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The map label for this gene is garR [H]

Identifier: 78223179

GI number: 78223179

Start: 2202631

End: 2203497

Strand: Reverse

Name: garR [H]

Synonym: Gmet_1972

Alternate gene names: 78223179

Gene position: 2203497-2202631 (Counterclockwise)

Preceding gene: 78223180

Following gene: 78223168

Centisome position: 55.12

GC content: 56.4

Gene sequence:

>867_bases
ATGTTGAAAAATGTCGGTTTCTTGGGTCTGGGTACCGTCGGCCGGCACATGGCCATCAATCTTCTCAAGGGAAGCTACAC
TCTTACGGTTTACGACTCGGATCCCGAAGTCGTTGCAGAACTTGTCAAGCAGGGAGCCCTCGGAGCCGGAACGCCGCGGG
AGGCTGCCAAGGGGCAAGATATTGTCATCTACATCCGTCCCGAGAAGGAGCGGCTAAAGCCTGACATTTACGGGGAAGAC
GGCATTTTCGCGGGGATCGACCCCGGCACGATCCTCGTTGACATGGGAACCCATTCCCTTGAGAGCACGAAGGAAATGGC
CGAAGAGGCCGCAAAGCACCGTGTCATGTTCCTTGATGCTCCGGTCTGGGGGACCAAGGAACACGCAGCCAATGGGCTCC
TCACGATTCTCGCCGGCGGGGATCCGTCGCTTCTCGGTCGGTGCCGTGAACTCTTCTCGTTCTTCGGACTCAACATCATC
CATGTCGGATCCATCGGTGACGCTACCCGGATGAAATTCGTCGTTAACCTGGTTCAGGCCGAGTTGATGGAGACTCTGGC
TGAAGCCATTGTCTTCGGCGAGAAGATGGGTTTCAACGTTGATAAGATTCTCGAAGTGCTCGATTCCGGTGGTGTTGCCT
CCCCCCTGTTCCACTCCAAGGGGCGCGTCATTGCCAGGGGAGATTTTACCCGTAACCTGGCCCTCAAGTACGTTCACGAA
CAGCTGGAACTGGTGCTCGAAAAGTCTCAGAAATTGGGTCTGGATCTGCCGGCCGCCATGGTGGCGTGCAAGACGTATGA
GCAGGGGGTCAAGGATGGCCGCGGCGAAGAGGACTTTTCCTCAGTGGTCAAGGTCCTGAGAAAATAG

Upstream 100 bases:

>100_bases
TTATTTTTTTAAACTCTTCTATTGTACAAGAGACAAACACATTGTACTATTAACACCGTTCGGAGATGTGATTACTTACT
GTAAATTCAGGAGGCATGCA

Downstream 100 bases:

>100_bases
TTACCAGGCACGATAGTCAGGTGGAGAGAGGGGCACCCGTTCAGGCGGATGCCCCTCTTCTTTTGTGCGTGAAATGTTGC
CGACCTTGGGGGGACGTTGT

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLKNVGFLGLGTVGRHMAINLLKGSYTLTVYDSDPEVVAELVKQGALGAGTPREAAKGQDIVIYIRPEKERLKPDIYGED
GIFAGIDPGTILVDMGTHSLESTKEMAEEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLLGRCRELFSFFGLNII
HVGSIGDATRMKFVVNLVQAELMETLAEAIVFGEKMGFNVDKILEVLDSGGVASPLFHSKGRVIARGDFTRNLALKYVHE
QLELVLEKSQKLGLDLPAAMVACKTYEQGVKDGRGEEDFSSVVKVLRK

Sequences:

>Translated_288_residues
MLKNVGFLGLGTVGRHMAINLLKGSYTLTVYDSDPEVVAELVKQGALGAGTPREAAKGQDIVIYIRPEKERLKPDIYGED
GIFAGIDPGTILVDMGTHSLESTKEMAEEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLLGRCRELFSFFGLNII
HVGSIGDATRMKFVVNLVQAELMETLAEAIVFGEKMGFNVDKILEVLDSGGVASPLFHSKGRVIARGDFTRNLALKYVHE
QLELVLEKSQKLGLDLPAAMVACKTYEQGVKDGRGEEDFSSVVKVLRK
>Mature_288_residues
MLKNVGFLGLGTVGRHMAINLLKGSYTLTVYDSDPEVVAELVKQGALGAGTPREAAKGQDIVIYIRPEKERLKPDIYGED
GIFAGIDPGTILVDMGTHSLESTKEMAEEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLLGRCRELFSFFGLNII
HVGSIGDATRMKFVVNLVQAELMETLAEAIVFGEKMGFNVDKILEVLDSGGVASPLFHSKGRVIARGDFTRNLALKYVHE
QLELVLEKSQKLGLDLPAAMVACKTYEQGVKDGRGEEDFSSVVKVLRK

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=30.7420494699647, Blast_Score=151, Evalue=5e-37,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=27.1477663230241, Blast_Score=112, Evalue=3e-25,
Organism=Escherichia coli, GI145693186, Length=278, Percent_Identity=29.136690647482, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=29.4736842105263, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=29.4326241134752, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789092, Length=286, Percent_Identity=25.1748251748252, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=293, Percent_Identity=28.3276450511945, Blast_Score=104, Evalue=7e-23,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=24.5551601423488, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=26.2798634812287, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=26.2798634812287, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31244; Mature: 31244

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNVGFLGLGTVGRHMAINLLKGSYTLTVYDSDPEVVAELVKQGALGAGTPREAAKGQD
CCCCCCEEECCHHHHHHEEEEEECEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHCCCCE
IVIYIRPEKERLKPDIYGEDGIFAGIDPGTILVDMGTHSLESTKEMAEEAAKHRVMFLDA
EEEEECCCHHHCCCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCEEEEEEC
PVWGTKEHAANGLLTILAGGDPSLLGRCRELFSFFGLNIIHVGSIGDATRMKFVVNLVQA
CCCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
ELMETLAEAIVFGEKMGFNVDKILEVLDSGGVASPLFHSKGRVIARGDFTRNLALKYVHE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
QLELVLEKSQKLGLDLPAAMVACKTYEQGVKDGRGEEDFSSVVKVLRK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLKNVGFLGLGTVGRHMAINLLKGSYTLTVYDSDPEVVAELVKQGALGAGTPREAAKGQD
CCCCCCEEECCHHHHHHEEEEEECEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHCCCCE
IVIYIRPEKERLKPDIYGEDGIFAGIDPGTILVDMGTHSLESTKEMAEEAAKHRVMFLDA
EEEEECCCHHHCCCCCCCCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCEEEEEEC
PVWGTKEHAANGLLTILAGGDPSLLGRCRELFSFFGLNIIHVGSIGDATRMKFVVNLVQA
CCCCCHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHH
ELMETLAEAIVFGEKMGFNVDKILEVLDSGGVASPLFHSKGRVIARGDFTRNLALKYVHE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
QLELVLEKSQKLGLDLPAAMVACKTYEQGVKDGRGEEDFSSVVKVLRK
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]