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The map label for this gene is coaE

Identifier: 78224219

GI number: 78224219

Start: 3412083

End: 3412688

Strand: Direct

Name: coaE

Synonym: Gmet_3026

Alternate gene names: 78224219

Gene position: 3412083-3412688 (Clockwise)

Preceding gene: 78224218

Following gene: 78224221

Centisome position: 85.36

GC content: 64.03

Gene sequence:

>606_bases
ATGCTAGTCATAGGACTGACCGGTGGGATAGCGTCGGGGAAAAGTACCGTTGCGCGGATATTGGAACGACTCGGCGCCAC
GATTATCGATGCCGACCTCCTCGCGAGGGAAGCTGTTCTTCCCGGCACCCCGGCCCACCGGGCCATCGTGGCCGCCTTCG
GCACGGAGATCCTCCTGCCGGACGCCACCATCGATCGCAAAGCGCTGGGGCGCATCGTCTTCGCCAATCCGGATGCGCGG
CGACGCCTGGAGGCCATAACCCATCCCGCCATCGCCCGCCTGTCACAAGCGCGGCTGGCAGAGGCCCGCCGCTCCGACGC
ACCAGCGGTCTTTTACGTGGCGCCCCTGCTCATCGAGGCGGGAGCGGCTGACCGGGTTGACGATATCTGGGTAGTGTACG
CCGATCGGGAGACACAGCTCGCTCGACTTACGGAGCGCGACGGAATCGGGCGAGGGGAGGCTGAACAGCGACTCGCAGCC
CAGATGCCCATGGACGAAAAGGCTTCCTATGGCTCGGCCGTCATTGACAACCGGGGGACGTCAGAGGAGACGGAACGGCA
GGTGGTTGCCCTTTGGAAGGAGAGAATAGAAAAAAACCCCCGGTAA

Upstream 100 bases:

>100_bases
CCATCGTCGCCTCCCAGTGAGCCTGCCACTTCGGGCCCCCTTCCCGATTGACAGCTTTAACAAAGTATGGAATGGTTCCT
GGTCATCAGGGGAGGGAGCC

Downstream 100 bases:

>100_bases
ATCCGGGGGTTTTTTTATTTGTGGTAGCCGAGTTTCATGGAAATCTCATCGGCGGCCTGCGTAATGAGGGGAATGAGTTC
CTTTGCCATCCTCTCGTCGG

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLPDATIDRKALGRIVFANPDAR
RRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEAGAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAA
QMPMDEKASYGSAVIDNRGTSEETERQVVALWKERIEKNPR

Sequences:

>Translated_201_residues
MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLPDATIDRKALGRIVFANPDAR
RRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEAGAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAA
QMPMDEKASYGSAVIDNRGTSEETERQVVALWKERIEKNPR
>Mature_201_residues
MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLPDATIDRKALGRIVFANPDAR
RRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEAGAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAA
QMPMDEKASYGSAVIDNRGTSEETERQVVALWKERIEKNPR

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=195, Percent_Identity=44.6153846153846, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI191252795, Length=195, Percent_Identity=44.6153846153846, Blast_Score=168, Evalue=3e-42,
Organism=Homo sapiens, GI110227607, Length=202, Percent_Identity=36.1386138613861, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI110227605, Length=202, Percent_Identity=36.1386138613861, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI110227603, Length=202, Percent_Identity=36.1386138613861, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI110227601, Length=202, Percent_Identity=36.1386138613861, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI205277394, Length=202, Percent_Identity=36.1386138613861, Blast_Score=118, Evalue=4e-27,
Organism=Escherichia coli, GI1786292, Length=195, Percent_Identity=38.4615384615385, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17554944, Length=190, Percent_Identity=37.3684210526316, Blast_Score=136, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI25143409, Length=187, Percent_Identity=29.9465240641711, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320402, Length=200, Percent_Identity=35.5, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24644728, Length=194, Percent_Identity=38.659793814433, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24658602, Length=193, Percent_Identity=34.1968911917098, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_GEOMG (Q39R83)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385966.1
- ProteinModelPortal:   Q39R83
- SMR:   Q39R83
- STRING:   Q39R83
- GeneID:   3740763
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3026
- NMPDR:   fig|269799.3.peg.3076
- eggNOG:   COG0237
- HOGENOM:   HBG650290
- OMA:   VVVYCDP
- PhylomeDB:   Q39R83
- ProtClustDB:   CLSK827890
- BioCyc:   GMET269799:GMET_3026-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21828; Mature: 21828

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLP
CEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECC
DATIDRKALGRIVFANPDARRRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEA
CCCCCHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAAQMPMDEKASYGSAVIDNRGT
CCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCC
SEETERQVVALWKERIEKNPR
CHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLP
CEEEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEECC
DATIDRKALGRIVFANPDARRRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEA
CCCCCHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
GAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAAQMPMDEKASYGSAVIDNRGT
CCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCCCC
SEETERQVVALWKERIEKNPR
CHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA