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The map label for this gene is lytS [H]

Identifier: 78223894

GI number: 78223894

Start: 3046903

End: 3048633

Strand: Reverse

Name: lytS [H]

Synonym: Gmet_2698

Alternate gene names: 78223894

Gene position: 3048633-3046903 (Counterclockwise)

Preceding gene: 78223895

Following gene: 78223893

Centisome position: 76.27

GC content: 65.57

Gene sequence:

>1731_bases
ATGCTGCACCTTCTCGTGAATCTTCTGGAGCGCCTCGGGCTGTTCGCCATCGCGTTCATCCTGGTCATGCGCTTCGCCAT
CGTCAAGCGGTTCCTGATCGGCAAGGCGAGCCGCTACGAAAAGCTCACCCTGTCGGTTCTCTTCGGCTTCATCGGCATTG
CTGGGACCTACATGGGGGTGCCGATCCAGAACGCCATCGCCAATTCGCGGGTGGTGGGGGTGGCCCTCGGGGGGATCCTC
GGCGGCCCCCTGGTCGGTTTCGGGGCCGGGCTCATCGCCGGTGGGCACCGTTTTCTCATCGATGTGGGGGGCTTCACGGC
GACGGCCTGCGGGGTGGCGACCATCGCGGAGGGGGTTGCCGGCGGCCTCATCTACCACCGCCTCAAGAGGGGGCAGTTCG
ATCCCGCCGTGGCCTTTATCACGGGGGTCGCGGTGGAAACCCTCCAGATGGTGATCCTCCTTGTCATGGCGAAGCCCTTC
ACCGCGGCGGTGAGCCTGGTGAGTGTCATCGGCTTCCCCATGATCCTGGTGAACTCCATCGGCTTGGCCCTGTTCGTGGA
ACTGGTGTCATCGGTGTTCCGGGAGAAGGAGCGCTTCGCCGCGGTCCAGGCCCAGACGGCCCTCAATATCGCCCTGCGCA
CGCTCCCCTTCCTCCGGGGGGGGCTCACCGAGGGGTCTGCCGCGGCAACGGCCCGGATCATCCGGGAGATGACTGATCTC
GATGCGGTGGCCATCACCGACGAGGCCGCCATCCTGGCCCACACCGGGGCCGAGGAGGATCACCACCGCCCCGGCTTGCC
GCTTCTGACCGCTTCCACCAGGTCTGCCCTCGCCTCGGGGGAGATCACCACCCCCCTGACCCGTGACGACATCGGCTGTA
CCCACGAAGGGTGCCGGCTCGGCTCGGCGATCATCGTTCCCCTCAAGAAGCGGGAGCGCACCGTGGGGGCCCTGAAGCTC
TACCGGCTCAAGGAAGGGGGAATTACCCCCCTCGACATGGAGCTGGCCAACGGTCTTGCCCACCTCTTTTCCAACCAGCT
GGAGATCTCGGAGCTGGAGGCCCAGCGAAAACTCGTCCGGGAGGCGGAAATCCGGGCGTTGCAGGCGCAGATCAACCCCC
ACTTTCTCTTCAACACCATCAACACCATCATCAGCTACACCCGGACCAGTCCCGAGACCGCTTCCGACCTCCTGGTGAAG
CTCGCCGATTTCTTCCGCAGGAACATCAACCCCGGGGGGGACAGCGTTCCCCTGGCGACCGAGCTTGAACACTGCCGCGC
CTACATTGCCATCGAAAAGGCGCGCTTCGAGGATCGGCTCAGGGTGGTGTTCGATGTCGACGAGGAGGCCCTGGGCTGCA
AACTTCCCACCCTGACCCTCCAGCCCCTCGTGGAGAATGCCCTGAAGCACGGCATCCTCCCCCGCGAGGAGGGGGGAGAG
ATCCGGGTCGGTGCCCACCGGGAAGGGGGCGTGGTCAGGATCGTGGTGGGGGATAATGGGGTGGGGATGCCCCCGGAGCA
GGTTGCCCGCCTCTTTTCCGGGGAATCGAGTCAGCTCCCGACGGAGGGGGCGGGGATTGCCCTGAACAATGTCAATGCCC
GGCTCTCGGCGCTGTACGGGCCGGAGCATGCCCTGCGGGTGGAAAGCACCCCGGGAGCGGGGACCACCGTGTCATTCACG
GTGCCCCAAGGGGGGAGGGGGGAGTATGCTCATGAGAGTCTTCATCGTTGA

Upstream 100 bases:

>100_bases
TGTCCCGCTTCCCCGAAGACTACAAGTCTTGACAGGGGCGGGACGACAACCGTAACCTGCTGACAGTACACAGGCATCGC
ACCGCTGCGGGGGGAGGACC

Downstream 100 bases:

>100_bases
CGACGAGGCACCGGCTCGGCGGGAGCTCAGGTACCTTCTGGAGCGCGTGGAGGGGGTGGAGGTTGCCGGCGAGGCCGCCA
ACGGCACCGAGGCCCTCAAG

Product: histidine kinase internal region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MLHLLVNLLERLGLFAIAFILVMRFAIVKRFLIGKASRYEKLTLSVLFGFIGIAGTYMGVPIQNAIANSRVVGVALGGIL
GGPLVGFGAGLIAGGHRFLIDVGGFTATACGVATIAEGVAGGLIYHRLKRGQFDPAVAFITGVAVETLQMVILLVMAKPF
TAAVSLVSVIGFPMILVNSIGLALFVELVSSVFREKERFAAVQAQTALNIALRTLPFLRGGLTEGSAAATARIIREMTDL
DAVAITDEAAILAHTGAEEDHHRPGLPLLTASTRSALASGEITTPLTRDDIGCTHEGCRLGSAIIVPLKKRERTVGALKL
YRLKEGGITPLDMELANGLAHLFSNQLEISELEAQRKLVREAEIRALQAQINPHFLFNTINTIISYTRTSPETASDLLVK
LADFFRRNINPGGDSVPLATELEHCRAYIAIEKARFEDRLRVVFDVDEEALGCKLPTLTLQPLVENALKHGILPREEGGE
IRVGAHREGGVVRIVVGDNGVGMPPEQVARLFSGESSQLPTEGAGIALNNVNARLSALYGPEHALRVESTPGAGTTVSFT
VPQGGRGEYAHESLHR

Sequences:

>Translated_576_residues
MLHLLVNLLERLGLFAIAFILVMRFAIVKRFLIGKASRYEKLTLSVLFGFIGIAGTYMGVPIQNAIANSRVVGVALGGIL
GGPLVGFGAGLIAGGHRFLIDVGGFTATACGVATIAEGVAGGLIYHRLKRGQFDPAVAFITGVAVETLQMVILLVMAKPF
TAAVSLVSVIGFPMILVNSIGLALFVELVSSVFREKERFAAVQAQTALNIALRTLPFLRGGLTEGSAAATARIIREMTDL
DAVAITDEAAILAHTGAEEDHHRPGLPLLTASTRSALASGEITTPLTRDDIGCTHEGCRLGSAIIVPLKKRERTVGALKL
YRLKEGGITPLDMELANGLAHLFSNQLEISELEAQRKLVREAEIRALQAQINPHFLFNTINTIISYTRTSPETASDLLVK
LADFFRRNINPGGDSVPLATELEHCRAYIAIEKARFEDRLRVVFDVDEEALGCKLPTLTLQPLVENALKHGILPREEGGE
IRVGAHREGGVVRIVVGDNGVGMPPEQVARLFSGESSQLPTEGAGIALNNVNARLSALYGPEHALRVESTPGAGTTVSFT
VPQGGRGEYAHESLHR
>Mature_576_residues
MLHLLVNLLERLGLFAIAFILVMRFAIVKRFLIGKASRYEKLTLSVLFGFIGIAGTYMGVPIQNAIANSRVVGVALGGIL
GGPLVGFGAGLIAGGHRFLIDVGGFTATACGVATIAEGVAGGLIYHRLKRGQFDPAVAFITGVAVETLQMVILLVMAKPF
TAAVSLVSVIGFPMILVNSIGLALFVELVSSVFREKERFAAVQAQTALNIALRTLPFLRGGLTEGSAAATARIIREMTDL
DAVAITDEAAILAHTGAEEDHHRPGLPLLTASTRSALASGEITTPLTRDDIGCTHEGCRLGSAIIVPLKKRERTVGALKL
YRLKEGGITPLDMELANGLAHLFSNQLEISELEAQRKLVREAEIRALQAQINPHFLFNTINTIISYTRTSPETASDLLVK
LADFFRRNINPGGDSVPLATELEHCRAYIAIEKARFEDRLRVVFDVDEEALGCKLPTLTLQPLVENALKHGILPREEGGE
IRVGAHREGGVVRIVVGDNGVGMPPEQVARLFSGESSQLPTEGAGIALNNVNARLSALYGPEHALRVESTPGAGTTVSFT
VPQGGRGEYAHESLHR

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=566, Percent_Identity=37.4558303886926, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1788446, Length=569, Percent_Identity=35.3251318101933, Blast_Score=319, Evalue=4e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR005467
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF01590 GAF; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 61553; Mature: 61553

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHLLVNLLERLGLFAIAFILVMRFAIVKRFLIGKASRYEKLTLSVLFGFIGIAGTYMGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PIQNAIANSRVVGVALGGILGGPLVGFGAGLIAGGHRFLIDVGGFTATACGVATIAEGVA
CHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
GGLIYHRLKRGQFDPAVAFITGVAVETLQMVILLVMAKPFTAAVSLVSVIGFPMILVNSI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLALFVELVSSVFREKERFAAVQAQTALNIALRTLPFLRGGLTEGSAAATARIIREMTDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
DAVAITDEAAILAHTGAEEDHHRPGLPLLTASTRSALASGEITTPLTRDDIGCTHEGCRL
CEEEEECCCEEEEECCCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GSAIIVPLKKRERTVGALKLYRLKEGGITPLDMELANGLAHLFSNQLEISELEAQRKLVR
CCEEEEECHHHCHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EAEIRALQAQINPHFLFNTINTIISYTRTSPETASDLLVKLADFFRRNINPGGDSVPLAT
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
ELEHCRAYIAIEKARFEDRLRVVFDVDEEALGCKLPTLTLQPLVENALKHGILPREEGGE
HHHHHHHHHHHHHHHHHCCEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
IRVGAHREGGVVRIVVGDNGVGMPPEQVARLFSGESSQLPTEGAGIALNNVNARLSALYG
EEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHEEEC
PEHALRVESTPGAGTTVSFTVPQGGRGEYAHESLHR
CCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHCC
>Mature Secondary Structure
MLHLLVNLLERLGLFAIAFILVMRFAIVKRFLIGKASRYEKLTLSVLFGFIGIAGTYMGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
PIQNAIANSRVVGVALGGILGGPLVGFGAGLIAGGHRFLIDVGGFTATACGVATIAEGVA
CHHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
GGLIYHRLKRGQFDPAVAFITGVAVETLQMVILLVMAKPFTAAVSLVSVIGFPMILVNSI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLALFVELVSSVFREKERFAAVQAQTALNIALRTLPFLRGGLTEGSAAATARIIREMTDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
DAVAITDEAAILAHTGAEEDHHRPGLPLLTASTRSALASGEITTPLTRDDIGCTHEGCRL
CEEEEECCCEEEEECCCCCCCCCCCCCEEECCHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GSAIIVPLKKRERTVGALKLYRLKEGGITPLDMELANGLAHLFSNQLEISELEAQRKLVR
CCEEEEECHHHCHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EAEIRALQAQINPHFLFNTINTIISYTRTSPETASDLLVKLADFFRRNINPGGDSVPLAT
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHH
ELEHCRAYIAIEKARFEDRLRVVFDVDEEALGCKLPTLTLQPLVENALKHGILPREEGGE
HHHHHHHHHHHHHHHHHCCEEEEEECCCHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCE
IRVGAHREGGVVRIVVGDNGVGMPPEQVARLFSGESSQLPTEGAGIALNNVNARLSALYG
EEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHEEEC
PEHALRVESTPGAGTTVSFTVPQGGRGEYAHESLHR
CCCEEEEECCCCCCCEEEEECCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]