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The map label for this gene is csd [H]

Identifier: 78223213

GI number: 78223213

Start: 2244290

End: 2245477

Strand: Reverse

Name: csd [H]

Synonym: Gmet_2006

Alternate gene names: 78223213

Gene position: 2245477-2244290 (Counterclockwise)

Preceding gene: 78223214

Following gene: 78223212

Centisome position: 56.17

GC content: 58.75

Gene sequence:

>1188_bases
ATGGACATTCAGAAAATCAGGGGAGATTTCCCCATCTTTGAGAGGCGCATCAACGGGAAGCCGATAGTCTATTTCGACAG
CGCCGCCACGACCCAGAAGCCTCGCCAGGTGATCGATACGCTTTCGAACTACTACGCGAACCACTGCGCCAATATCCACC
GCGGGGTGCACACCCTTTCCCAGGAGTCGTCGGAGCTCTATGAGGAAGCGCGCCGGACCGTTGCCCGTTTCATCAATGCC
GACGAGCGGGAAATCGTCTTTGTCAGGAACACGACCGAAGCGATCAATCTGGTAAGCACCTGCCTGAAGGGGGAGGGGCA
GATTCTGTCCACCGTTACCGAGCACCACTCGAATCTCCTTCCGTGGGGACGTTCACGGAAGGTAGACTATGTGGATATCG
ACGCCCAGGGGCGGATAGATGTGGCGGATCTGAAGGAAAAATTGCTGAAACCGACGCTCCTGGTCGCGGTGACCCACGTC
TCCAACGTACTTGGTCTGGTCAATCCGGTGGAAGAGGTGATAGCCGAGGCGCGGAAAAACGGGGCGCTGACACTGGTTGA
TGCGGCCCAGTCGGCGCCGCACATGGAGATCGACGTCAAGGCGATGGGATGCGATTTCCTGGTTTTCAGCGGGCACAAGA
TGCTGGCGCCCTCGGGTATCGGCGTCCTCTATGTGCGGGAAGAGCTCTATGAGCGGATGGAACCGTATCTCATGGGGGGG
AGCACCATCAAGGAGGCCCACCTGGGAAGTTATGTTCCTGAGGAACCCCCCACCTGCTATGAGGCGGGAACGCCCAACAT
CGAGGGTGCTATTGCGCTGGCCAGCGCCATCGACTACCTGAACGACATCGGCATGGACAACGTGCTGGCCCACGACAAGG
CCTTGATGGCGTTGGCCCTGGAGAGGATGAAGGCCATCGACAATGTAGAACTATACGGCAGCCTCGATCCCACGGACCGG
CTCTCCGTCATCACCTTCAATGTCAAGGGGATGGGGTGCCACGGCGTGGCCAAGGTGCTGAACCTGCGGGAGAACATCAT
GATCCGCTCGGGCTTCCACTGCGCTCAACCGCTCCATGACCGGCTCGGCATCGGGCCGACGGCGCGGATGTCCTTCTATA
TCTACAATACGCCTGAAGAGATCGAGCTTGCGGCGGAGCTTCTCGGGAAGATTGCGGAGTTTATGTGA

Upstream 100 bases:

>100_bases
GGTAAAGACCATCAAGGCCGAGGATGGCGGGAAGTTCCGGTTTATCAAGGCAAAGGGGCACGACAGGCTGTAATGCTGAA
GTAGTGAAGGAGATTTTTCG

Downstream 100 bases:

>100_bases
ATCAAGAACAAACATCTCACGAAAGCACGAAAGGTTGAAAGTACGAAAAGAGGCATAAAACACAAAGAGGCTAAAGGTCT
TGGGGTTTATTTTCGTGTTT

Product: cysteine desulphurases, SufS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MDIQKIRGDFPIFERRINGKPIVYFDSAATTQKPRQVIDTLSNYYANHCANIHRGVHTLSQESSELYEEARRTVARFINA
DEREIVFVRNTTEAINLVSTCLKGEGQILSTVTEHHSNLLPWGRSRKVDYVDIDAQGRIDVADLKEKLLKPTLLVAVTHV
SNVLGLVNPVEEVIAEARKNGALTLVDAAQSAPHMEIDVKAMGCDFLVFSGHKMLAPSGIGVLYVREELYERMEPYLMGG
STIKEAHLGSYVPEEPPTCYEAGTPNIEGAIALASAIDYLNDIGMDNVLAHDKALMALALERMKAIDNVELYGSLDPTDR
LSVITFNVKGMGCHGVAKVLNLRENIMIRSGFHCAQPLHDRLGIGPTARMSFYIYNTPEEIELAAELLGKIAEFM

Sequences:

>Translated_395_residues
MDIQKIRGDFPIFERRINGKPIVYFDSAATTQKPRQVIDTLSNYYANHCANIHRGVHTLSQESSELYEEARRTVARFINA
DEREIVFVRNTTEAINLVSTCLKGEGQILSTVTEHHSNLLPWGRSRKVDYVDIDAQGRIDVADLKEKLLKPTLLVAVTHV
SNVLGLVNPVEEVIAEARKNGALTLVDAAQSAPHMEIDVKAMGCDFLVFSGHKMLAPSGIGVLYVREELYERMEPYLMGG
STIKEAHLGSYVPEEPPTCYEAGTPNIEGAIALASAIDYLNDIGMDNVLAHDKALMALALERMKAIDNVELYGSLDPTDR
LSVITFNVKGMGCHGVAKVLNLRENIMIRSGFHCAQPLHDRLGIGPTARMSFYIYNTPEEIELAAELLGKIAEFM
>Mature_395_residues
MDIQKIRGDFPIFERRINGKPIVYFDSAATTQKPRQVIDTLSNYYANHCANIHRGVHTLSQESSELYEEARRTVARFINA
DEREIVFVRNTTEAINLVSTCLKGEGQILSTVTEHHSNLLPWGRSRKVDYVDIDAQGRIDVADLKEKLLKPTLLVAVTHV
SNVLGLVNPVEEVIAEARKNGALTLVDAAQSAPHMEIDVKAMGCDFLVFSGHKMLAPSGIGVLYVREELYERMEPYLMGG
STIKEAHLGSYVPEEPPTCYEAGTPNIEGAIALASAIDYLNDIGMDNVLAHDKALMALALERMKAIDNVELYGSLDPTDR
LSVITFNVKGMGCHGVAKVLNLRENIMIRSGFHCAQPLHDRLGIGPTARMSFYIYNTPEEIELAAELLGKIAEFM

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=229, Percent_Identity=32.7510917030568, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI156713448, Length=257, Percent_Identity=25.6809338521401, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=38.5749385749386, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1789175, Length=390, Percent_Identity=34.8717948717949, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI48994898, Length=233, Percent_Identity=30.9012875536481, Blast_Score=106, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25143064, Length=228, Percent_Identity=31.5789473684211, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193211090, Length=371, Percent_Identity=23.989218328841, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=245, Percent_Identity=35.1020408163265, Blast_Score=143, Evalue=5e-35,
Organism=Drosophila melanogaster, GI20129463, Length=243, Percent_Identity=33.7448559670782, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43755; Mature: 43755

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQKIRGDFPIFERRINGKPIVYFDSAATTQKPRQVIDTLSNYYANHCANIHRGVHTLS
CCHHHHCCCCCHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QESSELYEEARRTVARFINADEREIVFVRNTTEAINLVSTCLKGEGQILSTVTEHHSNLL
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PWGRSRKVDYVDIDAQGRIDVADLKEKLLKPTLLVAVTHVSNVLGLVNPVEEVIAEARKN
CCCCCCCCEEEEECCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GALTLVDAAQSAPHMEIDVKAMGCDFLVFSGHKMLAPSGIGVLYVREELYERMEPYLMGG
CCEEEEECCCCCCCCEEEEEEECCEEEEECCCEEECCCCCEEEEEHHHHHHHHCCEEECC
STIKEAHLGSYVPEEPPTCYEAGTPNIEGAIALASAIDYLNDIGMDNVLAHDKALMALAL
CHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ERMKAIDNVELYGSLDPTDRLSVITFNVKGMGCHGVAKVLNLRENIMIRSGFHCAQPLHD
HHHHHHCCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHEEEECCCCHHHHHHH
RLGIGPTARMSFYIYNTPEEIELAAELLGKIAEFM
HHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDIQKIRGDFPIFERRINGKPIVYFDSAATTQKPRQVIDTLSNYYANHCANIHRGVHTLS
CCHHHHCCCCCHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QESSELYEEARRTVARFINADEREIVFVRNTTEAINLVSTCLKGEGQILSTVTEHHSNLL
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
PWGRSRKVDYVDIDAQGRIDVADLKEKLLKPTLLVAVTHVSNVLGLVNPVEEVIAEARKN
CCCCCCCCEEEEECCCCCEEHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GALTLVDAAQSAPHMEIDVKAMGCDFLVFSGHKMLAPSGIGVLYVREELYERMEPYLMGG
CCEEEEECCCCCCCCEEEEEEECCEEEEECCCEEECCCCCEEEEEHHHHHHHHCCEEECC
STIKEAHLGSYVPEEPPTCYEAGTPNIEGAIALASAIDYLNDIGMDNVLAHDKALMALAL
CHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
ERMKAIDNVELYGSLDPTDRLSVITFNVKGMGCHGVAKVLNLRENIMIRSGFHCAQPLHD
HHHHHHCCEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHEEEECCCCHHHHHHH
RLGIGPTARMSFYIYNTPEEIELAAELLGKIAEFM
HHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]