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The map label for this gene is sppA [C]

Identifier: 78222959

GI number: 78222959

Start: 1965564

End: 1966469

Strand: Direct

Name: sppA [C]

Synonym: Gmet_1750

Alternate gene names: 78222959

Gene position: 1965564-1966469 (Clockwise)

Preceding gene: 78222957

Following gene: 78222971

Centisome position: 49.17

GC content: 57.84

Gene sequence:

>906_bases
ATGAAGAAAAACCATGTAGTGATCGGCGTGATCATCGTGGCTGCCCTTGCCCTTCTTTTCACCCTTTCGATCCAGATTGC
GCGGCTGATTTTGGGCGATGGACCCATGGTGAGTTCCGGCGAAGGGGTCGGGTATGTGGAGGTCAAGGGACCTATCCTGG
AATCCGAGGAAATCGTCAAACAACTCAGCGAAATGCGGAAAAAGACCAATGTGAAAGCGGTCGTCCTGCGGATTGAGTCC
CCCGGCGGGGTCATCGGTCCGTCCCAGGAGATTTATGAAGCGGTGAAGAAGCTCGCCAAGACCAAGAAGGTCGTGGTTTC
CATGGGGAGCGTGGCCGCATCCGGAGGGTACCATATTGCCATCCCCGCCGCGGTCATCTATGCCAATCCCGGCACCATAA
CCGGGAGTATCGGCGTTTTGATGAAACTTGCCAATGTCGAGGGTTTGATGGACAAGGTGGGGATGAAGGCCTTTACCCTC
AAGAGCGGTAAGTTCAAGGACGCAGGCTCACCGGTACGTGCCTTGACCGATGAGGACAGGGCGCTGCTTCAGGGAGTAAT
CGACAATCTTCACACCCAGTTTGTGAAGGCCGTCGCCGAGGCGCGGAAACTCCCGGTCGAAGAGGTCAGGCGTCTCGCGG
ACGGGCGGGTGTATACCGGCGAGCAGGCTGTGTCGCTCAAACTCGTTGACCGGCTCGGGACCCTTGAGGATGCCGTTGAG
GAGGCGGGTCGCCTGGCAGGAATCAAGGGTGAGCCGACATTGCTGATGCCGCCGAAAAAACGGAAGCATCTCAGGGATTA
TCTGCTGGAAGAAGCATCGGGCTTCTTTCGGGAGATAGTGCGGCGCGAGGGGGGATTCAGCGTCAACTACGAGCTTGATC
CGGCCGTGGGCAATGGAGGCCGTTGA

Upstream 100 bases:

>100_bases
GAATATTGTCCTCCATTCATGTCTGTAAACGGTTGCCGATGAAGTTTCCGCATCCGGATGAGGGGGACCATACTGACGCT
CAGTCCCTGCGGAGAATCCC

Downstream 100 bases:

>100_bases
CGGTATGGCGGGGCGCCATACCACTCACCAGGTTCTGAAAGCGCCTGAGTCGATGTGAACAAATCCCGAGTTGGGGTAGA
AACCGACACCGCCCATGTGG

Product: signal peptide peptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKKNHVVIGVIIVAALALLFTLSIQIARLILGDGPMVSSGEGVGYVEVKGPILESEEIVKQLSEMRKKTNVKAVVLRIES
PGGVIGPSQEIYEAVKKLAKTKKVVVSMGSVAASGGYHIAIPAAVIYANPGTITGSIGVLMKLANVEGLMDKVGMKAFTL
KSGKFKDAGSPVRALTDEDRALLQGVIDNLHTQFVKAVAEARKLPVEEVRRLADGRVYTGEQAVSLKLVDRLGTLEDAVE
EAGRLAGIKGEPTLLMPPKKRKHLRDYLLEEASGFFREIVRREGGFSVNYELDPAVGNGGR

Sequences:

>Translated_301_residues
MKKNHVVIGVIIVAALALLFTLSIQIARLILGDGPMVSSGEGVGYVEVKGPILESEEIVKQLSEMRKKTNVKAVVLRIES
PGGVIGPSQEIYEAVKKLAKTKKVVVSMGSVAASGGYHIAIPAAVIYANPGTITGSIGVLMKLANVEGLMDKVGMKAFTL
KSGKFKDAGSPVRALTDEDRALLQGVIDNLHTQFVKAVAEARKLPVEEVRRLADGRVYTGEQAVSLKLVDRLGTLEDAVE
EAGRLAGIKGEPTLLMPPKKRKHLRDYLLEEASGFFREIVRREGGFSVNYELDPAVGNGGR
>Mature_301_residues
MKKNHVVIGVIIVAALALLFTLSIQIARLILGDGPMVSSGEGVGYVEVKGPILESEEIVKQLSEMRKKTNVKAVVLRIES
PGGVIGPSQEIYEAVKKLAKTKKVVVSMGSVAASGGYHIAIPAAVIYANPGTITGSIGVLMKLANVEGLMDKVGMKAFTL
KSGKFKDAGSPVRALTDEDRALLQGVIDNLHTQFVKAVAEARKLPVEEVRRLADGRVYTGEQAVSLKLVDRLGTLEDAVE
EAGRLAGIKGEPTLLMPPKKRKHLRDYLLEEASGFFREIVRREGGFSVNYELDPAVGNGGR

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=257, Percent_Identity=35.408560311284, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787527, Length=194, Percent_Identity=28.8659793814433, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 32252; Mature: 32252

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNHVVIGVIIVAALALLFTLSIQIARLILGDGPMVSSGEGVGYVEVKGPILESEEIVK
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHH
QLSEMRKKTNVKAVVLRIESPGGVIGPSQEIYEAVKKLAKTKKVVVSMGSVAASGGYHIA
HHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
IPAAVIYANPGTITGSIGVLMKLANVEGLMDKVGMKAFTLKSGKFKDAGSPVRALTDEDR
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHCCHHH
ALLQGVIDNLHTQFVKAVAEARKLPVEEVRRLADGRVYTGEQAVSLKLVDRLGTLEDAVE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEECCCHHHHHHHHHHHCHHHHHHH
EAGRLAGIKGEPTLLMPPKKRKHLRDYLLEEASGFFREIVRREGGFSVNYELDPAVGNGG
HHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
R
C
>Mature Secondary Structure
MKKNHVVIGVIIVAALALLFTLSIQIARLILGDGPMVSSGEGVGYVEVKGPILESEEIVK
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHH
QLSEMRKKTNVKAVVLRIESPGGVIGPSQEIYEAVKKLAKTKKVVVSMGSVAASGGYHIA
HHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
IPAAVIYANPGTITGSIGVLMKLANVEGLMDKVGMKAFTLKSGKFKDAGSPVRALTDEDR
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHCCHHH
ALLQGVIDNLHTQFVKAVAEARKLPVEEVRRLADGRVYTGEQAVSLKLVDRLGTLEDAVE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEECCCHHHHHHHHHHHCHHHHHHH
EAGRLAGIKGEPTLLMPPKKRKHLRDYLLEEASGFFREIVRREGGFSVNYELDPAVGNGG
HHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]