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The map label for this gene is pyrD

Identifier: 78223048

GI number: 78223048

Start: 2054377

End: 2055294

Strand: Reverse

Name: pyrD

Synonym: Gmet_1841

Alternate gene names: 78223048

Gene position: 2055294-2054377 (Counterclockwise)

Preceding gene: 78223049

Following gene: 78223047

Centisome position: 51.42

GC content: 59.69

Gene sequence:

>918_bases
ATGAAAAGACCAGACCTCTCTGTCGAGATAGCGGGAATCAAACTCAGGAACCCGGTCATGACCGCTTCGGGGACTTTCGG
CTACGGCGAAGAATTTGCCGCGTACGTGAATCTCGAAAAGATCGGCGCCATCATCACCAAGGGACTCTCTCTGAAGCCCA
AGGCCGGCAACCCGACGCCACGCATCCAGGAAACCACCGGCGGGATGCTGAACGCTATTGGTCTCCAGAATGTGGGAATA
GATGCCTTTATCGAGAAAAAGGTGCCGTTTCTCCGCACCGTCAACACGCCTGCCATCGTCAACTTTTTCGGCAATACCGT
CGAGGAATACGCCGAGCTCGCCGAGCGGCTCGACAAGATTCCCGAAGTGGCCGGGATGGAGATCAACATCTCGTGTCCGA
ATGTGAAGCACGGCGGTATCGTTTTCGGCACCGAGCCCAAGGCGGCATATTCGGTGGTGAAGGCGGTACGGGAGGCCACC
ATCAAGCCGGTAATTGTGAAGCTCTCCCCCAACGTCACCGACATCGTGGAGATGGCCTGGGCCTGTGCTGACGCCGAGGC
TGATGCCCTGTCCCTCATCAATACCCTGACCGGCATGGCCATCGACCTCAAGTCCCGGCGGCCCATCCTTGCCAACGTGA
CCGGCGGCCTTTCGGGACCGGCGGTGAAACCGGTGGCCCTCAGGATGGTCTGGCAGGTGGCTAAGGCGGTGAAAATTCCG
GTGATCGGCATCGGCGGCATCATGTCCGGGACCGACGCCCTGGAGTTCATGCTGGCCGGCGCCACGGCCGTTCAGGTCGG
GACCGCCAACTTTCTTGACCCGGCCGCTTCCGAGCGGATTGCGGCGGAAATGGAGCAGTATCTGGTTAACAACGGAATTA
CGGACGTGAAGGAGCTAATCGGCGCACTGCAGGTCTGA

Upstream 100 bases:

>100_bases
GGCAGGGACCATGGCGACGAGACCCCGGATTACCGGTGCGTCTGTAAGGACGGACCTGTGTTCGCCTTCGATCAACTGAT
GTGGGTATAGTGGAGTGCCA

Downstream 100 bases:

>100_bases
AAACCAGCAGACGAGTTGCTTCTGTGAGCGAAGGCGGGGTTCCTCCCCGCCTTTGTCCGTTTGTGGAAGGAGAGCGTAAA
GATGGAAACGTGGCGAAAGG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKRPDLSVEIAGIKLRNPVMTASGTFGYGEEFAAYVNLEKIGAIITKGLSLKPKAGNPTPRIQETTGGMLNAIGLQNVGI
DAFIEKKVPFLRTVNTPAIVNFFGNTVEEYAELAERLDKIPEVAGMEINISCPNVKHGGIVFGTEPKAAYSVVKAVREAT
IKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLKSRRPILANVTGGLSGPAVKPVALRMVWQVAKAVKIP
VIGIGGIMSGTDALEFMLAGATAVQVGTANFLDPAASERIAAEMEQYLVNNGITDVKELIGALQV

Sequences:

>Translated_305_residues
MKRPDLSVEIAGIKLRNPVMTASGTFGYGEEFAAYVNLEKIGAIITKGLSLKPKAGNPTPRIQETTGGMLNAIGLQNVGI
DAFIEKKVPFLRTVNTPAIVNFFGNTVEEYAELAERLDKIPEVAGMEINISCPNVKHGGIVFGTEPKAAYSVVKAVREAT
IKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLKSRRPILANVTGGLSGPAVKPVALRMVWQVAKAVKIP
VIGIGGIMSGTDALEFMLAGATAVQVGTANFLDPAASERIAAEMEQYLVNNGITDVKELIGALQV
>Mature_305_residues
MKRPDLSVEIAGIKLRNPVMTASGTFGYGEEFAAYVNLEKIGAIITKGLSLKPKAGNPTPRIQETTGGMLNAIGLQNVGI
DAFIEKKVPFLRTVNTPAIVNFFGNTVEEYAELAERLDKIPEVAGMEINISCPNVKHGGIVFGTEPKAAYSVVKAVREAT
IKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLKSRRPILANVTGGLSGPAVKPVALRMVWQVAKAVKIP
VIGIGGIMSGTDALEFMLAGATAVQVGTANFLDPAASERIAAEMEQYLVNNGITDVKELIGALQV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=292, Percent_Identity=32.5342465753425, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI45006951, Length=321, Percent_Identity=28.0373831775701, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI87082059, Length=319, Percent_Identity=29.153605015674, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71984108, Length=288, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=26.0061919504644, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322633, Length=326, Percent_Identity=30.3680981595092, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24640763, Length=299, Percent_Identity=31.7725752508361, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18858217, Length=299, Percent_Identity=31.7725752508361, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281361352, Length=320, Percent_Identity=27.5, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137316, Length=320, Percent_Identity=27.5, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_GEOMG (Q39UK4)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384795.1
- ProteinModelPortal:   Q39UK4
- SMR:   Q39UK4
- STRING:   Q39UK4
- GeneID:   3741518
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1841
- NMPDR:   fig|269799.3.peg.1896
- eggNOG:   COG0167
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- PhylomeDB:   Q39UK4
- ProtClustDB:   PRK07259
- BioCyc:   GMET269799:GMET_1841-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32214; Mature: 32214

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRPDLSVEIAGIKLRNPVMTASGTFGYGEEFAAYVNLEKIGAIITKGLSLKPKAGNPTP
CCCCCCEEEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RIQETTGGMLNAIGLQNVGIDAFIEKKVPFLRTVNTPAIVNFFGNTVEEYAELAERLDKI
CEECCCCCCEECCCCCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
PEVAGMEINISCPNVKHGGIVFGTEPKAAYSVVKAVREATIKPVIVKLSPNVTDIVEMAW
HHHCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
ACADAEADALSLINTLTGMAIDLKSRRPILANVTGGLSGPAVKPVALRMVWQVAKAVKIP
HHCCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
VIGIGGIMSGTDALEFMLAGATAVQVGTANFLDPAASERIAAEMEQYLVNNGITDVKELI
EEEECCCCCCHHHHHHHHHCCCEEEECCCHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
GALQV
HHHCC
>Mature Secondary Structure
MKRPDLSVEIAGIKLRNPVMTASGTFGYGEEFAAYVNLEKIGAIITKGLSLKPKAGNPTP
CCCCCCEEEEEEEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
RIQETTGGMLNAIGLQNVGIDAFIEKKVPFLRTVNTPAIVNFFGNTVEEYAELAERLDKI
CEECCCCCCEECCCCCCCCHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHC
PEVAGMEINISCPNVKHGGIVFGTEPKAAYSVVKAVREATIKPVIVKLSPNVTDIVEMAW
HHHCCCEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHH
ACADAEADALSLINTLTGMAIDLKSRRPILANVTGGLSGPAVKPVALRMVWQVAKAVKIP
HHCCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
VIGIGGIMSGTDALEFMLAGATAVQVGTANFLDPAASERIAAEMEQYLVNNGITDVKELI
EEEECCCCCCHHHHHHHHHCCCEEEECCCHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
GALQV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA