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The map label for this gene is hisS

Identifier: 78223120

GI number: 78223120

Start: 2135237

End: 2136478

Strand: Reverse

Name: hisS

Synonym: Gmet_1913

Alternate gene names: 78223120

Gene position: 2136478-2135237 (Counterclockwise)

Preceding gene: 78223121

Following gene: 78223119

Centisome position: 53.45

GC content: 60.06

Gene sequence:

>1242_bases
ATGATCACTGGCATCAAGGGTTTTAACGATATTCTTCCCGGCGAGGTGGAGCGGTGGCAGCACATCGAGGCGACCGCTCG
CCGCGTTTTCGGTCTTTATGGCTATGCCGAGATTCGTGTTCCGATTCTTGAAAAAACCGAACTTTTTTGCCGCTCCATCG
GCGACACCACCGACATCGTGGAGAAGGAGATGTACTCCTTTGTGGACAAGGGAGAAAATGCCGTAACCATGCGCCCCGAG
GGGACCGCGAGCGTGATGCGCGCATATATTGAGCATAAGCTTTACGCCCAGGATCCGGTGGCAAAACTCTACTACATGGG
ACCGATGTTTCGGTACGAACGCCCTCAAAAGGGGCGCTATCGGCAATTCCACCAGATCGGCGCCGAGGTTACCGGCGTCA
CCGACCCCAAGGTGGACGCTCAGGTTCTCACCATGCTCTGCCATTTCTTTGCGGAACTCGGTCTTACGGAGCCGACCCTC
CAGATAAACTCCCTCGGCTGCCCCGAGTGCCGTCCCGTCTATCGGGAGGCGCTGAAGAGCTTTCTTCGTGAGCGGCTCGA
CCGACTCTGCGATGACTGCAAGAGACGCTACGAAACCAACCCCCTCAGGGCGCTTGACTGCAAGTCTGCACACTGCAAGG
AGGCGACAGCCGACGCTCCGGCCATGCTCGACCACCTCTGCGCCGGCTGCGACGACCACTTTGCCGCCACGCGCCGCCAC
CTGGAGCGGGCGGGCACCCCCTACAGCATCAATAACAGGATGGTGCGCGGCCTCGACTATTACACCCGTACCACTTTCGA
GCTGGTCACGGGGCTCCTCGGCGCCCAGAGCGCCGTGGCGGCCGGCGGTCGTTACGACGGGCTCATTGCCGATCTGGACG
GTCCCGCCGTTCCCGGCATCGGCTTTGCCATGGGTGTCGAACGGGTGGCTCTGCTGCTGGGTCAGCAGGAGTTCGCGCGG
CGCCCCGACCTCTTTATCGCCGCCCTTGGAACTGAAGCCCAGGATGAAGCTTTTCGGCTCATGTGCGGCCTCCAGCGTCT
TGGCGTTTCAGTGGAGATGGACTACGAGGGGAAGAGCCTCAAAAGCCAGATGCGCCGCTCCGATAAATTCAACTCCCGCT
TCACCCTCATAATTGGAAGCGATGAGATGGCCAGTGGTAGAGCAACACTCAAAGCCATGGACACCGGCACCCAGTCCGAT
GTCCTCCTGGACCCGACCGCCATTGCAGGTCAGGTAAAATAA

Upstream 100 bases:

>100_bases
GTACCAGGGGAAGGAGCAGGGTAAAAACTGTGTGTTCAGGGCAACTGCAATTCGTTGATAATTTAGCTAGTTATTTAAAG
TTTAAGGAGTAGGTAAGTAC

Downstream 100 bases:

>100_bases
CGAGCGCAGGGGGGGAGGTGAGGGTGAACTTTCCTTCCCCCTTCTGCGCTGTTTTGTGCCCCCTCTTCCCCTTCTCATAA
GCCCCACTTAAGCAATTGAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MITGIKGFNDILPGEVERWQHIEATARRVFGLYGYAEIRVPILEKTELFCRSIGDTTDIVEKEMYSFVDKGENAVTMRPE
GTASVMRAYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHFFAELGLTEPTL
QINSLGCPECRPVYREALKSFLRERLDRLCDDCKRRYETNPLRALDCKSAHCKEATADAPAMLDHLCAGCDDHFAATRRH
LERAGTPYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLIADLDGPAVPGIGFAMGVERVALLLGQQEFAR
RPDLFIAALGTEAQDEAFRLMCGLQRLGVSVEMDYEGKSLKSQMRRSDKFNSRFTLIIGSDEMASGRATLKAMDTGTQSD
VLLDPTAIAGQVK

Sequences:

>Translated_413_residues
MITGIKGFNDILPGEVERWQHIEATARRVFGLYGYAEIRVPILEKTELFCRSIGDTTDIVEKEMYSFVDKGENAVTMRPE
GTASVMRAYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHFFAELGLTEPTL
QINSLGCPECRPVYREALKSFLRERLDRLCDDCKRRYETNPLRALDCKSAHCKEATADAPAMLDHLCAGCDDHFAATRRH
LERAGTPYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLIADLDGPAVPGIGFAMGVERVALLLGQQEFAR
RPDLFIAALGTEAQDEAFRLMCGLQRLGVSVEMDYEGKSLKSQMRRSDKFNSRFTLIIGSDEMASGRATLKAMDTGTQSD
VLLDPTAIAGQVK
>Mature_413_residues
MITGIKGFNDILPGEVERWQHIEATARRVFGLYGYAEIRVPILEKTELFCRSIGDTTDIVEKEMYSFVDKGENAVTMRPE
GTASVMRAYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHFFAELGLTEPTL
QINSLGCPECRPVYREALKSFLRERLDRLCDDCKRRYETNPLRALDCKSAHCKEATADAPAMLDHLCAGCDDHFAATRRH
LERAGTPYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLIADLDGPAVPGIGFAMGVERVALLLGQQEFAR
RPDLFIAALGTEAQDEAFRLMCGLQRLGVSVEMDYEGKSLKSQMRRSDKFNSRFTLIIGSDEMASGRATLKAMDTGTQSD
VLLDPTAIAGQVK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=452, Percent_Identity=23.8938053097345, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788861, Length=417, Percent_Identity=47.4820143884892, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_GEOMG (Q39UD2)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384867.1
- ProteinModelPortal:   Q39UD2
- SMR:   Q39UD2
- STRING:   Q39UD2
- GeneID:   3740317
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1913
- NMPDR:   fig|269799.3.peg.2176
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   WIRFASE
- PhylomeDB:   Q39UD2
- ProtClustDB:   PRK00037
- BioCyc:   GMET269799:GMET_1913-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 46091; Mature: 46091

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITGIKGFNDILPGEVERWQHIEATARRVFGLYGYAEIRVPILEKTELFCRSIGDTTDIV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHH
EKEMYSFVDKGENAVTMRPEGTASVMRAYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRY
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHCCCCCCCHH
RQFHQIGAEVTGVTDPKVDAQVLTMLCHFFAELGLTEPTLQINSLGCPECRPVYREALKS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHH
FLRERLDRLCDDCKRRYETNPLRALDCKSAHCKEATADAPAMLDHLCAGCDDHFAATRRH
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
LERAGTPYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLIADLDGPAVPGI
HHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCCCCC
GFAMGVERVALLLGQQEFARRPDLFIAALGTEAQDEAFRLMCGLQRLGVSVEMDYEGKSL
HHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCHHH
KSQMRRSDKFNSRFTLIIGSDEMASGRATLKAMDTGTQSDVLLDPTAIAGQVK
HHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCHHHCCCCC
>Mature Secondary Structure
MITGIKGFNDILPGEVERWQHIEATARRVFGLYGYAEIRVPILEKTELFCRSIGDTTDIV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCHHHHH
EKEMYSFVDKGENAVTMRPEGTASVMRAYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRY
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHCCCCCCCHH
RQFHQIGAEVTGVTDPKVDAQVLTMLCHFFAELGLTEPTLQINSLGCPECRPVYREALKS
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHH
FLRERLDRLCDDCKRRYETNPLRALDCKSAHCKEATADAPAMLDHLCAGCDDHFAATRRH
HHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHH
LERAGTPYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLIADLDGPAVPGI
HHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCEEEECCCCCCCCC
GFAMGVERVALLLGQQEFARRPDLFIAALGTEAQDEAFRLMCGLQRLGVSVEMDYEGKSL
HHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEECCCCHHH
KSQMRRSDKFNSRFTLIIGSDEMASGRATLKAMDTGTQSDVLLDPTAIAGQVK
HHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEECCCCCCCEEECCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA