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The map label for this gene is engA

Identifier: 78223517

GI number: 78223517

Start: 2622411

End: 2623730

Strand: Reverse

Name: engA

Synonym: Gmet_2314

Alternate gene names: 78223517

Gene position: 2623730-2622411 (Counterclockwise)

Preceding gene: 78223518

Following gene: 78223516

Centisome position: 65.64

GC content: 61.67

Gene sequence:

>1320_bases
ATGATGCCACTCGTTGCCATAGTGGGTCGCCCCAACGTGGGGAAATCGACCCTGTTCAACCGTCTCGTGGGGCGCCGCAA
GGCCATTGTCGACGACATGCCCGGCGTCACCCGGGACCGGAACTACGAAACCGTCACCCGCTTCGAGGCGCCGTTCATTC
TCATCGACACCGGCGGCTTCGAGCCGGTGAGCGAAGACCGGCTCCTGCAGCAGATGAGGGAGCAGTCCCAGCTCGCCATG
GAGGAGGCGGACGTCATCATCTTCCTCATGGATGGCCGGGCCGGGCTCACCCCATCCGACGTGGAGGTGGTGGAGATGCT
CCGTCGGGTGAAAAAGCCCGTTTTCTTCGTGGTCAACAAGGTGGACGGCGAAAAGATCGAGAACGAGGCGGCCGATTTCT
ACACCCTGGGGATCGGCACCCTTCACACCATCTCCGCCGAGCACAACCGGGGGGTGAACGACCTCATGGAGGAGGTGGTG
GCGGCCCTTCCCAAAAGCTCGACCCGCCTTGATGACGAGGATATCACCCGGATCGCCGTGGTGGGGCGCCCCAACGTGGG
GAAGTCGTCCCTGGTGAACCGGCTCCTCGGTTTCGAGCGGGTGGTGGCCAACCCCACCCCCGGCACCACCCGGGATTCCG
TCGATACTCTCTTCGCCTGCAACAAGAAGCGCTACCTCCTCATCGACACGGCCGGCATCCGGCGCAAAGGTAAGACCACC
CAGAAGCTGGAGAAGTACAGCGTGGTGGACAGCCTGCGGAGTATCGAGCGGGCCGACGTGGTGCTCATCATCATCAATGC
CGAGGAAGGGGTGACGGAACAGGACGAGCGGATCGCCGGCTACGCCTTTGAGGCGGGCAAGGCCTGCATCTTCGTGGTCA
ACAAGTGGGATACCCTGGCCAAGGACAACAGCACCCTTGGGAAATTCGTCGACCAGATCAAGACGGAATTCAAGTATCTC
TCATTCGCGCCGATAGTATTTGTATCAGCCAAGAGTGGCCAGCGGATCAACCGGGTCATGGAGGAGGTGGAGCGGGTCAT
GGCCCAGTATTCCAAGCGGGTAAGCACCTCCGACCTGAACCGGGTCTTCTCCGAGGCGGTGGAGAAACACCACGCCCCCC
TTTCCCACGGGCGGCGGGTGAAGTTCTACTTCGCCACTCAGGTGGGGACGAAGCCGCCGACATTCGTACTGTTCACCAAT
CAGCCGGAGGGGGTGCATTTTTCCTACGAGCGGTACCTCATGAACAAGTTCCGCGAGGCGTTCGATTTCACCGGCAGCCC
GCTCAAGATCATCTTCCGGGGCAGGGATCGCCGGGAGTAA

Upstream 100 bases:

>100_bases
TCGAGAAACTACTCAATACGAAAGTTTTCCTGGAACTCTTCGTCCGGGTCCGCAAGGACTGGAGCGAAGACGAGCGGATG
CTGAAGGAGCTTGGATACAC

Downstream 100 bases:

>100_bases
ACGTGCTTTACTTGAACCGGACGAGTAGTTTATGATGAGCGCCGTTTCTACCACTGTTTTCCGGGTTTTTGACCCTCTCA
TGCCATGAGCCTTGTCGGGA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MMPLVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFEAPFILIDTGGFEPVSEDRLLQQMREQSQLAM
EEADVIIFLMDGRAGLTPSDVEVVEMLRRVKKPVFFVVNKVDGEKIENEAADFYTLGIGTLHTISAEHNRGVNDLMEEVV
AALPKSSTRLDDEDITRIAVVGRPNVGKSSLVNRLLGFERVVANPTPGTTRDSVDTLFACNKKRYLLIDTAGIRRKGKTT
QKLEKYSVVDSLRSIERADVVLIIINAEEGVTEQDERIAGYAFEAGKACIFVVNKWDTLAKDNSTLGKFVDQIKTEFKYL
SFAPIVFVSAKSGQRINRVMEEVERVMAQYSKRVSTSDLNRVFSEAVEKHHAPLSHGRRVKFYFATQVGTKPPTFVLFTN
QPEGVHFSYERYLMNKFREAFDFTGSPLKIIFRGRDRRE

Sequences:

>Translated_439_residues
MMPLVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFEAPFILIDTGGFEPVSEDRLLQQMREQSQLAM
EEADVIIFLMDGRAGLTPSDVEVVEMLRRVKKPVFFVVNKVDGEKIENEAADFYTLGIGTLHTISAEHNRGVNDLMEEVV
AALPKSSTRLDDEDITRIAVVGRPNVGKSSLVNRLLGFERVVANPTPGTTRDSVDTLFACNKKRYLLIDTAGIRRKGKTT
QKLEKYSVVDSLRSIERADVVLIIINAEEGVTEQDERIAGYAFEAGKACIFVVNKWDTLAKDNSTLGKFVDQIKTEFKYL
SFAPIVFVSAKSGQRINRVMEEVERVMAQYSKRVSTSDLNRVFSEAVEKHHAPLSHGRRVKFYFATQVGTKPPTFVLFTN
QPEGVHFSYERYLMNKFREAFDFTGSPLKIIFRGRDRRE
>Mature_439_residues
MMPLVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFEAPFILIDTGGFEPVSEDRLLQQMREQSQLAM
EEADVIIFLMDGRAGLTPSDVEVVEMLRRVKKPVFFVVNKVDGEKIENEAADFYTLGIGTLHTISAEHNRGVNDLMEEVV
AALPKSSTRLDDEDITRIAVVGRPNVGKSSLVNRLLGFERVVANPTPGTTRDSVDTLFACNKKRYLLIDTAGIRRKGKTT
QKLEKYSVVDSLRSIERADVVLIIINAEEGVTEQDERIAGYAFEAGKACIFVVNKWDTLAKDNSTLGKFVDQIKTEFKYL
SFAPIVFVSAKSGQRINRVMEEVERVMAQYSKRVSTSDLNRVFSEAVEKHHAPLSHGRRVKFYFATQVGTKPPTFVLFTN
QPEGVHFSYERYLMNKFREAFDFTGSPLKIIFRGRDRRE

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=463, Percent_Identity=42.3326133909287, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1788919, Length=181, Percent_Identity=30.939226519337, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI2367268, Length=155, Percent_Identity=34.8387096774194, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17507259, Length=91, Percent_Identity=36.2637362637363, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323665, Length=169, Percent_Identity=31.9526627218935, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_GEOMG (Q39T85)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385264.1
- ProteinModelPortal:   Q39T85
- SMR:   Q39T85
- STRING:   Q39T85
- GeneID:   3740469
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2314
- NMPDR:   fig|269799.3.peg.2558
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   KCEKAFD
- PhylomeDB:   Q39T85
- ProtClustDB:   PRK00093
- BioCyc:   GMET269799:GMET_2314-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 49604; Mature: 49604

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPLVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFEAPFILIDTGGF
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCEEEEECCCC
EPVSEDRLLQQMREQSQLAMEEADVIIFLMDGRAGLTPSDVEVVEMLRRVKKPVFFVVNK
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
VDGEKIENEAADFYTLGIGTLHTISAEHNRGVNDLMEEVVAALPKSSTRLDDEDITRIAV
CCCHHHHHCCCCEEEECCCCEEEECCHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
VGRPNVGKSSLVNRLLGFERVVANPTPGTTRDSVDTLFACNKKRYLLIDTAGIRRKGKTT
ECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCHH
QKLEKYSVVDSLRSIERADVVLIIINAEEGVTEQDERIAGYAFEAGKACIFVVNKWDTLA
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHEEEEEECCCEEEEEEECCCHHH
KDNSTLGKFVDQIKTEFKYLSFAPIVFVSAKSGQRINRVMEEVERVMAQYSKRVSTSDLN
CCCCHHHHHHHHHHHHHHHHEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
RVFSEAVEKHHAPLSHGRRVKFYFATQVGTKPPTFVLFTNQPEGVHFSYERYLMNKFREA
HHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHH
FDFTGSPLKIIFRGRDRRE
HCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MMPLVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFEAPFILIDTGGF
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEECCCEEEEECCCC
EPVSEDRLLQQMREQSQLAMEEADVIIFLMDGRAGLTPSDVEVVEMLRRVKKPVFFVVNK
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEEC
VDGEKIENEAADFYTLGIGTLHTISAEHNRGVNDLMEEVVAALPKSSTRLDDEDITRIAV
CCCHHHHHCCCCEEEECCCCEEEECCHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
VGRPNVGKSSLVNRLLGFERVVANPTPGTTRDSVDTLFACNKKRYLLIDTAGIRRKGKTT
ECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCHH
QKLEKYSVVDSLRSIERADVVLIIINAEEGVTEQDERIAGYAFEAGKACIFVVNKWDTLA
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHEEEEEECCCEEEEEEECCCHHH
KDNSTLGKFVDQIKTEFKYLSFAPIVFVSAKSGQRINRVMEEVERVMAQYSKRVSTSDLN
CCCCHHHHHHHHHHHHHHHHEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
RVFSEAVEKHHAPLSHGRRVKFYFATQVGTKPPTFVLFTNQPEGVHFSYERYLMNKFREA
HHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCEEEEECCCCCCCEEHHHHHHHHHHHHH
FDFTGSPLKIIFRGRDRRE
HCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA