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The map label for this gene is fur [H]

Identifier: 78223648

GI number: 78223648

Start: 2769472

End: 2769903

Strand: Reverse

Name: fur [H]

Synonym: Gmet_2445

Alternate gene names: 78223648

Gene position: 2769903-2769472 (Counterclockwise)

Preceding gene: 78223649

Following gene: 78223647

Centisome position: 69.29

GC content: 58.56

Gene sequence:

>432_bases
ATGAAACGGGTGAAACAGAAAATATTCCAGGACTATATTGCCAGGCAGGGTCTCAAGTCGACCCGCCAGCGCGACATCAT
CCTCGACGCCTTTCTTTCCTCCGACCGGCACCTGAGCATCGAGGAACTGTACCTTAAGCTCAGGGCCAAGCATCCCAACA
TCGGCTACGCCACGGTCTATCGCACCCTGAAGCTCTTCGCCGAGTCGGGAATCGCCCGGGAGATCCACTTCGGCGACGGC
CAGACCCGCTACGAGCACGTCTCGGAGGGGGAGCACCACGACCACCTGGTATGCACGGGATGCGGCACCATCATCGAGTT
TGAGAACGAGAGCATCGAAAAGCTCCAGGATGAGGTGGCGGCGGCCCACAACTTTCTCATCAAGCACCACAAGCTGGAAC
TCTACGGCCTCTGCGCGAAATGCCGTTCGTAG

Upstream 100 bases:

>100_bases
AAAGGAGTTCGCGACGGTTCCGGAATTTACATGCAGAAAGAGATTGACAGAATGCGTGTCCGTGTCCTATATTGAAAATC
ACTTTCAGCTCGGAGCGGAA

Downstream 100 bases:

>100_bases
TCCGTTCGTACGCGACGGAAAATTTCTGTCGTGTCTTTTTTTGCTTGTGTGATTGAAAGTGAATATCAATAGCATAATTT
CATGAAGGAGTGACCATAGA

Product: ferric uptake regulator family protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MKRVKQKIFQDYIARQGLKSTRQRDIILDAFLSSDRHLSIEELYLKLRAKHPNIGYATVYRTLKLFAESGIAREIHFGDG
QTRYEHVSEGEHHDHLVCTGCGTIIEFENESIEKLQDEVAAAHNFLIKHHKLELYGLCAKCRS

Sequences:

>Translated_143_residues
MKRVKQKIFQDYIARQGLKSTRQRDIILDAFLSSDRHLSIEELYLKLRAKHPNIGYATVYRTLKLFAESGIAREIHFGDG
QTRYEHVSEGEHHDHLVCTGCGTIIEFENESIEKLQDEVAAAHNFLIKHHKLELYGLCAKCRS
>Mature_143_residues
MKRVKQKIFQDYIARQGLKSTRQRDIILDAFLSSDRHLSIEELYLKLRAKHPNIGYATVYRTLKLFAESGIAREIHFGDG
QTRYEHVSEGEHHDHLVCTGCGTIIEFENESIEKLQDEVAAAHNFLIKHHKLELYGLCAKCRS

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=133, Percent_Identity=42.1052631578947, Blast_Score=97, Evalue=4e-22,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16538; Mature: 16538

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVKQKIFQDYIARQGLKSTRQRDIILDAFLSSDRHLSIEELYLKLRAKHPNIGYATVY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHH
RTLKLFAESGIAREIHFGDGQTRYEHVSEGEHHDHLVCTGCGTIIEFENESIEKLQDEVA
HHHHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHH
AAHNFLIKHHKLELYGLCAKCRS
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRVKQKIFQDYIARQGLKSTRQRDIILDAFLSSDRHLSIEELYLKLRAKHPNIGYATVY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHH
RTLKLFAESGIAREIHFGDGQTRYEHVSEGEHHDHLVCTGCGTIIEFENESIEKLQDEVA
HHHHHHHHCCCCEEEECCCCCCHHHHCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHH
AAHNFLIKHHKLELYGLCAKCRS
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083178 [H]