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The map label for this gene is acdA [H]

Identifier: 78223403

GI number: 78223403

Start: 2485637

End: 2486773

Strand: Reverse

Name: acdA [H]

Synonym: Gmet_2198

Alternate gene names: 78223403

Gene position: 2486773-2485637 (Counterclockwise)

Preceding gene: 78223404

Following gene: 78223402

Centisome position: 62.21

GC content: 53.74

Gene sequence:

>1137_bases
ATGAACTACAGTTTGAATGATGAACAGAAGATACTTAAAGATACCGCTCGGTCCTTTTTTACGGAGGAGTTGAAGAGTTC
GCTTGTTCGCGAAGTTGAAGAAGATGAACAGGGGTACAGTCGCAAACTGTGGGAGAGCATAGCGGAATTTGGCTGGATGG
GAACGATAATCCCCGAGGAATTCGGAGGGTTCGAAGCAACATTCTTTGAACTCTCCCTGATCTTGGAGGAAATGGGCTAC
GCCGGGTATGCCGGCCCCTTTTTCTCCACGGTGGTTTTGGGCGCGCTCACCATCCTGACAGCAGGTACCCCTGAACAGAA
ACGGTCGGTCCTGGAGGAAGTCTCCCTGGGGAAGCGGTTGATGACACTGGCGCTGGAGGAGACCGGCGACGGACCGTCAG
CGTGCGAGATTGCGACTACTGCGAAAAAAGTGGCTGATGGTTTTCTGTTGAATGGATGCAAGCGCTTTGTCCCCTTTGCC
CATGTAGCTGATACGATCATCTGCGCTGCCAGGACAGGCGACGGCGGTAAAAATGGTGAAGAGGGAATAAGCCTCTTTCT
TGTCGACAGAAGATCTCAGGGAGTGTCGATAGAGGTTCTCAATACCATTGCCAGGGACAAACAGTGTGACGTTGTCTTCA
ATAATGTTCTGGTGTCGGGAGATTCCCTACTAGGTGAAGCGGGGGAAGGGTGGCAGCTGCTGCAAGGTGTGCTACGGGTA
GCCTCGGTTGCAAAGTGTGCGGAGATGGTAGGCGGAGCACGGAAGGTCCTGGAGATGGTCGTGGAGTATGCCAAGACGCG
CAAGCAGTTCGGTCAACCCATCGGGAGCTTCCAGGCGATCCAGCACCATTGTGCCAATATGCTCACCTGTCTGGACAGTT
CAGCGCTTCTGACCTTTTATGCCAGTAAGCGCATCGGTCAGGGGCTTTCCTATGAAAAGGAAGCTGCCATGTGCAAGGCG
TGGGTGAGCGACTCCTATCGGAAATTGACCGCATTGGGGCATCAGGTGATGGGTGGCGTCGGCTTTATTGACGAGAGCGA
TTTGCAGATCTATTTCCGTCGTGCAAAGGCCGCGGAGCAGGCACTCGGAGATGCGACCTACCATCGGGAAATCGTAGCGC
AGTTGATGGGACTCTAA

Upstream 100 bases:

>100_bases
GGACTGTTATTGAGACCATTTACGGGGGGACCGCCGAAATCCAGCGGAATATCATGGCACAACGCGGTTTAGGGTTGCCG
AGAGCATAGGGGGGCGAGGA

Downstream 100 bases:

>100_bases
TTTAGCAAGAGGGGATCTGTATGAAAAATGAAGCATACATCTATGACGCGATACGTACGCCGCGAGGCAAGGGAAAGAGT
GATGGATCGCTGCACGAGGT

Product: Acyl-CoA dehydrogenase-like

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MNYSLNDEQKILKDTARSFFTEELKSSLVREVEEDEQGYSRKLWESIAEFGWMGTIIPEEFGGFEATFFELSLILEEMGY
AGYAGPFFSTVVLGALTILTAGTPEQKRSVLEEVSLGKRLMTLALEETGDGPSACEIATTAKKVADGFLLNGCKRFVPFA
HVADTIICAARTGDGGKNGEEGISLFLVDRRSQGVSIEVLNTIARDKQCDVVFNNVLVSGDSLLGEAGEGWQLLQGVLRV
ASVAKCAEMVGGARKVLEMVVEYAKTRKQFGQPIGSFQAIQHHCANMLTCLDSSALLTFYASKRIGQGLSYEKEAAMCKA
WVSDSYRKLTALGHQVMGGVGFIDESDLQIYFRRAKAAEQALGDATYHREIVAQLMGL

Sequences:

>Translated_378_residues
MNYSLNDEQKILKDTARSFFTEELKSSLVREVEEDEQGYSRKLWESIAEFGWMGTIIPEEFGGFEATFFELSLILEEMGY
AGYAGPFFSTVVLGALTILTAGTPEQKRSVLEEVSLGKRLMTLALEETGDGPSACEIATTAKKVADGFLLNGCKRFVPFA
HVADTIICAARTGDGGKNGEEGISLFLVDRRSQGVSIEVLNTIARDKQCDVVFNNVLVSGDSLLGEAGEGWQLLQGVLRV
ASVAKCAEMVGGARKVLEMVVEYAKTRKQFGQPIGSFQAIQHHCANMLTCLDSSALLTFYASKRIGQGLSYEKEAAMCKA
WVSDSYRKLTALGHQVMGGVGFIDESDLQIYFRRAKAAEQALGDATYHREIVAQLMGL
>Mature_378_residues
MNYSLNDEQKILKDTARSFFTEELKSSLVREVEEDEQGYSRKLWESIAEFGWMGTIIPEEFGGFEATFFELSLILEEMGY
AGYAGPFFSTVVLGALTILTAGTPEQKRSVLEEVSLGKRLMTLALEETGDGPSACEIATTAKKVADGFLLNGCKRFVPFA
HVADTIICAARTGDGGKNGEEGISLFLVDRRSQGVSIEVLNTIARDKQCDVVFNNVLVSGDSLLGEAGEGWQLLQGVLRV
ASVAKCAEMVGGARKVLEMVVEYAKTRKQFGQPIGSFQAIQHHCANMLTCLDSSALLTFYASKRIGQGLSYEKEAAMCKA
WVSDSYRKLTALGHQVMGGVGFIDESDLQIYFRRAKAAEQALGDATYHREIVAQLMGL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=358, Percent_Identity=29.0502793296089, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=27.3936170212766, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4501857, Length=388, Percent_Identity=26.5463917525773, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=24.1379310344828, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=27.7486910994764, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=27.7486910994764, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI76496475, Length=367, Percent_Identity=27.5204359673025, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4557235, Length=367, Percent_Identity=27.5204359673025, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=23.7536656891496, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=26.5536723163842, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=24.2744063324538, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI38505218, Length=323, Percent_Identity=23.8390092879257, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786223, Length=355, Percent_Identity=26.4788732394366, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI87081958, Length=360, Percent_Identity=27.2222222222222, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87081702, Length=290, Percent_Identity=27.2413793103448, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508101, Length=379, Percent_Identity=31.6622691292876, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17506239, Length=380, Percent_Identity=28.9473684210526, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17538396, Length=381, Percent_Identity=26.509186351706, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=32.1428571428571, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=25.3926701570681, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=27.2479564032698, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=23.3160621761658, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=30.0847457627119, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71985192, Length=341, Percent_Identity=26.9794721407625, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71982178, Length=286, Percent_Identity=30.4195804195804, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=23.4375, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17533517, Length=369, Percent_Identity=24.1192411924119, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17534353, Length=262, Percent_Identity=23.2824427480916, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=28.9124668435013, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24666513, Length=357, Percent_Identity=28.8515406162465, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=26.4550264550265, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=28.4574468085106, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=27.2251308900524, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281363737, Length=328, Percent_Identity=28.6585365853659, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19920834, Length=296, Percent_Identity=25.3378378378378, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41290; Mature: 41290

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYSLNDEQKILKDTARSFFTEELKSSLVREVEEDEQGYSRKLWESIAEFGWMGTIIPEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FGGFEATFFELSLILEEMGYAGYAGPFFSTVVLGALTILTAGTPEQKRSVLEEVSLGKRL
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
MTLALEETGDGPSACEIATTAKKVADGFLLNGCKRFVPFAHVADTIICAARTGDGGKNGE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCCCC
EGISLFLVDRRSQGVSIEVLNTIARDKQCDVVFNNVLVSGDSLLGEAGEGWQLLQGVLRV
CCEEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHH
ASVAKCAEMVGGARKVLEMVVEYAKTRKQFGQPIGSFQAIQHHCANMLTCLDSSALLTFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
ASKRIGQGLSYEKEAAMCKAWVSDSYRKLTALGHQVMGGVGFIDESDLQIYFRRAKAAEQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ALGDATYHREIVAQLMGL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYSLNDEQKILKDTARSFFTEELKSSLVREVEEDEQGYSRKLWESIAEFGWMGTIIPEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
FGGFEATFFELSLILEEMGYAGYAGPFFSTVVLGALTILTAGTPEQKRSVLEEVSLGKRL
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
MTLALEETGDGPSACEIATTAKKVADGFLLNGCKRFVPFAHVADTIICAARTGDGGKNGE
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCCCC
EGISLFLVDRRSQGVSIEVLNTIARDKQCDVVFNNVLVSGDSLLGEAGEGWQLLQGVLRV
CCEEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHH
ASVAKCAEMVGGARKVLEMVVEYAKTRKQFGQPIGSFQAIQHHCANMLTCLDSSALLTFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
ASKRIGQGLSYEKEAAMCKAWVSDSYRKLTALGHQVMGGVGFIDESDLQIYFRRAKAAEQ
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ALGDATYHREIVAQLMGL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]