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The map label for this gene is acdA [H]

Identifier: 78222924

GI number: 78222924

Start: 1928021

End: 1929160

Strand: Reverse

Name: acdA [H]

Synonym: Gmet_1715

Alternate gene names: 78222924

Gene position: 1929160-1928021 (Counterclockwise)

Preceding gene: 78222925

Following gene: 78222923

Centisome position: 48.26

GC content: 59.91

Gene sequence:

>1140_bases
ATGAACTTCGAACTGAGCCAGGACCACAAGGTATTGCAGGACGCCGTGCGTGACTTCGTGGAGAAGGAGGTAAAACCCGT
CGCCGTGCAGATCGACGAAGAGCACATGATCCCTGACAGTCTTGTCAGAAAGATGGGAGAGATGGGGTTCATGGGAAGCT
ATCTCCCCGAGCAGTACGGCGGGGCCGGACTCGACATGCTCTCCTACTCCATCGTGGTGGAGGAGGTTTCCAAGGCCTGC
GGCTCCAGCGGCGTCCTCATCTCGGCCCACACCTCCCTTGCCTGCGGCCCCATTTACACCTTCGGCACCGAAGAGCAGAA
GAAGAAGTGGCTTCCGGCCCTGAACAGCGGCGAGACCATCGGCTGCTTCCTCCTGACCGAGCCCGACGCTGGTTCCGACG
CCGGTGCCATCGCCACTACCTACCGCCGCGAGGGGGACGAATTCGTCATCAACGGTTCCAAGATATTCATCACCAATGGT
GGCTACCGGGGAACCGGCGTCCTCTTTGCCACTTCCGACAAGAGCCTCAAGCACAAAGGAGTTTCGGCATTCATCATCGA
TCTCCGCTCCCACGGTGTGGAGATCCTGAAAAACGAGAAGAAACTGGGGATACGGGGAAGCTACACCACCGCCTTCGCCC
TCGACAACGTCCGGATCCCTGCGGAAAACCTCCTGGGGCAGGAAGGCCAGGGATTCAAGATCGCCATGGACACCCTGAAC
GGCGGCCGCATCGGCATCGCCTCCCAGGCCCTGGGAATCGCCGAAGGAGCCTTCGAGCGGGCACTGGCCTACTCCAAGGA
GCGCAAGCAGTTCGGCGCCCCCATCTGCGACCTGCAGGCGATACAGTTCAAGCTGGCCGACATGTGGGCAAAGATCGAGA
CCAGCAAGCTCATGACCTACAAGGCCGCGTGGCTCAAGGATCACAAGAAGAACTACACCATGGAGTCGGCCATGTGCAAG
ATGCTCGCCTCCGAGGCCGCCACCTACGTCACCAAGGAAGCGATCCAGATCCACGGCGGTTACGGCTTCATCTGCGATTA
CGAGGTGGAGCGGATGTACCGCGACGCCAAGATCACCGAGATATACGAGGGGACCAACGAGGTGCAGCGGGTGGTTATCT
CGAAGCTGCTGTTGAGCTGA

Upstream 100 bases:

>100_bases
GGCACCGCCGACCAGAAGGAAGGGATGGGGGCCTTTGTGGAAAAGCGGAAAGCAGTATTTACGGGGAAATAATTTCACAA
TCAACCATAGGGAGGTTGTC

Downstream 100 bases:

>100_bases
CAGGACAAGACTAAAAGCTTCAAGGCTGGAAAGGAATAAGGAGGCATCATGGAAGCCACCCGCGAAATCTATTGGAACAT
CGGCCACGGGGTCGTGATCC

Product: Acyl-CoA dehydrogenase-like

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNFELSQDHKVLQDAVRDFVEKEVKPVAVQIDEEHMIPDSLVRKMGEMGFMGSYLPEQYGGAGLDMLSYSIVVEEVSKAC
GSSGVLISAHTSLACGPIYTFGTEEQKKKWLPALNSGETIGCFLLTEPDAGSDAGAIATTYRREGDEFVINGSKIFITNG
GYRGTGVLFATSDKSLKHKGVSAFIIDLRSHGVEILKNEKKLGIRGSYTTAFALDNVRIPAENLLGQEGQGFKIAMDTLN
GGRIGIASQALGIAEGAFERALAYSKERKQFGAPICDLQAIQFKLADMWAKIETSKLMTYKAAWLKDHKKNYTMESAMCK
MLASEAATYVTKEAIQIHGGYGFICDYEVERMYRDAKITEIYEGTNEVQRVVISKLLLS

Sequences:

>Translated_379_residues
MNFELSQDHKVLQDAVRDFVEKEVKPVAVQIDEEHMIPDSLVRKMGEMGFMGSYLPEQYGGAGLDMLSYSIVVEEVSKAC
GSSGVLISAHTSLACGPIYTFGTEEQKKKWLPALNSGETIGCFLLTEPDAGSDAGAIATTYRREGDEFVINGSKIFITNG
GYRGTGVLFATSDKSLKHKGVSAFIIDLRSHGVEILKNEKKLGIRGSYTTAFALDNVRIPAENLLGQEGQGFKIAMDTLN
GGRIGIASQALGIAEGAFERALAYSKERKQFGAPICDLQAIQFKLADMWAKIETSKLMTYKAAWLKDHKKNYTMESAMCK
MLASEAATYVTKEAIQIHGGYGFICDYEVERMYRDAKITEIYEGTNEVQRVVISKLLLS
>Mature_379_residues
MNFELSQDHKVLQDAVRDFVEKEVKPVAVQIDEEHMIPDSLVRKMGEMGFMGSYLPEQYGGAGLDMLSYSIVVEEVSKAC
GSSGVLISAHTSLACGPIYTFGTEEQKKKWLPALNSGETIGCFLLTEPDAGSDAGAIATTYRREGDEFVINGSKIFITNG
GYRGTGVLFATSDKSLKHKGVSAFIIDLRSHGVEILKNEKKLGIRGSYTTAFALDNVRIPAENLLGQEGQGFKIAMDTLN
GGRIGIASQALGIAEGAFERALAYSKERKQFGAPICDLQAIQFKLADMWAKIETSKLMTYKAAWLKDHKKNYTMESAMCK
MLASEAATYVTKEAIQIHGGYGFICDYEVERMYRDAKITEIYEGTNEVQRVVISKLLLS

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=51.4588859416446, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=38.0053908355795, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=35.978835978836, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=35.978835978836, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=36, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI21361497, Length=384, Percent_Identity=40.3645833333333, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=36.6492146596859, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=36.6492146596859, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI226958414, Length=335, Percent_Identity=34.9253731343284, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=31.8181818181818, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=28.8, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI7669494, Length=363, Percent_Identity=29.2011019283747, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI38505218, Length=391, Percent_Identity=29.4117647058824, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI48976061, Length=397, Percent_Identity=28.463476070529, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI211971008, Length=397, Percent_Identity=28.463476070529, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI218563752, Length=238, Percent_Identity=29.8319327731092, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786223, Length=382, Percent_Identity=29.3193717277487, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=31.151832460733, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87081702, Length=359, Percent_Identity=26.1838440111421, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082384, Length=262, Percent_Identity=22.9007633587786, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=39.0374331550802, Blast_Score=293, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=40.5759162303665, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=38.8739946380697, Blast_Score=291, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=39.2670157068063, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=36.1256544502618, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=37.4005305039788, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=34.5646437994723, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71985184, Length=360, Percent_Identity=38.6111111111111, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=39.4557823129252, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=32.9787234042553, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=41.991341991342, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17505929, Length=372, Percent_Identity=29.8387096774194, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=30.5630026809651, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=36.5448504983389, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.2116788321168, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17562446, Length=389, Percent_Identity=27.5064267352185, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.5439330543933, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=30.6818181818182, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=26.7924528301887, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=27.1698113207547, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=49.7326203208556, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=44.6524064171123, Blast_Score=335, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=39.142091152815, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=38.0952380952381, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=35, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI281363737, Length=380, Percent_Identity=36.3157894736842, Blast_Score=224, Evalue=5e-59,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=30.2872062663185, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281365206, Length=409, Percent_Identity=25.4278728606357, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585193, Length=409, Percent_Identity=25.4278728606357, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585195, Length=409, Percent_Identity=25.4278728606357, Blast_Score=68, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24585191, Length=409, Percent_Identity=25.4278728606357, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41634; Mature: 41634

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELSQDHKVLQDAVRDFVEKEVKPVAVQIDEEHMIPDSLVRKMGEMGFMGSYLPEQYG
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHC
GAGLDMLSYSIVVEEVSKACGSSGVLISAHTSLACGPIYTFGTEEQKKKWLPALNSGETI
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCEEECCCCHHHHHCCCCCCCCCEE
GCFLLTEPDAGSDAGAIATTYRREGDEFVINGSKIFITNGGYRGTGVLFATSDKSLKHKG
EEEEEECCCCCCCCCCCHHHHCCCCCEEEEECCEEEEECCCCCCEEEEEEECCCCHHHCC
VSAFIIDLRSHGVEILKNEKKLGIRGSYTTAFALDNVRIPAENLLGQEGQGFKIAMDTLN
CEEEEEEEHHCCHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEECCC
GGRIGIASQALGIAEGAFERALAYSKERKQFGAPICDLQAIQFKLADMWAKIETSKLMTY
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KAAWLKDHKKNYTMESAMCKMLASEAATYVTKEAIQIHGGYGFICDYEVERMYRDAKITE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECHHHHHHHCCCHHHH
IYEGTNEVQRVVISKLLLS
HHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFELSQDHKVLQDAVRDFVEKEVKPVAVQIDEEHMIPDSLVRKMGEMGFMGSYLPEQYG
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHHC
GAGLDMLSYSIVVEEVSKACGSSGVLISAHTSLACGPIYTFGTEEQKKKWLPALNSGETI
CCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEECCCEEECCCCHHHHHCCCCCCCCCEE
GCFLLTEPDAGSDAGAIATTYRREGDEFVINGSKIFITNGGYRGTGVLFATSDKSLKHKG
EEEEEECCCCCCCCCCCHHHHCCCCCEEEEECCEEEEECCCCCCEEEEEEECCCCHHHCC
VSAFIIDLRSHGVEILKNEKKLGIRGSYTTAFALDNVRIPAENLLGQEGQGFKIAMDTLN
CEEEEEEEHHCCHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCCCCEEEEEECCC
GGRIGIASQALGIAEGAFERALAYSKERKQFGAPICDLQAIQFKLADMWAKIETSKLMTY
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KAAWLKDHKKNYTMESAMCKMLASEAATYVTKEAIQIHGGYGFICDYEVERMYRDAKITE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECHHHHHHHCCCHHHH
IYEGTNEVQRVVISKLLLS
HHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]