Click here to switch to the map view.

The map label for this gene is trpC

Identifier: 78223695

GI number: 78223695

Start: 2836618

End: 2837418

Strand: Reverse

Name: trpC

Synonym: Gmet_2494

Alternate gene names: 78223695

Gene position: 2837418-2836618 (Counterclockwise)

Preceding gene: 78223696

Following gene: 78223694

Centisome position: 70.98

GC content: 66.67

Gene sequence:

>801_bases
ATGCCCACAACCCCTGACATCCTGAAAAAGATAGTCGAACACAAGCGCCGTGAGGTGACAGCGGCCCGTTCCGCCACCCC
CCTTGCCGAGCTGAAGGCCCGCATCGCCGACCTGGAGGACCAGCCCCGGGGCTTCGAGCGGGCTCTGCGGGACTGCCACG
CCTCCGGCTGGACCGCCGTCATCGCCGAGGTGAAGAAGGGGTCCCCCTCCAAGGGGCTCATCCGCCCCGACTTCGATCCC
CTGGAGATCGCCGAAACCTACGAGCAGAACGGCGCCGCCTGCCTCTCGGTCCTGACCGACGAACATTTCTTTCTGGGGAA
CCTCCGCTACCTGGCCCTGATCCGCGAGCAGGTGCGGCTGCCGCTGCTGCGCAAGGATTTCCTCTTCGATCCCTACCAGG
TCTTCGAAGCCCGGGCTGCCGGGGCCGACGCCATCCTCCTCATCGCCGCCATGCTGGAGCGGGAGCAGATCGAGGAGCTG
GCCGGAATCGCCCGGGAGCTTTCCCTCGACGTGCTCCTGGAGGTCCACGACGAGCCGGAGATGGAGACGGCCCTTGCCAC
CAATTGCGCCCTTATCGGCATCAATAACCGCAACCTCCGCACCTTTGTTGTGGACCTGGCCACCACCGAGCAGCTCCTCC
CCATGGTCCCCGCCGACCGGTTCGTGGTGGCCGAGAGCGGCGTGAACACCCGCGCCGACATCCTCCGTCTCCAGACCGCC
GGTGCCCGCGGCTTCCTCATTGGCGAGTCCCTCATGCGGGAGGAGGACATCGGGGCCAAGCTCCGGGAGTTGTTGGGGTG
A

Upstream 100 bases:

>100_bases
CCGCGCCCTGGCAAAGCTGGAAGAGCTGATTGCATTGACAAATGAATAATGTTGTAGGGGCGGACTGTGTCCGCCCGATT
CTGAAATTTGGAAACCCACT

Downstream 100 bases:

>100_bases
AAAACAACTGAAACATACAAGCAACTGAGCAACTGAGTAAAACCTGAGAAAACAAATAAACGAGGATGCTTCTGCTTCTA
TTGATAGGATCAGGCGTTAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MPTTPDILKKIVEHKRREVTAARSATPLAELKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGLIRPDFDP
LEIAETYEQNGAACLSVLTDEHFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVFEARAAGADAILLIAAMLEREQIEEL
AGIARELSLDVLLEVHDEPEMETALATNCALIGINNRNLRTFVVDLATTEQLLPMVPADRFVVAESGVNTRADILRLQTA
GARGFLIGESLMREEDIGAKLRELLG

Sequences:

>Translated_266_residues
MPTTPDILKKIVEHKRREVTAARSATPLAELKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGLIRPDFDP
LEIAETYEQNGAACLSVLTDEHFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVFEARAAGADAILLIAAMLEREQIEEL
AGIARELSLDVLLEVHDEPEMETALATNCALIGINNRNLRTFVVDLATTEQLLPMVPADRFVVAESGVNTRADILRLQTA
GARGFLIGESLMREEDIGAKLRELLG
>Mature_265_residues
PTTPDILKKIVEHKRREVTAARSATPLAELKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGLIRPDFDPL
EIAETYEQNGAACLSVLTDEHFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVFEARAAGADAILLIAAMLEREQIEELA
GIARELSLDVLLEVHDEPEMETALATNCALIGINNRNLRTFVVDLATTEQLLPMVPADRFVVAESGVNTRADILRLQTAG
ARGFLIGESLMREEDIGAKLRELLG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=41.3127413127413, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322638, Length=213, Percent_Identity=40.3755868544601, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29525; Mature: 29394

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTPDILKKIVEHKRREVTAARSATPLAELKARIADLEDQPRGFERALRDCHASGWTAV
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHH
IAEVKKGSPSKGLIRPDFDPLEIAETYEQNGAACLSVLTDEHFFLGNLRYLALIREQVRL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PLLRKDFLFDPYQVFEARAAGADAILLIAAMLEREQIEELAGIARELSLDVLLEVHDEPE
CHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCH
METALATNCALIGINNRNLRTFVVDLATTEQLLPMVPADRFVVAESGVNTRADILRLQTA
HHHHHHCCEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCC
GARGFLIGESLMREEDIGAKLRELLG
CCCEEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTTPDILKKIVEHKRREVTAARSATPLAELKARIADLEDQPRGFERALRDCHASGWTAV
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHH
IAEVKKGSPSKGLIRPDFDPLEIAETYEQNGAACLSVLTDEHFFLGNLRYLALIREQVRL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PLLRKDFLFDPYQVFEARAAGADAILLIAAMLEREQIEELAGIARELSLDVLLEVHDEPE
CHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCH
METALATNCALIGINNRNLRTFVVDLATTEQLLPMVPADRFVVAESGVNTRADILRLQTA
HHHHHHCCEEEEEECCCCEEEEEEEHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCC
GARGFLIGESLMREEDIGAKLRELLG
CCCEEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA