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The map label for this gene is pncB [H]

Identifier: 78223576

GI number: 78223576

Start: 2682523

End: 2683953

Strand: Direct

Name: pncB [H]

Synonym: Gmet_2373

Alternate gene names: 78223576

Gene position: 2682523-2683953 (Clockwise)

Preceding gene: 78223575

Following gene: 78223577

Centisome position: 67.11

GC content: 63.24

Gene sequence:

>1431_bases
ATGAGCTACTCACCGCTTCTGACCGACCTCTACCAACTCACCATGCTTGCCGGATACCTGGAAGAAGGGATGGCGGACAA
ACCGGCGGTGTTCGACATCTTCTTCCGGCACAACCCCTTCCAGGGGGGGTATGCGGTGTTCGCCGGCCTTGACACGGCCC
TCGGCTACCTGGAGAACCTCCAGTTCACGGAGGATGATCTCGAGTATCTCCAGGGGCTGGAAATCTTCCGCCCCCGATTC
ATCGATTTTCTCCGCTCATTCCGGTTCCGGGGAAAAGTAACGGCGCCTCCCGAGGGAACAGTGGTTTTCGCCAATGAGCC
CCTTGTGACCATCGAGGCCCCCCTGGCCCAGGCGCAACTGGTGGAGACGGCGCTCTTGAACATCATCAATTTCCAGACCC
TGGTGGCCACCAAGGGTGCCCGAATCGTCCATGCGGCGGTGGACGGCACGGTGCTGGAGTTCGGCCTGCGCCGCGCCCAA
GGGCCCGACGGGGGAGTGAGCGAAGCCCGGGCCGCCTACATTGGCGGGGTTCGGAGCACGAGCAACGTGCTGGCGGGGAA
GCTCTTCGGCATCCCGGTAAAAGGAACCCATGCCCACAGCTGGATCATGGCCTTTCCCGATGAGCTGACCGCCTTCCGCG
CCTATGCCGAGGTATTCCCCGACACCTGCATCCTCCTGGTGGACACCTACGACACCCTCAAAAGCGGCATCCCCAACGCC
ATCACCGTTGCCCAGGAACTCCGCTCCCAGGGGCACGAACTGGTCGGGGTGCGGATCGATTCGGGTGACCTGGCCTACCT
CTCCCGGGAGGGACGCCGGATGTTCGACGAGGCGGGCTTCCCCGGCGTAAAGATTGTCGCCTCCAACGAGCTGGACGAAT
ACGTGATCGAATCGATGCGGAGCGAAGGGGGCCGGGTCGACATCTACGGCGTGGGGACACGTCTCGCCACCTGCGCCGGA
GAGGGGGGAGGAGCCCTGGGCGGAGTCTACAAGCTGGTCAGGATCGGCGACCGCCCAAAACTCAAGGTGACCAGCGACGT
CGCCAAGGCGACCCTTCCCGACCGCAAGCGGCTCCTGCGGGCCGTGGCCCCCGACGGCTCCTTCATCCAGGACGTGCTCT
GCCTCGCCGACGAGGACATTGCCCCCGGAGCCACGGTGTACGACCCTTCCAATCCCCTTCAGTTCGTTGCCATCCCGCAA
CAGGCCCGCTTCGTCGAGATTCGTGGCGTTGTGATGGAGGACGGTGTGCGAACGGCGAAATCTCCTCCCAGCCTGGACGA
GATGGCCGACCGCAGCCGTGACCAGCTCACCCGCCTCCCCCAGGGATGCATGCGTTTCATCAATCCGCATAAATACAAGG
TCTCCATCAGCGCCGGTCTCAACGAGCTACGGCTGCAGCTTATGGACGAGGTTCAACGGGGATATAAATAG

Upstream 100 bases:

>100_bases
GCCTTTCATTCGTTTGGGCACCTCGCGCCCCTGAACCGCCAGCCAGTGCGAATGTGGTATACTCATCACCAATCACCATC
CCTCGCAACGGAGACATGCC

Downstream 100 bases:

>100_bases
ATCCAGCAGGAGAACTATCCATGAAGAGCACGTCAGCCCTTCTGATCGTCGACGTCCAGAACGATTTCTGCCCCGGAGGC
TTGCTACCCGTACCAGAGGG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSYSPLLTDLYQLTMLAGYLEEGMADKPAVFDIFFRHNPFQGGYAVFAGLDTALGYLENLQFTEDDLEYLQGLEIFRPRF
IDFLRSFRFRGKVTAPPEGTVVFANEPLVTIEAPLAQAQLVETALLNIINFQTLVATKGARIVHAAVDGTVLEFGLRRAQ
GPDGGVSEARAAYIGGVRSTSNVLAGKLFGIPVKGTHAHSWIMAFPDELTAFRAYAEVFPDTCILLVDTYDTLKSGIPNA
ITVAQELRSQGHELVGVRIDSGDLAYLSREGRRMFDEAGFPGVKIVASNELDEYVIESMRSEGGRVDIYGVGTRLATCAG
EGGGALGGVYKLVRIGDRPKLKVTSDVAKATLPDRKRLLRAVAPDGSFIQDVLCLADEDIAPGATVYDPSNPLQFVAIPQ
QARFVEIRGVVMEDGVRTAKSPPSLDEMADRSRDQLTRLPQGCMRFINPHKYKVSISAGLNELRLQLMDEVQRGYK

Sequences:

>Translated_476_residues
MSYSPLLTDLYQLTMLAGYLEEGMADKPAVFDIFFRHNPFQGGYAVFAGLDTALGYLENLQFTEDDLEYLQGLEIFRPRF
IDFLRSFRFRGKVTAPPEGTVVFANEPLVTIEAPLAQAQLVETALLNIINFQTLVATKGARIVHAAVDGTVLEFGLRRAQ
GPDGGVSEARAAYIGGVRSTSNVLAGKLFGIPVKGTHAHSWIMAFPDELTAFRAYAEVFPDTCILLVDTYDTLKSGIPNA
ITVAQELRSQGHELVGVRIDSGDLAYLSREGRRMFDEAGFPGVKIVASNELDEYVIESMRSEGGRVDIYGVGTRLATCAG
EGGGALGGVYKLVRIGDRPKLKVTSDVAKATLPDRKRLLRAVAPDGSFIQDVLCLADEDIAPGATVYDPSNPLQFVAIPQ
QARFVEIRGVVMEDGVRTAKSPPSLDEMADRSRDQLTRLPQGCMRFINPHKYKVSISAGLNELRLQLMDEVQRGYK
>Mature_475_residues
SYSPLLTDLYQLTMLAGYLEEGMADKPAVFDIFFRHNPFQGGYAVFAGLDTALGYLENLQFTEDDLEYLQGLEIFRPRFI
DFLRSFRFRGKVTAPPEGTVVFANEPLVTIEAPLAQAQLVETALLNIINFQTLVATKGARIVHAAVDGTVLEFGLRRAQG
PDGGVSEARAAYIGGVRSTSNVLAGKLFGIPVKGTHAHSWIMAFPDELTAFRAYAEVFPDTCILLVDTYDTLKSGIPNAI
TVAQELRSQGHELVGVRIDSGDLAYLSREGRRMFDEAGFPGVKIVASNELDEYVIESMRSEGGRVDIYGVGTRLATCAGE
GGGALGGVYKLVRIGDRPKLKVTSDVAKATLPDRKRLLRAVAPDGSFIQDVLCLADEDIAPGATVYDPSNPLQFVAIPQQ
ARFVEIRGVVMEDGVRTAKSPPSLDEMADRSRDQLTRLPQGCMRFINPHKYKVSISAGLNELRLQLMDEVQRGYK

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=519, Percent_Identity=35.4527938342967, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71997947, Length=522, Percent_Identity=38.3141762452107, Blast_Score=349, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI71997952, Length=522, Percent_Identity=38.3141762452107, Blast_Score=348, Evalue=3e-96,
Organism=Caenorhabditis elegans, GI71997955, Length=205, Percent_Identity=50.7317073170732, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24581587, Length=526, Percent_Identity=37.2623574144487, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI161076680, Length=276, Percent_Identity=41.304347826087, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24581595, Length=276, Percent_Identity=41.304347826087, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI28574709, Length=276, Percent_Identity=41.304347826087, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24581593, Length=276, Percent_Identity=41.304347826087, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24581591, Length=276, Percent_Identity=41.304347826087, Blast_Score=188, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 52078; Mature: 51947

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSPLLTDLYQLTMLAGYLEEGMADKPAVFDIFFRHNPFQGGYAVFAGLDTALGYLENL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCC
QFTEDDLEYLQGLEIFRPRFIDFLRSFRFRGKVTAPPEGTVVFANEPLVTIEAPLAQAQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCHHHHHH
VETALLNIINFQTLVATKGARIVHAAVDGTVLEFGLRRAQGPDGGVSEARAAYIGGVRST
HHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SNVLAGKLFGIPVKGTHAHSWIMAFPDELTAFRAYAEVFPDTCILLVDTYDTLKSGIPNA
CHHHHHHEEECCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECHHHHHHCCCHH
ITVAQELRSQGHELVGVRIDSGDLAYLSREGRRMFDEAGFPGVKIVASNELDEYVIESMR
HHHHHHHHHCCCEEEEEEECCCCEEHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
SEGGRVDIYGVGTRLATCAGEGGGALGGVYKLVRIGDRPKLKVTSDVAKATLPDRKRLLR
CCCCEEEEEECCCHHEEECCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHCCCHHHHHHH
AVAPDGSFIQDVLCLADEDIAPGATVYDPSNPLQFVAIPQQARFVEIRGVVMEDGVRTAK
HHCCCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCCCEEEEEECEEECCCCCCCC
SPPSLDEMADRSRDQLTRLPQGCMRFINPHKYKVSISAGLNELRLQLMDEVQRGYK
CCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYSPLLTDLYQLTMLAGYLEEGMADKPAVFDIFFRHNPFQGGYAVFAGLDTALGYLENL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHCC
QFTEDDLEYLQGLEIFRPRFIDFLRSFRFRGKVTAPPEGTVVFANEPLVTIEAPLAQAQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCHHHHHH
VETALLNIINFQTLVATKGARIVHAAVDGTVLEFGLRRAQGPDGGVSEARAAYIGGVRST
HHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCC
SNVLAGKLFGIPVKGTHAHSWIMAFPDELTAFRAYAEVFPDTCILLVDTYDTLKSGIPNA
CHHHHHHEEECCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECHHHHHHCCCHH
ITVAQELRSQGHELVGVRIDSGDLAYLSREGRRMFDEAGFPGVKIVASNELDEYVIESMR
HHHHHHHHHCCCEEEEEEECCCCEEHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
SEGGRVDIYGVGTRLATCAGEGGGALGGVYKLVRIGDRPKLKVTSDVAKATLPDRKRLLR
CCCCEEEEEECCCHHEEECCCCCCHHHHHHHHHHCCCCCCEEEEHHHHHHCCCHHHHHHH
AVAPDGSFIQDVLCLADEDIAPGATVYDPSNPLQFVAIPQQARFVEIRGVVMEDGVRTAK
HHCCCCHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCCCEEEEEECEEECCCCCCCC
SPPSLDEMADRSRDQLTRLPQGCMRFINPHKYKVSISAGLNELRLQLMDEVQRGYK
CCCCHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]