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The map label for this gene is purE [H]

Identifier: 78224099

GI number: 78224099

Start: 3285763

End: 3286272

Strand: Reverse

Name: purE [H]

Synonym: Gmet_2903

Alternate gene names: 78224099

Gene position: 3286272-3285763 (Counterclockwise)

Preceding gene: 78224100

Following gene: 78224098

Centisome position: 82.21

GC content: 65.49

Gene sequence:

>510_bases
ATGGGTAATCCACAGGTTCTTATTGTCATGGGGAGCGATTCGGACCTCTCTATCATGGAGGAGGCCGCGAAGGTTCTCGA
CGAGTTCGGTGTGGCGTGGGAGATGCGCGTCGCCTCGGCCCACCGTTCGCCGAAGAAGGCTGCGGCACTGGCTGCAGGCG
CTGCGGCAAGGGGGGTCAAGGCGATCATCGCCGGTGCCGGCATGGCTGCCCACCTGGCCGGGGTCATCGCCGCCGATACC
GTTCTGCCGGTGATCGCCGTGCCGATCCCCGGCGGAGCCCTTAACGGCGTCGATGCCCTCTACGCCATGGTCCAGATGCC
GGGCGGAATTCCCGTGGCCACCATGGCCATCGGCAAGGCTGGGGCCAAAAACGCAGGACTTCTTGCGGTGCAGATCATTG
CCCTCGGCGACCCGGCGCTCACCGCGGAGCTTGTTGCCCACAAGCAGGCCATGGCCGACGAGGTGGAGGCGAAGGACAAC
GCTCTCCAGGAGCGATTGCGCAGATCCTAG

Upstream 100 bases:

>100_bases
ATCTGCTGGGAAGGGGTCCATTTCAGGAAGGATATCGGGGCAAAGGCGCTGAAGCGGTAGCCGGCGCACGGAATCGAGAC
TGCATACACTAGGGGTACGT

Downstream 100 bases:

>100_bases
CCTGTTGTGTTAGTTGTGTGTAATTCAACCTGAATGAACAACTTTTTGACTTGCAGGGTTACTCTTGACAAACAAAATTG
CTCGGGTATAAGTTTCTGAC

Product: 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MGNPQVLIVMGSDSDLSIMEEAAKVLDEFGVAWEMRVASAHRSPKKAAALAAGAAARGVKAIIAGAGMAAHLAGVIAADT
VLPVIAVPIPGGALNGVDALYAMVQMPGGIPVATMAIGKAGAKNAGLLAVQIIALGDPALTAELVAHKQAMADEVEAKDN
ALQERLRRS

Sequences:

>Translated_169_residues
MGNPQVLIVMGSDSDLSIMEEAAKVLDEFGVAWEMRVASAHRSPKKAAALAAGAAARGVKAIIAGAGMAAHLAGVIAADT
VLPVIAVPIPGGALNGVDALYAMVQMPGGIPVATMAIGKAGAKNAGLLAVQIIALGDPALTAELVAHKQAMADEVEAKDN
ALQERLRRS
>Mature_168_residues
GNPQVLIVMGSDSDLSIMEEAAKVLDEFGVAWEMRVASAHRSPKKAAALAAGAAARGVKAIIAGAGMAAHLAGVIAADTV
LPVIAVPIPGGALNGVDALYAMVQMPGGIPVATMAIGKAGAKNAGLLAVQIIALGDPALTAELVAHKQAMADEVEAKDNA
LQERLRRS

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220559, Length=143, Percent_Identity=30.0699300699301, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119220557, Length=143, Percent_Identity=30.0699300699301, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI5453539, Length=143, Percent_Identity=30.0699300699301, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=52.258064516129, Blast_Score=115, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=163, Percent_Identity=48.4662576687117, Blast_Score=148, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16993; Mature: 16862

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNPQVLIVMGSDSDLSIMEEAAKVLDEFGVAWEMRVASAHRSPKKAAALAAGAAARGVK
CCCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHH
AIIAGAGMAAHLAGVIAADTVLPVIAVPIPGGALNGVDALYAMVQMPGGIPVATMAIGKA
HHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCC
GAKNAGLLAVQIIALGDPALTAELVAHKQAMADEVEAKDNALQERLRRS
CCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNPQVLIVMGSDSDLSIMEEAAKVLDEFGVAWEMRVASAHRSPKKAAALAAGAAARGVK
CCCEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHH
AIIAGAGMAAHLAGVIAADTVLPVIAVPIPGGALNGVDALYAMVQMPGGIPVATMAIGKA
HHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCC
GAKNAGLLAVQIIALGDPALTAELVAHKQAMADEVEAKDNALQERLRRS
CCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]