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The map label for this gene is acuC [H]

Identifier: 78222948

GI number: 78222948

Start: 1955415

End: 1956572

Strand: Direct

Name: acuC [H]

Synonym: Gmet_1739

Alternate gene names: 78222948

Gene position: 1955415-1956572 (Clockwise)

Preceding gene: 78222945

Following gene: 78222949

Centisome position: 48.92

GC content: 59.76

Gene sequence:

>1158_bases
TTGCCTGCCAAGACCGCCCTCATATACTCGAACGACTTCAGCCGGTTCAGTTACGGTGACGACCATCCGTTCAAGATCCA
GCGTATCATTCTTGCCCGCGAGCTCATGGGCATGCTGGGACTCACGGAGTTGCCCGGCGCTTGTATCCATGACTGCCCGC
GTGCGGACGAGGCATCCCTTCTCACGTTTCATTCCCCGGACTATCTACAGCGGCTCCGGGAATTCAGCGATTCCGACGAA
CCTCGCGCAGACTTCCGGTATGGTCTGGGAGATCTGGACAACCCGGTCTTCAAGGGATTCTATGACTGGGCAATACTCGG
CGTCGGAGGGACCATGGAGGCCGCCCGACTCGTGACCGAGGAGGGGTACGACATCGCCTTCACCATGGCAGGGGGGTGGC
ACCACGCCCACCGGAGCAAGGCATCGGGTTTCTCGTATCTGAATGACGCAGTTATCGCCATTAACACGCTTGTTGCGAAG
GGATTGCGGGTTGCGTACCTGGACATCGACGCCCACCACGGCGACGGGGTTCAGGAGGCCTTTTACGATACCGACCAGGT
CCTGACCGTCTCTATCCACGAGAGCGGCATCTATTTTTTCCCCGGCACCGGCTTCGAGGACGAGATCGGTAGGGGGCAGG
GGAGGGGATACTCGGTGAATGTTCCCCTCGTGGCCCACACCGACGACGCTCTGTTCATGAAGGCCTTTGACGAAGTGGCC
TATCCCCTGATCGCCGCCTACAACCCCGATGTTCTGGTAACCCAACTCGGCGTTGACACGTTTCGCACCGACCCCCTCAC
GCGCCTCGAAATAACCACCCACAGCTACACCTATATCCTGCGCAAGCTGAAGGCGCTGAAAATTCCGTGGGTGGCAGTGG
GTGGCGGCGGATATAACATGATCAACGTTGCCCGGGGATGGACCCTTGCCTGGGGGATCATGAACGGCGTGGAACTGCCG
CCGAAGCTGCCGGCCCAATTCGTGGATATGATCGCGCCCATGGGACATCCGAACCGGATGCTTCTTGACGCCATGCACTG
GGCAGAGGAGGATGACCGGAACCGGGCCCTCGACGCGGTGGAGAGGAGTATCGCTGCCATTCGGGAAACGGTCTTTCCCG
TGATTATCGGAAATTATGCCGCGGCTGCCGGGGAATAG

Upstream 100 bases:

>100_bases
GTCTTTTGGCAAATTTGGAGTTGACGCTCGTGTGTCTACGTTGTAAAGTCGCGGCATTAAAAGAAAATCATGCATAACAC
CGTTGTGACCGGGATGCCGA

Downstream 100 bases:

>100_bases
TGCACTCGTTGACGCTGCCGGACGGGTGCTCCACTCCCTTCGGGAGATCAATTTCCTATCTCAGGTGGAGCGTGAGCGAT
TCTACGTCGGCATACTTCCT

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MPAKTALIYSNDFSRFSYGDDHPFKIQRIILARELMGMLGLTELPGACIHDCPRADEASLLTFHSPDYLQRLREFSDSDE
PRADFRYGLGDLDNPVFKGFYDWAILGVGGTMEAARLVTEEGYDIAFTMAGGWHHAHRSKASGFSYLNDAVIAINTLVAK
GLRVAYLDIDAHHGDGVQEAFYDTDQVLTVSIHESGIYFFPGTGFEDEIGRGQGRGYSVNVPLVAHTDDALFMKAFDEVA
YPLIAAYNPDVLVTQLGVDTFRTDPLTRLEITTHSYTYILRKLKALKIPWVAVGGGGYNMINVARGWTLAWGIMNGVELP
PKLPAQFVDMIAPMGHPNRMLLDAMHWAEEDDRNRALDAVERSIAAIRETVFPVIIGNYAAAAGE

Sequences:

>Translated_385_residues
MPAKTALIYSNDFSRFSYGDDHPFKIQRIILARELMGMLGLTELPGACIHDCPRADEASLLTFHSPDYLQRLREFSDSDE
PRADFRYGLGDLDNPVFKGFYDWAILGVGGTMEAARLVTEEGYDIAFTMAGGWHHAHRSKASGFSYLNDAVIAINTLVAK
GLRVAYLDIDAHHGDGVQEAFYDTDQVLTVSIHESGIYFFPGTGFEDEIGRGQGRGYSVNVPLVAHTDDALFMKAFDEVA
YPLIAAYNPDVLVTQLGVDTFRTDPLTRLEITTHSYTYILRKLKALKIPWVAVGGGGYNMINVARGWTLAWGIMNGVELP
PKLPAQFVDMIAPMGHPNRMLLDAMHWAEEDDRNRALDAVERSIAAIRETVFPVIIGNYAAAAGE
>Mature_384_residues
PAKTALIYSNDFSRFSYGDDHPFKIQRIILARELMGMLGLTELPGACIHDCPRADEASLLTFHSPDYLQRLREFSDSDEP
RADFRYGLGDLDNPVFKGFYDWAILGVGGTMEAARLVTEEGYDIAFTMAGGWHHAHRSKASGFSYLNDAVIAINTLVAKG
LRVAYLDIDAHHGDGVQEAFYDTDQVLTVSIHESGIYFFPGTGFEDEIGRGQGRGYSVNVPLVAHTDDALFMKAFDEVAY
PLIAAYNPDVLVTQLGVDTFRTDPLTRLEITTHSYTYILRKLKALKIPWVAVGGGGYNMINVARGWTLAWGIMNGVELPP
KLPAQFVDMIAPMGHPNRMLLDAMHWAEEDDRNRALDAVERSIAAIRETVFPVIIGNYAAAAGE

Specific function: Role in growth and sporulation on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128860, Length=324, Percent_Identity=37.6543209876543, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI13128862, Length=370, Percent_Identity=35.1351351351351, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI8923769, Length=297, Percent_Identity=38.3838383838384, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI293336691, Length=324, Percent_Identity=36.7283950617284, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI262073088, Length=219, Percent_Identity=38.8127853881278, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI262073092, Length=198, Percent_Identity=42.4242424242424, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI13128864, Length=325, Percent_Identity=29.8461538461538, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI17158039, Length=235, Percent_Identity=28.936170212766, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI30795202, Length=235, Percent_Identity=28.936170212766, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI30795204, Length=235, Percent_Identity=28.936170212766, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI20070354, Length=339, Percent_Identity=28.6135693215339, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI153085395, Length=240, Percent_Identity=29.5833333333333, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI148539870, Length=162, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI169234807, Length=162, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI62750349, Length=296, Percent_Identity=29.0540540540541, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI62750347, Length=296, Percent_Identity=29.0540540540541, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI209862883, Length=242, Percent_Identity=26.8595041322314, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI217272877, Length=198, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI226529806, Length=339, Percent_Identity=27.4336283185841, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17508561, Length=325, Percent_Identity=37.8461538461538, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17534739, Length=328, Percent_Identity=36.280487804878, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17561978, Length=376, Percent_Identity=33.7765957446808, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17540332, Length=199, Percent_Identity=32.6633165829146, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193206283, Length=199, Percent_Identity=32.6633165829146, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17540334, Length=199, Percent_Identity=32.6633165829146, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI193209491, Length=212, Percent_Identity=29.2452830188679, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17537347, Length=281, Percent_Identity=26.3345195729537, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323999, Length=324, Percent_Identity=40.1234567901235, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321244, Length=331, Percent_Identity=37.1601208459215, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324307, Length=361, Percent_Identity=30.1939058171745, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6325325, Length=225, Percent_Identity=31.1111111111111, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24644244, Length=338, Percent_Identity=37.2781065088757, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24657891, Length=324, Percent_Identity=36.4197530864198, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24642146, Length=333, Percent_Identity=27.9279279279279, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642142, Length=333, Percent_Identity=27.9279279279279, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24642144, Length=333, Percent_Identity=27.9279279279279, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360899, Length=333, Percent_Identity=27.9279279279279, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281360799, Length=214, Percent_Identity=32.2429906542056, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24641720, Length=214, Percent_Identity=32.2429906542056, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI281360801, Length=214, Percent_Identity=32.2429906542056, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003085
- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 42615; Mature: 42484

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAKTALIYSNDFSRFSYGDDHPFKIQRIILARELMGMLGLTELPGACIHDCPRADEASL
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCE
LTFHSPDYLQRLREFSDSDEPRADFRYGLGDLDNPVFKGFYDWAILGVGGTMEAARLVTE
EEECCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHCCEEEEEEECCCCHHHHHHHHC
EGYDIAFTMAGGWHHAHRSKASGFSYLNDAVIAINTLVAKGLRVAYLDIDAHHGDGVQEA
CCCEEEEEECCCCHHHHHCCCCCCHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH
FYDTDQVLTVSIHESGIYFFPGTGFEDEIGRGQGRGYSVNVPLVAHTDDALFMKAFDEVA
HCCCCCEEEEEEECCCEEEECCCCCHHHHCCCCCCCEEEECCEEEECCCHHHHHHHHHHH
YPLIAAYNPDVLVTQLGVDTFRTDPLTRLEITTHSYTYILRKLKALKIPWVAVGGGGYNM
HHEEEECCCCEEEEECCCHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCEE
INVARGWTLAWGIMNGVELPPKLPAQFVDMIAPMGHPNRMLLDAMHWAEEDDRNRALDAV
EEECCCCEEEEHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
ERSIAAIRETVFPVIIGNYAAAAGE
HHHHHHHHHHHHHHEECCCHHCCCC
>Mature Secondary Structure 
PAKTALIYSNDFSRFSYGDDHPFKIQRIILARELMGMLGLTELPGACIHDCPRADEASL
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCE
LTFHSPDYLQRLREFSDSDEPRADFRYGLGDLDNPVFKGFYDWAILGVGGTMEAARLVTE
EEECCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHCCEEEEEEECCCCHHHHHHHHC
EGYDIAFTMAGGWHHAHRSKASGFSYLNDAVIAINTLVAKGLRVAYLDIDAHHGDGVQEA
CCCEEEEEECCCCHHHHHCCCCCCHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH
FYDTDQVLTVSIHESGIYFFPGTGFEDEIGRGQGRGYSVNVPLVAHTDDALFMKAFDEVA
HCCCCCEEEEEEECCCEEEECCCCCHHHHCCCCCCCEEEECCEEEECCCHHHHHHHHHHH
YPLIAAYNPDVLVTQLGVDTFRTDPLTRLEITTHSYTYILRKLKALKIPWVAVGGGGYNM
HHEEEECCCCEEEEECCCHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCEE
INVARGWTLAWGIMNGVELPPKLPAQFVDMIAPMGHPNRMLLDAMHWAEEDDRNRALDAV
EEECCCCEEEEHHHCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHH
ERSIAAIRETVFPVIIGNYAAAAGE
HHHHHHHHHHHHHHEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]