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The map label for this gene is rmlA1 [H]

Identifier: 78222144

GI number: 78222144

Start: 1018777

End: 1019685

Strand: Direct

Name: rmlA1 [H]

Synonym: Gmet_0924

Alternate gene names: 78222144

Gene position: 1018777-1019685 (Clockwise)

Preceding gene: 78222143

Following gene: 78222145

Centisome position: 25.49

GC content: 62.27

Gene sequence:

>909_bases
ATGGCCATCAAGAAGGGTATCATCCTCGCCGGCGGCGCCGGCAGCCGCCTCTATCCCCTTACCCTCGTTGCCAGCAAGCA
GTTGCAGCCGGTCTACGACAAGCCGATGATCTACTATCCCCTGGCCACCCTCATGATGGCAGGGATCAGTGACATCCTCA
TCATCTCTACCCCCCATGACACCCCCCGCTTCCAGTCGCTCCTCGGCGACGGCTCCCGCTGGGGGATCCGGCTCACCTAC
AAGGTGCAGCCCGAGCCCAAGGGAATTGCCCAGGCATTCCTGGTGGGGGAGGAGTTCATTGCCGGCGATCCGGTCTGTCT
CATCCTCGGCGACAACATCTTCTACGGCAAGATGGGGCTCGACCGGGCCATCCGCGATTTCGCCGGAGGCGCCCTTGTCT
TCGGCTACTACGTGAACGACCCCGAACGGTACGGGGTGGTGCAGTTCGACGGTTCCGGCAAGGCCATCGGCATCGAGGAG
AAACCGGCTGCCCCCAAGAGCAACTACGCCGTGCCAGGGCTCTACCTCTACGACGGGAAGGTTTCTGAGATCGCCCGCAA
TCTTGCCCCTTCCGCCCGGGGGGAGCTGGAGATCACCGACGTGAACCTGGAGTACCTGCGGCGGGGCGAACTCATGGTGG
AAAAGCTCGGCCGGGGAATCGCCTGGCTCGACACCGGCACCCACCAGAGTCTCCTGGAGGCATCCCACTTCATCGGCACC
CTGGAGGCCCGGCAGGGTCTCAAGATCGCCTGTCTCGAAGAGATAGCCCTGAGGATGGGGTATATCGACTGTCGCAAGAT
GGCGGAGGTGATTGCCGCCACTCCCAACTCCTCGTACCGGGAATACCTGGTGCGGGTCCATAACGAAACAAACCTGTGCG
GAGGGCATGACGATGCAAAACTTTCCTGA

Upstream 100 bases:

>100_bases
CCAGAAGGGGGGAGTTACGGTTTGACGCTCTTTTCCCTGCTGTGCTATAACCGCTTGTCAGAAGGACCATTTTGATTCAA
TCCCCGGTATGGAGTTCGTA

Downstream 100 bases:

>100_bases
GTTCAAGAAAGGGAAGATTCACGATGTAGCGGTGCGCCCCTTGACGAAATTCCTCGACGAGCGGGGGTGGCTCGCCGAAC
TGTTCCGCAGCGATGAAACC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MAIKKGIILAGGAGSRLYPLTLVASKQLQPVYDKPMIYYPLATLMMAGISDILIISTPHDTPRFQSLLGDGSRWGIRLTY
KVQPEPKGIAQAFLVGEEFIAGDPVCLILGDNIFYGKMGLDRAIRDFAGGALVFGYYVNDPERYGVVQFDGSGKAIGIEE
KPAAPKSNYAVPGLYLYDGKVSEIARNLAPSARGELEITDVNLEYLRRGELMVEKLGRGIAWLDTGTHQSLLEASHFIGT
LEARQGLKIACLEEIALRMGYIDCRKMAEVIAATPNSSYREYLVRVHNETNLCGGHDDAKLS

Sequences:

>Translated_302_residues
MAIKKGIILAGGAGSRLYPLTLVASKQLQPVYDKPMIYYPLATLMMAGISDILIISTPHDTPRFQSLLGDGSRWGIRLTY
KVQPEPKGIAQAFLVGEEFIAGDPVCLILGDNIFYGKMGLDRAIRDFAGGALVFGYYVNDPERYGVVQFDGSGKAIGIEE
KPAAPKSNYAVPGLYLYDGKVSEIARNLAPSARGELEITDVNLEYLRRGELMVEKLGRGIAWLDTGTHQSLLEASHFIGT
LEARQGLKIACLEEIALRMGYIDCRKMAEVIAATPNSSYREYLVRVHNETNLCGGHDDAKLS
>Mature_301_residues
AIKKGIILAGGAGSRLYPLTLVASKQLQPVYDKPMIYYPLATLMMAGISDILIISTPHDTPRFQSLLGDGSRWGIRLTYK
VQPEPKGIAQAFLVGEEFIAGDPVCLILGDNIFYGKMGLDRAIRDFAGGALVFGYYVNDPERYGVVQFDGSGKAIGIEEK
PAAPKSNYAVPGLYLYDGKVSEIARNLAPSARGELEITDVNLEYLRRGELMVEKLGRGIAWLDTGTHQSLLEASHFIGTL
EARQGLKIACLEEIALRMGYIDCRKMAEVIAATPNSSYREYLVRVHNETNLCGGHDDAKLS

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=293, Percent_Identity=62.7986348122867, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1790224, Length=285, Percent_Identity=58.9473684210526, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI133931050, Length=181, Percent_Identity=28.1767955801105, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=26.4822134387352, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33035; Mature: 32903

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKKGIILAGGAGSRLYPLTLVASKQLQPVYDKPMIYYPLATLMMAGISDILIISTPHD
CCCCCCEEEECCCCCCEEEEEEEECCCCCCCCCCCEEEHHHHHHHHCCCCCEEEEECCCC
TPRFQSLLGDGSRWGIRLTYKVQPEPKGIAQAFLVGEEFIAGDPVCLILGDNIFYGKMGL
CHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHCCHHHCCCCEEEEEECCEEEECCCH
DRAIRDFAGGALVFGYYVNDPERYGVVQFDGSGKAIGIEEKPAAPKSNYAVPGLYLYDGK
HHHHHHHCCCEEEEEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEEEEECCC
VSEIARNLAPSARGELEITDVNLEYLRRGELMVEKLGRGIAWLDTGTHQSLLEASHFIGT
HHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHEE
LEARQGLKIACLEEIALRMGYIDCRKMAEVIAATPNSSYREYLVRVHNETNLCGGHDDAK
HHHCCCCEEEHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCCCCC
LS
CC
>Mature Secondary Structure 
AIKKGIILAGGAGSRLYPLTLVASKQLQPVYDKPMIYYPLATLMMAGISDILIISTPHD
CCCCCEEEECCCCCCEEEEEEEECCCCCCCCCCCEEEHHHHHHHHCCCCCEEEEECCCC
TPRFQSLLGDGSRWGIRLTYKVQPEPKGIAQAFLVGEEFIAGDPVCLILGDNIFYGKMGL
CHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHCCHHHCCCCEEEEEECCEEEECCCH
DRAIRDFAGGALVFGYYVNDPERYGVVQFDGSGKAIGIEEKPAAPKSNYAVPGLYLYDGK
HHHHHHHCCCEEEEEEEECCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCEEEEECCC
VSEIARNLAPSARGELEITDVNLEYLRRGELMVEKLGRGIAWLDTGTHQSLLEASHFIGT
HHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHEE
LEARQGLKIACLEEIALRMGYIDCRKMAEVIAATPNSSYREYLVRVHNETNLCGGHDDAK
HHHCCCCEEEHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCCCCCCCCC
LS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]