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The map label for this gene is degP [H]

Identifier: 78222234

GI number: 78222234

Start: 1126874

End: 1128304

Strand: Direct

Name: degP [H]

Synonym: Gmet_1014

Alternate gene names: 78222234

Gene position: 1126874-1128304 (Clockwise)

Preceding gene: 78222233

Following gene: 78222235

Centisome position: 28.19

GC content: 57.51

Gene sequence:

>1431_bases
ATGAAGCATTGGACGCTGAAATCTGCTGGCAAAATATCCCTTCTGACAGCTTTTCTCCTGATTTCGCTAATTTTCCTGGG
GGGATGCGACGGGAGGAGCAAGACCGAATTCGTGGGATTCCCCCAATCATTCGCCGATCTCGCCGAAAAAATCAGACCCG
CCGTGGTGAACATCAGCACCACATCAACCGTCAAAGTACCCGGCAATCCCTTCAGGCACTTTTTCGGCCCCGAGGAAGAA
GGGCCGTTTGGTGATTTCTTCAAGCATTTTTTCGGCGACATGCCCGACCGTGAGCTGAAACAGCAGAGTCTCGGCTCCGG
GATCATCACCGACAAGGACGGGTACATCGTCACCAACAACCACGTGGTGGATAATGCCGAGGAGATAAAGGTCAAGATCT
CTGACGGCAGAGAATTCAAGGCCAAGGTTATCGGAAGGGATCCCAAAACCGATCTTGCGCTGATCAAGATATCTTCCCCC
TTCAGAAATCTCCCCGTCCTCCCCCTCGGCGACTCCGACAAAATGAGAGTTGGTGATTGGGTGCTTGCAGTGGGGAACCC
GTTCGGTCTCGAACACACCGTGACCCAGGGGATCATCAGCGCCACCGGGAGGGTGATCGGTTCCGGGCCCTATGACAATT
TCCTCCAGACCGACGCCCCCATCAACCCTGGCAACAGCGGCGGCCCCCTGGTCAACCTCAAAGGGGAGGTGATCGGGATC
AATACCGCCATCGTCCCCGGCGGGCAGGGGCTCGGCTTTGCCATCCCGAGCAGCATGGCCAAAATGGTGCTCAAGCAGTT
GCAGGAGAAGGGGAAAGTGGTGCGGGGATGGCTCGGTGTTACGATCCAGACCGTAACCCCCGACCTGGCCGCCTCCTTTG
GCCTCAAGGAGGCGAAGGGGGCCCTCGTCTCCGACATCGCGGAAGGAGGACCGGCCGCCAAAGGGGGAATCAGGCGGGGA
GATATCATCCTTTCCTTTGACGGGAAAAATGTGAAGGACTCCATGGAACTGCCCCGAATCGTAGCGGAAACCCCGGTCGG
CAAAGAGGTGGATGTCACGGTGCTCAGGGAAGGGAAAGAGGTGCATTGCAGGGTGAGGGTCGAGGAACTCACGGAACAGA
GGATTGCCGCCCAGACCGAGGCGCCGACGGACAGCTTCGGAATGACGTTTGTCGACATTACCCCCAAGGTGCGGCAACAA
CTCGGGATCAAAGAGAAAACGGGAGTTGTCGTTGCCGGAGTGGAGCCCGGGAGCATCGCCGAAGATGCGGGTATCCGGGC
GGGGGATGTGATCAAGGAAGTTAATCGCAAACCGGTCAGAAACCTGGCGGACTTGAGCAGTGCCTTGGAGAAGTCCGCAA
AGGGGCAACCGGTCCTCTTGCTGCTCAATCGGGGAAGTCAGACTTTCTATGTGACGCTGGAAACTTCGTAG

Upstream 100 bases:

>100_bases
GCTCTGTGAGAAAAATTATGATGCTCTGAGTCCTTGTCGCCGAGAGCCTGATGGCCAACTTGCTCCTATCTCCATGGGCT
TTCGTTCAGGGAGGAACACC

Downstream 100 bases:

>100_bases
GGGTGTCTCTCAGGCACGGCAGTAAGATTGGTGCCTATCGGCTGAAGCATTGACTAAAGGAGGAGTAAGGCATGAAACGA
TCAGCGTTCGTTCTCTTGGC

Product: peptidase S1C, Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKHWTLKSAGKISLLTAFLLISLIFLGGCDGRSKTEFVGFPQSFADLAEKIRPAVVNISTTSTVKVPGNPFRHFFGPEEE
GPFGDFFKHFFGDMPDRELKQQSLGSGIITDKDGYIVTNNHVVDNAEEIKVKISDGREFKAKVIGRDPKTDLALIKISSP
FRNLPVLPLGDSDKMRVGDWVLAVGNPFGLEHTVTQGIISATGRVIGSGPYDNFLQTDAPINPGNSGGPLVNLKGEVIGI
NTAIVPGGQGLGFAIPSSMAKMVLKQLQEKGKVVRGWLGVTIQTVTPDLAASFGLKEAKGALVSDIAEGGPAAKGGIRRG
DIILSFDGKNVKDSMELPRIVAETPVGKEVDVTVLREGKEVHCRVRVEELTEQRIAAQTEAPTDSFGMTFVDITPKVRQQ
LGIKEKTGVVVAGVEPGSIAEDAGIRAGDVIKEVNRKPVRNLADLSSALEKSAKGQPVLLLLNRGSQTFYVTLETS

Sequences:

>Translated_476_residues
MKHWTLKSAGKISLLTAFLLISLIFLGGCDGRSKTEFVGFPQSFADLAEKIRPAVVNISTTSTVKVPGNPFRHFFGPEEE
GPFGDFFKHFFGDMPDRELKQQSLGSGIITDKDGYIVTNNHVVDNAEEIKVKISDGREFKAKVIGRDPKTDLALIKISSP
FRNLPVLPLGDSDKMRVGDWVLAVGNPFGLEHTVTQGIISATGRVIGSGPYDNFLQTDAPINPGNSGGPLVNLKGEVIGI
NTAIVPGGQGLGFAIPSSMAKMVLKQLQEKGKVVRGWLGVTIQTVTPDLAASFGLKEAKGALVSDIAEGGPAAKGGIRRG
DIILSFDGKNVKDSMELPRIVAETPVGKEVDVTVLREGKEVHCRVRVEELTEQRIAAQTEAPTDSFGMTFVDITPKVRQQ
LGIKEKTGVVVAGVEPGSIAEDAGIRAGDVIKEVNRKPVRNLADLSSALEKSAKGQPVLLLLNRGSQTFYVTLETS
>Mature_476_residues
MKHWTLKSAGKISLLTAFLLISLIFLGGCDGRSKTEFVGFPQSFADLAEKIRPAVVNISTTSTVKVPGNPFRHFFGPEEE
GPFGDFFKHFFGDMPDRELKQQSLGSGIITDKDGYIVTNNHVVDNAEEIKVKISDGREFKAKVIGRDPKTDLALIKISSP
FRNLPVLPLGDSDKMRVGDWVLAVGNPFGLEHTVTQGIISATGRVIGSGPYDNFLQTDAPINPGNSGGPLVNLKGEVIGI
NTAIVPGGQGLGFAIPSSMAKMVLKQLQEKGKVVRGWLGVTIQTVTPDLAASFGLKEAKGALVSDIAEGGPAAKGGIRRG
DIILSFDGKNVKDSMELPRIVAETPVGKEVDVTVLREGKEVHCRVRVEELTEQRIAAQTEAPTDSFGMTFVDITPKVRQQ
LGIKEKTGVVVAGVEPGSIAEDAGIRAGDVIKEVNRKPVRNLADLSSALEKSAKGQPVLLLLNRGSQTFYVTLETS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=329, Percent_Identity=37.6899696048632, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4506141, Length=325, Percent_Identity=37.8461538461538, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=39.1129032258064, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI7019477, Length=350, Percent_Identity=34.5714285714286, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1786356, Length=453, Percent_Identity=41.0596026490066, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1789629, Length=438, Percent_Identity=40.8675799086758, Blast_Score=274, Evalue=9e-75,
Organism=Escherichia coli, GI1789630, Length=280, Percent_Identity=42.5, Blast_Score=213, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24646839, Length=291, Percent_Identity=39.1752577319588, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50976; Mature: 50976

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHWTLKSAGKISLLTAFLLISLIFLGGCDGRSKTEFVGFPQSFADLAEKIRPAVVNIST
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEC
TSTVKVPGNPFRHFFGPEEEGPFGDFFKHFFGDMPDRELKQQSLGSGIITDKDGYIVTNN
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCEEEECC
HVVDNAEEIKVKISDGREFKAKVIGRDPKTDLALIKISSPFRNLPVLPLGDSDKMRVGDW
EEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCEEECCCCCCEEECCE
VLAVGNPFGLEHTVTQGIISATGRVIGSGPYDNFLQTDAPINPGNSGGPLVNLKGEVIGI
EEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEE
NTAIVPGGQGLGFAIPSSMAKMVLKQLQEKGKVVRGWLGVTIQTVTPDLAASFGLKEAKG
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECEEEEEECCHHHHHCCCHHHCC
ALVSDIAEGGPAAKGGIRRGDIILSFDGKNVKDSMELPRIVAETPVGKEVDVTVLREGKE
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCHHHHCCCCCCCEEEEEEECCCE
VHCRVRVEELTEQRIAAQTEAPTDSFGMTFVDITPKVRQQLGIKEKTGVVVAGVEPGSIA
EEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHCCCCCCCCEEEEECCCCCCH
EDAGIRAGDVIKEVNRKPVRNLADLSSALEKSAKGQPVLLLLNRGSQTFYVTLETS
HHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEECC
>Mature Secondary Structure
MKHWTLKSAGKISLLTAFLLISLIFLGGCDGRSKTEFVGFPQSFADLAEKIRPAVVNIST
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCEEEEEEC
TSTVKVPGNPFRHFFGPEEEGPFGDFFKHFFGDMPDRELKQQSLGSGIITDKDGYIVTNN
CEEEECCCCHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEECCCCEEEECC
HVVDNAEEIKVKISDGREFKAKVIGRDPKTDLALIKISSPFRNLPVLPLGDSDKMRVGDW
EEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCCCCCEEECCCCCCEEECCE
VLAVGNPFGLEHTVTQGIISATGRVIGSGPYDNFLQTDAPINPGNSGGPLVNLKGEVIGI
EEEECCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEECCEEEEE
NTAIVPGGQGLGFAIPSSMAKMVLKQLQEKGKVVRGWLGVTIQTVTPDLAASFGLKEAKG
EEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECEEEEEECCHHHHHCCCHHHCC
ALVSDIAEGGPAAKGGIRRGDIILSFDGKNVKDSMELPRIVAETPVGKEVDVTVLREGKE
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCHHHHCCCCCCCEEEEEEECCCE
VHCRVRVEELTEQRIAAQTEAPTDSFGMTFVDITPKVRQQLGIKEKTGVVVAGVEPGSIA
EEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHCCCCCCCCEEEEECCCCCCH
EDAGIRAGDVIKEVNRKPVRNLADLSSALEKSAKGQPVLLLLNRGSQTFYVTLETS
HHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]