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The map label for this gene is proC [H]

Identifier: 78222119

GI number: 78222119

Start: 988961

End: 989773

Strand: Reverse

Name: proC [H]

Synonym: Gmet_0899

Alternate gene names: 78222119

Gene position: 989773-988961 (Counterclockwise)

Preceding gene: 78222120

Following gene: 78222108

Centisome position: 24.76

GC content: 66.54

Gene sequence:

>813_bases
ATGCTGAAGGGATGCAGAGTGGGGTTCATCGGCGGCGGCAACATGGCGGAGGCGATCATCAGGGGACTTCTGGCCGGCGG
GGTAACGGCGGCGGAACTGGTGGTGGCGGAGCCCATGGCCGAGCGGCGGGAATTTCTGCGGGAGACCTACGGTATTGATG
CCCGTGCCGACAACGGCGAGGTGGCCACGATGACCGACGCCCTGATCGTTGCCGTGAAGCCCCAGGTATTTCGGGGCATG
GCTGCGGCCCTCGGGGCAGCAGGCTTTGCCGGGAAGCTCGTCATCTCCATCATGGCGGGGATATCCATCAACGGCATCGA
GGAGGTCTGCGGCGACTCTTCCCGGGTGATCCGGGTCATGCCGAACACGCCGGCCCTGGTGCTGGAGGGGGCCTCGGCCC
TCTCCCGAGGGAAGAACGCCACCGACGACGATTTGTTCTTCGCCCAGGGAATCTTCGAGCTGGTGGGAACCACCTGCGTC
GTGGACGAGAAACTCATGGATGCCGTCACCGGCCTCTCGGGGAGCGGGCCTGCCTACGTGTTCATGTTCATCGAGGCCCT
CTCCGATGCCGGCGTGAAGAACGGCCTCCCCCGCGACGTAGCAACCCGCCTTGCGGCCCAGACGGTCCTGGGCTCCGCGA
GACTCCTTCTGGAGACCGGCGACCACCCCGGAGTCCTCAAGGAAAAGGTCACCTCCCCCGGCGGCACCACCATCGCCGGC
GTAGCCGCCTTGGAACGGGGCTCCTTCCGGGGGACGGTCATGGCGGCCGTGGACGCGGCCACCGCCCGCTCTGCCGAGTT
GGGGAAAAAATAA

Upstream 100 bases:

>100_bases
CCTGCAAGTGGCGCTATATCACACACTTGGCGACTTGCCAGAACCCCTGTGTCACCACAGATTCTGCTAAAGAGCCACTT
TTTTTTGAGGAGGAACGGCG

Downstream 100 bases:

>100_bases
CGACTTTTAGCCACAGAGGACACAGAGGGCCACAGAGAAGAACCTTCAAGGAATAAGGACGTCTATCCGCACCGCCGATG
AATCCTGTATTTGATCAGGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MLKGCRVGFIGGGNMAEAIIRGLLAGGVTAAELVVAEPMAERREFLRETYGIDARADNGEVATMTDALIVAVKPQVFRGM
AAALGAAGFAGKLVISIMAGISINGIEEVCGDSSRVIRVMPNTPALVLEGASALSRGKNATDDDLFFAQGIFELVGTTCV
VDEKLMDAVTGLSGSGPAYVFMFIEALSDAGVKNGLPRDVATRLAAQTVLGSARLLLETGDHPGVLKEKVTSPGGTTIAG
VAALERGSFRGTVMAAVDAATARSAELGKK

Sequences:

>Translated_270_residues
MLKGCRVGFIGGGNMAEAIIRGLLAGGVTAAELVVAEPMAERREFLRETYGIDARADNGEVATMTDALIVAVKPQVFRGM
AAALGAAGFAGKLVISIMAGISINGIEEVCGDSSRVIRVMPNTPALVLEGASALSRGKNATDDDLFFAQGIFELVGTTCV
VDEKLMDAVTGLSGSGPAYVFMFIEALSDAGVKNGLPRDVATRLAAQTVLGSARLLLETGDHPGVLKEKVTSPGGTTIAG
VAALERGSFRGTVMAAVDAATARSAELGKK
>Mature_270_residues
MLKGCRVGFIGGGNMAEAIIRGLLAGGVTAAELVVAEPMAERREFLRETYGIDARADNGEVATMTDALIVAVKPQVFRGM
AAALGAAGFAGKLVISIMAGISINGIEEVCGDSSRVIRVMPNTPALVLEGASALSRGKNATDDDLFFAQGIFELVGTTCV
VDEKLMDAVTGLSGSGPAYVFMFIEALSDAGVKNGLPRDVATRLAAQTVLGSARLLLETGDHPGVLKEKVTSPGGTTIAG
VAALERGSFRGTVMAAVDAATARSAELGKK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=40, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=42.3220973782771, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=42.3220973782771, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=41.1985018726592, Blast_Score=186, Evalue=1e-47,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=41.1320754716981, Blast_Score=201, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=44.1947565543071, Blast_Score=211, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=36.2007168458781, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=246, Percent_Identity=32.520325203252, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=43.0711610486891, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=42.9090909090909, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=50.2923976608187, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27645; Mature: 27645

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGCRVGFIGGGNMAEAIIRGLLAGGVTAAELVVAEPMAERREFLRETYGIDARADNGE
CCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
VATMTDALIVAVKPQVFRGMAAALGAAGFAGKLVISIMAGISINGIEEVCGDSSRVIRVM
EEEEEEEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEC
PNTPALVLEGASALSRGKNATDDDLFFAQGIFELVGTTCVVDEKLMDAVTGLSGSGPAYV
CCCCEEEEECCHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHH
FMFIEALSDAGVKNGLPRDVATRLAAQTVLGSARLLLETGDHPGVLKEKVTSPGGTTIAG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCCHHHH
VAALERGSFRGTVMAAVDAATARSAELGKK
HHHHHCCCCCCCEEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKGCRVGFIGGGNMAEAIIRGLLAGGVTAAELVVAEPMAERREFLRETYGIDARADNGE
CCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCC
VATMTDALIVAVKPQVFRGMAAALGAAGFAGKLVISIMAGISINGIEEVCGDSSRVIRVM
EEEEEEEEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEC
PNTPALVLEGASALSRGKNATDDDLFFAQGIFELVGTTCVVDEKLMDAVTGLSGSGPAYV
CCCCEEEEECCHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHH
FMFIEALSDAGVKNGLPRDVATRLAAQTVLGSARLLLETGDHPGVLKEKVTSPGGTTIAG
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHCCCCCCHHHH
VAALERGSFRGTVMAAVDAATARSAELGKK
HHHHHCCCCCCCEEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]