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The map label for this gene is aroK

Identifier: 78222197

GI number: 78222197

Start: 1086692

End: 1087198

Strand: Direct

Name: aroK

Synonym: Gmet_0977

Alternate gene names: 78222197

Gene position: 1086692-1087198 (Clockwise)

Preceding gene: 78222196

Following gene: 78222198

Centisome position: 27.18

GC content: 60.36

Gene sequence:

>507_bases
GTGCGCAACGTCATTCTCACCGGCTTCATGGGGACGGGAAAAAGCAGCGTCGGCAGGCTTCTGGCCCATCGGCTCGGCTT
CCGCTACTGCGACCTGGATGCGCTCATCGTCGAAGGGGAGGGAGTCTCCATTAACGAGATCTTTGCCCGACATGGGGAAC
CCCACTTTCGGGCTCTCGAAACCGAGGCGGTGCGATCCGTGTCCCGGGAAGAACGATGTGTCGTTTCCACCGGCGGCGGA
GCGGTTATCTCTCCTGAAAACCGTTGTCTCTTGCGGAAGGCGGGAGTTGTGGTGAACCTGACCGCCACGGTGGAGGAAGT
ATGCAGGCGGCTGCGGGAGGAGACGGACCGCCCCCTTCTGAAGGACGATCGTTCGGGCGAGCGGATTGCGGCCATGATGG
CGGAACGTGAACAGTTCTACGCGGATGCGGAGTTGAGGATTGACACTACCGGCAAAAGCGTGGAAGATGTGGTCGCTGAA
ATCACCGGGTACTTGGAAGGAAGGTAG

Upstream 100 bases:

>100_bases
GAGATTGCCAGCGCGTTCCTGGAGAAGTTCGGTGGCGACTCCCTTGCCGAGATACGGCGCAACTACGATGGCTACCTCGA
CTATCTCCGCTCCTTCTAGC

Downstream 100 bases:

>100_bases
CGTGGAAACGCTGACGGTAGGACTTGGCGACAGAAGCTACACGATTCGGGGAGGAAGCGGAATCCTCCCGGGGATCGGTG
CGTTCTGCAGGGAGTTGGGG

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALETEAVRSVSREERCVVSTGGG
AVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLLKDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAE
ITGYLEGR

Sequences:

>Translated_168_residues
MRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALETEAVRSVSREERCVVSTGGG
AVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLLKDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAE
ITGYLEGR
>Mature_168_residues
MRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALETEAVRSVSREERCVVSTGGG
AVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLLKDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAE
ITGYLEGR

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=167, Percent_Identity=35.3293413173653, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1786587, Length=168, Percent_Identity=32.7380952380952, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_GEOMG (Q39X05)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383944.1
- ProteinModelPortal:   Q39X05
- SMR:   Q39X05
- STRING:   Q39X05
- GeneID:   3738218
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0977
- NMPDR:   fig|269799.3.peg.1052
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- PhylomeDB:   Q39X05
- ProtClustDB:   CLSK828692
- BioCyc:   GMET269799:GMET_0977-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 18598; Mature: 18598

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 33-33 BINDING 57-57 BINDING 79-79 BINDING 117-117 BINDING 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALE
CCCEEEEEECCCCHHHHHHHHHHHHCCEEECCEEEEEECCCCCHHHHHHHCCCCHHHHHH
TEAVRSVSREERCVVSTGGGAVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLL
HHHHHHHHHCCCEEEECCCCEEECCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHCCCCC
KDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAEITGYLEGR
CCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALE
CCCEEEEEECCCCHHHHHHHHHHHHCCEEECCEEEEEECCCCCHHHHHHHCCCCHHHHHH
TEAVRSVSREERCVVSTGGGAVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLL
HHHHHHHHHCCCEEEECCCCEEECCCCCEEEEECCEEEEEHHHHHHHHHHHHHHHCCCCC
KDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAEITGYLEGR
CCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA