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The map label for this gene is ygcA [C]

Identifier: 78223042

GI number: 78223042

Start: 2049288

End: 2050610

Strand: Reverse

Name: ygcA [C]

Synonym: Gmet_1835

Alternate gene names: 78223042

Gene position: 2050610-2049288 (Counterclockwise)

Preceding gene: 78223043

Following gene: 78223041

Centisome position: 51.3

GC content: 59.11

Gene sequence:

>1323_bases
ATGACTGAAGCCGTTGTCCGGATTGAGTCCCTGGCTTTCGGTGGAGCCGGCTTCGGCCGTGTCGAGGGGAAAGCCTGTTT
CGTACCGTTCACCGCGCCGGATGACCTTGCCCGCATACGGCTGAGCCTGGTAAAGAACTCCTATCTTGAAGGGGAAATCG
TCGAGCTCCTTGAAGCATCACCACGCAGAGTGGTTCCCCTGTGTCCGGTTTTTGGCATCTGTGGCGGATGCACATGGCAG
CATCTTTCCTACGATGACCAGCTTGAGGCGAAGGAACGAATTGTTGGCGACACCCTCTGGCGTTTCGGTCGGATTGAGTC
GGAGCGGGTCGCCAGGGCTGTTCCCTCCGACTCCCCCTACGGCTACCGCTCACGGGTCCAGTTCAAGGTGCGCTGGACCG
CCGGAAAGCTCCAGATGGGCTTCTACCGCCGCGGATCCCACTATGTCGTGGATATCCCCGAAGGGTGCGCTATCTGCAAT
TCGGCCCTCAATCAGGTATTGGCGGAGATTCGCCCTGTCATCAGTTGTTTCGCTGAGCCCGACCGTATTCCCCAAGTGGA
CGTGGCCGTGGGAGATGACGGCGTCACCTTGGCCGTAGTGCATTATATCGGCGACAATCGAGATCGTGCACGGGCGCATT
TTACCGCCTGCCGTAGTGATCTCCCAGCGGTGGGTGGACTCCATCTTCAGTGCGGCCGAAAGGAAAGCATTGAACCCCTC
TGGGGGGATGATGCTCTCACCTACCGCTTCCCTGGCGACTTCTTGCCGAAACTTCCCTCCATGACCCTGAGCTTCAGCCG
AGGCGGCTTCTCTCAGGTCAATTACCGTCAGAACCGGGAACTGCTGCGCGCGGTTCATCGAATGGCGGATCTGACCGGGG
AAGAACGGTTGCTGGACCTGTTCTGTGGCAACGGCAACTTTGCCATTCCTCTGTCCCGATATGCCATGGCAGTTGTGGGG
ATCGAAGACTATGGCCCCTCACTGGAAGATGCAAGGCGCAATGCAGCGGCCAACGGTGCAGGAAAGATCGAGTTCATCCG
TTCCGATGCCGCCGCTGGAGTGCGTCAGCTTGTCTCCCGTGAGAAACACTATTCGGTGGTTGTTCTCGACCCTCCGCGGA
CCGGCGCCAAAGAGGCGGTGACAGAGGTGACCTCCCTCAGGCCGGAGCGGGTTGTCTATGTTTCCTGCGACCCTGCCACC
CTGGGAAGGGATCTCGGGCTCTTCCGCAAGTCCGGTTACGATGTCCGCGAATGCCTCCCCGTCGACATGTTCCCCCAAAC
GTTCCATATTGAAAGTGTCACCTTGCTGAGTAGAGCCGACTGA

Upstream 100 bases:

>100_bases
TATTTTTCCGCGTCTGACTTTCCGCGCAAATTCCTCATGACTGAGCTCGCGAGGGCTCGAAATAAGCGCAATCTTTCTGC
CCGCATCACGGCGTATCACC

Downstream 100 bases:

>100_bases
TCCCTGGCCGTTTTAACAGACTTCCCCATACGTTCACGATTTAACGAACAGGAGGATCCATCATGTTTTTTTCCAAGTTA
TTCCGGAAGGATGCAGCGTC

Product: 23S rRNA methyltransferase/RumA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MTEAVVRIESLAFGGAGFGRVEGKACFVPFTAPDDLARIRLSLVKNSYLEGEIVELLEASPRRVVPLCPVFGICGGCTWQ
HLSYDDQLEAKERIVGDTLWRFGRIESERVARAVPSDSPYGYRSRVQFKVRWTAGKLQMGFYRRGSHYVVDIPEGCAICN
SALNQVLAEIRPVISCFAEPDRIPQVDVAVGDDGVTLAVVHYIGDNRDRARAHFTACRSDLPAVGGLHLQCGRKESIEPL
WGDDALTYRFPGDFLPKLPSMTLSFSRGGFSQVNYRQNRELLRAVHRMADLTGEERLLDLFCGNGNFAIPLSRYAMAVVG
IEDYGPSLEDARRNAAANGAGKIEFIRSDAAAGVRQLVSREKHYSVVVLDPPRTGAKEAVTEVTSLRPERVVYVSCDPAT
LGRDLGLFRKSGYDVRECLPVDMFPQTFHIESVTLLSRAD

Sequences:

>Translated_440_residues
MTEAVVRIESLAFGGAGFGRVEGKACFVPFTAPDDLARIRLSLVKNSYLEGEIVELLEASPRRVVPLCPVFGICGGCTWQ
HLSYDDQLEAKERIVGDTLWRFGRIESERVARAVPSDSPYGYRSRVQFKVRWTAGKLQMGFYRRGSHYVVDIPEGCAICN
SALNQVLAEIRPVISCFAEPDRIPQVDVAVGDDGVTLAVVHYIGDNRDRARAHFTACRSDLPAVGGLHLQCGRKESIEPL
WGDDALTYRFPGDFLPKLPSMTLSFSRGGFSQVNYRQNRELLRAVHRMADLTGEERLLDLFCGNGNFAIPLSRYAMAVVG
IEDYGPSLEDARRNAAANGAGKIEFIRSDAAAGVRQLVSREKHYSVVVLDPPRTGAKEAVTEVTSLRPERVVYVSCDPAT
LGRDLGLFRKSGYDVRECLPVDMFPQTFHIESVTLLSRAD
>Mature_439_residues
TEAVVRIESLAFGGAGFGRVEGKACFVPFTAPDDLARIRLSLVKNSYLEGEIVELLEASPRRVVPLCPVFGICGGCTWQH
LSYDDQLEAKERIVGDTLWRFGRIESERVARAVPSDSPYGYRSRVQFKVRWTAGKLQMGFYRRGSHYVVDIPEGCAICNS
ALNQVLAEIRPVISCFAEPDRIPQVDVAVGDDGVTLAVVHYIGDNRDRARAHFTACRSDLPAVGGLHLQCGRKESIEPLW
GDDALTYRFPGDFLPKLPSMTLSFSRGGFSQVNYRQNRELLRAVHRMADLTGEERLLDLFCGNGNFAIPLSRYAMAVVGI
EDYGPSLEDARRNAAANGAGKIEFIRSDAAAGVRQLVSREKHYSVVVLDPPRTGAKEAVTEVTSLRPERVVYVSCDPATL
GRDLGLFRKSGYDVRECLPVDMFPQTFHIESVTLLSRAD

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=193, Percent_Identity=33.6787564766839, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI51173878, Length=193, Percent_Identity=33.6787564766839, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI269784680, Length=427, Percent_Identity=25.2927400468384, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI269784676, Length=427, Percent_Identity=25.2927400468384, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI20149688, Length=427, Percent_Identity=25.2927400468384, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI269784678, Length=370, Percent_Identity=25.6756756756757, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789148, Length=438, Percent_Identity=31.0502283105023, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1790403, Length=338, Percent_Identity=26.0355029585799, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787083, Length=390, Percent_Identity=22.0512820512821, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24666579, Length=191, Percent_Identity=27.2251308900524, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 48681; Mature: 48550

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVVRIESLAFGGAGFGRVEGKACFVPFTAPDDLARIRLSLVKNSYLEGEIVELLEAS
CCCHHEEEEHHEECCCCCCEECCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCC
PRRVVPLCPVFGICGGCTWQHLSYDDQLEAKERIVGDTLWRFGRIESERVARAVPSDSPY
CCCEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
GYRSRVQFKVRWTAGKLQMGFYRRGSHYVVDIPEGCAICNSALNQVLAEIRPVISCFAEP
CCCEEEEEEEEEECCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DRIPQVDVAVGDDGVTLAVVHYIGDNRDRARAHFTACRSDLPAVGGLHLQCGRKESIEPL
CCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
WGDDALTYRFPGDFLPKLPSMTLSFSRGGFSQVNYRQNRELLRAVHRMADLTGEERLLDL
CCCCEEEEECCCHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
FCGNGNFAIPLSRYAMAVVGIEDYGPSLEDARRNAAANGAGKIEFIRSDAAAGVRQLVSR
EECCCCEEEEHHHHEEEEEEEHHCCCCHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCC
EKHYSVVVLDPPRTGAKEAVTEVTSLRPERVVYVSCDPATLGRDLGLFRKSGYDVRECLP
CCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHCCC
VDMFPQTFHIESVTLLSRAD
CCCCCCEEEECEEEEEECCC
>Mature Secondary Structure 
TEAVVRIESLAFGGAGFGRVEGKACFVPFTAPDDLARIRLSLVKNSYLEGEIVELLEAS
CCHHEEEEHHEECCCCCCEECCCEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCC
PRRVVPLCPVFGICGGCTWQHLSYDDQLEAKERIVGDTLWRFGRIESERVARAVPSDSPY
CCCEEECCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
GYRSRVQFKVRWTAGKLQMGFYRRGSHYVVDIPEGCAICNSALNQVLAEIRPVISCFAEP
CCCEEEEEEEEEECCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DRIPQVDVAVGDDGVTLAVVHYIGDNRDRARAHFTACRSDLPAVGGLHLQCGRKESIEPL
CCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
WGDDALTYRFPGDFLPKLPSMTLSFSRGGFSQVNYRQNRELLRAVHRMADLTGEERLLDL
CCCCEEEEECCCHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
FCGNGNFAIPLSRYAMAVVGIEDYGPSLEDARRNAAANGAGKIEFIRSDAAAGVRQLVSR
EECCCCEEEEHHHHEEEEEEEHHCCCCHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCC
EKHYSVVVLDPPRTGAKEAVTEVTSLRPERVVYVSCDPATLGRDLGLFRKSGYDVRECLP
CCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHCCC
VDMFPQTFHIESVTLLSRAD
CCCCCCEEEECEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA