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The map label for this gene is hldE

Identifier: 78222142

GI number: 78222142

Start: 1016630

End: 1018102

Strand: Direct

Name: hldE

Synonym: Gmet_0922

Alternate gene names: 78222142

Gene position: 1016630-1018102 (Clockwise)

Preceding gene: 78222141

Following gene: 78222143

Centisome position: 25.43

GC content: 64.49

Gene sequence:

>1473_bases
ATGGAACGCAAAAACGTCGAATCGCTCTTCGCCCATGCCCGGGATATCAACGCCCTTGTCATCGGCGACCTGATGCTTGA
CGAGTACCTCTGGGGAAGGGCCGAGCGCATATCCCCCGAGGCCCCGGTGCAGGTGCTCGACGTGACCCGGGAGGAAGTCC
GCATCGGAGGCGCCGGCAACGTGGCCAACAACCTGGTGGCCCTGGGGTGCCGGGTGAGCGTCGCCAGTGTCGTGGGGGGA
GACGAGAACGGCACGATCCTTCTCCATGCATTCTCCGGCAAGGGGGTCGACGTGTCGGGGGTTTTTGAGGACCCGCAGCG
GACCACAAGCCGCAAGACCCGCGTGGTGGCGGCCAACCAGCAGATCGTCCGGATCGACCGGGAGTCCCGCGATCCCATCG
GGGCCGGTTACGAGGAGAAGATCGTTGGTTTCCTCCGGGAGCAGGGAAGCCGGTTCAATGTGATCCTCATCTCCGATTAC
CTGAAGGGGGTACTCACCCCGACGCTTCTGGCCGCGGTGATCGCCGTTGCCCGGGAGCGGAAGATACCGGTGGTGGTGGA
TCCCAAGGGGAACGATTACACCAAGTACCGGGGCGCCACGCTCCTCACCCCGAACCGCAAGGAGGCCGAGGCAGCGTCGG
GGATCGCCATTCGCGACGAGGCGAGCCTTTGCAGGGCCGGCGAGCGGCTTCTGGCAACGGCCGACCTCACGGCCCTCGTC
ATTACCCGAAGCGAGGAGGGGATGTCTCTCTTTCTGCGCGACGGCGGCGTGGTCCACATTCCCACCTTCGCCCGGGAGGT
GTTCGACGTGACCGGCGCCGGCGACACGGTGCTGGCAATACTGGGGCTGGCCCTTGCCTGCGGGGTCGGATTCGCCGATG
CGGCAGGGCTCGCCAATGTGGCGGCGGGGATAGCGGTGGGGAAGGTGGGAACCTCCACGGTGTCGCCCGCCGAGGTTATC
GGCTCCATGGGGTTCCAGCACTCCGACAGCGATGCCAAGATCAAGAACCTGGACGGCCTGGCCGGGATCATCGAAGCGGA
AAAGGCGAGGGGGAAGAAGATCGTCTTCACCAACGGTTGCTTCGACCTCCTCCACGTGGGGCACGTAAAGTATCTCCAGA
AGGCAAAAAGCTATGGCGACGTTCTGGTGCTGGGGCTCAACAGTGATGCCTCGGTCCGCCGGCTCAAGGGGGAGAAGCGT
CCCCTCATCGACGAGGCCGAGCGGGCCCACATCCTGGCGGCCCTCGACTGCATCGACTACGTGGTTATTTTCGACGAGGA
CACCCCGCTGCGCCTCATCGAAACCCTGAAGCCGGCGGTCCTCGTCAAGGGGGGAGACTATACGCCGGAAGGGGTCGTGG
GGAAGGATGTGGTGGAGTCCTACGGCGGCAGGGTCGAGCTCGTGACCTTCGTGGATGGCCGCTCCACCACGAACATCATC
GATAAGATTCTGAGGGCCTATGGTGAGGAGTGA

Upstream 100 bases:

>100_bases
CGGCCACCACGAGATCATGCTTCCGCTTCTGGCCGCGGCGATCTTGGACCGGTTGAACTGAACGAGGGGCGCCCTGAGGG
CGCCCTTGGAGAGAGGACGC

Downstream 100 bases:

>100_bases
GGAGGGCCGCGCGGCCGTCTTTCTTGACCGGGACGGCACCATCAACGTGGAGAAGGAGTACCTCCACCGGGCCGAGGAGT
TCGAGTTCGTCCCCGGGGCG

Product: D-beta-D-heptose 1-phosphate adenylyltransferase/D-alpha,beta-D-heptose 7-phosphate 1-kinase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MERKNVESLFAHARDINALVIGDLMLDEYLWGRAERISPEAPVQVLDVTREEVRIGGAGNVANNLVALGCRVSVASVVGG
DENGTILLHAFSGKGVDVSGVFEDPQRTTSRKTRVVAANQQIVRIDRESRDPIGAGYEEKIVGFLREQGSRFNVILISDY
LKGVLTPTLLAAVIAVARERKIPVVVDPKGNDYTKYRGATLLTPNRKEAEAASGIAIRDEASLCRAGERLLATADLTALV
ITRSEEGMSLFLRDGGVVHIPTFAREVFDVTGAGDTVLAILGLALACGVGFADAAGLANVAAGIAVGKVGTSTVSPAEVI
GSMGFQHSDSDAKIKNLDGLAGIIEAEKARGKKIVFTNGCFDLLHVGHVKYLQKAKSYGDVLVLGLNSDASVRRLKGEKR
PLIDEAERAHILAALDCIDYVVIFDEDTPLRLIETLKPAVLVKGGDYTPEGVVGKDVVESYGGRVELVTFVDGRSTTNII
DKILRAYGEE

Sequences:

>Translated_490_residues
MERKNVESLFAHARDINALVIGDLMLDEYLWGRAERISPEAPVQVLDVTREEVRIGGAGNVANNLVALGCRVSVASVVGG
DENGTILLHAFSGKGVDVSGVFEDPQRTTSRKTRVVAANQQIVRIDRESRDPIGAGYEEKIVGFLREQGSRFNVILISDY
LKGVLTPTLLAAVIAVARERKIPVVVDPKGNDYTKYRGATLLTPNRKEAEAASGIAIRDEASLCRAGERLLATADLTALV
ITRSEEGMSLFLRDGGVVHIPTFAREVFDVTGAGDTVLAILGLALACGVGFADAAGLANVAAGIAVGKVGTSTVSPAEVI
GSMGFQHSDSDAKIKNLDGLAGIIEAEKARGKKIVFTNGCFDLLHVGHVKYLQKAKSYGDVLVLGLNSDASVRRLKGEKR
PLIDEAERAHILAALDCIDYVVIFDEDTPLRLIETLKPAVLVKGGDYTPEGVVGKDVVESYGGRVELVTFVDGRSTTNII
DKILRAYGEE
>Mature_490_residues
MERKNVESLFAHARDINALVIGDLMLDEYLWGRAERISPEAPVQVLDVTREEVRIGGAGNVANNLVALGCRVSVASVVGG
DENGTILLHAFSGKGVDVSGVFEDPQRTTSRKTRVVAANQQIVRIDRESRDPIGAGYEEKIVGFLREQGSRFNVILISDY
LKGVLTPTLLAAVIAVARERKIPVVVDPKGNDYTKYRGATLLTPNRKEAEAASGIAIRDEASLCRAGERLLATADLTALV
ITRSEEGMSLFLRDGGVVHIPTFAREVFDVTGAGDTVLAILGLALACGVGFADAAGLANVAAGIAVGKVGTSTVSPAEVI
GSMGFQHSDSDAKIKNLDGLAGIIEAEKARGKKIVFTNGCFDLLHVGHVKYLQKAKSYGDVLVLGLNSDASVRRLKGEKR
PLIDEAERAHILAALDCIDYVVIFDEDTPLRLIETLKPAVLVKGGDYTPEGVVGKDVVESYGGRVELVTFVDGRSTTNII
DKILRAYGEE

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family

Homologues:

Organism=Escherichia coli, GI1789432, Length=469, Percent_Identity=43.4968017057569, Blast_Score=359, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921220, Length=75, Percent_Identity=45.3333333333333, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550973, Length=75, Percent_Identity=45.3333333333333, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550974, Length=75, Percent_Identity=45.3333333333333, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550975, Length=75, Percent_Identity=45.3333333333333, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLDE_GEOMG (Q39X60)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383889.1
- HSSP:   O05155
- ProteinModelPortal:   Q39X60
- SMR:   Q39X60
- STRING:   Q39X60
- GeneID:   3740078
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0922
- NMPDR:   fig|269799.3.peg.997
- eggNOG:   COG2870
- HOGENOM:   HBG545535
- OMA:   LTPNRKE
- PhylomeDB:   Q39X60
- ProtClustDB:   CLSK828725
- BioCyc:   GMET269799:GMET_0922-MONOMER
- HAMAP:   MF_01603
- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR02198
- TIGRFAMs:   TIGR02199

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB

EC number: 2.7.-.-

Molecular weight: Translated: 52332; Mature: 52332

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2

Important sites: ACT_SITE 275-275

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKNVESLFAHARDINALVIGDLMLDEYLWGRAERISPEAPVQVLDVTREEVRIGGAGN
CCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCHHCCCCCCCCHHEECCHHHEEECCCCC
VANNLVALGCRVSVASVVGGDENGTILLHAFSGKGVDVSGVFEDPQRTTSRKTRVVAANQ
HHHCCEEEECCEEEEHHCCCCCCCEEEEEEECCCCCEEECCCCCCHHHHCCCEEEEECCC
QIVRIDRESRDPIGAGYEEKIVGFLREQGSRFNVILISDYLKGVLTPTLLAAVIAVARER
EEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCC
KIPVVVDPKGNDYTKYRGATLLTPNRKEAEAASGIAIRDEASLCRAGERLLATADLTALV
CCCEEECCCCCCCCEECCEEEECCCCCHHHHHCCEEEECCHHHHHCCCCEEEECCEEEEE
ITRSEEGMSLFLRDGGVVHIPTFAREVFDVTGAGDTVLAILGLALACGVGFADAAGLANV
EEECCCCCEEEEECCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AAGIAVGKVGTSTVSPAEVIGSMGFQHSDSDAKIKNLDGLAGIIEAEKARGKKIVFTNGC
HHHHEECCCCCCCCCHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHCCCCEEEEECCC
FDLLHVGHVKYLQKAKSYGDVLVLGLNSDASVRRLKGEKRPLIDEAERAHILAALDCIDY
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHEEE
VVIFDEDTPLRLIETLKPAVLVKGGDYTPEGVVGKDVVESYGGRVELVTFVDGRSTTNII
EEEECCCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCCEEEEEEEECCCCHHHHH
DKILRAYGEE
HHHHHHHCCC
>Mature Secondary Structure
MERKNVESLFAHARDINALVIGDLMLDEYLWGRAERISPEAPVQVLDVTREEVRIGGAGN
CCCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCHHCCCCCCCCHHEECCHHHEEECCCCC
VANNLVALGCRVSVASVVGGDENGTILLHAFSGKGVDVSGVFEDPQRTTSRKTRVVAANQ
HHHCCEEEECCEEEEHHCCCCCCCEEEEEEECCCCCEEECCCCCCHHHHCCCEEEEECCC
QIVRIDRESRDPIGAGYEEKIVGFLREQGSRFNVILISDYLKGVLTPTLLAAVIAVARER
EEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCC
KIPVVVDPKGNDYTKYRGATLLTPNRKEAEAASGIAIRDEASLCRAGERLLATADLTALV
CCCEEECCCCCCCCEECCEEEECCCCCHHHHHCCEEEECCHHHHHCCCCEEEECCEEEEE
ITRSEEGMSLFLRDGGVVHIPTFAREVFDVTGAGDTVLAILGLALACGVGFADAAGLANV
EEECCCCCEEEEECCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
AAGIAVGKVGTSTVSPAEVIGSMGFQHSDSDAKIKNLDGLAGIIEAEKARGKKIVFTNGC
HHHHEECCCCCCCCCHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHHCCCCEEEEECCC
FDLLHVGHVKYLQKAKSYGDVLVLGLNSDASVRRLKGEKRPLIDEAERAHILAALDCIDY
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHEEE
VVIFDEDTPLRLIETLKPAVLVKGGDYTPEGVVGKDVVESYGGRVELVTFVDGRSTTNII
EEEECCCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCCEEEEEEEECCCCHHHHH
DKILRAYGEE
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA