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The map label for this gene is arnA [H]

Identifier: 78222103

GI number: 78222103

Start: 972445

End: 973485

Strand: Reverse

Name: arnA [H]

Synonym: Gmet_0883

Alternate gene names: 78222103

Gene position: 973485-972445 (Counterclockwise)

Preceding gene: 78222104

Following gene: 78222102

Centisome position: 24.35

GC content: 60.33

Gene sequence:

>1041_bases
ATGAAAATCCTCATCCTCGGCGTCAACGGCTTCATCGGCAACGCCCTCACCAAACGCATCCTCGACACCACCGACTGGGA
GGTGTACGGCCTCGACATGAGCGACAACAAGCTCGAGCACTCCATCGGCCACCCCCGCTTCCACTTCCTGGAAGGTGACA
TCACCATCAACAAGGAGTGGATCGAGTACAACATCAAGAAGTGCGACGTGGTCCTCCCCCTGGTGGCCATCGCCACGCCG
GTCACCTACGTGAAGGACCCGCTCCGGGTCTTCGAGCTCGACTTCGAGGAGAACCTCAAGATCATCCGCCAGTGCGTGAA
GTACAAGAAGCGGGTCATCTTCCCCTCCACCTCCGAGGTCTACGGCATGAGCCCGGACCGGGAGTTCGACGAGGAGAACT
CGCCCCTCATGCTCGGCCCCATCAACAAGCAGCGCTGGATATACTCCTGCGCCAAGCAGATGCTCGACCGGGTGATCTAC
GCCTACGGCGAGCAGGAGGGGCTGCGCTACACCCTGTTCCGCCCCTTCAACTGGATCGGTCCGAAGCTGGATTCCATCTC
CACCGCCAAGGAGGGAAGCTCCCGGGTCCTGACCCAGTTTCTCTACAACATCCTGGCCGGCGAGCCGATCCAGCTCGTGG
ACGGCGGCAACCAGCGCCGCTCCTTCACCTTCGTGGAGGACGGCATCGACTGCCTCATGAAAATCATCGAGAACAAGGAC
GGGAGCGCCGACGGCGGCATCTTCAACATCGGCAATCCGGGGAACGACCTGTCGGTGAAGGAACTGGCGGAGAAACTGAT
CACCCTGGTAAAGGAGTATCCCGCCTACCGCGACAGGGCCGAGGCATGCAGGATCATCGAGGTTTCCTCCGGCCAGTTCT
ACGGCAAGGGGTACCAGGACATGCTGACCCGCGTCCCCTCCGTGAAGAACGCCAAGGCGCGGCTTGGCTGGGAGCCGAAG
ACCGTCATCGACGACGCACTGCGGAAGACCCTCGACTTTTATCTGATAGAAGAAAAAGAGAAGATCGAACACCTGCTGTG
A

Upstream 100 bases:

>100_bases
TTTTCCGCCATCGTCCACCCCGCAGGGAAAAGGTTTGCAAACCCATAGCATCACCGTCGGCAGGATTGCCGCCGGTCACA
TTTTACCCACTGGAGATACC

Downstream 100 bases:

>100_bases
AAATGCCGCTTTTCCGCCATCTCGGCGTTGTCGTTCGGAATCACCTTGTGCGGCGTAGCCCTGCTACGCCTCCGCGGGAT
CCCTCCTCCGCCTTGACCTT

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKILILGVNGFIGNALTKRILDTTDWEVYGLDMSDNKLEHSIGHPRFHFLEGDITINKEWIEYNIKKCDVVLPLVAIATP
VTYVKDPLRVFELDFEENLKIIRQCVKYKKRVIFPSTSEVYGMSPDREFDEENSPLMLGPINKQRWIYSCAKQMLDRVIY
AYGEQEGLRYTLFRPFNWIGPKLDSISTAKEGSSRVLTQFLYNILAGEPIQLVDGGNQRRSFTFVEDGIDCLMKIIENKD
GSADGGIFNIGNPGNDLSVKELAEKLITLVKEYPAYRDRAEACRIIEVSSGQFYGKGYQDMLTRVPSVKNAKARLGWEPK
TVIDDALRKTLDFYLIEEKEKIEHLL

Sequences:

>Translated_346_residues
MKILILGVNGFIGNALTKRILDTTDWEVYGLDMSDNKLEHSIGHPRFHFLEGDITINKEWIEYNIKKCDVVLPLVAIATP
VTYVKDPLRVFELDFEENLKIIRQCVKYKKRVIFPSTSEVYGMSPDREFDEENSPLMLGPINKQRWIYSCAKQMLDRVIY
AYGEQEGLRYTLFRPFNWIGPKLDSISTAKEGSSRVLTQFLYNILAGEPIQLVDGGNQRRSFTFVEDGIDCLMKIIENKD
GSADGGIFNIGNPGNDLSVKELAEKLITLVKEYPAYRDRAEACRIIEVSSGQFYGKGYQDMLTRVPSVKNAKARLGWEPK
TVIDDALRKTLDFYLIEEKEKIEHLL
>Mature_346_residues
MKILILGVNGFIGNALTKRILDTTDWEVYGLDMSDNKLEHSIGHPRFHFLEGDITINKEWIEYNIKKCDVVLPLVAIATP
VTYVKDPLRVFELDFEENLKIIRQCVKYKKRVIFPSTSEVYGMSPDREFDEENSPLMLGPINKQRWIYSCAKQMLDRVIY
AYGEQEGLRYTLFRPFNWIGPKLDSISTAKEGSSRVLTQFLYNILAGEPIQLVDGGNQRRSFTFVEDGIDCLMKIIENKD
GSADGGIFNIGNPGNDLSVKELAEKLITLVKEYPAYRDRAEACRIIEVSSGQFYGKGYQDMLTRVPSVKNAKARLGWEPK
TVIDDALRKTLDFYLIEEKEKIEHLL

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=336, Percent_Identity=27.9761904761905, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI7657641, Length=346, Percent_Identity=24.2774566473988, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1788589, Length=334, Percent_Identity=57.4850299401198, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17539532, Length=345, Percent_Identity=27.2463768115942, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21356223, Length=337, Percent_Identity=26.4094955489614, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 39640; Mature: 39640

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILILGVNGFIGNALTKRILDTTDWEVYGLDMSDNKLEHSIGHPRFHFLEGDITINKEW
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCEEEEEECCEEEEHHH
IEYNIKKCDVVLPLVAIATPVTYVKDPLRVFELDFEENLKIIRQCVKYKKRVIFPSTSEV
HHCCCHHHHHHHHHHHHHCCHHHHHCCHHEEECCHHHHHHHHHHHHHHHHEEECCCCCCC
YGMSPDREFDEENSPLMLGPINKQRWIYSCAKQMLDRVIYAYGEQEGLRYTLFRPFNWIG
CCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
PKLDSISTAKEGSSRVLTQFLYNILAGEPIQLVDGGNQRRSFTFVEDGIDCLMKIIENKD
CCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCC
GSADGGIFNIGNPGNDLSVKELAEKLITLVKEYPAYRDRAEACRIIEVSSGQFYGKGYQD
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCCCCCCCCHHH
MLTRVPSVKNAKARLGWEPKTVIDDALRKTLDFYLIEEKEKIEHLL
HHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHCC
>Mature Secondary Structure
MKILILGVNGFIGNALTKRILDTTDWEVYGLDMSDNKLEHSIGHPRFHFLEGDITINKEW
CEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCEEEEEECCEEEEHHH
IEYNIKKCDVVLPLVAIATPVTYVKDPLRVFELDFEENLKIIRQCVKYKKRVIFPSTSEV
HHCCCHHHHHHHHHHHHHCCHHHHHCCHHEEECCHHHHHHHHHHHHHHHHEEECCCCCCC
YGMSPDREFDEENSPLMLGPINKQRWIYSCAKQMLDRVIYAYGEQEGLRYTLFRPFNWIG
CCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
PKLDSISTAKEGSSRVLTQFLYNILAGEPIQLVDGGNQRRSFTFVEDGIDCLMKIIENKD
CCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHCCC
GSADGGIFNIGNPGNDLSVKELAEKLITLVKEYPAYRDRAEACRIIEVSSGQFYGKGYQD
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCCCCCCCCHHH
MLTRVPSVKNAKARLGWEPKTVIDDALRKTLDFYLIEEKEKIEHLL
HHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA