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The map label for this gene is hupA [H]

Identifier: 78222818

GI number: 78222818

Start: 1808018

End: 1808308

Strand: Direct

Name: hupA [H]

Synonym: Gmet_1608

Alternate gene names: 78222818

Gene position: 1808018-1808308 (Clockwise)

Preceding gene: 78222815

Following gene: 78222819

Centisome position: 45.23

GC content: 57.73

Gene sequence:

>291_bases
ATGACCAAAGCAGAACTCGTGGACGCCGTAGCAAAATCCGCAGAACTCACCAAGGCTGCCGCTGACAAGGCGGTGAACGG
GGTGATCGAAGCAGTTACTGCAGCTCTCAAAAAAGGTGACAAGGTGACATTGGTTGGCTTCGGCAGCTTTGAGGTCGCTA
CCCGCAAGGCCCGTACCGGCCGCAACCCCCAAACCGGTAAAGAGATCAAGATTGCTGCCGCCAAGGTTCCCAAGTTCCGC
CCCGGCAAGGCCCTCAAGGACGCCGTGGCCGGCGCCAAGAAAAAGAAGTAA

Upstream 100 bases:

>100_bases
AGCTGATAAAAGATCTTGAGCTTTGTCCTCTATAAAAACCCTTGCAAAATGGATAGTTGCCGCTATAGTAGCCATAGAAT
CCCATAAACAGGAGGGTTAT

Downstream 100 bases:

>100_bases
TCCGCTTTTTTCAAGAGTAACAGGAAAGCCTCTCGTGTCAGACATGAGGGGCTTTTTTCGTTGTAATCTCCCCTAAATGA
GCTTTCCACGGCAGGTGTGG

Product: histone-like DNA-binding protein

Products: NA

Alternate protein names: DNA-binding protein II; HB [H]

Number of amino acids: Translated: 96; Mature: 95

Protein sequence:

>96_residues
MTKAELVDAVAKSAELTKAAADKAVNGVIEAVTAALKKGDKVTLVGFGSFEVATRKARTGRNPQTGKEIKIAAAKVPKFR
PGKALKDAVAGAKKKK

Sequences:

>Translated_96_residues
MTKAELVDAVAKSAELTKAAADKAVNGVIEAVTAALKKGDKVTLVGFGSFEVATRKARTGRNPQTGKEIKIAAAKVPKFR
PGKALKDAVAGAKKKK
>Mature_95_residues
TKAELVDAVAKSAELTKAAADKAVNGVIEAVTAALKKGDKVTLVGFGSFEVATRKARTGRNPQTGKEIKIAAAKVPKFRP
GKALKDAVAGAKKKK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=64.0449438202247, Blast_Score=116, Evalue=4e-28,
Organism=Escherichia coli, GI1790433, Length=89, Percent_Identity=60.6741573033708, Blast_Score=108, Evalue=7e-26,
Organism=Escherichia coli, GI1787141, Length=88, Percent_Identity=37.5, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI1788005, Length=95, Percent_Identity=40, Blast_Score=75, Evalue=1e-15,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9933; Mature: 9802

Theoretical pI: Translated: 11.09; Mature: 11.09

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAELVDAVAKSAELTKAAADKAVNGVIEAVTAALKKGDKVTLVGFGSFEVATRKARTG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCC
RNPQTGKEIKIAAAKVPKFRPGKALKDAVAGAKKKK
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKAELVDAVAKSAELTKAAADKAVNGVIEAVTAALKKGDKVTLVGFGSFEVATRKARTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCC
RNPQTGKEIKIAAAKVPKFRPGKALKDAVAGAKKKK
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3595600; 1633819; 1902464; 1644313; 9384377; 8439548 [H]