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The map label for this gene is comEB [H]

Identifier: 78222831

GI number: 78222831

Start: 1820578

End: 1821042

Strand: Direct

Name: comEB [H]

Synonym: Gmet_1622

Alternate gene names: 78222831

Gene position: 1820578-1821042 (Clockwise)

Preceding gene: 78222830

Following gene: 78222832

Centisome position: 45.54

GC content: 58.06

Gene sequence:

>465_bases
ATGACCCGACCCACCTGGGACGAATATTTCATGGAAATCACCCATCTGGTTGCCAAGCGTTCCACCTGTCTGCGCCGGCA
GGTGGGTGCTGTTATCGTGAAGGACAAGAATATCCTGGCCACGGGCTATAATGGTGCCCCATCAGGCGTTGCCCATTGTC
TCGAGGTGGGATGTCTTCGGGCCAAACTCGGCATTCCGTCGGGTGAGCGACACGAACTCTGCCGGGGCCTCCATGCCGAG
CAGAACGCCATTATCCAGGCGGCAAAGCACGGCATCAACATCGATGGCGGCACCCTTTACTGCACCACCATGCCGTGCAT
CATCTGCTCGAAGATGCTCATCAATGCCGGCATCCGCCGCGTTGTCTACGAAGAGGGCTACTCGGACGAACTGGCCCGGG
AGATGATCGGCGAATCGGGGGTCGTGGTGGAAAAATTTGGTGATATAAGGGGGGAAACCCCGTGA

Upstream 100 bases:

>100_bases
ACTCCTTCAGAGGATTAGCCGTATGCGTATTTGGCTAATTCCTTGACCTTGCGGCGTTTCTCGGGTATTCTTGCCCACCA
CTTCACCCCACGGAGCCCCC

Downstream 100 bases:

>100_bases
AATGCCCCTTTTGCGCCCATCCTGACAGCAAGGTCGTTGACTCCCGCCCCGACAAGGGTGGGGCTGCTATCCGGCGTCGC
CGCGAGTGCGAATCCTGCGC

Product: CMP/dCMP deaminase, zinc-binding protein

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTRPTWDEYFMEITHLVAKRSTCLRRQVGAVIVKDKNILATGYNGAPSGVAHCLEVGCLRAKLGIPSGERHELCRGLHAE
QNAIIQAAKHGINIDGGTLYCTTMPCIICSKMLINAGIRRVVYEEGYSDELAREMIGESGVVVEKFGDIRGETP

Sequences:

>Translated_154_residues
MTRPTWDEYFMEITHLVAKRSTCLRRQVGAVIVKDKNILATGYNGAPSGVAHCLEVGCLRAKLGIPSGERHELCRGLHAE
QNAIIQAAKHGINIDGGTLYCTTMPCIICSKMLINAGIRRVVYEEGYSDELAREMIGESGVVVEKFGDIRGETP
>Mature_153_residues
TRPTWDEYFMEITHLVAKRSTCLRRQVGAVIVKDKNILATGYNGAPSGVAHCLEVGCLRAKLGIPSGERHELCRGLHAEQ
NAIIQAAKHGINIDGGTLYCTTMPCIICSKMLINAGIRRVVYEEGYSDELAREMIGESGVVVEKFGDIRGETP

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=147, Percent_Identity=34.6938775510204, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI61742821, Length=147, Percent_Identity=34.6938775510204, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321938, Length=148, Percent_Identity=39.1891891891892, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24667298, Length=144, Percent_Identity=36.8055555555556, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667302, Length=144, Percent_Identity=36.8055555555556, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 16863; Mature: 16732

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPTWDEYFMEITHLVAKRSTCLRRQVGAVIVKDKNILATGYNGAPSGVAHCLEVGCLR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEEEECCCCCHHHHHHHHHHHHHH
AKLGIPSGERHELCRGLHAEQNAIIQAAKHGINIDGGTLYCTTMPCIICSKMLINAGIRR
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
VVYEEGYSDELAREMIGESGVVVEKFGDIRGETP
HHHHCCCHHHHHHHHHCCCCEEEEHHCCCCCCCC
>Mature Secondary Structure 
TRPTWDEYFMEITHLVAKRSTCLRRQVGAVIVKDKNILATGYNGAPSGVAHCLEVGCLR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCEEEECCCCCHHHHHHHHHHHHHH
AKLGIPSGERHELCRGLHAEQNAIIQAAKHGINIDGGTLYCTTMPCIICSKMLINAGIRR
HHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHH
VVYEEGYSDELAREMIGESGVVVEKFGDIRGETP
HHHHCCCHHHHHHHHHCCCCEEEEHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]