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The map label for this gene is atoC [H]

Identifier: 78223656

GI number: 78223656

Start: 2775636

End: 2777021

Strand: Reverse

Name: atoC [H]

Synonym: Gmet_2453

Alternate gene names: 78223656

Gene position: 2777021-2775636 (Counterclockwise)

Preceding gene: 78223657

Following gene: 78223655

Centisome position: 69.47

GC content: 63.56

Gene sequence:

>1386_bases
GTGGCAAATGGCGAGAAGAAAACCGTGCGGGTGCTGATCGTTGACGATGATGTGTCGCTGCGCCGGGTGCTCGAGTATAA
TCTCCAGGAGGAGGGGTACGAAGTGCTCACCGCCGGCAGCGGCGAGGAGGGGCTTCGCCTCTTCGAGGATGGCGCGCCGA
CCCTCGTGGTGACCGACCTGAAGATGCCCGGCATGGGTGGATTTCAGCTCCTCAGGGAGGTGAAGGAGCGCTTCCCCGAC
ACGGTCGTCATCGTCATCACCGCCTTCGGCGCGGTGGAAGCGGCGGTGGAGGCCATGAAGGCCGGGGCCTACGACTTCAT
TACCAAGCCTTTCAATCGGGAGGCATTGAAGCTGACGGTTCGCAAGGCCCTGGACATGCAGGGGCTTTCCCGGGAGAACC
GGCGCCTCAGGGAGGAGCTTTCCGAACGGGAGGAGTTCCGCAGCATCATCGGCATTTCCCCTCCCATGGAGGAGGTCTTC
CGTGTCATCGACCGGGTGGCCGATACCGACGCAACCGTTCTCATCACCGGTGAGTCGGGGACCGGCAAGGAACTGGTGGC
CCGGGCCATTCACAACCGGAGCTCGCGGCGCGCCGCACCCTTCGTCGCCATCAACTGCGCCGCCATCCCCCGCGATCTCC
TTGAGAGTGAGCTCTTCGGCCACGTGAAGGGGGCCTTCACCGGGGCAGTGCAGGACAAGGAGGGTAAGTTCCGGCAGGCC
GAGGCGGGAACCCTTTTCCTCGACGAGGTGGGGGAACTGCCGGTGGAGCTCCAGTCGAAACTTCTGCGCGCGCTCCAGGA
AAAGGAAGTGCAGCCGGTCGGGGGGGCTCACACCATCAAGCTCGACGTGCGGGTGGTGGCAGCCACCAACGCCGACCTGG
AGGAAGCCATCGCGGAAGGGCGCTTCCGGGAGGATCTCTTCTACCGCCTTTCGGTTATTCCCGTCCACCTCCCCCCCTTG
AGGGAGCGGAAGGAGGATATCCCGCTGCTCGTGCGCCATTTTGCCGCCAAACACGGCGGGGCCTCCGTCACTTTTTCTCC
CGAGATCCTGGCAGTCATGGCCGCCTACGGCTGGCCCGGCAACGTGCGGGAACTGGAGAACACCGTGGAGCGGATCCTCA
TCATGCGCAACGCCGACACGATCCACCCCGACGATCTTCCCGAGAAGGTGCGGCGTGGGCGCTCTCCCCAGAGGGAATGC
CGGGTCATCAACCTCCCCGACGAGGGGTATTCCCTAGAGCAACTCGAACGGGAGATCGTCGTCGAGGCCCTGGAGCGCAA
CAACTGGAACCAGAGTTCGGCGGCGCGCTTTCTGCGCATACCGCGTCATACCCTCATCTACCGCATGGAGAAATACTCCA
TCACAACGCCGGAGAGAAAAAAATGA

Upstream 100 bases:

>100_bases
CAACGGATCGTGGAGGGACACGGCGGGACCGTGACGGTGGAGAGCGAGCCGGGGCAGGGGACAACGTTCCGGGTGCGGCT
TCCCCTGTAAGGAGTGACGG

Downstream 100 bases:

>100_bases
GAAAGATTTTCCTGATTCTGCCGATCTTGTTCCTGTTGGCCCTTACGGGATGCTCAAAAGAGTCGAAGCCTCCCGTCGAG
GAGAACCCTGCCCCCGATTT

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MANGEKKTVRVLIVDDDVSLRRVLEYNLQEEGYEVLTAGSGEEGLRLFEDGAPTLVVTDLKMPGMGGFQLLREVKERFPD
TVVIVITAFGAVEAAVEAMKAGAYDFITKPFNREALKLTVRKALDMQGLSRENRRLREELSEREEFRSIIGISPPMEEVF
RVIDRVADTDATVLITGESGTGKELVARAIHNRSSRRAAPFVAINCAAIPRDLLESELFGHVKGAFTGAVQDKEGKFRQA
EAGTLFLDEVGELPVELQSKLLRALQEKEVQPVGGAHTIKLDVRVVAATNADLEEAIAEGRFREDLFYRLSVIPVHLPPL
RERKEDIPLLVRHFAAKHGGASVTFSPEILAVMAAYGWPGNVRELENTVERILIMRNADTIHPDDLPEKVRRGRSPQREC
RVINLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYSITTPERKK

Sequences:

>Translated_461_residues
MANGEKKTVRVLIVDDDVSLRRVLEYNLQEEGYEVLTAGSGEEGLRLFEDGAPTLVVTDLKMPGMGGFQLLREVKERFPD
TVVIVITAFGAVEAAVEAMKAGAYDFITKPFNREALKLTVRKALDMQGLSRENRRLREELSEREEFRSIIGISPPMEEVF
RVIDRVADTDATVLITGESGTGKELVARAIHNRSSRRAAPFVAINCAAIPRDLLESELFGHVKGAFTGAVQDKEGKFRQA
EAGTLFLDEVGELPVELQSKLLRALQEKEVQPVGGAHTIKLDVRVVAATNADLEEAIAEGRFREDLFYRLSVIPVHLPPL
RERKEDIPLLVRHFAAKHGGASVTFSPEILAVMAAYGWPGNVRELENTVERILIMRNADTIHPDDLPEKVRRGRSPQREC
RVINLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYSITTPERKK
>Mature_460_residues
ANGEKKTVRVLIVDDDVSLRRVLEYNLQEEGYEVLTAGSGEEGLRLFEDGAPTLVVTDLKMPGMGGFQLLREVKERFPDT
VVIVITAFGAVEAAVEAMKAGAYDFITKPFNREALKLTVRKALDMQGLSRENRRLREELSEREEFRSIIGISPPMEEVFR
VIDRVADTDATVLITGESGTGKELVARAIHNRSSRRAAPFVAINCAAIPRDLLESELFGHVKGAFTGAVQDKEGKFRQAE
AGTLFLDEVGELPVELQSKLLRALQEKEVQPVGGAHTIKLDVRVVAATNADLEEAIAEGRFREDLFYRLSVIPVHLPPLR
ERKEDIPLLVRHFAAKHGGASVTFSPEILAVMAAYGWPGNVRELENTVERILIMRNADTIHPDDLPEKVRRGRSPQRECR
VINLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYSITTPERKK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=454, Percent_Identity=44.0528634361233, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=40.9381663113006, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1790437, Length=449, Percent_Identity=42.0935412026726, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1788905, Length=435, Percent_Identity=42.2988505747126, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI87082117, Length=354, Percent_Identity=45.7627118644068, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=45.141065830721, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1789087, Length=356, Percent_Identity=43.8202247191011, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI87082152, Length=300, Percent_Identity=44.6666666666667, Blast_Score=247, Evalue=9e-67,
Organism=Escherichia coli, GI1786524, Length=357, Percent_Identity=40.8963585434174, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=39.375, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1787583, Length=245, Percent_Identity=41.6326530612245, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI1789828, Length=291, Percent_Identity=36.426116838488, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87081858, Length=292, Percent_Identity=30.4794520547945, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=123, Percent_Identity=32.520325203252, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787375, Length=132, Percent_Identity=31.0606060606061, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786599, Length=135, Percent_Identity=28.1481481481481, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790863, Length=118, Percent_Identity=31.3559322033898, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=30.1724137931034, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51784; Mature: 51653

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4 ; PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANGEKKTVRVLIVDDDVSLRRVLEYNLQEEGYEVLTAGSGEEGLRLFEDGAPTLVVTDL
CCCCCCEEEEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHCCCCCEEEEEEC
KMPGMGGFQLLREVKERFPDTVVIVITAFGAVEAAVEAMKAGAYDFITKPFNREALKLTV
CCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHH
RKALDMQGLSRENRRLREELSEREEFRSIIGISPPMEEVFRVIDRVADTDATVLITGESG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
TGKELVARAIHNRSSRRAAPFVAINCAAIPRDLLESELFGHVKGAFTGAVQDKEGKFRQA
CCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEC
EAGTLFLDEVGELPVELQSKLLRALQEKEVQPVGGAHTIKLDVRVVAATNADLEEAIAEG
CCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHCC
RFREDLFYRLSVIPVHLPPLRERKEDIPLLVRHFAAKHGGASVTFSPEILAVMAAYGWPG
CHHHHHHEEEEEEEEECCCHHHHHCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCC
NVRELENTVERILIMRNADTIHPDDLPEKVRRGRSPQRECRVINLPDEGYSLEQLEREIV
CHHHHHHHHHHHEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHH
VEALERNNWNQSSAARFLRIPRHTLIYRMEKYSITTPERKK
HHHHHCCCCCHHHHHHHHHCCCHHHHEEEHHCCCCCCCCCC
>Mature Secondary Structure 
ANGEKKTVRVLIVDDDVSLRRVLEYNLQEEGYEVLTAGSGEEGLRLFEDGAPTLVVTDL
CCCCCEEEEEEEEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHCCCCCEEEEEEC
KMPGMGGFQLLREVKERFPDTVVIVITAFGAVEAAVEAMKAGAYDFITKPFNREALKLTV
CCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHH
RKALDMQGLSRENRRLREELSEREEFRSIIGISPPMEEVFRVIDRVADTDATVLITGESG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCC
TGKELVARAIHNRSSRRAAPFVAINCAAIPRDLLESELFGHVKGAFTGAVQDKEGKFRQA
CCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEC
EAGTLFLDEVGELPVELQSKLLRALQEKEVQPVGGAHTIKLDVRVVAATNADLEEAIAEG
CCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEECCCCHHHHHHCC
RFREDLFYRLSVIPVHLPPLRERKEDIPLLVRHFAAKHGGASVTFSPEILAVMAAYGWPG
CHHHHHHEEEEEEEEECCCHHHHHCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCC
NVRELENTVERILIMRNADTIHPDDLPEKVRRGRSPQRECRVINLPDEGYSLEQLEREIV
CHHHHHHHHHHHEEEECCCCCCCCCCHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHH
VEALERNNWNQSSAARFLRIPRHTLIYRMEKYSITTPERKK
HHHHHCCCCCHHHHHHHHHCCCHHHHEEEHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]