLDEARIKAMADGLREVAGLPDPVGEVTRMWKRPNNLMVGKMRIPLGVI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEECCEEEE
GIIYEARPNVTADAAALCLKAGNSVILRGGSEAIHSNLAIARILGEEMERAGIPKAALSV
EEEEECCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
IPFPEREGVLEMLKQEEFIDLIIPRGGESLIRFVVEHSKIPVIKHYKGVCHVFVDASADF
CCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCHHHHCCCEEEEEEECCCCH
DMAERIVVNAKVQRPGVCNALETLLIHKDVAEAFIPRIAATLTDLKVELRGDDCVRQFAP
HHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHCC
QAKKATEEDWQAEYLELILAVRVVDGLNEAIDHINAYGSLHTEAIVTRDYHNSQRFIREV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEECCCCHHHHHHHHC
NSSTVLVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLEDLTTTKFIVYGDGQVRQ
CCCEEEEECCCEECCCCCCCCCCCCCCCHHEECCCCCCCCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA