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The map label for this gene is lolC [H]

Identifier: 78223562

GI number: 78223562

Start: 2666677

End: 2667948

Strand: Reverse

Name: lolC [H]

Synonym: Gmet_2359

Alternate gene names: 78223562

Gene position: 2667948-2666677 (Counterclockwise)

Preceding gene: 78223563

Following gene: 78223561

Centisome position: 66.74

GC content: 57.08

Gene sequence:

>1272_bases
ATGTCCTACGAACTCTTTATTGGCCTCCGCTACCTCAAGGCAAAGCGGAAGTCGACCTTCATATCGATCATCACCTTTAT
CTCCACCGCCGGAGTCGCCCTCGGGGTAATGGCTCTCATTGTCGTGCTGGCGGTTATGACCGGTTTCGAGGAGGATCTGA
AGGAAAAGATCCTCGGAACCAACGCCCACGTGGTGGTCCTGAAGTCCAGCGGCACCATGGAAGACTATCCCGCCATCATG
GAGCGGCTCAAGAAGATGAAGGGGGTTGTGGCCGCCACCCCGTTTATTTACAGCCAGGTCATGCTTTCCACCGGCTCCAA
TGTCTCCGGCGTGGTGCTCCGTGGCATCGACGTCAAGACCGATCCCCTGGTAACCAATCTTTACCGATCACTTGTGGAGG
GTAAGCTCGGAGACCTGGAGCGTTCGCCCCTTCCTCTCGCGACCCCGGAGCCTCCCAAGCCGGGCATCATCATCGGTCGG
GAGCTTGCCCGTTCCCTCAATATTTACCCCGGCGACACGGTCAACGTCATTTCCCCCCTCGGCAACATAACACCCCTCGG
CATGGTACCTAAGATGAAGCAGTTCCGTGTCGTGGGGCTCTTCAATACCGGCATGTTCGAGTATGATTCCACCCTCGCCT
ATGTGGGGCTCTCAGAGGCCCAGGAGTTCCTCTCCCTCGGTCACGCCGCCACCGGCATTCAGCTCCGGGTGCAGGATGTC
TATCGTACCGGAGAGCTGGTACGAAAAATCGACCGCGAGCTCGGCTTCCCCTTCCATGCTCGGGACTGGATGCAGATGAA
CAAGAACATTCTTTTTGCGTTGAAGACGGAAAAGATGGTAATGTTCGTCATTCTGACCCTGATCGTGCTGGTCGCTGCCT
TCGGCATTGCCTCGACGCTCTTCATGGTGGTTCTGGAAAAGACGAAGGACATTGCGATCCTCAAGTCCATGGGGGCCACG
GGACGAAGCATCATGAAGATTTTCGTGCTGGAGGGCCTCATAATAGGGATTTCCGGGACTGTCATCGGGGTCATCGGTGG
CCTCCTCGTGGCCTACAATCTGGAACCGATCGTCGGCGTCGTGCAGAAGGTGACCGGTTTCGAACTCTTTAGTAAGGATG
TCTATTATCTGGATCACTTCCCTTCCCGGGTGGTCCTTTCCGACGTTGTCCTGATTTCCGTGACGGCGGTACTCATATCG
CTCGTGGCGACCCTCTACCCGTCCTGGCAGGCGTCGAAGCTGCCGCCTGCGGAGGCGCTGCGCTATGAGTAG

Upstream 100 bases:

>100_bases
CGCAACTTCGCAAGGAGAAATAACGGGATTACGTAAGCAGATCGAGAATCAGGGGCCTTCTGCGGTCCCTGATTTCCGGT
CCACAGTCCCCGGATCCAAA

Downstream 100 bases:

>100_bases
TCTCCTTGAGGTGATGGATCTCACGAAGGGTTACGGTTCCGGGGAAACCCGAGTCGATGTTCTGAAGGGGATAAACCTGA
CCGTGGCCGAAGGCGAAACC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSYELFIGLRYLKAKRKSTFISIITFISTAGVALGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVLKSSGTMEDYPAIM
ERLKKMKGVVAATPFIYSQVMLSTGSNVSGVVLRGIDVKTDPLVTNLYRSLVEGKLGDLERSPLPLATPEPPKPGIIIGR
ELARSLNIYPGDTVNVISPLGNITPLGMVPKMKQFRVVGLFNTGMFEYDSTLAYVGLSEAQEFLSLGHAATGIQLRVQDV
YRTGELVRKIDRELGFPFHARDWMQMNKNILFALKTEKMVMFVILTLIVLVAAFGIASTLFMVVLEKTKDIAILKSMGAT
GRSIMKIFVLEGLIIGISGTVIGVIGGLLVAYNLEPIVGVVQKVTGFELFSKDVYYLDHFPSRVVLSDVVLISVTAVLIS
LVATLYPSWQASKLPPAEALRYE

Sequences:

>Translated_423_residues
MSYELFIGLRYLKAKRKSTFISIITFISTAGVALGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVLKSSGTMEDYPAIM
ERLKKMKGVVAATPFIYSQVMLSTGSNVSGVVLRGIDVKTDPLVTNLYRSLVEGKLGDLERSPLPLATPEPPKPGIIIGR
ELARSLNIYPGDTVNVISPLGNITPLGMVPKMKQFRVVGLFNTGMFEYDSTLAYVGLSEAQEFLSLGHAATGIQLRVQDV
YRTGELVRKIDRELGFPFHARDWMQMNKNILFALKTEKMVMFVILTLIVLVAAFGIASTLFMVVLEKTKDIAILKSMGAT
GRSIMKIFVLEGLIIGISGTVIGVIGGLLVAYNLEPIVGVVQKVTGFELFSKDVYYLDHFPSRVVLSDVVLISVTAVLIS
LVATLYPSWQASKLPPAEALRYE
>Mature_422_residues
SYELFIGLRYLKAKRKSTFISIITFISTAGVALGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVLKSSGTMEDYPAIME
RLKKMKGVVAATPFIYSQVMLSTGSNVSGVVLRGIDVKTDPLVTNLYRSLVEGKLGDLERSPLPLATPEPPKPGIIIGRE
LARSLNIYPGDTVNVISPLGNITPLGMVPKMKQFRVVGLFNTGMFEYDSTLAYVGLSEAQEFLSLGHAATGIQLRVQDVY
RTGELVRKIDRELGFPFHARDWMQMNKNILFALKTEKMVMFVILTLIVLVAAFGIASTLFMVVLEKTKDIAILKSMGATG
RSIMKIFVLEGLIIGISGTVIGVIGGLLVAYNLEPIVGVVQKVTGFELFSKDVYYLDHFPSRVVLSDVVLISVTAVLISL
VATLYPSWQASKLPPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=420, Percent_Identity=31.9047619047619, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787360, Length=425, Percent_Identity=33.6470588235294, Blast_Score=184, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46231; Mature: 46099

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYELFIGLRYLKAKRKSTFISIITFISTAGVALGVMALIVVLAVMTGFEEDLKEKILGT
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
NAHVVVLKSSGTMEDYPAIMERLKKMKGVVAATPFIYSQVMLSTGSNVSGVVLRGIDVKT
CCEEEEEECCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCC
DPLVTNLYRSLVEGKLGDLERSPLPLATPEPPKPGIIIGRELARSLNIYPGDTVNVISPL
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHCCCCCCCCHHHHHCC
GNITPLGMVPKMKQFRVVGLFNTGMFEYDSTLAYVGLSEAQEFLSLGHAATGIQLRVQDV
CCCCCCCCCCCCHHEEEEEEECCCCEEECCCEEEEEHHHHHHHHHHCCCCCCCEEEHHHH
YRTGELVRKIDRELGFPFHARDWMQMNKNILFALKTEKMVMFVILTLIVLVAAFGIASTL
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FMVVLEKTKDIAILKSMGATGRSIMKIFVLEGLIIGISGTVIGVIGGLLVAYNLEPIVGV
HHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCHHHHHH
VQKVTGFELFSKDVYYLDHFPSRVVLSDVVLISVTAVLISLVATLYPSWQASKLPPAEAL
HHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
RYE
CCC
>Mature Secondary Structure 
SYELFIGLRYLKAKRKSTFISIITFISTAGVALGVMALIVVLAVMTGFEEDLKEKILGT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
NAHVVVLKSSGTMEDYPAIMERLKKMKGVVAATPFIYSQVMLSTGSNVSGVVLRGIDVKT
CCEEEEEECCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCC
DPLVTNLYRSLVEGKLGDLERSPLPLATPEPPKPGIIIGRELARSLNIYPGDTVNVISPL
CHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHCCCCCCCCHHHHHCC
GNITPLGMVPKMKQFRVVGLFNTGMFEYDSTLAYVGLSEAQEFLSLGHAATGIQLRVQDV
CCCCCCCCCCCCHHEEEEEEECCCCEEECCCEEEEEHHHHHHHHHHCCCCCCCEEEHHHH
YRTGELVRKIDRELGFPFHARDWMQMNKNILFALKTEKMVMFVILTLIVLVAAFGIASTL
HHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FMVVLEKTKDIAILKSMGATGRSIMKIFVLEGLIIGISGTVIGVIGGLLVAYNLEPIVGV
HHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCHHHHHH
VQKVTGFELFSKDVYYLDHFPSRVVLSDVVLISVTAVLISLVATLYPSWQASKLPPAEAL
HHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
RYE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]