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The map label for this gene is era

Identifier: 78223518

GI number: 78223518

Start: 2623727

End: 2624623

Strand: Reverse

Name: era

Synonym: Gmet_2315

Alternate gene names: 78223518

Gene position: 2624623-2623727 (Counterclockwise)

Preceding gene: 78223519

Following gene: 78223517

Centisome position: 65.66

GC content: 60.76

Gene sequence:

>897_bases
TTGTCAGATAACCCGTTCCGATCCGGATTCGTGTCCATCATCGGGCGCCCCAACGTAGGGAAATCGACTCTGCTGAACCG
GATTCTCGGCGAAAAGATTGTTATTACCTCGGACAAGCCCCAGACGACCCGTAACCGGATACAGGGGATCCACAACGTCC
CCGGCGCCCAGATCGTTTTCATCGACACGCCGGGAATCCACCAGGCCCGCTCGCGGCTCAACAAGTACATGGTGGAGGTG
GCCCTGTCCGCCATCCGGGAGGTGGACCTGGTCCTCTTCCTTGTTGAGGCTAATCAGAAGCCGGGGGAGCAGGAGCAGGA
GATCATCGACGTTCTTGCCGGGGCCACGGCGCCGGTCTTCCTTGTCATCAACAAGGTGGACCTGACGGAGAAGGGGGCGG
TGCTGGAGCGGATCGCCGCCTACAAGGACCGCTATCCATTCCGGGAGATCGTGCCCATTTCGGCCGGCACCGGCGACGGT
GTCGACCATCTGGTGGAACTGGTTCGCAAGGCCCTCCCCCAGGGACCGGTCTACTTTCCCGACGACATCCTGACCGACGT
GCCGGAGCGCTTCATTGCCGCGGAGATCATCCGGGAGAAGGTCTTTCGCATGACCCGCGACGAGGTCCCCTACGCCACCG
CCGTGGAGGTGGACAGCTTCAAGGAGCGGGAGGACGGAGGCCTCGTCTCCATTGCCGCCACCATCACCGTGGAACGGGAT
TCCCAGAAGGGGATCATCATCGGCAAAAAGGGGGCGATGCTGAAAAAGATCGGCTCGGCAGCCCGGGTCGAGATCGAGAA
ACTACTCAATACGAAAGTTTTCCTGGAACTCTTCGTCCGGGTCCGCAAGGACTGGAGCGAAGACGAGCGGATGCTGAAGG
AGCTTGGATACACATGA

Upstream 100 bases:

>100_bases
CGCACCTCTCCCCCTACGATCTCGAAGTTGTTTATGCCGGCGGAACCATTGCCGGCAACGTGCTGGATTGACCTGCACGT
TTCACGAAAGGAGTTGCACT

Downstream 100 bases:

>100_bases
TGCCACTCGTTGCCATAGTGGGTCGCCCCAACGTGGGGAAATCGACCCTGTTCAACCGTCTCGTGGGGCGCCGCAAGGCC
ATTGTCGACGACATGCCCGG

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSDNPFRSGFVSIIGRPNVGKSTLLNRILGEKIVITSDKPQTTRNRIQGIHNVPGAQIVFIDTPGIHQARSRLNKYMVEV
ALSAIREVDLVLFLVEANQKPGEQEQEIIDVLAGATAPVFLVINKVDLTEKGAVLERIAAYKDRYPFREIVPISAGTGDG
VDHLVELVRKALPQGPVYFPDDILTDVPERFIAAEIIREKVFRMTRDEVPYATAVEVDSFKEREDGGLVSIAATITVERD
SQKGIIIGKKGAMLKKIGSAARVEIEKLLNTKVFLELFVRVRKDWSEDERMLKELGYT

Sequences:

>Translated_298_residues
MSDNPFRSGFVSIIGRPNVGKSTLLNRILGEKIVITSDKPQTTRNRIQGIHNVPGAQIVFIDTPGIHQARSRLNKYMVEV
ALSAIREVDLVLFLVEANQKPGEQEQEIIDVLAGATAPVFLVINKVDLTEKGAVLERIAAYKDRYPFREIVPISAGTGDG
VDHLVELVRKALPQGPVYFPDDILTDVPERFIAAEIIREKVFRMTRDEVPYATAVEVDSFKEREDGGLVSIAATITVERD
SQKGIIIGKKGAMLKKIGSAARVEIEKLLNTKVFLELFVRVRKDWSEDERMLKELGYT
>Mature_297_residues
SDNPFRSGFVSIIGRPNVGKSTLLNRILGEKIVITSDKPQTTRNRIQGIHNVPGAQIVFIDTPGIHQARSRLNKYMVEVA
LSAIREVDLVLFLVEANQKPGEQEQEIIDVLAGATAPVFLVINKVDLTEKGAVLERIAAYKDRYPFREIVPISAGTGDGV
DHLVELVRKALPQGPVYFPDDILTDVPERFIAAEIIREKVFRMTRDEVPYATAVEVDSFKEREDGGLVSIAATITVERDS
QKGIIIGKKGAMLKKIGSAARVEIEKLLNTKVFLELFVRVRKDWSEDERMLKELGYT

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=324, Percent_Identity=28.3950617283951, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1788919, Length=299, Percent_Identity=45.4849498327759, Blast_Score=255, Evalue=2e-69,
Organism=Escherichia coli, GI87082120, Length=159, Percent_Identity=37.7358490566038, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI2367268, Length=172, Percent_Identity=31.3953488372093, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323665, Length=162, Percent_Identity=30.8641975308642, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24646434, Length=291, Percent_Identity=27.1477663230241, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_GEOMG (Q39T84)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385265.1
- ProteinModelPortal:   Q39T84
- SMR:   Q39T84
- STRING:   Q39T84
- GeneID:   3740470
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2315
- NMPDR:   fig|269799.3.peg.2559
- eggNOG:   COG1159
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- PhylomeDB:   Q39T84
- ProtClustDB:   PRK00089
- BioCyc:   GMET269799:GMET_2315-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 33224; Mature: 33093

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNPFRSGFVSIIGRPNVGKSTLLNRILGEKIVITSDKPQTTRNRIQGIHNVPGAQIVF
CCCCCCCCHHHHEECCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCCCEEEE
IDTPGIHQARSRLNKYMVEVALSAIREVDLVLFLVEANQKPGEQEQEIIDVLAGATAPVF
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCEE
LVINKVDLTEKGAVLERIAAYKDRYPFREIVPISAGTGDGVDHLVELVRKALPQGPVYFP
EEEEECCCCHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
DDILTDVPERFIAAEIIREKVFRMTRDEVPYATAVEVDSFKEREDGGLVSIAATITVERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCEEEEEEEEEEEEC
SQKGIIIGKKGAMLKKIGSAARVEIEKLLNTKVFLELFVRVRKDWSEDERMLKELGYT
CCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDNPFRSGFVSIIGRPNVGKSTLLNRILGEKIVITSDKPQTTRNRIQGIHNVPGAQIVF
CCCCCCCHHHHEECCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCCCCCEEEE
IDTPGIHQARSRLNKYMVEVALSAIREVDLVLFLVEANQKPGEQEQEIIDVLAGATAPVF
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCEE
LVINKVDLTEKGAVLERIAAYKDRYPFREIVPISAGTGDGVDHLVELVRKALPQGPVYFP
EEEEECCCCHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCHHHHHHHHHHHCCCCCCCCC
DDILTDVPERFIAAEIIREKVFRMTRDEVPYATAVEVDSFKEREDGGLVSIAATITVERD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCEEEEEEEEEEEEC
SQKGIIIGKKGAMLKKIGSAARVEIEKLLNTKVFLELFVRVRKDWSEDERMLKELGYT
CCCCEEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA