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The map label for this gene is atoC [H]

Identifier: 78222181

GI number: 78222181

Start: 1070933

End: 1072297

Strand: Direct

Name: atoC [H]

Synonym: Gmet_0961

Alternate gene names: 78222181

Gene position: 1070933-1072297 (Clockwise)

Preceding gene: 78222180

Following gene: 78222182

Centisome position: 26.79

GC content: 64.32

Gene sequence:

>1365_bases
ATGAAACAACGGGTGCTGGTCATCGACGACGAGGAGAACCTGCGGCACATGCTTGGGGCCATGCTTCGCAAGAACGGCTA
CCATGCCGACGAGGCGGCGGACGGTGAGCAGGCCCTCGCCATGGCGGGGGAGCATCCCTATGACTTTATCATCTGCGATA
TCCGGATGCCGGTCCTGGATGGGCTCGGTTTCCTCCGCAGGGCCCAGGAGGCGGGGATAGGTGGCACCATCATCATGATG
TCCGCCTATGGCACCATCGATACGGCGCTCCAGTGCATGAAGGAGGGGGCCTACGACTACGTTTCCAAGCCCTTCAAAAA
CGACGAGATCCTGCTGGTGCTCAAGAAGGCCGAGGAGCGGGAGCGGCTCAAAACGGAAAACTGCCGGCTGCGGGCTGAGG
TTGCCCGGGAGTACTCCTTCGGCGCCATCGTGAGCCGCAATCCTCGGATGCGGGAGATTTTCGAGCTCATCCGCAAGGTC
TGCGACGTGAAGACTTCGGTCCTCGTCCTGGGCGAATCGGGCACCGGCAAGGAACTGGTGGCCCGGGCCATTCACCACAA
CGGGAGCCGCCGGGATGCTCCCTTTGTGGCGGTAAACTGCGGCGCCATCCCCGAGCACCTTCTGGAATCGGAGCTCTTCG
GCCACGTGCGGGGCGCCTTCACCGACGCCGCCTCCGACCGGACCGGGCTCTTCGAGGAGGCCCACGGCGGCACCCTTTTC
CTGGACGAAATTGGCGAGATGCCCCCCTCGCTCCAGGTGAAGCTGTTGCGGGTCCTCCAGGAGGGGGAGGTGCGGCGCGT
GGGGGCCGAGCGCCTCTCAAAGGTCGACGTGCGGGTTATCTCGGCCACATCCCGGGATCTGGAGCGGGAGGTGGCCGAGG
GGCACTTCCGCGAGGATCTCTTCTTCCGTCTTAACGTCGTCAGCATCACCCTTCCCCCCCTGCGGGAGCGGCTGGAGGAC
GTGCCGCTCCTCGCGGGCCATTTTCTTAATAAACACGGCACTTCCCTTGGGAGGCCGGGAGCGCGGGTGTCTCCCGAGGC
GTTGCGGCTCCTTTCCGCGTACGCATGGCCCGGCAACGTGCGGGAGTTGGAGAACTGCATTGAGCGGGCCCTCATCCTGG
GAGACGGTGATGTTGTCGGCCCCGGGGCGCTCCCGGACGGGCTGCGGGGAGGTGGCGCGGGGTGGGCTATGGTGGGCCCG
GACAACGACAATCTCTCCATCAAAAAGGCCGAGGAGCGGCTTGAGCGGGAGTTCATACGCCGCGCCCTCGAAAAGACCGG
CGGCAACCGCACCCACGCGGCCCGGATCCTGGAAATCAGCCACCGTGCTTTGCTCTACAAACTGAAAGAGTATGATATGG
AATAA

Upstream 100 bases:

>100_bases
TCGACGGGCGGATCACCGTGGAGAGCTCTGTGGGGAAGGGGACCACGTTTGTCATCTGGCTCCCGGTCGCCGGGAGCGTG
ACGGACAAAGGAATGGAGCA

Downstream 100 bases:

>100_bases
TGTTGGCACGTATTAATAAAATTGTTGTAATCTTACGAGGGCTGTGCAATTATTGCGCAGCCTTTTTTAATGTTATCCAT
GGGGGAGGTGCCGGGGATGG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKQRVLVIDDEENLRHMLGAMLRKNGYHADEAADGEQALAMAGEHPYDFIICDIRMPVLDGLGFLRRAQEAGIGGTIIMM
SAYGTIDTALQCMKEGAYDYVSKPFKNDEILLVLKKAEERERLKTENCRLRAEVAREYSFGAIVSRNPRMREIFELIRKV
CDVKTSVLVLGESGTGKELVARAIHHNGSRRDAPFVAVNCGAIPEHLLESELFGHVRGAFTDAASDRTGLFEEAHGGTLF
LDEIGEMPPSLQVKLLRVLQEGEVRRVGAERLSKVDVRVISATSRDLEREVAEGHFREDLFFRLNVVSITLPPLRERLED
VPLLAGHFLNKHGTSLGRPGARVSPEALRLLSAYAWPGNVRELENCIERALILGDGDVVGPGALPDGLRGGGAGWAMVGP
DNDNLSIKKAEERLEREFIRRALEKTGGNRTHAARILEISHRALLYKLKEYDME

Sequences:

>Translated_454_residues
MKQRVLVIDDEENLRHMLGAMLRKNGYHADEAADGEQALAMAGEHPYDFIICDIRMPVLDGLGFLRRAQEAGIGGTIIMM
SAYGTIDTALQCMKEGAYDYVSKPFKNDEILLVLKKAEERERLKTENCRLRAEVAREYSFGAIVSRNPRMREIFELIRKV
CDVKTSVLVLGESGTGKELVARAIHHNGSRRDAPFVAVNCGAIPEHLLESELFGHVRGAFTDAASDRTGLFEEAHGGTLF
LDEIGEMPPSLQVKLLRVLQEGEVRRVGAERLSKVDVRVISATSRDLEREVAEGHFREDLFFRLNVVSITLPPLRERLED
VPLLAGHFLNKHGTSLGRPGARVSPEALRLLSAYAWPGNVRELENCIERALILGDGDVVGPGALPDGLRGGGAGWAMVGP
DNDNLSIKKAEERLEREFIRRALEKTGGNRTHAARILEISHRALLYKLKEYDME
>Mature_454_residues
MKQRVLVIDDEENLRHMLGAMLRKNGYHADEAADGEQALAMAGEHPYDFIICDIRMPVLDGLGFLRRAQEAGIGGTIIMM
SAYGTIDTALQCMKEGAYDYVSKPFKNDEILLVLKKAEERERLKTENCRLRAEVAREYSFGAIVSRNPRMREIFELIRKV
CDVKTSVLVLGESGTGKELVARAIHHNGSRRDAPFVAVNCGAIPEHLLESELFGHVRGAFTDAASDRTGLFEEAHGGTLF
LDEIGEMPPSLQVKLLRVLQEGEVRRVGAERLSKVDVRVISATSRDLEREVAEGHFREDLFFRLNVVSITLPPLRERLED
VPLLAGHFLNKHGTSLGRPGARVSPEALRLLSAYAWPGNVRELENCIERALILGDGDVVGPGALPDGLRGGGAGWAMVGP
DNDNLSIKKAEERLEREFIRRALEKTGGNRTHAARILEISHRALLYKLKEYDME

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=45.9518599562363, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=43.8202247191011, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1790299, Length=472, Percent_Identity=41.3135593220339, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=41.7977528089888, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI87082117, Length=258, Percent_Identity=51.5503875968992, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=45.5128205128205, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1789087, Length=268, Percent_Identity=51.1194029850746, Blast_Score=258, Evalue=7e-70,
Organism=Escherichia coli, GI87082152, Length=301, Percent_Identity=45.8471760797342, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1786524, Length=326, Percent_Identity=44.7852760736196, Blast_Score=227, Evalue=9e-61,
Organism=Escherichia coli, GI1787583, Length=315, Percent_Identity=40.6349206349206, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081872, Length=306, Percent_Identity=38.2352941176471, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1789828, Length=284, Percent_Identity=34.8591549295775, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081858, Length=353, Percent_Identity=31.1614730878187, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1787375, Length=108, Percent_Identity=33.3333333333333, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=29.5081967213115, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=32.4074074074074, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50480; Mature: 50480

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRVLVIDDEENLRHMLGAMLRKNGYHADEAADGEQALAMAGEHPYDFIICDIRMPVLD
CCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECHHHHH
GLGFLRRAQEAGIGGTIIMMSAYGTIDTALQCMKEGAYDYVSKPFKNDEILLVLKKAEER
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCCEEEEEECHHHH
ERLKTENCRLRAEVAREYSFGAIVSRNPRMREIFELIRKVCDVKTSVLVLGESGTGKELV
HHHHHHCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
ARAIHHNGSRRDAPFVAVNCGAIPEHLLESELFGHVRGAFTDAASDRTGLFEEAHGGTLF
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEE
LDEIGEMPPSLQVKLLRVLQEGEVRRVGAERLSKVDVRVISATSRDLEREVAEGHFREDL
HHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHHCCCHHHCC
FFRLNVVSITLPPLRERLEDVPLLAGHFLNKHGTSLGRPGARVSPEALRLLSAYAWPGNV
EEEEEEEEEECHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCH
RELENCIERALILGDGDVVGPGALPDGLRGGGAGWAMVGPDNDNLSIKKAEERLEREFIR
HHHHHHHHHHEEECCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
RALEKTGGNRTHAARILEISHRALLYKLKEYDME
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQRVLVIDDEENLRHMLGAMLRKNGYHADEAADGEQALAMAGEHPYDFIICDIRMPVLD
CCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCEEEEEEECHHHHH
GLGFLRRAQEAGIGGTIIMMSAYGTIDTALQCMKEGAYDYVSKPFKNDEILLVLKKAEER
HHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCCEEEEEECHHHH
ERLKTENCRLRAEVAREYSFGAIVSRNPRMREIFELIRKVCDVKTSVLVLGESGTGKELV
HHHHHHCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHH
ARAIHHNGSRRDAPFVAVNCGAIPEHLLESELFGHVRGAFTDAASDRTGLFEEAHGGTLF
HHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEE
LDEIGEMPPSLQVKLLRVLQEGEVRRVGAERLSKVDVRVISATSRDLEREVAEGHFREDL
HHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHHCCCHHHCC
FFRLNVVSITLPPLRERLEDVPLLAGHFLNKHGTSLGRPGARVSPEALRLLSAYAWPGNV
EEEEEEEEEECHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCH
RELENCIERALILGDGDVVGPGALPDGLRGGGAGWAMVGPDNDNLSIKKAEERLEREFIR
HHHHHHHHHHEEECCCCEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
RALEKTGGNRTHAARILEISHRALLYKLKEYDME
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]