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The map label for this gene is serA [H]

Identifier: 78223581

GI number: 78223581

Start: 2687765

End: 2689390

Strand: Reverse

Name: serA [H]

Synonym: Gmet_2378

Alternate gene names: 78223581

Gene position: 2689390-2687765 (Counterclockwise)

Preceding gene: 78223584

Following gene: 78223580

Centisome position: 67.28

GC content: 59.53

Gene sequence:

>1626_bases
ATGAAGATCATCGTTACCGACGAGGTGGCTCAGGAAGGGTTGGCGCTTTTGGCCCAGGACCCGCGTGTGGAGATCAACAT
CAAGCTGGGGCTCAAGAAGGAGGAGCTGCTGGCGATCATCGGCAACTACGACGCCATTATCACCCGCAGTGGCACCACCG
TTGACAAGAATCTCCTCGACGCCGGCACAAAGCTTCGGCTCATCGCTAGGGCCGGGGTCGGCATCGACAACGTGGATGTG
GACTACGCCAGTTCCCGTGGCGTAATCGTGGTGAACGCCCCCTTCGGCAACACCAACAGTGCCGCCGAGCACGCCATGGC
GCTGCTTCTTTCATTTTGCCGCAACGTACCCCGCGCCAACGGCAGCCTCAAGAGCGGTGAATGGAAACGGGCCCCCTTCA
CCGGCTACGAGCTCAAGGGGAAAACCGCCGGCGTCATCGGCCTCGGCAAGGTTGGTGGACGGGTCGCCACCCGGCTCAAG
GCCTTCGAGTGCGAGGTTCTAGCCTGTGACCCCTACATCGCCGTGAAGCGCGCCCATGACCTGGGGGTCAAGCTCGTCTC
CCACGACGAGATATACCGCAACTGCGATATCATCACCGTCCACACCCCCCTCACCGATGAAACCCGCAACATGATCGGCG
AGCGGGAGTTGGCCATGATGAAGGACGGCGTCATCATCGTGAACGCCGCCCGGGGGGGGATCATCGAAGAAGAGGCTCTC
CTGAAATATCTGGAATCGGGAAAAATTACCGGTGCCGCCATCGACGTCTTCAGCGTTGAGCCGCCGAAGACCGACGTGCT
GCAAAAACTCATTGCCCACGAGCGGGTAATTGTTACTCCGCACCTGGGGGCCAATACCTTCGAGGCCCAGGTCAACGTGG
CGGTGGACGTCTCCAAAGAGATCCTCAACTACCTGGACGACCTCCCCCTGGAGAACGCCGTGAACATCCCGCGCTTCGAC
CTGGCTCTCATGGACCAGATGCGGCCGTTCCTGAACCTCATGAGTGTCATGAGCGACTTCGTCATTCAGCTTGTGGACGC
CAATATCGACACCGTGACGTTCTCCTATGCGGGAAACATCGCTCACTATGACTGCACTCCTCTGAGTGTCTGCGGGCTGT
CGTCGATCCTTAACCGGCTGGTGGAGCAGGACGTGAATATGGTAAACGCCACTCTCATTGCCGACCAGATGGGGATTACC
GTGGAGGAGAACAAGTCCACCCAATCTCCCTCCTTCTCCAACATGATAACCCTCACCATCGAGGGTAAAGGTGAAAAGCG
GACTATTGCCGGCACACTCTTCGAAGGGAGCCCCCGCATCGTCAAGCTCCGTGACTACCAGGTGGACTTCGCTCCGGACG
AACACATGCTCAGCCTTACCTATGAGGACCGGCCGGGGATGATCGGCAAGATCGGTACCATCATGGGTGCCCACGATATC
AACATCGCCTCCATGAACCTGGGGCGCCGCGAGAAGCGGGGCGAGGCCATGGTCATTCTTTCTCTCGACTCGGCGGTTCC
CCCCTTTGTCGTGGAGGAAGTTCGCAAGGCGACCGACGCCACTTTCATCAAACCGATCCACATGCCGGGCGTCAAGTGCA
GCCGTGGGTGCGGGTGCGGCATCTGA

Upstream 100 bases:

>100_bases
GGTCTATTATTAACGCTTCTTCGCAGTCTCGCAAAGTACTTTCTTCCCGTCAGGATTATCACGGATACACGCACCACATT
CCATTGAAAAGGGAGCAGCA

Downstream 100 bases:

>100_bases
CGTTCTTGAGGTGGATAAAATGAATAGAGGGGCCGGTCTCATGGCGAGGCCGGCCCTTCTTGCTGGAGGGGAGAAGGCAT
GGTGAAACGGGGCGCTTCGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKIIVTDEVAQEGLALLAQDPRVEINIKLGLKKEELLAIIGNYDAIITRSGTTVDKNLLDAGTKLRLIARAGVGIDNVDV
DYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVPRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLK
AFECEVLACDPYIAVKRAHDLGVKLVSHDEIYRNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEEAL
LKYLESGKITGAAIDVFSVEPPKTDVLQKLIAHERVIVTPHLGANTFEAQVNVAVDVSKEILNYLDDLPLENAVNIPRFD
LALMDQMRPFLNLMSVMSDFVIQLVDANIDTVTFSYAGNIAHYDCTPLSVCGLSSILNRLVEQDVNMVNATLIADQMGIT
VEENKSTQSPSFSNMITLTIEGKGEKRTIAGTLFEGSPRIVKLRDYQVDFAPDEHMLSLTYEDRPGMIGKIGTIMGAHDI
NIASMNLGRREKRGEAMVILSLDSAVPPFVVEEVRKATDATFIKPIHMPGVKCSRGCGCGI

Sequences:

>Translated_541_residues
MKIIVTDEVAQEGLALLAQDPRVEINIKLGLKKEELLAIIGNYDAIITRSGTTVDKNLLDAGTKLRLIARAGVGIDNVDV
DYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVPRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLK
AFECEVLACDPYIAVKRAHDLGVKLVSHDEIYRNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEEAL
LKYLESGKITGAAIDVFSVEPPKTDVLQKLIAHERVIVTPHLGANTFEAQVNVAVDVSKEILNYLDDLPLENAVNIPRFD
LALMDQMRPFLNLMSVMSDFVIQLVDANIDTVTFSYAGNIAHYDCTPLSVCGLSSILNRLVEQDVNMVNATLIADQMGIT
VEENKSTQSPSFSNMITLTIEGKGEKRTIAGTLFEGSPRIVKLRDYQVDFAPDEHMLSLTYEDRPGMIGKIGTIMGAHDI
NIASMNLGRREKRGEAMVILSLDSAVPPFVVEEVRKATDATFIKPIHMPGVKCSRGCGCGI
>Mature_541_residues
MKIIVTDEVAQEGLALLAQDPRVEINIKLGLKKEELLAIIGNYDAIITRSGTTVDKNLLDAGTKLRLIARAGVGIDNVDV
DYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVPRANGSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLK
AFECEVLACDPYIAVKRAHDLGVKLVSHDEIYRNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEEAL
LKYLESGKITGAAIDVFSVEPPKTDVLQKLIAHERVIVTPHLGANTFEAQVNVAVDVSKEILNYLDDLPLENAVNIPRFD
LALMDQMRPFLNLMSVMSDFVIQLVDANIDTVTFSYAGNIAHYDCTPLSVCGLSSILNRLVEQDVNMVNATLIADQMGIT
VEENKSTQSPSFSNMITLTIEGKGEKRTIAGTLFEGSPRIVKLRDYQVDFAPDEHMLSLTYEDRPGMIGKIGTIMGAHDI
NIASMNLGRREKRGEAMVILSLDSAVPPFVVEEVRKATDATFIKPIHMPGVKCSRGCGCGI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=393, Percent_Identity=36.1323155216285, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI6912396, Length=324, Percent_Identity=29.6296296296296, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI4557497, Length=265, Percent_Identity=32.4528301886792, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI61743967, Length=282, Percent_Identity=32.2695035460993, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI145580578, Length=299, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI4557499, Length=299, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI145580575, Length=299, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=7e-26,
Organism=Escherichia coli, GI1789279, Length=331, Percent_Identity=32.02416918429, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=32.4, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI87082289, Length=275, Percent_Identity=31.2727272727273, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788660, Length=291, Percent_Identity=27.8350515463918, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081824, Length=242, Percent_Identity=28.099173553719, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=304, Percent_Identity=42.7631578947368, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=29.8449612403101, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=332, Percent_Identity=32.2289156626506, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322116, Length=336, Percent_Identity=30.0595238095238, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324055, Length=284, Percent_Identity=32.0422535211268, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=317, Percent_Identity=28.7066246056782, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=149, Percent_Identity=34.2281879194631, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=186, Percent_Identity=29.0322580645161, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=44.7019867549669, Blast_Score=250, Evalue=2e-66,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=32.3717948717949, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646446, Length=281, Percent_Identity=30.9608540925267, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646448, Length=281, Percent_Identity=30.9608540925267, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646452, Length=281, Percent_Identity=30.9608540925267, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646450, Length=281, Percent_Identity=30.9608540925267, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI62472511, Length=281, Percent_Identity=30.9608540925267, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28574284, Length=322, Percent_Identity=26.3975155279503, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24585514, Length=322, Percent_Identity=26.3975155279503, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI28574282, Length=322, Percent_Identity=26.3975155279503, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45551003, Length=322, Percent_Identity=26.3975155279503, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45552429, Length=322, Percent_Identity=26.3975155279503, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24585516, Length=282, Percent_Identity=25.177304964539, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28574286, Length=316, Percent_Identity=27.2151898734177, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 58807; Mature: 58807

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIVTDEVAQEGLALLAQDPRVEINIKLGLKKEELLAIIGNYDAIITRSGTTVDKNLLD
CEEEEEHHHHHCCHHEEECCCCEEEEEEECCCHHHHEEEECCCEEEEEECCCCCCHHHHC
AGTKLRLIARAGVGIDNVDVDYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVPRAN
CCCEEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLKAFECEVLACDPYIAVKRAHD
CCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHEEEEEEEEEECCEEEEEEHHC
LGVKLVSHDEIYRNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEEAL
CCEEEEECCHHHHCCCEEEEECCCCHHHHHHHCCHHHHHCCCCEEEEEECCCCCCCHHHH
LKYLESGKITGAAIDVFSVEPPKTDVLQKLIAHERVIVTPHLGANTFEAQVNVAVDVSKE
HHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEEEECHHH
ILNYLDDLPLENAVNIPRFDLALMDQMRPFLNLMSVMSDFVIQLVDANIDTVTFSYAGNI
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCE
AHYDCTPLSVCGLSSILNRLVEQDVNMVNATLIADQMGITVEENKSTQSPSFSNMITLTI
EEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCEEECCCCCCCCCCCCEEEEEE
EGKGEKRTIAGTLFEGSPRIVKLRDYQVDFAPDEHMLSLTYEDRPGMIGKIGTIMGAHDI
ECCCCCEEEEEEEECCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCEEEHHHEECCCCC
NIASMNLGRREKRGEAMVILSLDSAVPPFVVEEVRKATDATFIKPIHMPGVKCSRGCGCG
EEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
I
C
>Mature Secondary Structure
MKIIVTDEVAQEGLALLAQDPRVEINIKLGLKKEELLAIIGNYDAIITRSGTTVDKNLLD
CEEEEEHHHHHCCHHEEECCCCEEEEEEECCCHHHHEEEECCCEEEEEECCCCCCHHHHC
AGTKLRLIARAGVGIDNVDVDYASSRGVIVVNAPFGNTNSAAEHAMALLLSFCRNVPRAN
CCCEEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GSLKSGEWKRAPFTGYELKGKTAGVIGLGKVGGRVATRLKAFECEVLACDPYIAVKRAHD
CCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCHHHHHHEEEEEEEEEECCEEEEEEHHC
LGVKLVSHDEIYRNCDIITVHTPLTDETRNMIGERELAMMKDGVIIVNAARGGIIEEEAL
CCEEEEECCHHHHCCCEEEEECCCCHHHHHHHCCHHHHHCCCCEEEEEECCCCCCCHHHH
LKYLESGKITGAAIDVFSVEPPKTDVLQKLIAHERVIVTPHLGANTFEAQVNVAVDVSKE
HHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEEEECHHH
ILNYLDDLPLENAVNIPRFDLALMDQMRPFLNLMSVMSDFVIQLVDANIDTVTFSYAGNI
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCE
AHYDCTPLSVCGLSSILNRLVEQDVNMVNATLIADQMGITVEENKSTQSPSFSNMITLTI
EEECCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCEEECCCCCCCCCCCCEEEEEE
EGKGEKRTIAGTLFEGSPRIVKLRDYQVDFAPDEHMLSLTYEDRPGMIGKIGTIMGAHDI
ECCCCCEEEEEEEECCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCEEEHHHEECCCCC
NIASMNLGRREKRGEAMVILSLDSAVPPFVVEEVRKATDATFIKPIHMPGVKCSRGCGCG
EEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]